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GSE58827: Dynamics of the Mouse Liver

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Results for Cbfb

Z-value: 0.33

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Transcription factors associated with Cbfb

Gene Symbol Gene ID Gene Info
Cbfb
ENSMUSG00000031885.15 core binding factor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Cbfbmm39_v1_chr8_+_105897300_1058974460.307.4e-02Click!

Activity profile of Cbfb motif

Sorted Z-values of Cbfb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_192946359 1.77 ENSMUST00000161737.8
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
chr13_-_96028412 0.95 ENSMUST00000068603.8
Iqgap2
IQ motif containing GTPase activating protein 2
chr1_-_140111138 0.93 ENSMUST00000111976.9
ENSMUST00000066859.13
Cfh
complement component factor h
chr14_+_101967343 0.65 ENSMUST00000100337.10
Lmo7
LIM domain only 7
chr5_+_104582978 0.64 ENSMUST00000086833.13
ENSMUST00000031243.15
ENSMUST00000112748.8
ENSMUST00000112746.8
ENSMUST00000145084.8
ENSMUST00000132457.8
Spp1
secreted phosphoprotein 1
chr11_-_73217298 0.56 ENSMUST00000155630.9
Aspa
aspartoacylase
chr5_+_90666791 0.55 ENSMUST00000113179.9
ENSMUST00000128740.2
Afm
afamin
chr15_+_99290832 0.54 ENSMUST00000160635.8
ENSMUST00000161250.8
ENSMUST00000229392.2
ENSMUST00000161778.8
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr15_-_102112657 0.53 ENSMUST00000231030.2
ENSMUST00000230687.2
ENSMUST00000229514.2
ENSMUST00000229345.2
Csad
cysteine sulfinic acid decarboxylase
chr15_+_99291100 0.52 ENSMUST00000159209.8
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr11_-_73217633 0.52 ENSMUST00000134079.2
Aspa
aspartoacylase
chr15_+_99291491 0.51 ENSMUST00000159531.3
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr15_+_99291455 0.47 ENSMUST00000162624.8
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr1_-_174749379 0.46 ENSMUST00000055294.4
Grem2
gremlin 2, DAN family BMP antagonist
chr1_+_151631088 0.44 ENSMUST00000188145.7
ENSMUST00000059498.12
Edem3
ER degradation enhancer, mannosidase alpha-like 3
chr6_+_113460258 0.37 ENSMUST00000032422.6
Creld1
cysteine-rich with EGF-like domains 1
chr10_+_128769642 0.36 ENSMUST00000099112.4
ENSMUST00000218290.2
Itga7
integrin alpha 7
chr12_+_95658987 0.35 ENSMUST00000057324.4
Flrt2
fibronectin leucine rich transmembrane protein 2
chr17_-_64638887 0.33 ENSMUST00000172818.8
Pja2
praja ring finger ubiquitin ligase 2
chr14_-_65187287 0.32 ENSMUST00000067843.10
ENSMUST00000176489.8
ENSMUST00000175905.8
ENSMUST00000022544.14
ENSMUST00000175744.8
ENSMUST00000176128.8
Hmbox1
homeobox containing 1
chr17_-_64638814 0.32 ENSMUST00000172733.2
Pja2
praja ring finger ubiquitin ligase 2
chr15_-_9529898 0.20 ENSMUST00000228782.2
ENSMUST00000003981.6
Il7r
interleukin 7 receptor
chr8_+_91555449 0.19 ENSMUST00000109614.9
Chd9
chromodomain helicase DNA binding protein 9
chrX_+_98179725 0.18 ENSMUST00000052839.7
Efnb1
ephrin B1
chr9_-_48391838 0.17 ENSMUST00000216470.2
ENSMUST00000217037.2
ENSMUST00000034524.5
ENSMUST00000213895.2
Rexo2
RNA exonuclease 2
chr1_-_63215812 0.17 ENSMUST00000185847.2
ENSMUST00000185732.7
ENSMUST00000188370.7
ENSMUST00000168099.9
Ndufs1
NADH:ubiquinone oxidoreductase core subunit S1
chrX_-_100777806 0.16 ENSMUST00000056614.7
Cxcr3
chemokine (C-X-C motif) receptor 3
chr9_+_66033893 0.15 ENSMUST00000034945.6
Ciao2a
cytosolic iron-sulfur assembly component 2A
chr16_-_16950241 0.14 ENSMUST00000023453.10
Sdf2l1
stromal cell-derived factor 2-like 1
chr8_+_3403415 0.14 ENSMUST00000098966.5
ENSMUST00000239102.2
Arhgef18
rho/rac guanine nucleotide exchange factor (GEF) 18
chr8_+_84852609 0.13 ENSMUST00000093380.5
Podnl1
podocan-like 1
chr5_+_24628802 0.13 ENSMUST00000153274.2
ENSMUST00000141966.8
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr19_+_5100815 0.13 ENSMUST00000224178.2
ENSMUST00000225799.3
ENSMUST00000025818.8
Rin1
Ras and Rab interactor 1
chr10_+_69761784 0.12 ENSMUST00000181974.8
ENSMUST00000182795.8
ENSMUST00000182437.8
Ank3
ankyrin 3, epithelial
chr2_+_35022178 0.11 ENSMUST00000113034.8
ENSMUST00000113037.10
ENSMUST00000150807.6
ENSMUST00000113033.6
Cntrl
centriolin
chr4_-_6990774 0.10 ENSMUST00000039987.4
Tox
thymocyte selection-associated high mobility group box
chr11_-_108234743 0.10 ENSMUST00000059595.11
Prkca
protein kinase C, alpha
chr19_+_5100475 0.10 ENSMUST00000225427.2
Rin1
Ras and Rab interactor 1
chrX_+_21581135 0.09 ENSMUST00000033414.8
Slc6a14
solute carrier family 6 (neurotransmitter transporter), member 14
chr18_+_69633741 0.09 ENSMUST00000207214.2
ENSMUST00000201094.4
ENSMUST00000200703.4
ENSMUST00000202765.4
Tcf4
transcription factor 4
chr1_-_74924481 0.08 ENSMUST00000159232.2
ENSMUST00000068631.4
Fev
FEV transcription factor, ETS family member
chr15_+_98687720 0.07 ENSMUST00000023734.8
Wnt1
wingless-type MMTV integration site family, member 1
chr9_-_51076724 0.07 ENSMUST00000210433.2
Gm32742
predicted gene, 32742
chr6_-_69037208 0.07 ENSMUST00000103343.4
Igkv4-78
immunoglobulin kappa variable 4-78
chr11_+_115331365 0.06 ENSMUST00000093914.5
Trim80
tripartite motif-containing 80
chr6_+_136931519 0.06 ENSMUST00000137768.2
Pde6h
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr16_-_38253507 0.05 ENSMUST00000002926.8
Pla1a
phospholipase A1 member A
chr11_+_20581952 0.05 ENSMUST00000109586.3
Sertad2
SERTA domain containing 2
chr7_-_46445305 0.04 ENSMUST00000107653.8
ENSMUST00000107654.8
ENSMUST00000014562.14
ENSMUST00000152759.8
Hps5
HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
chr11_+_108812474 0.03 ENSMUST00000144511.2
Axin2
axin 2
chr15_-_101778130 0.03 ENSMUST00000087996.7
Krt77
keratin 77
chr4_+_132903646 0.02 ENSMUST00000105912.2
Wasf2
WASP family, member 2
chr16_-_92622972 0.02 ENSMUST00000023673.14
Runx1
runt related transcription factor 1
chr3_-_151960948 0.01 ENSMUST00000199423.5
ENSMUST00000198460.5
Nexn
nexilin
chr2_+_153780138 0.01 ENSMUST00000109757.8
ENSMUST00000154281.3
Bpifb4
BPI fold containing family B, member 4
chr4_+_10874498 0.01 ENSMUST00000080517.14
2610301B20Rik
RIKEN cDNA 2610301B20 gene
chr4_+_10874537 0.01 ENSMUST00000101504.3
2610301B20Rik
RIKEN cDNA 2610301B20 gene
chr11_-_59266483 0.00 ENSMUST00000061481.7
Prss38
protease, serine 38
chr3_+_82265474 0.00 ENSMUST00000195471.6
ENSMUST00000195640.2
Map9
microtubule-associated protein 9
chr6_+_129385816 0.00 ENSMUST00000058352.15
ENSMUST00000088075.8
Clec9a
C-type lectin domain family 9, member a

Network of associatons between targets according to the STRING database.

First level regulatory network of Cbfb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0006713 glucocorticoid catabolic process(GO:0006713)
0.4 2.0 GO:1904720 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.2 0.6 GO:2000863 positive regulation of estrogen secretion(GO:2000863)
0.2 1.1 GO:0006083 acetate metabolic process(GO:0006083)
0.2 0.5 GO:0060300 regulation of cytokine activity(GO:0060300)
0.1 0.5 GO:0042412 taurine biosynthetic process(GO:0042412)
0.1 0.9 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.1 0.4 GO:1904382 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.1 0.9 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.1 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.0 0.3 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.1 GO:1904954 Spemann organizer formation(GO:0060061) positive regulation of dermatome development(GO:0061184) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.6 GO:0035329 hippo signaling(GO:0035329)
0.0 0.2 GO:1900118 negative regulation of execution phase of apoptosis(GO:1900118)
0.0 0.3 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.1 GO:0051611 regulation of serotonin uptake(GO:0051611)
0.0 0.6 GO:0051180 vitamin transport(GO:0051180)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.0 1.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.9 GO:0031941 filamentous actin(GO:0031941)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.4 1.1 GO:0019807 aspartoacylase activity(GO:0019807)
0.3 2.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.2 0.6 GO:0008431 vitamin E binding(GO:0008431)
0.1 0.9 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.5 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.1 0.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.5 GO:0036122 BMP binding(GO:0036122)
0.0 0.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.6 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.2 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 1.8 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism