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GSE58827: Dynamics of the Mouse Liver

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Results for Bhlhe40

Z-value: 0.49

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Transcription factors associated with Bhlhe40

Gene Symbol Gene ID Gene Info
Bhlhe40
ENSMUSG00000030103.12 basic helix-loop-helix family, member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Bhlhe40mm39_v1_chr6_+_108637816_1086378350.538.9e-04Click!

Activity profile of Bhlhe40 motif

Sorted Z-values of Bhlhe40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_135039745 1.35 ENSMUST00000116527.2
Bex4
brain expressed X-linked 4
chr19_-_60779077 1.16 ENSMUST00000025955.8
Eif3a
eukaryotic translation initiation factor 3, subunit A
chr4_+_148123554 1.06 ENSMUST00000141283.8
Mthfr
methylenetetrahydrofolate reductase
chr12_+_3476857 0.88 ENSMUST00000111215.10
ENSMUST00000092003.12
ENSMUST00000144247.9
ENSMUST00000153102.9
Asxl2
ASXL transcriptional regulator 2
chr16_-_43959361 0.80 ENSMUST00000124102.8
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr7_-_35502392 0.79 ENSMUST00000187282.3
ENSMUST00000205670.2
ENSMUST00000061586.11
Zfp507
zinc finger protein 507
chr7_+_82297803 0.76 ENSMUST00000141726.8
ENSMUST00000179489.8
ENSMUST00000039881.4
Efl1
elongation factor like GTPase 1
chr8_+_85763780 0.72 ENSMUST00000211601.2
ENSMUST00000166592.2
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chrX_-_7054952 0.72 ENSMUST00000004428.14
Clcn5
chloride channel, voltage-sensitive 5
chr2_-_37593856 0.71 ENSMUST00000155237.2
Strbp
spermatid perinuclear RNA binding protein
chr11_-_75239084 0.69 ENSMUST00000000767.6
ENSMUST00000092907.12
Rpa1
replication protein A1
chr4_+_148123490 0.68 ENSMUST00000097788.11
Mthfr
methylenetetrahydrofolate reductase
chr1_+_87254729 0.68 ENSMUST00000172794.8
ENSMUST00000164992.9
ENSMUST00000173173.8
Gigyf2
GRB10 interacting GYF protein 2
chrX_-_135104589 0.66 ENSMUST00000066819.11
Tceal5
transcription elongation factor A (SII)-like 5
chr6_+_72074545 0.66 ENSMUST00000069994.11
ENSMUST00000114112.4
St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr11_+_55095144 0.65 ENSMUST00000108872.9
ENSMUST00000147506.8
ENSMUST00000020499.14
Slc36a1
solute carrier family 36 (proton/amino acid symporter), member 1
chr11_+_97340962 0.65 ENSMUST00000107601.8
Arhgap23
Rho GTPase activating protein 23
chr9_+_107879700 0.63 ENSMUST00000035214.11
ENSMUST00000176854.7
ENSMUST00000175874.2
Ip6k1
inositol hexaphosphate kinase 1
chr17_-_12988492 0.63 ENSMUST00000024599.14
Igf2r
insulin-like growth factor 2 receptor
chr16_-_43959993 0.63 ENSMUST00000137557.8
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr10_-_62322451 0.63 ENSMUST00000217868.2
Vps26a
VPS26 retromer complex component A
chr2_+_84669739 0.62 ENSMUST00000146816.8
ENSMUST00000028469.14
Slc43a1
solute carrier family 43, member 1
chr18_-_21029135 0.56 ENSMUST00000097658.2
ENSMUST00000225661.3
Trappc8
trafficking protein particle complex 8
chr16_+_43960183 0.55 ENSMUST00000159514.8
ENSMUST00000161326.8
ENSMUST00000063520.15
ENSMUST00000063542.8
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr11_-_117671436 0.50 ENSMUST00000026659.10
ENSMUST00000127227.2
Tmc6
transmembrane channel-like gene family 6
chr1_+_58432629 0.50 ENSMUST00000186949.2
Bzw1
basic leucine zipper and W2 domains 1
chrX_+_133501928 0.49 ENSMUST00000074950.11
ENSMUST00000113203.2
ENSMUST00000113202.8
ENSMUST00000050331.13
ENSMUST00000059297.6
Hnrnph2
heterogeneous nuclear ribonucleoprotein H2
chr8_+_85763534 0.46 ENSMUST00000093360.12
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr14_-_78774201 0.46 ENSMUST00000123853.9
Akap11
A kinase (PRKA) anchor protein 11
chr1_-_152642073 0.46 ENSMUST00000111857.3
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr14_+_26300693 0.46 ENSMUST00000203874.3
ENSMUST00000037585.9
Dennd6a
DENN/MADD domain containing 6A
chr5_-_72325482 0.45 ENSMUST00000196241.2
ENSMUST00000013693.11
Commd8
COMM domain containing 8
chr4_-_45084564 0.42 ENSMUST00000052236.13
Fbxo10
F-box protein 10
chrX_-_135104386 0.42 ENSMUST00000151592.8
ENSMUST00000131510.2
Tceal5
transcription elongation factor A (SII)-like 5
chr6_+_116314975 0.41 ENSMUST00000079012.13
ENSMUST00000101032.10
ENSMUST00000123405.8
ENSMUST00000204657.3
ENSMUST00000203116.2
ENSMUST00000203193.3
ENSMUST00000126376.8
Marchf8
membrane associated ring-CH-type finger 8
chr1_-_136888118 0.41 ENSMUST00000192357.6
ENSMUST00000027649.14
Nr5a2
nuclear receptor subfamily 5, group A, member 2
chr16_-_43959559 0.40 ENSMUST00000063661.13
ENSMUST00000114666.9
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr12_-_79343040 0.39 ENSMUST00000218377.2
ENSMUST00000021547.8
Zfyve26
zinc finger, FYVE domain containing 26
chr3_-_31023547 0.38 ENSMUST00000064718.12
ENSMUST00000177992.8
ENSMUST00000129817.9
ENSMUST00000168645.8
ENSMUST00000108255.8
ENSMUST00000099163.5
Phc3
polyhomeotic 3
chr19_+_29499671 0.37 ENSMUST00000043610.13
Ric1
RAB6A GEF complex partner 1
chr7_+_128346655 0.37 ENSMUST00000042942.10
Sec23ip
Sec23 interacting protein
chr16_+_4867876 0.37 ENSMUST00000230703.2
ENSMUST00000052449.6
Ubn1
ubinuclein 1
chr11_+_49094292 0.37 ENSMUST00000150284.8
ENSMUST00000109197.8
ENSMUST00000151228.2
Zfp62
zinc finger protein 62
chr6_-_35110560 0.35 ENSMUST00000202143.4
ENSMUST00000114993.9
ENSMUST00000114989.9
ENSMUST00000044163.10
ENSMUST00000202417.2
Cnot4
CCR4-NOT transcription complex, subunit 4
chrX_+_67722390 0.31 ENSMUST00000114654.8
ENSMUST00000114655.8
ENSMUST00000114657.9
ENSMUST00000114653.2
Fmr1
FMRP translational regulator 1
chr8_+_41692755 0.30 ENSMUST00000210862.2
ENSMUST00000045218.9
ENSMUST00000211247.2
Pcm1
pericentriolar material 1
chr5_+_104194383 0.30 ENSMUST00000150226.8
Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr4_-_48473403 0.30 ENSMUST00000164866.2
ENSMUST00000030030.15
Tex10
testis expressed gene 10
chr5_-_123711098 0.29 ENSMUST00000031388.13
Vps33a
VPS33A CORVET/HOPS core subunit
chr10_-_62322356 0.27 ENSMUST00000092473.5
Vps26a
VPS26 retromer complex component A
chr3_-_96634769 0.27 ENSMUST00000141377.8
ENSMUST00000125183.2
Polr3c
polymerase (RNA) III (DNA directed) polypeptide C
chr11_-_109986763 0.26 ENSMUST00000046223.14
ENSMUST00000106664.10
ENSMUST00000106662.2
Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr11_+_75239259 0.26 ENSMUST00000044530.3
Smyd4
SET and MYND domain containing 4
chr3_+_138233004 0.24 ENSMUST00000196990.5
ENSMUST00000200239.5
ENSMUST00000200100.2
Eif4e
eukaryotic translation initiation factor 4E
chr3_+_96634974 0.24 ENSMUST00000029740.14
Rnf115
ring finger protein 115
chr10_-_62322551 0.23 ENSMUST00000105447.11
Vps26a
VPS26 retromer complex component A
chr1_-_152642032 0.23 ENSMUST00000111859.8
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chrX_-_112095181 0.23 ENSMUST00000026607.15
ENSMUST00000113388.3
Chm
choroidermia (RAB escort protein 1)
chr4_-_141518202 0.22 ENSMUST00000038014.11
ENSMUST00000153880.2
Dnajc16
DnaJ heat shock protein family (Hsp40) member C16
chr11_-_94544748 0.22 ENSMUST00000039949.5
Eme1
essential meiotic structure-specific endonuclease 1
chr2_+_144210881 0.21 ENSMUST00000028911.15
ENSMUST00000147747.8
ENSMUST00000183618.3
Kat14
Pet117
lysine acetyltransferase 14
PET117 homolog
chr5_+_104194930 0.21 ENSMUST00000134313.8
Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr9_-_13738204 0.19 ENSMUST00000147115.8
Cep57
centrosomal protein 57
chr11_-_109986804 0.19 ENSMUST00000100287.9
Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr15_+_84807640 0.19 ENSMUST00000230411.2
Nup50
nucleoporin 50
chr11_+_49094119 0.19 ENSMUST00000109198.8
ENSMUST00000137061.9
Zfp62
zinc finger protein 62
chr12_+_86993805 0.17 ENSMUST00000189246.7
Cipc
CLOCK interacting protein, circadian
chr7_-_82297676 0.16 ENSMUST00000207693.2
ENSMUST00000056728.5
ENSMUST00000156720.8
ENSMUST00000126478.2
Saxo2
stabilizer of axonemal microtubules 2
chr15_+_66449385 0.16 ENSMUST00000230882.2
ENSMUST00000048188.10
ENSMUST00000230948.2
ENSMUST00000229160.2
Phf20l1
PHD finger protein 20-like 1
chr1_+_87254719 0.16 ENSMUST00000027475.15
Gigyf2
GRB10 interacting GYF protein 2
chr4_-_136776006 0.16 ENSMUST00000049583.8
Zbtb40
zinc finger and BTB domain containing 40
chrX_+_152615221 0.15 ENSMUST00000148708.2
ENSMUST00000123264.2
ENSMUST00000049999.9
Spin2c
spindlin family, member 2C
chr18_+_77153332 0.14 ENSMUST00000114776.4
ENSMUST00000168882.9
Pias2
protein inhibitor of activated STAT 2
chr8_+_26091607 0.13 ENSMUST00000155861.8
Nsd3
nuclear receptor binding SET domain protein 3
chr5_+_104194735 0.13 ENSMUST00000031250.14
Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr9_-_13738304 0.12 ENSMUST00000148086.8
ENSMUST00000034398.12
Cep57
centrosomal protein 57
chr15_+_84807582 0.11 ENSMUST00000165443.4
Nup50
nucleoporin 50
chr16_-_43960045 0.11 ENSMUST00000147025.2
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr4_+_134195631 0.11 ENSMUST00000030636.11
ENSMUST00000127279.8
ENSMUST00000105867.8
Stmn1
stathmin 1
chr3_-_95014090 0.10 ENSMUST00000005768.8
ENSMUST00000107232.9
ENSMUST00000107236.9
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr10_-_17898977 0.09 ENSMUST00000020002.9
Abracl
ABRA C-terminal like
chr9_-_53578729 0.09 ENSMUST00000166367.8
ENSMUST00000034529.14
Cul5
cullin 5
chr8_+_111760521 0.09 ENSMUST00000034441.8
Aars
alanyl-tRNA synthetase
chr11_-_75345482 0.09 ENSMUST00000173320.8
Wdr81
WD repeat domain 81
chr19_-_4251589 0.08 ENSMUST00000237923.2
ENSMUST00000025740.8
ENSMUST00000237723.2
Rad9a
RAD9 checkpoint clamp component A
chr18_+_77152890 0.08 ENSMUST00000114777.10
Pias2
protein inhibitor of activated STAT 2
chr14_-_51162346 0.08 ENSMUST00000159292.8
Osgep
O-sialoglycoprotein endopeptidase
chr11_-_51891575 0.06 ENSMUST00000109086.8
Ube2b
ubiquitin-conjugating enzyme E2B
chr14_-_51162083 0.06 ENSMUST00000160375.8
ENSMUST00000162177.8
Osgep
O-sialoglycoprotein endopeptidase
chr12_+_86994117 0.06 ENSMUST00000187814.7
ENSMUST00000038369.11
Cipc
CLOCK interacting protein, circadian
chr5_-_137531463 0.05 ENSMUST00000170293.8
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr1_-_75195127 0.03 ENSMUST00000079464.13
Tuba4a
tubulin, alpha 4A
chr11_+_99764215 0.01 ENSMUST00000093936.5
Krtap9-1
keratin associated protein 9-1
chr19_-_53378990 0.01 ENSMUST00000025997.7
Smndc1
survival motor neuron domain containing 1
chr5_-_137531413 0.01 ENSMUST00000168746.8
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr1_+_166081755 0.00 ENSMUST00000194964.6
ENSMUST00000192638.6
ENSMUST00000192426.6
ENSMUST00000195557.6
ENSMUST00000192732.6
ENSMUST00000193860.2
Ildr2
immunoglobulin-like domain containing receptor 2
chr3_+_85481416 0.00 ENSMUST00000107672.8
ENSMUST00000127348.8
ENSMUST00000107674.2
Gatb
glutamyl-tRNA(Gln) amidotransferase, subunit B

Network of associatons between targets according to the STRING database.

First level regulatory network of Bhlhe40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0070829 heterochromatin maintenance(GO:0070829)
0.3 1.2 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.2 0.6 GO:0046032 ADP catabolic process(GO:0046032)
0.2 0.9 GO:1900157 regulation of bone mineralization involved in bone maturation(GO:1900157)
0.1 0.8 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 1.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.6 GO:0015808 L-alanine transport(GO:0015808)
0.1 1.9 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 0.2 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.1 0.5 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.1 0.6 GO:0030242 pexophagy(GO:0030242)
0.0 0.6 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.6 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 1.1 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.4 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.7 GO:0006298 mismatch repair(GO:0006298)
0.0 0.8 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.3 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.0 0.4 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.6 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.7 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.2 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.3 GO:0034453 microtubule anchoring(GO:0034453)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0043614 multi-eIF complex(GO:0043614)
0.2 1.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 1.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.4 GO:0034066 RIC1-RGP1 guanyl-nucleotide exchange factor complex(GO:0034066)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.6 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.3 GO:0000242 pericentriolar material(GO:0000242)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.2 0.7 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.2 0.6 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
0.1 0.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.6 GO:0052724 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.2 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.1 0.6 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.9 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.7 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.1 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 0.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors