ISMARA results: Esr1

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GSE58827: Dynamics of the Mouse Liver

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Results for Esr1

Z-value: 1.90

Motif logo

Transcription factors associated with Esr1

Gene Symbol	Gene ID	Gene Info
Esr1 Ensembl NCBI MGI UniProt	ENSMUSG00000019768.17	estrogen receptor 1 (alpha)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Esr1	mm39_v1_chr10_+_4561974_4562075	-0.72	9.5e-07	Click!

Activity profile of Esr1 motif

Sorted Z-values of Esr1 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_110848339 Show fit	21.16	ENSMUST00000198884.5 ENSMUST00000196777.5 ENSMUST00000196209.5 ENSMUST00000035077.8 ENSMUST00000196122.3	Ltf Ensembl NCBI MGI UniProt Show fit	lactotransferrin
chr11_-_102255999 Show fit	20.23	ENSMUST00000006749.10	Slc4a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 4 (anion exchanger), member 1
chr10_+_79722081 Show fit	19.13	ENSMUST00000046091.7	Elane Ensembl NCBI MGI UniProt Show fit	elastase, neutrophil expressed
chr11_+_87685032 Show fit	17.34	ENSMUST00000121303.8	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr11_+_87684299 Show fit	16.41	ENSMUST00000020779.11	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr1_+_131566044 Show fit	14.72	ENSMUST00000073350.13	Ctse Ensembl NCBI MGI UniProt Show fit	cathepsin E
chr1_+_131566223 Show fit	13.87	ENSMUST00000112411.2	Ctse Ensembl NCBI MGI UniProt Show fit	cathepsin E
chr11_+_58808830 Show fit	12.57	ENSMUST00000020792.12 ENSMUST00000108818.4	Btnl10 Ensembl NCBI MGI UniProt Show fit	butyrophilin-like 10
chr11_-_83177548 Show fit	11.12	ENSMUST00000163961.3	Slfn14 Ensembl NCBI MGI UniProt Show fit	schlafen 14
chr9_-_70328816 Show fit	10.94	ENSMUST00000034742.8	Ccnb2 Ensembl NCBI MGI UniProt Show fit	cyclin B2
chr4_-_119047202 Show fit	10.30	ENSMUST00000239029.2 ENSMUST00000138395.9 ENSMUST00000156746.3	Ermap Ensembl NCBI MGI UniProt Show fit	erythroblast membrane-associated protein
chr4_-_133601990 Show fit	9.75	ENSMUST00000168974.9	Rps6ka1 Ensembl NCBI MGI UniProt Show fit	ribosomal protein S6 kinase polypeptide 1
chr8_+_23629080 Show fit	8.92	ENSMUST00000033947.15	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr7_+_99184858 Show fit	8.86	ENSMUST00000032995.15 ENSMUST00000162404.8	Arrb1 Ensembl NCBI MGI UniProt Show fit	arrestin, beta 1
chr14_-_56322654 Show fit	8.77	ENSMUST00000015594.9	Mcpt8 Ensembl NCBI MGI UniProt Show fit	mast cell protease 8
chr11_+_87684548 Show fit	8.25	ENSMUST00000143021.9	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr4_-_119047167 Show fit	8.24	ENSMUST00000030396.15	Ermap Ensembl NCBI MGI UniProt Show fit	erythroblast membrane-associated protein
chrX_+_8137881 Show fit	8.03	ENSMUST00000115590.2	Slc38a5 Ensembl NCBI MGI UniProt Show fit	solute carrier family 38, member 5
chr9_-_21874802 Show fit	7.92	ENSMUST00000006397.7	Epor Ensembl NCBI MGI UniProt Show fit	erythropoietin receptor
chr8_+_85428059 Show fit	7.87	ENSMUST00000238364.2 ENSMUST00000238562.2 ENSMUST00000037165.6	Lyl1 Ensembl NCBI MGI UniProt Show fit	lymphoblastomic leukemia 1
chr7_-_142209755 Show fit	7.49	ENSMUST00000178921.2	Igf2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor 2
chr14_-_70873385 Show fit	7.25	ENSMUST00000228295.2 ENSMUST00000022695.16	Dmtn Ensembl NCBI MGI UniProt Show fit	dematin actin binding protein
chr17_-_35304582 Show fit	7.16	ENSMUST00000038507.7	Ly6g6f Ensembl NCBI MGI UniProt Show fit	lymphocyte antigen 6 complex, locus G6F
chr1_-_170755136 Show fit	7.11	ENSMUST00000046322.14 ENSMUST00000159171.2	Fcrla Ensembl NCBI MGI UniProt Show fit	Fc receptor-like A
chr2_+_164790139 Show fit	7.10	ENSMUST00000017881.3	Mmp9 Ensembl NCBI MGI UniProt Show fit	matrix metallopeptidase 9
chr19_-_5776268 Show fit	7.10	ENSMUST00000075606.6 ENSMUST00000236215.2 ENSMUST00000235730.2 ENSMUST00000237081.2 ENSMUST00000049295.15	Ehbp1l1 Ensembl NCBI MGI UniProt Show fit	EH domain binding protein 1-like 1
chr16_-_16687119 Show fit	6.77	ENSMUST00000075017.5	Vpreb1 Ensembl NCBI MGI UniProt Show fit	pre-B lymphocyte gene 1
chr17_+_36132567 Show fit	6.74	ENSMUST00000003635.7	Ier3 Ensembl NCBI MGI UniProt Show fit	immediate early response 3
chr11_+_104468107 Show fit	6.63	ENSMUST00000106956.10	Myl4 Ensembl NCBI MGI UniProt Show fit	myosin, light polypeptide 4
chr9_-_44253588 Show fit	6.62	ENSMUST00000215091.2	Hmbs Ensembl NCBI MGI UniProt Show fit	hydroxymethylbilane synthase
chr8_+_94905710 Show fit	6.61	ENSMUST00000034215.8 ENSMUST00000212291.2 ENSMUST00000211807.2	Mt1 Ensembl NCBI MGI UniProt Show fit	metallothionein 1
chr16_+_18247666 Show fit	6.49	ENSMUST00000144233.3	Txnrd2 Ensembl NCBI MGI UniProt Show fit	thioredoxin reductase 2
chr8_+_23629046 Show fit	6.32	ENSMUST00000121075.8	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr4_-_119047146 Show fit	6.29	ENSMUST00000124626.9	Ermap Ensembl NCBI MGI UniProt Show fit	erythroblast membrane-associated protein
chr4_-_119047180 Show fit	6.28	ENSMUST00000150864.3 ENSMUST00000141227.9	Ermap Ensembl NCBI MGI UniProt Show fit	erythroblast membrane-associated protein
chr14_-_44112974 Show fit	6.22	ENSMUST00000179200.2	Ear1 Ensembl NCBI MGI UniProt Show fit	eosinophil-associated, ribonuclease A family, member 1
chr8_+_73488496 Show fit	6.14	ENSMUST00000058099.9	F2rl3 Ensembl NCBI MGI UniProt Show fit	coagulation factor II (thrombin) receptor-like 3
chr11_+_69737437 Show fit	5.98	ENSMUST00000152566.8 ENSMUST00000108633.9	Plscr3 Ensembl NCBI MGI UniProt Show fit	phospholipid scramblase 3
chr19_+_58717319 Show fit	5.93	ENSMUST00000048644.6 ENSMUST00000236445.2	Pnliprp1 Ensembl NCBI MGI UniProt Show fit	pancreatic lipase related protein 1
chr17_+_25517363 Show fit	5.89	ENSMUST00000037453.4	Prss34 Ensembl NCBI MGI UniProt Show fit	protease, serine 34
chr11_+_117740077 Show fit	5.84	ENSMUST00000081387.11	Birc5 Ensembl NCBI MGI UniProt Show fit	baculoviral IAP repeat-containing 5
chr1_+_63215976 Show fit	5.82	ENSMUST00000129339.8	Eef1b2 Ensembl NCBI MGI UniProt Show fit	eukaryotic translation elongation factor 1 beta 2
chr6_+_145067457 Show fit	5.78	ENSMUST00000032396.13	Lrmp Ensembl NCBI MGI UniProt Show fit	lymphoid-restricted membrane protein
chr5_-_31102829 Show fit	5.77	ENSMUST00000031051.8	Cgref1 Ensembl NCBI MGI UniProt Show fit	cell growth regulator with EF hand domain 1
chr6_+_72074545 Show fit	5.75	ENSMUST00000069994.11 ENSMUST00000114112.4	St3gal5 Ensembl NCBI MGI UniProt Show fit	ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr11_+_69737491 Show fit	5.74	ENSMUST00000019605.4	Plscr3 Ensembl NCBI MGI UniProt Show fit	phospholipid scramblase 3
chr6_+_66512401 Show fit	5.74	ENSMUST00000101343.2	Mad2l1 Ensembl NCBI MGI UniProt Show fit	MAD2 mitotic arrest deficient-like 1
chr11_+_69737200 Show fit	5.68	ENSMUST00000108632.8	Plscr3 Ensembl NCBI MGI UniProt Show fit	phospholipid scramblase 3
chr19_+_4644425 Show fit	5.67	ENSMUST00000238089.2	Pcx Ensembl NCBI MGI UniProt Show fit	pyruvate carboxylase
chr11_-_69838971 Show fit	5.55	ENSMUST00000179298.3 ENSMUST00000018710.13 ENSMUST00000135437.3 ENSMUST00000141837.9 ENSMUST00000142500.8	Slc2a4 Ensembl NCBI MGI UniProt Show fit	solute carrier family 2 (facilitated glucose transporter), member 4
chr4_+_140427799 Show fit	5.46	ENSMUST00000071169.9	Rcc2 Ensembl NCBI MGI UniProt Show fit	regulator of chromosome condensation 2
chr7_+_28140352 Show fit	5.44	ENSMUST00000078845.13	Gmfg Ensembl NCBI MGI UniProt Show fit	glia maturation factor, gamma
chr14_-_63654478 Show fit	5.42	ENSMUST00000014597.5	Blk Ensembl NCBI MGI UniProt Show fit	B lymphoid kinase
chr19_-_46033353 Show fit	5.32	ENSMUST00000026252.14 ENSMUST00000156585.9 ENSMUST00000185355.7 ENSMUST00000152946.8	Ldb1 Ensembl NCBI MGI UniProt Show fit	LIM domain binding 1
chr7_-_126303351 Show fit	5.29	ENSMUST00000106364.8	Coro1a Ensembl NCBI MGI UniProt Show fit	coronin, actin binding protein 1A
chr1_+_135656885 Show fit	5.25	ENSMUST00000027677.8	Csrp1 Ensembl NCBI MGI UniProt Show fit	cysteine and glycine-rich protein 1
chr15_-_103161237 Show fit	5.07	ENSMUST00000154510.8	Nfe2 Ensembl NCBI MGI UniProt Show fit	nuclear factor, erythroid derived 2
chr9_+_62765362 Show fit	5.02	ENSMUST00000213643.2 ENSMUST00000034777.14 ENSMUST00000163820.3 ENSMUST00000215870.2 ENSMUST00000214633.2 ENSMUST00000215968.2	Calml4 Ensembl NCBI MGI UniProt Show fit	calmodulin-like 4
chr1_+_134890288 Show fit	4.96	ENSMUST00000027687.8	Ube2t Ensembl NCBI MGI UniProt Show fit	ubiquitin-conjugating enzyme E2T
chr2_+_130119077 Show fit	4.95	ENSMUST00000028890.15 ENSMUST00000159373.2	Nop56 Ensembl NCBI MGI UniProt Show fit	NOP56 ribonucleoprotein
chr10_+_128744689 Show fit	4.88	ENSMUST00000105229.9	Cd63 Ensembl NCBI MGI UniProt Show fit	CD63 antigen
chr11_+_116422570 Show fit	4.88	ENSMUST00000106387.9	Sphk1 Ensembl NCBI MGI UniProt Show fit	sphingosine kinase 1
chr11_+_116422712 Show fit	4.85	ENSMUST00000100201.10	Sphk1 Ensembl NCBI MGI UniProt Show fit	sphingosine kinase 1
chr1_+_107456731 Show fit	4.68	ENSMUST00000182198.8	Serpinb10 Ensembl NCBI MGI UniProt Show fit	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
chr2_-_153079828 Show fit	4.68	ENSMUST00000109795.2	Plagl2 Ensembl NCBI MGI UniProt Show fit	pleiomorphic adenoma gene-like 2
chr5_-_148336711 Show fit	4.62	ENSMUST00000048116.15	Slc7a1 Ensembl NCBI MGI UniProt Show fit	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr17_-_26160872 Show fit	4.56	ENSMUST00000139226.2 ENSMUST00000097368.10 ENSMUST00000140304.2 ENSMUST00000026823.16	Pigq Ensembl NCBI MGI UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis, class Q
chr4_-_132073048 Show fit	4.56	ENSMUST00000084250.11	Rcc1 Ensembl NCBI MGI UniProt Show fit	regulator of chromosome condensation 1
chr10_+_79650496 Show fit	4.54	ENSMUST00000218857.2 ENSMUST00000220365.2	Palm Ensembl NCBI MGI UniProt Show fit	paralemmin
chr4_-_41098174 Show fit	4.41	ENSMUST00000055327.8	Aqp3 Ensembl NCBI MGI UniProt Show fit	aquaporin 3
chr4_-_132072988 Show fit	4.40	ENSMUST00000030726.13	Rcc1 Ensembl NCBI MGI UniProt Show fit	regulator of chromosome condensation 1
chr5_+_122347792 Show fit	4.31	ENSMUST00000072602.14	Hvcn1 Ensembl NCBI MGI UniProt Show fit	hydrogen voltage-gated channel 1
chr15_-_89310060 Show fit	4.25	ENSMUST00000109313.9	Cpt1b Ensembl NCBI MGI UniProt Show fit	carnitine palmitoyltransferase 1b, muscle
chr5_+_122348140 Show fit	4.23	ENSMUST00000196187.5 ENSMUST00000100747.3	Hvcn1 Ensembl NCBI MGI UniProt Show fit	hydrogen voltage-gated channel 1
chr1_-_170755109 Show fit	4.22	ENSMUST00000162136.2 ENSMUST00000162887.2	Fcrla Ensembl NCBI MGI UniProt Show fit	Fc receptor-like A
chr9_-_44253630 Show fit	4.22	ENSMUST00000097558.5	Hmbs Ensembl NCBI MGI UniProt Show fit	hydroxymethylbilane synthase
chr7_+_28140450 Show fit	4.19	ENSMUST00000135686.2	Gmfg Ensembl NCBI MGI UniProt Show fit	glia maturation factor, gamma
chr18_+_34758062 Show fit	4.15	ENSMUST00000166044.3	Kif20a Ensembl NCBI MGI UniProt Show fit	kinesin family member 20A
chr5_+_30824121 Show fit	4.10	ENSMUST00000144742.6 ENSMUST00000149759.2 ENSMUST00000199320.5	Cenpa Ensembl NCBI MGI UniProt Show fit	centromere protein A
chr12_+_83572774 Show fit	4.08	ENSMUST00000223291.2	Dcaf4 Ensembl NCBI MGI UniProt Show fit	DDB1 and CUL4 associated factor 4
chr6_+_91492988 Show fit	4.06	ENSMUST00000206947.2	Lsm3 Ensembl NCBI MGI UniProt Show fit	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
chr16_-_18880821 Show fit	4.04	ENSMUST00000200568.2	Iglc1 Ensembl NCBI MGI UniProt Show fit	immunoglobulin lambda constant 1
chr9_-_44255456 Show fit	4.02	ENSMUST00000077353.15	Hmbs Ensembl NCBI MGI UniProt Show fit	hydroxymethylbilane synthase
chr1_+_63216281 Show fit	4.02	ENSMUST00000188524.2	Eef1b2 Ensembl NCBI MGI UniProt Show fit	eukaryotic translation elongation factor 1 beta 2
chr6_+_91492910 Show fit	4.00	ENSMUST00000040607.6	Lsm3 Ensembl NCBI MGI UniProt Show fit	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
chr7_-_126398343 Show fit	3.97	ENSMUST00000032934.12	Aldoa Ensembl NCBI MGI UniProt Show fit	aldolase A, fructose-bisphosphate
chr17_+_25235039 Show fit	3.96	ENSMUST00000142000.9 ENSMUST00000137386.8	Ift140 Ensembl NCBI MGI UniProt Show fit	intraflagellar transport 140
chr6_-_70149254 Show fit	3.94	ENSMUST00000197272.2	Igkv8-27 Ensembl NCBI MGI UniProt Show fit	immunoglobulin kappa chain variable 8-27
chr17_+_48607405 Show fit	3.94	ENSMUST00000170941.3	Treml2 Ensembl NCBI MGI UniProt Show fit	triggering receptor expressed on myeloid cells-like 2
chr2_-_31973795 Show fit	3.92	ENSMUST00000056406.7	Fam78a Ensembl NCBI MGI UniProt Show fit	family with sequence similarity 78, member A
chr14_+_66534478 Show fit	3.92	ENSMUST00000022623.13	Trim35 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 35
chr6_-_5496261 Show fit	3.91	ENSMUST00000203347.3 ENSMUST00000019721.7	Pdk4 Ensembl NCBI MGI UniProt Show fit	pyruvate dehydrogenase kinase, isoenzyme 4
chr7_-_126398165 Show fit	3.81	ENSMUST00000205890.2 ENSMUST00000205336.2 ENSMUST00000087566.11	Aldoa Ensembl NCBI MGI UniProt Show fit	aldolase A, fructose-bisphosphate
chr10_+_75399920 Show fit	3.80	ENSMUST00000141062.8 ENSMUST00000152657.8	Ggt1 Ensembl NCBI MGI UniProt Show fit	gamma-glutamyltransferase 1
chr10_+_127350820 Show fit	3.76	ENSMUST00000035735.11	Ndufa4l2 Ensembl NCBI MGI UniProt Show fit	Ndufa4, mitochondrial complex associated like 2
chr15_+_78784043 Show fit	3.76	ENSMUST00000001226.11	Sh3bp1 Ensembl NCBI MGI UniProt Show fit	SH3-domain binding protein 1
chr8_-_72175949 Show fit	3.74	ENSMUST00000125092.2	Fcho1 Ensembl NCBI MGI UniProt Show fit	FCH domain only 1
chr19_-_4240984 Show fit	3.71	ENSMUST00000045864.4	Tbc1d10c Ensembl NCBI MGI UniProt Show fit	TBC1 domain family, member 10c
chr6_+_66512374 Show fit	3.70	ENSMUST00000116605.8	Mad2l1 Ensembl NCBI MGI UniProt Show fit	MAD2 mitotic arrest deficient-like 1
chr18_+_34757687 Show fit	3.67	ENSMUST00000237407.2	Kif20a Ensembl NCBI MGI UniProt Show fit	kinesin family member 20A
chr12_+_31123860 Show fit	3.66	ENSMUST00000041133.10	Fam110c Ensembl NCBI MGI UniProt Show fit	family with sequence similarity 110, member C
chr9_+_110173253 Show fit	3.63	ENSMUST00000199709.3	Scap Ensembl NCBI MGI UniProt Show fit	SREBF chaperone
chr7_+_127846121 Show fit	3.56	ENSMUST00000167965.8	Tgfb1i1 Ensembl NCBI MGI UniProt Show fit	transforming growth factor beta 1 induced transcript 1
chr10_-_60588539 Show fit	3.56	ENSMUST00000117513.8 ENSMUST00000119595.8	Slc29a3 Ensembl NCBI MGI UniProt Show fit	solute carrier family 29 (nucleoside transporters), member 3
chr10_+_80692948 Show fit	3.52	ENSMUST00000220091.2	Sppl2b Ensembl NCBI MGI UniProt Show fit	signal peptide peptidase like 2B
chr7_+_127845984 Show fit	3.47	ENSMUST00000164710.8 ENSMUST00000070656.12	Tgfb1i1 Ensembl NCBI MGI UniProt Show fit	transforming growth factor beta 1 induced transcript 1
chr18_+_34757666 Show fit	3.45	ENSMUST00000167161.9	Kif20a Ensembl NCBI MGI UniProt Show fit	kinesin family member 20A
chr16_+_17798292 Show fit	3.44	ENSMUST00000075371.5	Vpreb2 Ensembl NCBI MGI UniProt Show fit	pre-B lymphocyte gene 2
chr15_+_79784365 Show fit	3.43	ENSMUST00000230135.2	Apobec3 Ensembl NCBI MGI UniProt Show fit	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr10_+_79833296 Show fit	3.41	ENSMUST00000171637.8 ENSMUST00000043866.8	Abca7 Ensembl NCBI MGI UniProt Show fit	ATP-binding cassette, sub-family A (ABC1), member 7
chr4_-_155737841 Show fit	3.38	ENSMUST00000030937.2	Mmp23 Ensembl NCBI MGI UniProt Show fit	matrix metallopeptidase 23
chr9_-_42035560 Show fit	3.37	ENSMUST00000060989.9	Sorl1 Ensembl NCBI MGI UniProt Show fit	sortilin-related receptor, LDLR class A repeats-containing
chr1_+_152683627 Show fit	3.36	ENSMUST00000027754.7	Ncf2 Ensembl NCBI MGI UniProt Show fit	neutrophil cytosolic factor 2
chr16_-_19801781 Show fit	3.35	ENSMUST00000058839.10	Klhl6 Ensembl NCBI MGI UniProt Show fit	kelch-like 6
chr7_+_46496929 Show fit	3.28	ENSMUST00000132157.2 ENSMUST00000210631.2	Ldha Ensembl NCBI MGI UniProt Show fit	lactate dehydrogenase A
chr19_-_7688628 Show fit	3.28	ENSMUST00000025666.8	Slc22a19 Ensembl NCBI MGI UniProt Show fit	solute carrier family 22 (organic anion transporter), member 19
chr12_-_110945415 Show fit	3.27	ENSMUST00000135131.2 ENSMUST00000043459.13 ENSMUST00000128353.8	Ankrd9 Ensembl NCBI MGI UniProt Show fit	ankyrin repeat domain 9
chrX_-_9335525 Show fit	3.25	ENSMUST00000015484.10	Cybb Ensembl NCBI MGI UniProt Show fit	cytochrome b-245, beta polypeptide
chr4_-_131802561 Show fit	3.24	ENSMUST00000105970.8 ENSMUST00000105975.8	Epb41 Ensembl NCBI MGI UniProt Show fit	erythrocyte membrane protein band 4.1
chr16_+_49675682 Show fit	3.19	ENSMUST00000114496.3	Cd47 Ensembl NCBI MGI UniProt Show fit	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr7_+_125202653 Show fit	3.19	ENSMUST00000206103.2 ENSMUST00000033000.8	Il21r Ensembl NCBI MGI UniProt Show fit	interleukin 21 receptor
chr4_-_49597425 Show fit	3.19	ENSMUST00000150664.2	Pgap4 Ensembl NCBI MGI UniProt Show fit	post-GPI attachment to proteins GalNAc transferase 4
chr10_-_81335966 Show fit	3.17	ENSMUST00000053646.7	S1pr4 Ensembl NCBI MGI UniProt Show fit	sphingosine-1-phosphate receptor 4
chr7_+_46496552 Show fit	3.14	ENSMUST00000005051.6	Ldha Ensembl NCBI MGI UniProt Show fit	lactate dehydrogenase A
chr5_+_145282064 Show fit	3.13	ENSMUST00000079268.9	Cyp3a57 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 3, subfamily a, polypeptide 57
chr1_+_91468409 Show fit	3.11	ENSMUST00000027538.9 ENSMUST00000190484.7 ENSMUST00000186068.2	Asb1 Ensembl NCBI MGI UniProt Show fit	ankyrin repeat and SOCS box-containing 1
chr4_-_131802606 Show fit	3.11	ENSMUST00000146021.8	Epb41 Ensembl NCBI MGI UniProt Show fit	erythrocyte membrane protein band 4.1
chr6_-_70051586 Show fit	3.11	ENSMUST00000103377.3	Igkv6-32 Ensembl NCBI MGI UniProt Show fit	immunoglobulin kappa variable 6-32
chr8_+_85428391 Show fit	3.10	ENSMUST00000238338.2	Lyl1 Ensembl NCBI MGI UniProt Show fit	lymphoblastomic leukemia 1
chr19_-_4109446 Show fit	3.09	ENSMUST00000189808.7	Gstp3 Ensembl NCBI MGI UniProt Show fit	glutathione S-transferase pi 3
chr4_+_52439237 Show fit	3.08	ENSMUST00000102915.10 ENSMUST00000117280.8 ENSMUST00000142227.3	Smc2 Ensembl NCBI MGI UniProt Show fit	structural maintenance of chromosomes 2
chr3_-_86049988 Show fit	3.05	ENSMUST00000029722.7	Rps3a1 Ensembl NCBI MGI UniProt Show fit	ribosomal protein S3A1
chr4_+_132701413 Show fit	3.05	ENSMUST00000030693.13	Fgr Ensembl NCBI MGI UniProt Show fit	FGR proto-oncogene, Src family tyrosine kinase
chr11_-_69786324 Show fit	3.04	ENSMUST00000001631.7	Acap1 Ensembl NCBI MGI UniProt Show fit	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr8_-_22675773 Show fit	3.00	ENSMUST00000046916.9	Ckap2 Ensembl NCBI MGI UniProt Show fit	cytoskeleton associated protein 2
chr3_+_157272504 Show fit	2.98	ENSMUST00000041175.13 ENSMUST00000173533.2	Ptger3 Ensembl NCBI MGI UniProt Show fit	prostaglandin E receptor 3 (subtype EP3)
chr2_+_91376650 Show fit	2.96	ENSMUST00000099716.11 ENSMUST00000046769.16 ENSMUST00000111337.3	Ckap5 Ensembl NCBI MGI UniProt Show fit	cytoskeleton associated protein 5
chr2_+_163500290 Show fit	2.95	ENSMUST00000164399.8 ENSMUST00000064703.13 ENSMUST00000099105.9 ENSMUST00000152418.8 ENSMUST00000126182.8 ENSMUST00000131228.8	Pkig Ensembl NCBI MGI UniProt Show fit	protein kinase inhibitor, gamma
chr3_+_51131868 Show fit	2.94	ENSMUST00000023849.15 ENSMUST00000167780.2	Noct Ensembl NCBI MGI UniProt Show fit	nocturnin
chr6_-_124710030 Show fit	2.93	ENSMUST00000173647.2	Ptpn6 Ensembl NCBI MGI UniProt Show fit	protein tyrosine phosphatase, non-receptor type 6
chr7_+_141995545 Show fit	2.93	ENSMUST00000105971.8 ENSMUST00000145287.8	Tnni2 Ensembl NCBI MGI UniProt Show fit	troponin I, skeletal, fast 2
chr19_-_4241034 Show fit	2.93	ENSMUST00000237495.2	Tbc1d10c Ensembl NCBI MGI UniProt Show fit	TBC1 domain family, member 10c
chr2_+_163503415 Show fit	2.92	ENSMUST00000135537.8	Pkig Ensembl NCBI MGI UniProt Show fit	protein kinase inhibitor, gamma
chr17_-_33937565 Show fit	2.91	ENSMUST00000174040.2 ENSMUST00000173015.8 ENSMUST00000066121.13 ENSMUST00000186022.7 ENSMUST00000173329.8 ENSMUST00000172767.9	Marchf2 Ensembl NCBI MGI UniProt Show fit	membrane associated ring-CH-type finger 2
chr10_+_117465397 Show fit	2.91	ENSMUST00000020399.6	Cpm Ensembl NCBI MGI UniProt Show fit	carboxypeptidase M
chr11_+_113510135 Show fit	2.90	ENSMUST00000146390.3	Sstr2 Ensembl NCBI MGI UniProt Show fit	somatostatin receptor 2
chr5_-_33432310 Show fit	2.86	ENSMUST00000201372.3 ENSMUST00000202962.4 ENSMUST00000201575.4 ENSMUST00000202868.4 ENSMUST00000079746.10	Ctbp1 Ensembl NCBI MGI UniProt Show fit	C-terminal binding protein 1
chr7_+_89814713 Show fit	2.84	ENSMUST00000207084.2	Picalm Ensembl NCBI MGI UniProt Show fit	phosphatidylinositol binding clathrin assembly protein
chr6_+_125529911 Show fit	2.79	ENSMUST00000112254.8 ENSMUST00000112253.6	Vwf Ensembl NCBI MGI UniProt Show fit	Von Willebrand factor
chr10_+_81012465 Show fit	2.78	ENSMUST00000047864.11	Eef2 Ensembl NCBI MGI UniProt Show fit	eukaryotic translation elongation factor 2
chr3_-_59118293 Show fit	2.78	ENSMUST00000040622.3	P2ry13 Ensembl NCBI MGI UniProt Show fit	purinergic receptor P2Y, G-protein coupled 13
chr15_+_80507671 Show fit	2.76	ENSMUST00000043149.9	Grap2 Ensembl NCBI MGI UniProt Show fit	GRB2-related adaptor protein 2
chr7_-_125090757 Show fit	2.76	ENSMUST00000033006.14	Nsmce1 Ensembl NCBI MGI UniProt Show fit	NSE1 homolog, SMC5-SMC6 complex component
chr12_-_114443071 Show fit	2.72	ENSMUST00000103492.2	Ighv10-1 Ensembl NCBI MGI UniProt Show fit	immunoglobulin heavy variable 10-1
chr16_+_49675969 Show fit	2.67	ENSMUST00000229101.2 ENSMUST00000230836.2 ENSMUST00000229206.2 ENSMUST00000084838.14 ENSMUST00000230281.2	Cd47 Ensembl NCBI MGI UniProt Show fit	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr7_+_110376859 Show fit	2.67	ENSMUST00000148292.2	Ampd3 Ensembl NCBI MGI UniProt Show fit	adenosine monophosphate deaminase 3
chr7_-_24919247 Show fit	2.62	ENSMUST00000058702.7	Dedd2 Ensembl NCBI MGI UniProt Show fit	death effector domain-containing DNA binding protein 2
chr12_-_69837434 Show fit	2.62	ENSMUST00000021377.5	Cdkl1 Ensembl NCBI MGI UniProt Show fit	cyclin-dependent kinase-like 1 (CDC2-related kinase)
chr14_+_24540745 Show fit	2.61	ENSMUST00000112384.10	Rps24 Ensembl NCBI MGI UniProt Show fit	ribosomal protein S24
chr14_-_30329765 Show fit	2.61	ENSMUST00000112207.8 ENSMUST00000112206.8 ENSMUST00000112202.8 ENSMUST00000112203.2	Prkcd Ensembl NCBI MGI UniProt Show fit	protein kinase C, delta
chr10_-_75600100 Show fit	2.60	ENSMUST00000218469.2 ENSMUST00000001712.8	Cabin1 Ensembl NCBI MGI UniProt Show fit	calcineurin binding protein 1
chr2_+_71219561 Show fit	2.59	ENSMUST00000028408.3	Hat1 Ensembl NCBI MGI UniProt Show fit	histone aminotransferase 1
chr6_-_69584812 Show fit	2.59	ENSMUST00000103359.3	Igkv4-55 Ensembl NCBI MGI UniProt Show fit	immunoglobulin kappa variable 4-55
chr15_+_78783867 Show fit	2.58	ENSMUST00000134703.8 ENSMUST00000061239.14 ENSMUST00000109698.9	Gm49510 Ensembl NCBI MGI UniProt Show fit Sh3bp1 Ensembl NCBI MGI UniProt Show fit	predicted gene, 49510 SH3-domain binding protein 1
chr15_-_86070338 Show fit	2.58	ENSMUST00000044332.16	Cerk Ensembl NCBI MGI UniProt Show fit	ceramide kinase
chr7_+_46496506 Show fit	2.57	ENSMUST00000209984.2	Ldha Ensembl NCBI MGI UniProt Show fit	lactate dehydrogenase A
chr14_+_24540815 Show fit	2.55	ENSMUST00000224568.2	Rps24 Ensembl NCBI MGI UniProt Show fit	ribosomal protein S24
chr9_+_45314436 Show fit	2.52	ENSMUST00000041005.6	Fxyd2 Ensembl NCBI MGI UniProt Show fit	FXYD domain-containing ion transport regulator 2
chr15_-_102097387 Show fit	2.49	ENSMUST00000230288.2	Csad Ensembl NCBI MGI UniProt Show fit	cysteine sulfinic acid decarboxylase
chr12_+_69215583 Show fit	2.46	ENSMUST00000110621.3 ENSMUST00000222520.2	Lrr1 Ensembl NCBI MGI UniProt Show fit	leucine rich repeat protein 1
chr6_-_143045731 Show fit	2.45	ENSMUST00000203673.3 ENSMUST00000203187.3 ENSMUST00000171349.8 ENSMUST00000087485.7	C2cd5 Ensembl NCBI MGI UniProt Show fit	C2 calcium-dependent domain containing 5
chr11_-_121120052 Show fit	2.44	ENSMUST00000169393.8 ENSMUST00000106115.8 ENSMUST00000038709.14 ENSMUST00000147490.6	Cybc1 Ensembl NCBI MGI UniProt Show fit	cytochrome b 245 chaperone 1
chr12_+_113112311 Show fit	2.42	ENSMUST00000199089.5	Crip1 Ensembl NCBI MGI UniProt Show fit	cysteine-rich protein 1 (intestinal)
chr16_-_20245071 Show fit	2.42	ENSMUST00000115547.9 ENSMUST00000096199.5	Abcc5 Ensembl NCBI MGI UniProt Show fit	ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr19_+_10819896 Show fit	2.41	ENSMUST00000025646.3	Slc15a3 Ensembl NCBI MGI UniProt Show fit	solute carrier family 15, member 3
chr2_-_180928867 Show fit	2.40	ENSMUST00000130475.8	Gmeb2 Ensembl NCBI MGI UniProt Show fit	glucocorticoid modulatory element binding protein 2
chr5_+_145051025 Show fit	2.40	ENSMUST00000085679.13	Arpc1b Ensembl NCBI MGI UniProt Show fit	actin related protein 2/3 complex, subunit 1B
chr3_+_88744323 Show fit	2.40	ENSMUST00000081695.14 ENSMUST00000090942.6	Gon4l Ensembl NCBI MGI UniProt Show fit	gon-4-like (C.elegans)
chr2_+_154633265 Show fit	2.38	ENSMUST00000140713.3 ENSMUST00000137333.8	Raly Ensembl NCBI MGI UniProt Show fit a Ensembl NCBI MGI UniProt Show fit	hnRNP-associated with lethal yellow nonagouti
chr4_-_59783780 Show fit	2.38	ENSMUST00000107526.8 ENSMUST00000095063.11	Inip Ensembl NCBI MGI UniProt Show fit	INTS3 and NABP interacting protein
chr14_+_62569517 Show fit	2.38	ENSMUST00000022499.13	Rnaseh2b Ensembl NCBI MGI UniProt Show fit	ribonuclease H2, subunit B
chr5_-_113957318 Show fit	2.37	ENSMUST00000201194.4	Selplg Ensembl NCBI MGI UniProt Show fit	selectin, platelet (p-selectin) ligand
chr11_-_59054521 Show fit	2.37	ENSMUST00000137433.2 ENSMUST00000054523.6	Iba57 Ensembl NCBI MGI UniProt Show fit	IBA57 homolog, iron-sulfur cluster assembly
chr6_+_4504814 Show fit	2.37	ENSMUST00000141483.8	Col1a2 Ensembl NCBI MGI UniProt Show fit	collagen, type I, alpha 2
chr14_+_24540777 Show fit	2.37	ENSMUST00000169826.3 ENSMUST00000225023.2 ENSMUST00000223999.2	Rps24 Ensembl NCBI MGI UniProt Show fit	ribosomal protein S24
chr17_-_79662514 Show fit	2.35	ENSMUST00000068958.9	Cdc42ep3 Ensembl NCBI MGI UniProt Show fit	CDC42 effector protein (Rho GTPase binding) 3
chr6_-_124710084 Show fit	2.34	ENSMUST00000112484.10	Ptpn6 Ensembl NCBI MGI UniProt Show fit	protein tyrosine phosphatase, non-receptor type 6
chr5_-_151574620 Show fit	2.34	ENSMUST00000038131.10	Rfc3 Ensembl NCBI MGI UniProt Show fit	replication factor C (activator 1) 3
chr13_+_69950509 Show fit	2.32	ENSMUST00000223376.2 ENSMUST00000222387.2	Med10 Ensembl NCBI MGI UniProt Show fit	mediator complex subunit 10
chr4_-_149783097 Show fit	2.32	ENSMUST00000038859.14 ENSMUST00000105690.9	Pik3cd Ensembl NCBI MGI UniProt Show fit	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
chr13_-_107073415 Show fit	2.28	ENSMUST00000080856.14	Ipo11 Ensembl NCBI MGI UniProt Show fit	importin 11
chr5_+_122347912 Show fit	2.26	ENSMUST00000143560.8	Hvcn1 Ensembl NCBI MGI UniProt Show fit	hydrogen voltage-gated channel 1
chr7_-_30741497 Show fit	2.25	ENSMUST00000162116.8 ENSMUST00000159924.8	Fxyd5 Ensembl NCBI MGI UniProt Show fit	FXYD domain-containing ion transport regulator 5
chr15_+_79982033 Show fit	2.25	ENSMUST00000143928.2	Syngr1 Ensembl NCBI MGI UniProt Show fit	synaptogyrin 1
chr9_-_66032134 Show fit	2.23	ENSMUST00000034946.15	Snx1 Ensembl NCBI MGI UniProt Show fit	sorting nexin 1
chr14_+_78141679 Show fit	2.22	ENSMUST00000022591.16 ENSMUST00000169978.2 ENSMUST00000227903.2	Epsti1 Ensembl NCBI MGI UniProt Show fit	epithelial stromal interaction 1 (breast)
chr11_-_5015275 Show fit	2.22	ENSMUST00000109895.2 ENSMUST00000152257.2 ENSMUST00000037146.10 ENSMUST00000056649.13	Gas2l1 Ensembl NCBI MGI UniProt Show fit	growth arrest-specific 2 like 1
chr18_-_36648850 Show fit	2.19	ENSMUST00000025363.7	Hbegf Ensembl NCBI MGI UniProt Show fit	heparin-binding EGF-like growth factor
chr11_+_51510555 Show fit	2.14	ENSMUST00000127405.2	Nhp2 Ensembl NCBI MGI UniProt Show fit	NHP2 ribonucleoprotein
chrX_-_165992311 Show fit	2.12	ENSMUST00000112172.4	Tmsb4x Ensembl NCBI MGI UniProt Show fit	thymosin, beta 4, X chromosome

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
14.0	42.0	GO:0002149	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
6.4	19.1	GO:0002780	antimicrobial peptide biosynthetic process(GO:0002777) antibacterial peptide biosynthetic process(GO:0002780) neutrophil mediated killing of fungus(GO:0070947)
5.3	21.2	GO:0044010	biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) membrane disruption in other organism(GO:0051673) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
5.0	14.9	GO:0018160	peptidyl-pyrromethane cofactor linkage(GO:0018160)
3.2	9.6	GO:0071846	actin filament debranching(GO:0071846)
2.4	7.1	GO:0071460	cellular response to cell-matrix adhesion(GO:0071460)
1.8	5.5	GO:0072356	chromosome passenger complex localization to kinetochore(GO:0072356)
1.8	5.4	GO:1901074	regulation of engulfment of apoptotic cell(GO:1901074)
1.8	5.3	GO:0043973	histone H3-K4 acetylation(GO:0043973)
1.6	4.7	GO:0034378	chylomicron assembly(GO:0034378)
1.5	29.0	GO:0016540	protein autoprocessing(GO:0016540)
1.4	9.7	GO:0019371	cyclooxygenase pathway(GO:0019371)
1.2	7.2	GO:0035585	calcium-mediated signaling using extracellular calcium source(GO:0035585)
1.2	5.9	GO:0042412	taurine biosynthetic process(GO:0042412)
1.2	17.4	GO:0071294	cellular response to zinc ion(GO:0071294)
1.1	5.7	GO:0019072	viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
1.1	5.4	GO:0006742	NADP catabolic process(GO:0006742)
1.1	9.8	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
1.1	8.7	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
1.1	8.5	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)
1.0	9.4	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
1.0	10.0	GO:0019661	glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
1.0	3.0	GO:1904328	gastrin-induced gastric acid secretion(GO:0001698) positive regulation of actin filament-based movement(GO:1903116) regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764) negative regulation of forebrain neuron differentiation(GO:2000978)
1.0	5.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
1.0	3.9	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
1.0	2.9	GO:0099526	presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.9	2.8	GO:0090649	response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.9	12.0	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.9	11.0	GO:0001955	blood vessel maturation(GO:0001955)
0.9	2.7	GO:0006233	dTDP biosynthetic process(GO:0006233) dTDP metabolic process(GO:0046072)
0.8	5.8	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.8	4.9	GO:2000680	regulation of rubidium ion transport(GO:2000680)
0.8	4.5	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.7	6.7	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.7	6.6	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.7	2.2	GO:0051542	elastin biosynthetic process(GO:0051542)
0.7	18.7	GO:0015701	bicarbonate transport(GO:0015701)
0.7	5.3	GO:0033277	abortive mitotic cell cycle(GO:0033277)
0.7	2.6	GO:0060697	positive regulation of phospholipid catabolic process(GO:0060697)
0.6	5.2	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.6	1.9	GO:0030472	mitotic spindle organization in nucleus(GO:0030472)
0.6	8.0	GO:0061032	visceral serous pericardium development(GO:0061032)
0.6	1.8	GO:2000977	regulation of forebrain neuron differentiation(GO:2000977)
0.6	2.4	GO:0040030	regulation of molecular function, epigenetic(GO:0040030)
0.6	1.2	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.6	2.8	GO:1902963	regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.6	6.2	GO:0008228	opsonization(GO:0008228)
0.5	3.3	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.5	5.4	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.5	1.6	GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
0.5	11.1	GO:0016075	rRNA catabolic process(GO:0016075)
0.5	2.1	GO:0021941	negative regulation of cerebellar granule cell precursor proliferation(GO:0021941)
0.5	1.6	GO:0031554	regulation of DNA-templated transcription, termination(GO:0031554)
0.5	1.5	GO:0002940	tRNA N2-guanine methylation(GO:0002940)
0.5	2.1	GO:0055011	atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.5	5.0	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.5	3.0	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.5	5.9	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.5	11.3	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.5	1.5	GO:0035544	negative regulation of SNARE complex assembly(GO:0035544)
0.5	3.8	GO:0031179	peptide modification(GO:0031179)
0.5	1.9	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990) negative regulation of t-circle formation(GO:1904430)
0.5	2.4	GO:0050902	leukocyte adhesive activation(GO:0050902)
0.5	7.8	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4	4.0	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.4	8.0	GO:0015816	glycine transport(GO:0015816)
0.4	1.3	GO:1904783	positive regulation of NMDA glutamate receptor activity(GO:1904783)
0.4	1.3	GO:0014739	positive regulation of muscle hyperplasia(GO:0014739)
0.4	1.3	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.4	2.8	GO:2000767	positive regulation of cytoplasmic translation(GO:2000767)
0.4	1.2	GO:1902938	regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.4	3.5	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.4	1.2	GO:0036145	dendritic cell homeostasis(GO:0036145)
0.4	1.9	GO:1902951	negative regulation of dendritic spine maintenance(GO:1902951)
0.4	1.8	GO:0035616	histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.4	2.1	GO:0031120	snRNA pseudouridine synthesis(GO:0031120)
0.4	1.1	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.4	2.5	GO:0031296	B cell costimulation(GO:0031296)
0.4	6.4	GO:1904778	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.3	1.0	GO:0030200	heparan sulfate proteoglycan catabolic process(GO:0030200)
0.3	3.1	GO:0015879	carnitine transport(GO:0015879)
0.3	5.1	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.3	11.0	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.3	4.9	GO:0030432	peristalsis(GO:0030432)
0.3	12.9	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
0.3	1.5	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.3	1.2	GO:0009816	defense response, incompatible interaction(GO:0009814) defense response to bacterium, incompatible interaction(GO:0009816) regulation of defense response to bacterium, incompatible interaction(GO:1902477)
0.3	0.9	GO:0036245	cellular response to menadione(GO:0036245)
0.3	1.1	GO:0001579	medium-chain fatty acid transport(GO:0001579)
0.3	1.4	GO:0042631	cellular response to water deprivation(GO:0042631)
0.3	1.4	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.3	5.9	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3	10.8	GO:0051290	protein heterotetramerization(GO:0051290)
0.3	0.8	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.3	4.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.3	1.4	GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.3	1.1	GO:0031204	posttranslational protein targeting to membrane, translocation(GO:0031204)
0.3	2.7	GO:0032264	IMP salvage(GO:0032264)
0.3	1.1	GO:0003273	cell migration involved in endocardial cushion formation(GO:0003273)
0.3	4.0	GO:0035721	intraciliary retrograde transport(GO:0035721)
0.3	1.6	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.3	2.3	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.3	4.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.3	4.1	GO:0071459	protein localization to chromosome, centromeric region(GO:0071459)
0.3	1.3	GO:0080154	regulation of fertilization(GO:0080154)
0.3	1.0	GO:0031118	rRNA pseudouridine synthesis(GO:0031118)
0.3	4.3	GO:0015809	arginine transport(GO:0015809)
0.3	2.0	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.2	0.7	GO:1904632	negative regulation of interleukin-12 biosynthetic process(GO:0045083) response to diterpene(GO:1904629) cellular response to diterpene(GO:1904630) response to glucoside(GO:1904631) cellular response to glucoside(GO:1904632)
0.2	0.7	GO:1901165	positive regulation of trophoblast cell migration(GO:1901165)
0.2	2.6	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2	0.5	GO:2000525	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.2	2.3	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.2	6.2	GO:0044381	glucose import in response to insulin stimulus(GO:0044381)
0.2	0.9	GO:0032901	positive regulation of neurotrophin production(GO:0032901)
0.2	0.7	GO:0051892	negative regulation of cardioblast differentiation(GO:0051892)
0.2	1.1	GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
0.2	2.1	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.2	0.6	GO:0002476	antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.2	1.6	GO:0000821	regulation of arginine metabolic process(GO:0000821)
0.2	0.4	GO:1900222	negative regulation of beta-amyloid clearance(GO:1900222)
0.2	1.7	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.2	0.6	GO:1903632	positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
0.2	0.8	GO:0023016	signal transduction by trans-phosphorylation(GO:0023016)
0.2	2.1	GO:0035878	nail development(GO:0035878)
0.2	1.7	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.2	4.8	GO:0000154	rRNA modification(GO:0000154)
0.2	0.6	GO:0070476	rRNA (guanine-N7)-methylation(GO:0070476)
0.2	8.0	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2	0.9	GO:1903847	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.2	0.5	GO:0006542	glutamine biosynthetic process(GO:0006542)
0.2	4.0	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.2	0.9	GO:1990743	protein sialylation(GO:1990743)
0.2	2.0	GO:0030916	otic vesicle formation(GO:0030916)
0.2	2.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.2	2.6	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336)
0.2	1.5	GO:0071231	neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.2	2.2	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.2	1.7	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.2	3.7	GO:0007194	negative regulation of adenylate cyclase activity(GO:0007194)
0.2	1.3	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.2	2.5	GO:0043248	proteasome assembly(GO:0043248)
0.2	10.1	GO:0043029	T cell homeostasis(GO:0043029)
0.2	0.3	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.2	1.4	GO:0038203	TORC2 signaling(GO:0038203)
0.2	2.4	GO:0043589	skin morphogenesis(GO:0043589)
0.2	3.6	GO:0006991	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.2	4.6	GO:0006301	postreplication repair(GO:0006301)
0.2	2.4	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
0.2	0.5	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.2	0.8	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.2	2.4	GO:0071493	cellular response to UV-B(GO:0071493)
0.1	9.2	GO:0006414	translational elongation(GO:0006414)
0.1	0.6	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.1	6.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.1	2.8	GO:0010529	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.1	2.2	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.1	1.1	GO:2000234	positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1	0.7	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.1	0.8	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1	1.0	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.1	0.5	GO:0019858	cytosine metabolic process(GO:0019858)
0.1	2.0	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.1	0.5	GO:0051311	meiotic metaphase I plate congression(GO:0043060) meiotic metaphase plate congression(GO:0051311)
0.1	0.4	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
0.1	0.7	GO:0034227	tRNA thio-modification(GO:0034227)
0.1	3.5	GO:0030539	male genitalia development(GO:0030539)
0.1	1.2	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.1	5.1	GO:0000305	response to oxygen radical(GO:0000305)
0.1	0.7	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1	3.7	GO:0048268	clathrin coat assembly(GO:0048268)
0.1	5.9	GO:0002026	regulation of the force of heart contraction(GO:0002026)
0.1	2.4	GO:0046457	prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1	0.9	GO:0010838	positive regulation of keratinocyte proliferation(GO:0010838)
0.1	1.8	GO:0006857	oligopeptide transport(GO:0006857)
0.1	2.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.1	1.0	GO:1905146	lysosomal lumen acidification(GO:0007042) lysosomal protein catabolic process(GO:1905146)
0.1	1.0	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.1	2.4	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.1	3.8	GO:0002467	germinal center formation(GO:0002467)
0.1	0.4	GO:0050713	negative regulation of interleukin-1 beta secretion(GO:0050713) positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.1	24.8	GO:0002377	immunoglobulin production(GO:0002377)
0.1	1.5	GO:2000671	regulation of motor neuron apoptotic process(GO:2000671)
0.1	2.4	GO:0015858	nucleoside transport(GO:0015858)
0.1	3.0	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1	15.9	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.1	0.7	GO:0000103	sulfate assimilation(GO:0000103)
0.1	0.3	GO:0048611	ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1	0.4	GO:0035582	sequestering of BMP in extracellular matrix(GO:0035582)
0.1	1.2	GO:0035330	regulation of hippo signaling(GO:0035330)
0.1	0.6	GO:0014052	regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.1	4.0	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1	1.4	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.1	0.4	GO:1903378	positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1	0.7	GO:0000042	protein targeting to Golgi(GO:0000042)
0.1	0.8	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1	2.1	GO:0097341	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.1	0.3	GO:0034552	respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.1	1.1	GO:0006308	DNA catabolic process(GO:0006308)
0.1	0.4	GO:0070889	platelet alpha granule organization(GO:0070889)
0.1	3.3	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.1	0.5	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.1	1.8	GO:0043968	histone H2A acetylation(GO:0043968)
0.1	1.4	GO:0035428	hexose transmembrane transport(GO:0035428)
0.1	0.2	GO:0051933	amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1	4.2	GO:0015909	long-chain fatty acid transport(GO:0015909)
0.1	0.8	GO:0031077	post-embryonic camera-type eye development(GO:0031077)
0.1	4.3	GO:0002181	cytoplasmic translation(GO:0002181)
0.1	0.8	GO:0001682	tRNA 5'-leader removal(GO:0001682)
0.1	1.6	GO:0030488	tRNA methylation(GO:0030488)
0.1	0.4	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.1	0.8	GO:0000492	box C/D snoRNP assembly(GO:0000492)
0.1	1.7	GO:0070208	protein heterotrimerization(GO:0070208)
0.1	1.4	GO:0034389	lipid particle organization(GO:0034389)
0.1	5.2	GO:0070527	platelet aggregation(GO:0070527)
0.1	3.2	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
0.1	0.3	GO:0010288	response to lead ion(GO:0010288)
0.1	1.5	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1	10.4	GO:0071222	cellular response to lipopolysaccharide(GO:0071222)
0.1	1.0	GO:0006379	mRNA cleavage(GO:0006379)
0.1	0.3	GO:0006222	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1	2.9	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.1	0.3	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1	0.3	GO:0060082	response to carbon monoxide(GO:0034465) eye blink reflex(GO:0060082)
0.1	0.5	GO:0090315	negative regulation of protein targeting to membrane(GO:0090315)
0.1	0.3	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1	0.3	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.1	1.9	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	1.9	GO:0030168	platelet activation(GO:0030168)
0.0	1.2	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.6	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.0	0.2	GO:0033563	dorsal/ventral axon guidance(GO:0033563)
0.0	0.5	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	1.1	GO:0030262	cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0	1.2	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	1.4	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.7	GO:0006656	phosphatidylcholine biosynthetic process(GO:0006656)
0.0	0.2	GO:0006421	asparaginyl-tRNA aminoacylation(GO:0006421)
0.0	0.5	GO:0060628	regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0	0.1	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0	0.6	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	1.2	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.7	GO:1903779	regulation of cardiac conduction(GO:1903779)
0.0	1.5	GO:0097194	execution phase of apoptosis(GO:0097194)
0.0	2.0	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0	0.0	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	1.7	GO:0086010	membrane depolarization during action potential(GO:0086010)
0.0	0.5	GO:0080182	histone H3-K4 trimethylation(GO:0080182)
0.0	0.5	GO:0021957	corticospinal tract morphogenesis(GO:0021957)
0.0	1.3	GO:0002548	monocyte chemotaxis(GO:0002548)
0.0	0.5	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	0.3	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0	1.0	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	1.1	GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0	0.6	GO:0002076	osteoblast development(GO:0002076)
0.0	1.2	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0	1.3	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.6	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	1.2	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.1	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) RNA surveillance(GO:0071025)
0.0	1.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	1.1	GO:0040019	positive regulation of embryonic development(GO:0040019)
0.0	0.5	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
0.0	0.3	GO:2000009	negative regulation of protein localization to cell surface(GO:2000009)
0.0	1.5	GO:0046324	regulation of glucose import(GO:0046324)
0.0	1.0	GO:0003009	skeletal muscle contraction(GO:0003009)
0.0	0.3	GO:0042832	defense response to protozoan(GO:0042832)
0.0	1.2	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.8	GO:0046039	GTP metabolic process(GO:0046039)
0.0	0.1	GO:0010968	regulation of microtubule nucleation(GO:0010968)
0.0	1.5	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	1.3	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.2	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:1903575	cornified envelope assembly(GO:1903575)
0.0	1.6	GO:0035914	skeletal muscle cell differentiation(GO:0035914)
0.0	0.7	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	0.2	GO:0034142	toll-like receptor 4 signaling pathway(GO:0034142)
0.0	0.0	GO:0006272	leading strand elongation(GO:0006272)
0.0	0.3	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.1	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.4	GO:0090662	ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0	1.1	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	0.6	GO:0006334	nucleosome assembly(GO:0006334)
0.0	4.3	GO:0008380	RNA splicing(GO:0008380)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.5	21.2	GO:0044218	other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
2.4	41.3	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.6	4.9	GO:0031904	endosome lumen(GO:0031904)
1.5	5.8	GO:0031021	interphase microtubule organizing center(GO:0031021)
1.4	9.8	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
1.0	7.2	GO:0031095	platelet dense tubular network membrane(GO:0031095)
1.0	4.1	GO:0000939	condensed chromosome inner kinetochore(GO:0000939)
0.9	8.1	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
0.8	2.4	GO:0005584	collagen type I trimer(GO:0005584)
0.7	3.0	GO:1990769	proximal neuron projection(GO:1990769)
0.7	2.2	GO:0030905	retromer, tubulation complex(GO:0030905)
0.7	17.8	GO:0035686	sperm fibrous sheath(GO:0035686)
0.7	2.0	GO:0071007	U2-type catalytic step 2 spliceosome(GO:0071007)
0.6	5.8	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.6	14.0	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.6	2.4	GO:0036284	tubulobulbar complex(GO:0036284)
0.6	3.5	GO:0071556	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.6	8.7	GO:0043020	NADPH oxidase complex(GO:0043020)
0.5	2.1	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
0.4	9.4	GO:0031143	pseudopodium(GO:0031143)
0.4	5.3	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.4	5.0	GO:0000796	condensin complex(GO:0000796)
0.4	2.8	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.4	4.0	GO:0019815	B cell receptor complex(GO:0019815)
0.4	2.4	GO:0070876	SOSS complex(GO:0070876)
0.4	2.4	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.4	4.0	GO:0030991	intraciliary transport particle A(GO:0030991)
0.4	2.3	GO:0005663	DNA replication factor C complex(GO:0005663)
0.4	1.4	GO:0014802	terminal cisterna(GO:0014802)
0.3	4.5	GO:0032591	dendritic spine membrane(GO:0032591)
0.3	2.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.3	1.6	GO:0032585	multivesicular body membrane(GO:0032585)
0.3	10.0	GO:0001891	phagocytic cup(GO:0001891)
0.3	5.6	GO:0032593	insulin-responsive compartment(GO:0032593)
0.3	2.3	GO:0070847	core mediator complex(GO:0070847)
0.3	2.8	GO:0033093	Weibel-Palade body(GO:0033093)
0.3	2.8	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.3	1.6	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.3	1.5	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.3	4.6	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2	4.2	GO:0005641	nuclear envelope lumen(GO:0005641)
0.2	1.2	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.2	5.5	GO:1990023	mitotic spindle midzone(GO:1990023)
0.2	0.7	GO:0034457	Mpp10 complex(GO:0034457)
0.2	1.6	GO:0016580	Sin3 complex(GO:0016580)
0.2	6.6	GO:0031527	filopodium membrane(GO:0031527)
0.2	2.5	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2	2.8	GO:0042788	polysomal ribosome(GO:0042788)
0.2	1.5	GO:0097422	tubular endosome(GO:0097422)
0.2	1.3	GO:0089701	U2AF(GO:0089701)
0.2	4.9	GO:0005682	U5 snRNP(GO:0005682)
0.2	0.5	GO:0005715	chiasma(GO:0005712) late recombination nodule(GO:0005715)
0.2	0.6	GO:0097543	ciliary inversin compartment(GO:0097543)
0.2	2.9	GO:0005861	troponin complex(GO:0005861)
0.2	1.5	GO:0042382	paraspeckles(GO:0042382)
0.2	1.1	GO:0071256	Sec61 translocon complex(GO:0005784) endoplasmic reticulum Sec complex(GO:0031205) translocon complex(GO:0071256)
0.2	9.3	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	2.4	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1	0.6	GO:0035976	AP1 complex(GO:0035976)
0.1	17.1	GO:0014704	intercalated disc(GO:0014704)
0.1	8.7	GO:0031672	A band(GO:0031672)
0.1	3.1	GO:0031528	microvillus membrane(GO:0031528)
0.1	11.3	GO:0005871	kinesin complex(GO:0005871)
0.1	1.0	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	20.0	GO:0017053	transcriptional repressor complex(GO:0017053)
0.1	0.8	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.1	1.2	GO:0061574	ASAP complex(GO:0061574)
0.1	0.8	GO:0005638	lamin filament(GO:0005638)
0.1	4.0	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	10.0	GO:0072686	mitotic spindle(GO:0072686)
0.1	0.3	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.1	3.6	GO:0035371	microtubule plus-end(GO:0035371)
0.1	3.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	1.8	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.1	0.5	GO:0097452	GAIT complex(GO:0097452)
0.1	0.5	GO:0001652	granular component(GO:0001652)
0.1	2.9	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	1.2	GO:0005686	U2 snRNP(GO:0005686)
0.1	22.4	GO:0000793	condensed chromosome(GO:0000793)
0.1	1.3	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1	1.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.1	1.7	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1	1.1	GO:0000812	Swr1 complex(GO:0000812)
0.1	1.6	GO:0031083	BLOC-1 complex(GO:0031083)
0.1	0.4	GO:0032389	MutLalpha complex(GO:0032389)
0.1	3.9	GO:0016235	aggresome(GO:0016235)
0.1	0.6	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	0.7	GO:0005642	annulate lamellae(GO:0005642)
0.1	2.1	GO:0005680	anaphase-promoting complex(GO:0005680)
0.1	0.4	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.1	8.7	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.1	3.8	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.1	1.6	GO:0097225	sperm midpiece(GO:0097225)
0.1	1.5	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	0.7	GO:0042587	glycogen granule(GO:0042587)
0.1	1.2	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.1	0.4	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.1	1.3	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	3.4	GO:0099738	cell cortex region(GO:0099738)
0.1	0.7	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	8.6	GO:0005819	spindle(GO:0005819)
0.1	2.1	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	1.0	GO:0002199	zona pellucida receptor complex(GO:0002199)
0.0	0.4	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.4	GO:0031597	cytosolic proteasome complex(GO:0031597)
0.0	9.7	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	5.4	GO:0042571	immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571)
0.0	0.3	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.3	GO:0070652	HAUS complex(GO:0070652)
0.0	1.7	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	2.6	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	3.8	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.0	0.7	GO:0043189	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0	2.9	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.8	GO:0032040	small-subunit processome(GO:0032040)
0.0	1.2	GO:0035861	site of double-strand break(GO:0035861)
0.0	3.5	GO:0000781	chromosome, telomeric region(GO:0000781)
0.0	0.6	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.3	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	3.7	GO:0032993	protein-DNA complex(GO:0032993)
0.0	0.2	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	1.8	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	0.6	GO:0000145	exocyst(GO:0000145)
0.0	0.5	GO:0036038	MKS complex(GO:0036038)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.4	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.3	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.0	2.3	GO:0016363	nuclear matrix(GO:0016363)
0.0	0.2	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	1.0	GO:0045171	intercellular bridge(GO:0045171)
0.0	0.3	GO:0031932	TORC2 complex(GO:0031932)
0.0	4.0	GO:0001726	ruffle(GO:0001726)
0.0	0.5	GO:0032155	cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610)
0.0	0.3	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.9	GO:0016234	inclusion body(GO:0016234)
0.0	9.6	GO:0031012	extracellular matrix(GO:0031012)
0.0	0.9	GO:0016459	myosin complex(GO:0016459)
0.0	0.1	GO:0097539	ciliary transition fiber(GO:0097539)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0	0.2	GO:0097449	astrocyte projection(GO:0097449)
0.0	0.7	GO:0030136	clathrin-coated vesicle(GO:0030136)
0.0	0.2	GO:0030119	AP-type membrane coat adaptor complex(GO:0030119)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.0	14.9	GO:0004418	hydroxymethylbilane synthase activity(GO:0004418)
3.0	8.9	GO:0031896	V2 vasopressin receptor binding(GO:0031896)
2.0	8.1	GO:0030629	U6 snRNA 3'-end binding(GO:0030629)
1.9	5.7	GO:0047291	lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
1.8	10.8	GO:0030171	voltage-gated proton channel activity(GO:0030171)
1.6	15.8	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
1.5	6.1	GO:0015057	thrombin receptor activity(GO:0015057)
1.4	5.7	GO:0004736	pyruvate carboxylase activity(GO:0004736)
1.3	9.0	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.2	7.2	GO:0048495	Roundabout binding(GO:0048495)
1.1	3.4	GO:0034188	apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
1.1	4.5	GO:0070976	TIR domain binding(GO:0070976)
1.1	5.6	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
1.0	32.1	GO:0004190	aspartic-type endopeptidase activity(GO:0004190)
1.0	8.8	GO:0008481	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
1.0	3.9	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.9	10.0	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.9	2.7	GO:0004798	thymidylate kinase activity(GO:0004798)
0.9	19.4	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.9	4.4	GO:0015254	glycerol channel activity(GO:0015254)
0.9	2.6	GO:0001729	ceramide kinase activity(GO:0001729)
0.8	5.9	GO:0004782	sulfinoalanine decarboxylase activity(GO:0004782)
0.8	8.7	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.8	7.8	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.7	4.4	GO:0004994	somatostatin receptor activity(GO:0004994)
0.7	2.1	GO:0005330	dopamine:sodium symporter activity(GO:0005330)
0.7	4.2	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.7	21.6	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.7	9.6	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.6	4.5	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.6	5.8	GO:0015181	arginine transmembrane transporter activity(GO:0015181)
0.6	5.9	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.6	17.5	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.6	8.0	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.6	2.2	GO:1990460	leptin receptor binding(GO:1990460)
0.5	5.4	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.5	1.6	GO:0001129	RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.5	3.2	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.5	3.0	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.5	12.9	GO:0003746	translation elongation factor activity(GO:0003746)
0.5	2.0	GO:0004052	arachidonate 12-lipoxygenase activity(GO:0004052)
0.5	1.9	GO:0008160	protein tyrosine phosphatase activator activity(GO:0008160)
0.5	2.8	GO:0047844	deoxycytidine deaminase activity(GO:0047844)
0.5	1.9	GO:0050347	trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.4	3.0	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.4	28.9	GO:0004601	peroxidase activity(GO:0004601)
0.4	5.3	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.4	20.7	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.4	3.1	GO:0005124	scavenger receptor binding(GO:0005124)
0.4	1.9	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.4	1.9	GO:0042610	CD8 receptor binding(GO:0042610)
0.4	1.8	GO:0061649	ubiquitinated histone binding(GO:0061649)
0.4	6.5	GO:1990226	histone methyltransferase binding(GO:1990226)
0.4	1.4	GO:0004667	prostaglandin-D synthase activity(GO:0004667)
0.4	5.3	GO:0030274	LIM domain binding(GO:0030274)
0.3	1.7	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.3	2.4	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3	4.6	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.3	16.1	GO:0003785	actin monomer binding(GO:0003785)
0.3	5.7	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.3	15.6	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3	4.0	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.3	1.5	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.3	2.1	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.3	3.7	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.3	2.1	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.3	2.9	GO:0031014	troponin T binding(GO:0031014)
0.3	9.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.3	1.7	GO:0031781	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.3	0.8	GO:0046899	nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.3	0.8	GO:0030622	U4atac snRNA binding(GO:0030622)
0.3	2.7	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3	1.5	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.3	1.3	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.2	1.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.2	5.9	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2	1.2	GO:0035614	snRNA stem-loop binding(GO:0035614)
0.2	1.5	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.2	1.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.2	11.9	GO:0004521	endoribonuclease activity(GO:0004521)
0.2	2.0	GO:0017070	U6 snRNA binding(GO:0017070)
0.2	1.3	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2	2.3	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2	3.7	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.2	1.4	GO:0047179	platelet-activating factor acetyltransferase activity(GO:0047179)
0.2	7.1	GO:0001968	fibronectin binding(GO:0001968)
0.2	1.3	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.2	1.7	GO:0042285	xylosyltransferase activity(GO:0042285)
0.2	2.3	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.2	7.5	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.2	2.4	GO:0008301	DNA binding, bending(GO:0008301)
0.2	0.5	GO:0016211	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.2	3.2	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.2	0.9	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.2	2.6	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.2	0.7	GO:0030519	snoRNP binding(GO:0030519)
0.2	0.7	GO:0004105	choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2	9.9	GO:0031369	translation initiation factor binding(GO:0031369)
0.2	3.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.2	0.8	GO:0034618	arginine-tRNA ligase activity(GO:0004814) arginine binding(GO:0034618)
0.2	0.5	GO:0004342	glucosamine-6-phosphate deaminase activity(GO:0004342)
0.2	0.9	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.1	2.8	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	1.5	GO:0051870	methotrexate binding(GO:0051870)
0.1	2.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	1.1	GO:0052851	ferric-chelate reductase activity(GO:0000293) cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1	0.7	GO:0030984	kininogen binding(GO:0030984)
0.1	1.9	GO:0019534	toxin transporter activity(GO:0019534)
0.1	2.9	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.1	2.9	GO:0017049	GTP-Rho binding(GO:0017049)
0.1	2.0	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1	0.4	GO:0016015	morphogen activity(GO:0016015)
0.1	0.5	GO:0005093	Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1	3.0	GO:0051010	microtubule plus-end binding(GO:0051010)
0.1	0.7	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.1	0.5	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.1	0.4	GO:0070336	forked DNA-dependent helicase activity(GO:0061749) flap-structured DNA binding(GO:0070336)
0.1	1.1	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1	0.7	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
0.1	0.5	GO:0019828	aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1	1.0	GO:0045545	syndecan binding(GO:0045545)
0.1	4.1	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.1	1.9	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.1	0.3	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.1	0.5	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1	11.3	GO:0003777	microtubule motor activity(GO:0003777)
0.1	1.6	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.1	5.1	GO:0004540	ribonuclease activity(GO:0004540)
0.1	2.0	GO:0004806	triglyceride lipase activity(GO:0004806)
0.1	0.7	GO:0004027	alcohol sulfotransferase activity(GO:0004027)
0.1	0.7	GO:0034452	dynactin binding(GO:0034452)
0.1	2.8	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.1	2.6	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.1	1.3	GO:0008097	5S rRNA binding(GO:0008097)
0.1	0.8	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	6.6	GO:0030507	spectrin binding(GO:0030507)
0.1	0.9	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1	1.3	GO:0015035	protein disulfide oxidoreductase activity(GO:0015035)
0.1	3.3	GO:0043014	alpha-tubulin binding(GO:0043014)
0.1	4.1	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	1.2	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.1	0.5	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1	0.9	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	1.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1	9.5	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	0.4	GO:0004905	interferon receptor activity(GO:0004904) type I interferon receptor activity(GO:0004905) type I interferon binding(GO:0019962)
0.1	5.9	GO:0048365	Rac GTPase binding(GO:0048365)
0.1	3.2	GO:0008536	Ran GTPase binding(GO:0008536)
0.1	5.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1	1.9	GO:0070182	DNA polymerase binding(GO:0070182)
0.1	0.8	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.1	0.9	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.1	0.5	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1	0.7	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1	0.7	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1	3.3	GO:0036002	pre-mRNA binding(GO:0036002)
0.1	0.3	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.1	1.6	GO:0031489	myosin V binding(GO:0031489)
0.1	0.4	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1	1.4	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	0.8	GO:0019869	chloride channel inhibitor activity(GO:0019869)
0.1	4.2	GO:0005507	copper ion binding(GO:0005507)
0.1	0.2	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.7	GO:0001164	RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0	1.6	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.3	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	3.8	GO:0005518	collagen binding(GO:0005518)
0.0	1.0	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	2.2	GO:0050699	WW domain binding(GO:0050699)
0.0	0.3	GO:0030249	guanylate cyclase regulator activity(GO:0030249)
0.0	0.3	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
0.0	0.3	GO:0008422	beta-glucosidase activity(GO:0008422)
0.0	0.4	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	1.5	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	1.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:1902121	NADP+ binding(GO:0070401) lithocholic acid binding(GO:1902121)
0.0	0.1	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.0	0.5	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.4	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	1.7	GO:0016860	intramolecular oxidoreductase activity(GO:0016860)
0.0	1.0	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.5	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0	4.2	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	3.3	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	0.7	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.9	GO:0005112	Notch binding(GO:0005112)
0.0	1.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	0.2	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	1.6	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	10.2	GO:0005096	GTPase activator activity(GO:0005096)
0.0	0.3	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	1.7	GO:0042805	actinin binding(GO:0042805)
0.0	1.9	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	1.0	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0	0.5	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.2	GO:1901612	cardiolipin binding(GO:1901612)
0.0	1.5	GO:0004519	endonuclease activity(GO:0004519)
0.0	0.4	GO:0004697	protein kinase C activity(GO:0004697)
0.0	1.9	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.5	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.8	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	0.3	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.5	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.2	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.3	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.0	GO:0098634	protein binding involved in cell-matrix adhesion(GO:0098634) integrin binding involved in cell-matrix adhesion(GO:0098640)
0.0	2.0	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	0.1	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	20.7	GO:0043565	sequence-specific DNA binding(GO:0043565)
0.0	2.0	GO:0017124	SH3 domain binding(GO:0017124)
0.0	0.1	GO:0016608	growth hormone-releasing hormone activity(GO:0016608)
0.0	0.4	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.2	GO:0015215	nucleotide transmembrane transporter activity(GO:0015215)
0.0	0.9	GO:0005550	pheromone binding(GO:0005550)
0.0	2.3	GO:0005549	odorant binding(GO:0005549)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	42.4	PID IL23 PATHWAY	IL23-mediated signaling events
0.5	26.2	PID AURORA B PATHWAY	Aurora B signaling
0.4	12.0	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.4	19.7	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.4	13.8	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.4	13.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.3	7.9	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.3	12.6	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.3	11.4	PID EPO PATHWAY	EPO signaling pathway
0.3	2.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	6.4	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.2	20.0	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.2	5.6	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.2	4.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2	10.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.2	12.2	PID RAC1 PATHWAY	RAC1 signaling pathway
0.2	7.3	PID FANCONI PATHWAY	Fanconi anemia pathway
0.1	2.7	PID ARF6 PATHWAY	Arf6 signaling events
0.1	5.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	4.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	3.6	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	2.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	2.6	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1	2.4	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	2.7	PID ATM PATHWAY	ATM pathway
0.1	25.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	9.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	4.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	0.8	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.1	3.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	1.9	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	7.4	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	3.5	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	2.6	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	2.4	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	2.2	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.0	2.8	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.0	0.5	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	1.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	1.1	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	1.9	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	0.5	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	0.9	PID CDC42 PATHWAY	CDC42 signaling events
0.0	0.7	ST ADRENERGIC	Adrenergic Pathway
0.0	0.4	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.4	PID INSULIN PATHWAY	Insulin Pathway
0.0	0.3	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.9	PID NOTCH PATHWAY	Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	26.2	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.6	14.9	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.6	29.8	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.6	13.9	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.5	10.9	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4	7.0	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.4	7.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4	9.4	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.4	8.1	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4	1.5	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.4	11.3	REACTOME KINESINS	Genes involved in Kinesins
0.3	11.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.3	17.2	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.3	4.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.3	3.0	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.3	15.4	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3	13.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.2	4.5	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.2	15.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	9.4	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.2	3.6	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.2	18.7	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	2.9	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.2	4.1	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2	5.0	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.2	2.4	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.2	10.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	7.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.2	14.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	1.1	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.2	2.8	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.2	9.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2	4.6	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1	2.6	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.1	2.4	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.1	5.9	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	12.3	REACTOME LATE PHASE OF HIV LIFE CYCLE	Genes involved in Late Phase of HIV Life Cycle
0.1	2.1	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.1	5.2	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.1	2.7	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	0.9	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	2.8	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	4.7	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1	1.1	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1	0.7	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.1	0.9	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1	2.9	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	0.9	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1	5.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	0.3	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.1	4.4	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	0.4	REACTOME DEFENSINS	Genes involved in Defensins
0.1	1.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	1.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	3.6	REACTOME TRANSLATION	Genes involved in Translation
0.0	0.7	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	1.1	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0	2.5	REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C	Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0	1.6	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	1.0	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	1.4	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	1.1	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	4.8	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	3.9	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.0	2.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	4.0	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.7	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	1.0	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.4	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	4.9	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	1.3	REACTOME PI3K EVENTS IN ERBB4 SIGNALING	Genes involved in PI3K events in ERBB4 signaling
0.0	0.7	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.4	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	4.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.4	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	1.7	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	0.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.5	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.3	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	0.3	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification

Results for Esr1

Z-value: 1.90

Motif logo

Transcription factors associated with Esr1

Activity-expression correlation:

Activity profile of Esr1 motif

Sorted Z-values of Esr1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: