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GSE58827: Dynamics of the Mouse Liver

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Results for Egr4

Z-value: 0.69

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Transcription factors associated with Egr4

Gene Symbol Gene ID Gene Info
Egr4
ENSMUSG00000071341.5 early growth response 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr4mm39_v1_chr6_-_85490568_85490573-0.221.9e-01Click!

Activity profile of Egr4 motif

Sorted Z-values of Egr4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_142211203 12.90 ENSMUST00000097936.9
ENSMUST00000000033.12
Igf2
insulin-like growth factor 2
chr2_+_117942357 8.18 ENSMUST00000039559.9
Thbs1
thrombospondin 1
chr10_+_43455157 7.27 ENSMUST00000058714.10
Cd24a
CD24a antigen
chr11_+_94900677 6.50 ENSMUST00000055947.10
Samd14
sterile alpha motif domain containing 14
chr7_-_37806912 4.84 ENSMUST00000108023.10
Ccne1
cyclin E1
chr2_+_13579092 3.96 ENSMUST00000193675.2
Vim
vimentin
chr2_+_13578738 3.90 ENSMUST00000141365.3
ENSMUST00000028062.8
Vim
vimentin
chr16_+_93680783 3.32 ENSMUST00000023666.11
ENSMUST00000117099.8
Chaf1b
chromatin assembly factor 1, subunit B (p60)
chr1_+_135060431 2.81 ENSMUST00000187985.7
ENSMUST00000049449.11
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr19_-_5323092 2.78 ENSMUST00000237463.2
ENSMUST00000025786.9
Pacs1
phosphofurin acidic cluster sorting protein 1
chrX_-_74174608 2.68 ENSMUST00000033775.9
Mpp1
membrane protein, palmitoylated
chr10_+_19467697 2.62 ENSMUST00000020188.13
Ifngr1
interferon gamma receptor 1
chrX_-_74174524 2.50 ENSMUST00000114091.8
Mpp1
membrane protein, palmitoylated
chr7_-_16007542 2.49 ENSMUST00000169612.3
Inafm1
InaF motif containing 1
chr7_+_3341597 2.40 ENSMUST00000164553.8
Myadm
myeloid-associated differentiation marker
chr10_-_80413119 2.33 ENSMUST00000038558.9
Klf16
Kruppel-like factor 16
chr7_+_127503812 2.12 ENSMUST00000151451.3
ENSMUST00000124533.3
ENSMUST00000206745.2
ENSMUST00000206140.2
Bckdk
branched chain ketoacid dehydrogenase kinase
chr9_-_44145309 2.10 ENSMUST00000206720.2
Cbl
Casitas B-lineage lymphoma
chr7_+_29991101 2.08 ENSMUST00000150892.2
ENSMUST00000126216.2
ENSMUST00000014065.16
Clip3
CAP-GLY domain containing linker protein 3
chr8_+_110595216 1.87 ENSMUST00000179721.8
ENSMUST00000034175.5
Phlpp2
PH domain and leucine rich repeat protein phosphatase 2
chrX_-_144288071 1.83 ENSMUST00000112835.8
ENSMUST00000143610.3
Amot
angiomotin
chr9_-_44145280 1.77 ENSMUST00000205968.2
ENSMUST00000206147.2
ENSMUST00000037644.8
Cbl
Casitas B-lineage lymphoma
chr13_+_55593116 1.58 ENSMUST00000001115.16
ENSMUST00000224995.2
ENSMUST00000225925.2
ENSMUST00000099482.5
ENSMUST00000224118.2
Grk6
G protein-coupled receptor kinase 6
chr14_+_71127540 1.53 ENSMUST00000022699.10
Gfra2
glial cell line derived neurotrophic factor family receptor alpha 2
chr19_-_8763609 1.45 ENSMUST00000177216.8
ENSMUST00000176610.9
ENSMUST00000177056.8
Taf6l
TATA-box binding protein associated factor 6 like
chr13_-_55661240 1.43 ENSMUST00000069929.13
ENSMUST00000069968.13
ENSMUST00000131306.8
ENSMUST00000046246.13
Pdlim7
PDZ and LIM domain 7
chr10_+_128067934 1.42 ENSMUST00000055539.11
ENSMUST00000105244.8
ENSMUST00000105243.9
Timeless
timeless circadian clock 1
chr1_-_36978602 1.42 ENSMUST00000027290.12
Tmem131
transmembrane protein 131
chr1_-_97589365 1.32 ENSMUST00000153115.8
ENSMUST00000142234.2
Macir
macrophage immunometabolism regulator
chr11_-_86648309 1.16 ENSMUST00000060766.16
ENSMUST00000103186.11
Cltc
clathrin, heavy polypeptide (Hc)
chr2_+_124452194 1.13 ENSMUST00000051419.15
ENSMUST00000076335.12
ENSMUST00000078621.12
ENSMUST00000077847.12
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_+_180231038 0.91 ENSMUST00000029087.4
Ogfr
opioid growth factor receptor
chr16_+_93629009 0.90 ENSMUST00000044068.10
ENSMUST00000202261.5
ENSMUST00000201097.3
Morc3
microrchidia 3
chr19_-_8763771 0.87 ENSMUST00000176496.8
Taf6l
TATA-box binding protein associated factor 6 like
chr11_-_96668318 0.84 ENSMUST00000127375.2
ENSMUST00000021246.9
ENSMUST00000107661.10
Snx11
sorting nexin 11
chr6_+_85428464 0.84 ENSMUST00000032078.9
Cct7
chaperonin containing Tcp1, subunit 7 (eta)
chr2_+_124452493 0.81 ENSMUST00000103239.10
ENSMUST00000103240.9
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr14_-_79718890 0.76 ENSMUST00000022601.7
Wbp4
WW domain binding protein 4
chr5_+_145020910 0.75 ENSMUST00000124379.3
Arpc1a
actin related protein 2/3 complex, subunit 1A
chrX_+_7708295 0.73 ENSMUST00000115667.10
ENSMUST00000115668.10
ENSMUST00000115665.2
Otud5
OTU domain containing 5
chr11_-_18968955 0.69 ENSMUST00000068264.14
ENSMUST00000185131.8
Meis1
Meis homeobox 1
chr3_+_145630017 0.61 ENSMUST00000029842.9
Bcl10
B cell leukemia/lymphoma 10
chr9_+_114517812 0.60 ENSMUST00000047404.7
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr16_+_93680846 0.60 ENSMUST00000142316.2
Chaf1b
chromatin assembly factor 1, subunit B (p60)
chr6_-_85938613 0.58 ENSMUST00000032071.13
Dusp11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr6_-_85428207 0.49 ENSMUST00000113770.2
ENSMUST00000032080.9
Pradc1
protease-associated domain containing 1
chr14_+_76082736 0.49 ENSMUST00000142061.3
Tpt1
tumor protein, translationally-controlled 1
chr17_-_31877703 0.48 ENSMUST00000236475.2
ENSMUST00000166526.9
ENSMUST00000014684.6
U2af1
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
chr10_+_17931459 0.46 ENSMUST00000154718.8
ENSMUST00000126390.8
ENSMUST00000164556.8
ENSMUST00000150029.8
Reps1
RalBP1 associated Eps domain containing protein
chr8_-_126296495 0.44 ENSMUST00000212168.2
ENSMUST00000212987.2
Sipa1l2
signal-induced proliferation-associated 1 like 2
chr17_+_83658354 0.41 ENSMUST00000096766.12
ENSMUST00000049503.10
ENSMUST00000112363.10
ENSMUST00000234460.2
Eml4
echinoderm microtubule associated protein like 4
chr7_+_122977205 0.40 ENSMUST00000033025.7
ENSMUST00000206574.2
Lcmt1
leucine carboxyl methyltransferase 1
chr9_-_95393909 0.40 ENSMUST00000190019.2
ENSMUST00000185515.7
ENSMUST00000217176.2
ENSMUST00000079659.12
ENSMUST00000078374.13
U2surp
U2 snRNP-associated SURP domain containing
chr14_+_76082533 0.38 ENSMUST00000110894.9
Tpt1
tumor protein, translationally-controlled 1
chr14_+_79718604 0.34 ENSMUST00000040131.13
Elf1
E74-like factor 1
chr12_+_70872266 0.26 ENSMUST00000057859.9
Frmd6
FERM domain containing 6
chr9_+_65816206 0.25 ENSMUST00000205379.2
ENSMUST00000206048.2
ENSMUST00000034949.10
ENSMUST00000154589.2
Csnk1g1
casein kinase 1, gamma 1
chr17_+_26357648 0.22 ENSMUST00000074370.10
ENSMUST00000118904.9
ENSMUST00000163421.8
Axin1
axin 1
chr9_-_88613967 0.21 ENSMUST00000098486.4
Bcl2a1d
B cell leukemia/lymphoma 2 related protein A1d
chr1_-_4563821 0.21 ENSMUST00000191939.2
Sox17
SRY (sex determining region Y)-box 17
chr2_-_119308094 0.16 ENSMUST00000110808.2
ENSMUST00000049920.14
Ino80
INO80 complex subunit
chrX_+_99019176 0.13 ENSMUST00000113781.8
ENSMUST00000113783.8
ENSMUST00000113779.8
ENSMUST00000113776.8
ENSMUST00000113775.8
ENSMUST00000113780.8
ENSMUST00000113778.8
ENSMUST00000113777.8
ENSMUST00000071453.3
Eda
ectodysplasin-A
chr4_+_99812912 0.12 ENSMUST00000102783.5
Pgm1
phosphoglucomutase 1
chr7_-_66339319 0.10 ENSMUST00000124899.8
Asb7
ankyrin repeat and SOCS box-containing 7
chr9_+_108183996 0.10 ENSMUST00000194701.6
ENSMUST00000193490.2
Rhoa
ras homolog family member A
chr12_+_76417040 0.09 ENSMUST00000042779.4
Zbtb1
zinc finger and BTB domain containing 1
chr6_-_28261881 0.08 ENSMUST00000115320.8
ENSMUST00000123098.8
ENSMUST00000115321.9
ENSMUST00000155494.2
Zfp800
zinc finger protein 800
chr2_+_32425327 0.07 ENSMUST00000133512.2
ENSMUST00000048375.6
Fam102a
family with sequence similarity 102, member A
chr2_+_164627743 0.05 ENSMUST00000174070.8
ENSMUST00000172577.8
ENSMUST00000056181.7
Snx21
sorting nexin family member 21
chrX_-_151820545 0.05 ENSMUST00000051484.5
Mageh1
MAGE family member H1
chr14_+_84680993 0.03 ENSMUST00000071370.7
Pcdh17
protocadherin 17
chr11_-_18968979 0.01 ENSMUST00000144988.8
Meis1
Meis homeobox 1
chrX_+_48559327 0.00 ENSMUST00000114904.10
Arhgap36
Rho GTPase activating protein 36

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.2 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752)
2.4 7.3 GO:0034118 erythrocyte aggregation(GO:0034117) regulation of erythrocyte aggregation(GO:0034118)
1.1 12.9 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
1.0 7.9 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.6 1.8 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.4 1.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.4 3.9 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 1.6 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.3 2.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.3 1.4 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.3 2.8 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 2.0 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.2 0.9 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.2 0.6 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.2 0.7 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.2 0.6 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1 5.2 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.1 2.1 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 2.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.4 GO:0006481 C-terminal protein methylation(GO:0006481)
0.1 4.8 GO:0007129 synapsis(GO:0007129)
0.1 0.2 GO:0048320 axial mesoderm formation(GO:0048320)
0.1 1.5 GO:0031953 negative regulation of protein autophosphorylation(GO:0031953)
0.1 0.6 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 0.8 GO:1904871 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.1 0.2 GO:0060807 cardiogenic plate morphogenesis(GO:0003142) regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification(GO:0060807)
0.0 1.9 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.1 GO:0002572 pro-T cell differentiation(GO:0002572)
0.0 0.9 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.8 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.3 GO:0003383 apical constriction(GO:0003383)
0.0 2.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.1 GO:1990869 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.0 2.3 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.8 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.2 GO:0070914 UV-damage excision repair(GO:0070914)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0033186 CAF-1 complex(GO:0033186)
0.9 8.2 GO:0005577 fibrinogen complex(GO:0005577)
0.7 7.9 GO:0045098 type III intermediate filament(GO:0045098)
0.4 2.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.3 7.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 1.2 GO:0031523 Myb complex(GO:0031523)
0.1 2.3 GO:0030914 STAGA complex(GO:0030914)
0.1 2.3 GO:0016600 flotillin complex(GO:0016600)
0.1 1.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.8 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.9 GO:0045298 tubulin complex(GO:0045298)
0.1 2.8 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 0.6 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.5 GO:0089701 U2AF(GO:0089701)
0.1 4.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 7.6 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.2 GO:0070052 collagen V binding(GO:0070052)
1.3 7.9 GO:1990254 keratin filament binding(GO:1990254)
0.5 1.8 GO:0043532 angiostatin binding(GO:0043532)
0.4 2.0 GO:0097001 ceramide binding(GO:0097001)
0.3 1.6 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.3 7.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.3 1.5 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.3 12.9 GO:0005159 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.1 4.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.6 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 1.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 1.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.4 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.1 0.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.5 GO:0050733 RS domain binding(GO:0050733)
0.0 0.6 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 2.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.6 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 3.9 GO:0042393 histone binding(GO:0042393)
0.0 2.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 2.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.2 8.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 12.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.8 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 7.9 PID AURORA B PATHWAY Aurora B signaling
0.1 2.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 1.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.6 PID CXCR4 PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 7.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 4.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 2.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 2.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.9 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 8.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.8 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 1.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling