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GSE58827: Dynamics of the Mouse Liver

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Results for E2f8

Z-value: 2.18

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Transcription factors associated with E2f8

Gene Symbol Gene ID Gene Info
E2f8
ENSMUSG00000046179.18 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f8mm39_v1_chr7_-_48531344_485313670.906.4e-14Click!

Activity profile of E2f8 motif

Sorted Z-values of E2f8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_162896602 60.49 ENSMUST00000018005.10
Mybl2
myeloblastosis oncogene-like 2
chr3_-_90603013 46.77 ENSMUST00000069960.12
ENSMUST00000117167.2
S100a9
S100 calcium binding protein A9 (calgranulin B)
chr8_+_75836187 33.62 ENSMUST00000164309.3
ENSMUST00000212426.2
ENSMUST00000212811.2
Mcm5
minichromosome maintenance complex component 5
chr1_-_128287347 24.66 ENSMUST00000190495.2
ENSMUST00000027601.11
Mcm6
minichromosome maintenance complex component 6
chr6_-_88875646 22.28 ENSMUST00000058011.8
Mcm2
minichromosome maintenance complex component 2
chr12_+_24758724 19.66 ENSMUST00000153058.8
Rrm2
ribonucleotide reductase M2
chr12_+_24758968 17.89 ENSMUST00000154588.2
Rrm2
ribonucleotide reductase M2
chr17_+_56610321 16.94 ENSMUST00000001258.15
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr7_-_44198157 15.81 ENSMUST00000145956.2
ENSMUST00000049343.15
Pold1
polymerase (DNA directed), delta 1, catalytic subunit
chr10_+_127851031 14.78 ENSMUST00000178041.8
ENSMUST00000026461.8
Prim1
DNA primase, p49 subunit
chr17_+_56610396 14.69 ENSMUST00000113038.8
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr17_+_56347424 12.92 ENSMUST00000002914.10
Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr16_-_15455141 12.62 ENSMUST00000023353.4
Mcm4
minichromosome maintenance complex component 4
chr8_+_57964956 12.51 ENSMUST00000210871.2
Hmgb2
high mobility group box 2
chr5_+_123887759 11.94 ENSMUST00000031366.12
Kntc1
kinetochore associated 1
chr5_-_33809640 11.57 ENSMUST00000151081.2
ENSMUST00000139518.8
ENSMUST00000101354.10
Slbp
stem-loop binding protein
chr16_-_18630365 10.98 ENSMUST00000096990.10
Cdc45
cell division cycle 45
chr4_+_132495636 9.75 ENSMUST00000102561.11
Rpa2
replication protein A2
chr5_-_33809683 9.60 ENSMUST00000075670.13
Slbp
stem-loop binding protein
chr15_+_61857226 9.52 ENSMUST00000161976.8
ENSMUST00000022971.8
Myc
myelocytomatosis oncogene
chr15_+_61857390 9.39 ENSMUST00000159327.2
ENSMUST00000167731.8
Myc
myelocytomatosis oncogene
chr5_-_33809872 9.09 ENSMUST00000057551.14
Slbp
stem-loop binding protein
chr6_+_35154319 8.22 ENSMUST00000201374.4
ENSMUST00000043815.16
Nup205
nucleoporin 205
chr15_+_78810919 7.46 ENSMUST00000089377.6
Lgals1
lectin, galactose binding, soluble 1
chr7_+_109721230 7.29 ENSMUST00000033326.10
Wee1
WEE 1 homolog 1 (S. pombe)
chr7_-_48531344 6.64 ENSMUST00000119223.2
E2f8
E2F transcription factor 8
chr1_-_93729650 6.21 ENSMUST00000027503.14
Dtymk
deoxythymidylate kinase
chr17_+_88282472 6.19 ENSMUST00000005503.5
Msh6
mutS homolog 6
chr2_-_154411765 6.09 ENSMUST00000103145.11
E2f1
E2F transcription factor 1
chr7_+_101714943 5.84 ENSMUST00000094130.4
ENSMUST00000084843.10
Xndc1
Xntrpc
Xrcc1 N-terminal domain containing 1
Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough
chr7_-_48530777 5.45 ENSMUST00000058745.15
E2f8
E2F transcription factor 8
chr10_-_128361731 5.34 ENSMUST00000026427.8
Esyt1
extended synaptotagmin-like protein 1
chr8_-_107792264 5.24 ENSMUST00000034393.7
Tmed6
transmembrane p24 trafficking protein 6
chr7_-_115423934 4.77 ENSMUST00000169129.8
Sox6
SRY (sex determining region Y)-box 6
chr2_-_154411640 4.76 ENSMUST00000000894.6
E2f1
E2F transcription factor 1
chr10_-_21036792 4.66 ENSMUST00000188495.8
Myb
myeloblastosis oncogene
chr6_+_35154545 4.65 ENSMUST00000170234.2
Nup205
nucleoporin 205
chr16_+_10652910 4.64 ENSMUST00000037913.9
Rmi2
RecQ mediated genome instability 2
chr9_-_36637923 4.56 ENSMUST00000034625.12
Chek1
checkpoint kinase 1
chr7_+_101714692 4.38 ENSMUST00000106950.8
ENSMUST00000146450.8
Xndc1
Xrcc1 N-terminal domain containing 1
chr10_-_21036824 4.26 ENSMUST00000020158.9
Myb
myeloblastosis oncogene
chr2_-_34803988 4.13 ENSMUST00000028232.7
ENSMUST00000202907.2
Phf19
PHD finger protein 19
chr16_-_18066591 3.85 ENSMUST00000115645.10
Ranbp1
RAN binding protein 1
chr11_+_87938519 3.78 ENSMUST00000079866.11
Srsf1
serine and arginine-rich splicing factor 1
chr15_-_97991114 3.74 ENSMUST00000180657.2
Senp1
SUMO1/sentrin specific peptidase 1
chr9_-_36637670 3.45 ENSMUST00000172702.9
ENSMUST00000172742.2
Chek1
checkpoint kinase 1
chr19_+_38919353 3.38 ENSMUST00000025965.12
Hells
helicase, lymphoid specific
chr17_+_29020744 3.28 ENSMUST00000136233.2
Brpf3
bromodomain and PHD finger containing, 3
chr11_+_26337194 3.23 ENSMUST00000136830.2
ENSMUST00000109509.8
Fancl
Fanconi anemia, complementation group L
chr3_-_126792056 3.22 ENSMUST00000044443.15
Ank2
ankyrin 2, brain
chr2_-_45003270 3.21 ENSMUST00000202935.4
ENSMUST00000068415.11
ENSMUST00000127520.8
Zeb2
zinc finger E-box binding homeobox 2
chr15_+_101071948 3.13 ENSMUST00000000544.12
Acvr1b
activin A receptor, type 1B
chr5_-_65492940 2.98 ENSMUST00000203471.3
ENSMUST00000172732.8
ENSMUST00000204965.3
Rfc1
replication factor C (activator 1) 1
chr13_+_44884740 2.83 ENSMUST00000173246.8
Jarid2
jumonji, AT rich interactive domain 2
chr6_+_38528738 2.77 ENSMUST00000161227.8
Luc7l2
LUC7-like 2 (S. cerevisiae)
chr2_-_45002902 2.74 ENSMUST00000076836.13
ENSMUST00000176732.8
ENSMUST00000200844.4
Zeb2
zinc finger E-box binding homeobox 2
chr11_+_79883885 2.64 ENSMUST00000163272.2
ENSMUST00000017692.15
Suz12
SUZ12 polycomb repressive complex 2 subunit
chr5_+_75312939 2.37 ENSMUST00000202681.4
ENSMUST00000000476.15
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr6_+_117893942 2.34 ENSMUST00000179478.8
Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr11_+_87938626 1.96 ENSMUST00000107920.10
Srsf1
serine and arginine-rich splicing factor 1
chr6_+_117894242 1.72 ENSMUST00000180020.8
ENSMUST00000177570.2
Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr13_+_19807274 1.49 ENSMUST00000222464.2
ENSMUST00000002883.7
Sfrp4
secreted frizzled-related protein 4
chr5_-_65492907 1.29 ENSMUST00000203581.3
Rfc1
replication factor C (activator 1) 1
chr2_-_157046386 1.26 ENSMUST00000029170.8
Rbl1
RB transcriptional corepressor like 1
chr1_+_131838294 1.10 ENSMUST00000062264.8
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr11_+_87938128 0.99 ENSMUST00000139129.9
Srsf1
serine and arginine-rich splicing factor 1
chr17_+_34128382 0.98 ENSMUST00000173028.8
ENSMUST00000079421.15
Daxx
Fas death domain-associated protein
chr4_-_126861918 0.96 ENSMUST00000106108.9
Zmym4
zinc finger, MYM-type 4
chr16_+_18066730 0.85 ENSMUST00000115640.8
ENSMUST00000140206.8
Trmt2a
TRM2 tRNA methyltransferase 2A
chr8_+_41379257 0.70 ENSMUST00000034004.10
Pdgfrl
platelet-derived growth factor receptor-like
chr10_+_59538467 0.69 ENSMUST00000171409.8
Micu1
mitochondrial calcium uptake 1
chr15_+_97990431 0.56 ENSMUST00000229280.2
ENSMUST00000163507.8
ENSMUST00000230445.2
Pfkm
phosphofructokinase, muscle
chr4_+_63133639 0.55 ENSMUST00000036300.13
Col27a1
collagen, type XXVII, alpha 1
chr1_-_172034354 0.55 ENSMUST00000013842.12
ENSMUST00000111247.8
Pea15a
phosphoprotein enriched in astrocytes 15A
chr15_+_55420795 0.54 ENSMUST00000022998.14
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr1_+_131838220 0.47 ENSMUST00000189946.7
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr17_+_34596098 0.45 ENSMUST00000080254.7
Btnl1
butyrophilin-like 1
chr17_+_34128455 0.44 ENSMUST00000173626.8
ENSMUST00000170075.9
Daxx
Fas death domain-associated protein
chr17_+_34129221 0.37 ENSMUST00000174541.9
Daxx
Fas death domain-associated protein
chr10_+_42736345 0.34 ENSMUST00000063063.14
Scml4
Scm polycomb group protein like 4
chr16_+_18066825 0.34 ENSMUST00000100099.10
Trmt2a
TRM2 tRNA methyltransferase 2A
chrX_-_41000746 0.23 ENSMUST00000047037.15
Thoc2
THO complex 2
chrX_+_152281200 0.22 ENSMUST00000060714.10
Ubqln2
ubiquilin 2
chr6_+_108760025 0.20 ENSMUST00000032196.9
Arl8b
ADP-ribosylation factor-like 8B
chrX_+_48559327 0.15 ENSMUST00000114904.10
Arhgap36
Rho GTPase activating protein 36
chr12_+_55883101 0.13 ENSMUST00000059250.8
Brms1l
breast cancer metastasis-suppressor 1-like
chr13_+_95012107 0.07 ENSMUST00000022195.13
Otp
orthopedia homeobox
chr3_+_32583681 0.06 ENSMUST00000147350.8
Mfn1
mitofusin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.6 46.8 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
5.3 15.8 GO:0045004 DNA replication proofreading(GO:0045004)
5.0 59.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
4.7 18.9 GO:0090096 lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
4.0 12.1 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
3.7 14.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
3.7 11.0 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
3.6 10.8 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
2.8 30.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
2.7 8.0 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
2.5 7.5 GO:0034118 erythrocyte aggregation(GO:0034117) regulation of erythrocyte aggregation(GO:0034118)
2.1 6.2 GO:0046072 dTDP biosynthetic process(GO:0006233) dTDP metabolic process(GO:0046072)
2.0 31.6 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
1.9 37.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.3 12.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
1.2 12.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.1 33.6 GO:0006270 DNA replication initiation(GO:0006270)
1.0 3.9 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.8 5.9 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.8 1.6 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.8 6.2 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.8 60.5 GO:0090307 mitotic spindle assembly(GO:0090307)
0.8 12.9 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.7 6.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.6 3.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.6 9.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.6 2.4 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.5 1.5 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.5 9.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.5 4.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.4 4.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.4 2.6 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.4 1.8 GO:0072737 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.4 3.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 3.7 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 1.0 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.6 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.1 4.6 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.1 0.5 GO:0045062 extrathymic T cell selection(GO:0045062)
0.1 0.2 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.6 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.1 0.7 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 7.9 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 0.2 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 3.0 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 4.8 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 1.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 5.3 GO:0006869 lipid transport(GO:0006869)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 60.5 GO:0031523 Myb complex(GO:0031523)
6.3 37.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
5.6 90.3 GO:0042555 MCM complex(GO:0042555)
4.0 11.9 GO:1990423 RZZ complex(GO:1990423)
3.8 30.3 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
3.7 11.0 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
3.2 12.9 GO:0033186 CAF-1 complex(GO:0033186)
3.2 15.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
2.2 10.8 GO:0035189 Rb-E2F complex(GO:0035189)
2.1 14.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.8 12.9 GO:0044611 nuclear pore inner ring(GO:0044611)
1.0 3.1 GO:0048179 activin receptor complex(GO:0048179)
0.8 53.7 GO:0005657 replication fork(GO:0005657)
0.7 6.2 GO:0032300 mismatch repair complex(GO:0032300)
0.4 3.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.4 18.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.3 7.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 5.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.2 3.9 GO:1904115 axon cytoplasm(GO:1904115)
0.2 6.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 3.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 2.8 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 0.7 GO:1990246 uniplex complex(GO:1990246)
0.1 1.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 6.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 3.2 GO:0031430 M band(GO:0031430)
0.1 43.7 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.8 GO:0001741 XY body(GO:0001741)
0.0 4.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 18.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 14.2 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.2 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 2.4 GO:0005902 microvillus(GO:0005902)
0.0 3.7 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 30.3 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
6.3 37.5 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
5.9 59.3 GO:0050786 RAGE receptor binding(GO:0050786)
5.8 69.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
4.9 14.8 GO:0003896 DNA primase activity(GO:0003896)
4.5 31.6 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
3.7 66.9 GO:0003688 DNA replication origin binding(GO:0003688)
2.1 6.2 GO:0004798 thymidylate kinase activity(GO:0004798)
2.1 6.2 GO:0032142 single guanine insertion binding(GO:0032142)
2.0 8.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.9 7.5 GO:0048030 disaccharide binding(GO:0048030)
1.2 12.9 GO:0070087 chromo shadow domain binding(GO:0070087)
1.0 6.7 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.9 3.7 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.9 37.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.9 15.8 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.8 2.4 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.7 9.8 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.4 3.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.4 12.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 4.3 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 2.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 18.9 GO:0070888 E-box binding(GO:0070888)
0.1 3.9 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 5.9 GO:0070412 R-SMAD binding(GO:0070412)
0.1 4.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 7.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 22.9 GO:0001047 core promoter binding(GO:0001047)
0.1 1.8 GO:0008432 JUN kinase binding(GO:0008432) SUMO binding(GO:0032183)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 3.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.2 GO:0030507 spectrin binding(GO:0030507)
0.0 4.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.4 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 15.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.3 46.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.2 132.9 PID E2F PATHWAY E2F transcription factor network
0.7 32.0 PID ATR PATHWAY ATR signaling pathway
0.2 21.5 PID CMYB PATHWAY C-MYB transcription factor network
0.1 7.5 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 2.4 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 5.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 1.8 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 4.3 PID FAS PATHWAY FAS (CD95) signaling pathway
0.1 3.7 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 104.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
3.8 37.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
2.3 30.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
2.2 69.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
2.1 25.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
2.1 14.8 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
1.3 15.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.0 12.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.5 18.9 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.4 12.9 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.2 6.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 6.7 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.2 3.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 3.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 8.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 3.9 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 2.4 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis