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GSE58827: Dynamics of the Mouse Liver

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Results for Foxc2

Z-value: 0.80

Motif logo

Transcription factors associated with Foxc2

Gene Symbol Gene ID Gene Info
ENSMUSG00000046714.8 forkhead box C2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxc2mm39_v1_chr8_+_121842902_1218429160.134.4e-01Click!

Activity profile of Foxc2 motif

Sorted Z-values of Foxc2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_20329823 10.79 ENSMUST00000011607.6
carboxypeptidase B1 (tissue)
chr6_+_30541581 9.30 ENSMUST00000096066.5
carboxypeptidase A2, pancreatic
chr4_-_87724533 8.49 ENSMUST00000126353.8
ENSMUST00000149357.8
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr14_-_20319242 5.53 ENSMUST00000024155.9
potassium channel, subfamily K, member 16
chr6_-_83513222 4.74 ENSMUST00000075161.12
actin, gamma 2, smooth muscle, enteric
chr11_-_99328969 4.21 ENSMUST00000017743.3
keratin 20
chr6_-_83513184 3.24 ENSMUST00000205926.2
actin, gamma 2, smooth muscle, enteric
chr17_-_31363245 3.18 ENSMUST00000024826.8
trefoil factor 2 (spasmolytic protein 1)
chr14_+_71011744 2.95 ENSMUST00000022698.8
docking protein 2
chr14_-_71003973 2.91 ENSMUST00000226448.2
ENSMUST00000022696.8
exportin 7
chr5_-_138169253 2.83 ENSMUST00000139983.8
minichromosome maintenance complex component 7
chr17_+_47816042 2.83 ENSMUST00000183044.8
ENSMUST00000037333.17
cyclin D3
chr17_+_47816074 2.79 ENSMUST00000183177.8
ENSMUST00000182848.8
cyclin D3
chr17_+_47815968 2.77 ENSMUST00000182129.8
ENSMUST00000171031.8
cyclin D3
chr19_+_45433899 2.76 ENSMUST00000224478.2
beta-transducin repeat containing protein
chr17_+_47816137 2.72 ENSMUST00000182935.8
ENSMUST00000182506.8
cyclin D3
chr6_+_142244145 2.31 ENSMUST00000041993.3
islet amyloid polypeptide
chr14_-_71004019 2.22 ENSMUST00000167242.8
exportin 7
chr3_+_107137924 2.21 ENSMUST00000179399.3
RIKEN cDNA A630076J17 gene
chr7_-_115459082 2.20 ENSMUST00000206123.2
SRY (sex determining region Y)-box 6
chr9_-_21202545 2.07 ENSMUST00000215619.2
cyclin dependent kinase inhibitor 2D
chr2_+_91376650 2.07 ENSMUST00000099716.11
ENSMUST00000046769.16
ENSMUST00000111337.3
cytoskeleton associated protein 5
chr11_-_16958647 1.98 ENSMUST00000102881.10
pleckstrin
chr2_-_163486998 1.94 ENSMUST00000017851.4
serine incorporator 3
chr9_-_21202353 1.88 ENSMUST00000086374.8
cyclin dependent kinase inhibitor 2D
chr1_-_160079007 1.83 ENSMUST00000191909.6
RAB GTPase activating protein 1-like
chr19_-_38032006 1.79 ENSMUST00000172095.3
ENSMUST00000041475.16
myoferlin
chr9_-_21202693 1.75 ENSMUST00000213407.2
cyclin dependent kinase inhibitor 2D
chr4_-_87724512 1.71 ENSMUST00000148059.2
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
chr3_-_102871440 1.70 ENSMUST00000058899.13
nuclear receptor subfamily 1, group H, member 5
chr18_-_47466378 1.64 ENSMUST00000126684.2
ENSMUST00000156422.8
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr2_-_62313981 1.58 ENSMUST00000136686.2
ENSMUST00000102733.10
glucagon
chr17_+_8144822 1.52 ENSMUST00000036370.8
T cell activation Rho GTPase activating protein
chr6_-_136899167 1.51 ENSMUST00000032343.7
endoplasmic reticulum protein 27
chr5_+_25452342 1.49 ENSMUST00000114950.2
polypeptide N-acetylgalactosaminyltransferase 11
chrX_+_162923474 1.47 ENSMUST00000073973.11
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr2_-_118558852 1.45 ENSMUST00000102524.8
phospholipase C, beta 2
chr18_+_61238632 1.43 ENSMUST00000025523.13
ENSMUST00000235447.2
colony stimulating factor 1 receptor
chr15_+_54274151 1.42 ENSMUST00000036737.4
collectin sub-family member 10
chr4_+_34893772 1.41 ENSMUST00000029975.10
ENSMUST00000135871.8
ENSMUST00000108130.2
glycoprotein hormones, alpha subunit
chr8_+_106785434 1.37 ENSMUST00000212742.2
ENSMUST00000211991.2
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
chr2_-_118558825 1.35 ENSMUST00000159756.2
phospholipase C, beta 2
chr6_+_8520006 1.34 ENSMUST00000162567.8
ENSMUST00000161217.8
glucocorticoid induced transcript 1
chr11_+_33997114 1.25 ENSMUST00000109329.9
lymphocyte cytosolic protein 2
chr17_+_46471950 1.22 ENSMUST00000024748.14
ENSMUST00000172170.8
GTP binding protein 2
chr19_-_38031774 1.22 ENSMUST00000226068.2
myoferlin
chrX_+_162694397 1.21 ENSMUST00000140845.2
adaptor-related protein complex 1, sigma 2 subunit
chr5_-_115236354 1.20 ENSMUST00000100848.3
predicted gene 10401
chr7_-_99994257 1.17 ENSMUST00000207634.2
protein phosphatase methylesterase 1
chr1_-_182929025 1.16 ENSMUST00000171366.7
dispatched RND transporter family member 1
chr11_+_33996920 1.13 ENSMUST00000052413.12
lymphocyte cytosolic protein 2
chr8_-_65489834 1.11 ENSMUST00000142822.4
apelin receptor early endogenous ligand
chr11_+_70323452 0.98 ENSMUST00000084954.13
ENSMUST00000108568.10
ENSMUST00000079056.9
ENSMUST00000102564.11
ENSMUST00000124943.8
ENSMUST00000150076.8
ENSMUST00000102563.2
arrestin, beta 2
chr8_-_45715049 0.98 ENSMUST00000034064.5
coagulation factor XI
chr5_-_18093739 0.98 ENSMUST00000169095.6
ENSMUST00000197574.2
CD36 molecule
chr1_+_40554513 0.93 ENSMUST00000027237.12
interleukin 18 receptor accessory protein
chr17_+_29309942 0.91 ENSMUST00000119901.9
cyclin-dependent kinase inhibitor 1A (P21)
chr5_-_104261556 0.90 ENSMUST00000031249.8
SPARC-like 1
chrX_+_95498965 0.90 ENSMUST00000033553.14
hephaestin
chrX_+_158086253 0.87 ENSMUST00000112491.2
ribosomal protein S6 kinase polypeptide 3
chr18_-_55123153 0.87 ENSMUST00000064763.7
zinc finger protein 608
chr9_+_53757448 0.80 ENSMUST00000048485.7
sarcolipin
chr7_-_131918926 0.78 ENSMUST00000080215.6
carbohydrate sulfotransferase 15
chr5_-_123127148 0.77 ENSMUST00000046073.16
lysine (K)-specific demethylase 2B
chr8_+_108271643 0.71 ENSMUST00000212543.2
WW domain containing E3 ubiquitin protein ligase 2
chr1_+_87332638 0.65 ENSMUST00000173152.2
ENSMUST00000173663.2
GRB10 interacting GYF protein 2
chr11_-_107238956 0.62 ENSMUST00000134763.2
phosphatidylinositol transfer protein, cytoplasmic 1
chr13_+_94954202 0.62 ENSMUST00000220825.2
tubulin cofactor A
chr17_+_28226319 0.61 ENSMUST00000139173.3
ankyrin repeat and SAM domain containing 1
chr7_+_113365235 0.60 ENSMUST00000046687.16
spondin 1, (f-spondin) extracellular matrix protein
chr1_-_97904958 0.59 ENSMUST00000161567.8
peptidylglycine alpha-amidating monooxygenase
chr14_+_20732804 0.56 ENSMUST00000228545.2
Sec24 related gene family, member C (S. cerevisiae)
chr15_-_101833160 0.55 ENSMUST00000023797.8
keratin 4
chr8_-_65489791 0.55 ENSMUST00000124790.8
apelin receptor early endogenous ligand
chr1_+_43484895 0.54 ENSMUST00000086421.9
non-catalytic region of tyrosine kinase adaptor protein 2
chr1_+_51328265 0.54 ENSMUST00000051572.8
caveolae associated 2
chr1_-_75119277 0.53 ENSMUST00000168720.8
ENSMUST00000041213.12
ENSMUST00000189809.2
cyclin Pas1/PHO80 domain containing 1
chr16_-_74208180 0.53 ENSMUST00000117200.8
roundabout guidance receptor 2
chr10_-_23112973 0.52 ENSMUST00000218049.2
EYA transcriptional coactivator and phosphatase 4
chr3_+_75982890 0.51 ENSMUST00000160261.8
follistatin-like 5
chr8_+_94537910 0.51 ENSMUST00000138659.9
guanine nucleotide binding protein, alpha O
chr19_-_42074777 0.50 ENSMUST00000051772.10
MORN repeat containing 4
chr7_-_26895141 0.49 ENSMUST00000163311.9
ENSMUST00000126211.2
small nuclear ribonucleoprotein polypeptide A
chr6_+_56979285 0.49 ENSMUST00000079669.7
vomeronasal 1 receptor 6
chr6_-_141719536 0.48 ENSMUST00000148411.2
predicted gene 5724
chr19_+_47217279 0.47 ENSMUST00000111807.5
neuralized E3 ubiquitin protein ligase 1A
chr3_-_27764522 0.47 ENSMUST00000195008.6
fibronectin type III domain containing 3B
chr9_-_103569984 0.43 ENSMUST00000049452.15
transmembrane protein 108
chr5_-_108943211 0.43 ENSMUST00000004943.2
transmembrane p24 trafficking protein 11
chr18_+_52958382 0.42 ENSMUST00000238707.2
predicted gene, 50457
chr6_-_137548004 0.42 ENSMUST00000100841.9
epidermal growth factor receptor pathway substrate 8
chr2_+_87853118 0.42 ENSMUST00000214438.2
olfactory receptor 1161
chr9_+_57921954 0.42 ENSMUST00000034874.14
cytochrome P450, family 11, subfamily a, polypeptide 1
chr3_+_94745009 0.41 ENSMUST00000107266.8
ENSMUST00000042402.12
ENSMUST00000107269.2
pogo transposable element with ZNF domain
chr13_-_100753419 0.41 ENSMUST00000168772.2
ENSMUST00000163163.9
ENSMUST00000022137.14
MARVEL (membrane-associating) domain containing 2
chr12_-_101924407 0.39 ENSMUST00000159883.2
ENSMUST00000160251.8
ENSMUST00000161011.8
ENSMUST00000021606.12
ataxin 3
chr16_-_45313244 0.38 ENSMUST00000232138.2
predicted gene 609
chr2_+_91560472 0.38 ENSMUST00000099712.10
ENSMUST00000111317.9
ENSMUST00000111316.9
ENSMUST00000045705.14
autophagy/beclin 1 regulator 1
chrX_+_132751729 0.36 ENSMUST00000033602.9
tenomodulin
chr6_-_134768288 0.34 ENSMUST00000149776.3
dual specificity phosphatase 16
chr8_+_68729219 0.32 ENSMUST00000066594.4
SH2 domain containing 4A
chr8_-_62576140 0.31 ENSMUST00000034052.14
ENSMUST00000034054.9
annexin A10
chr16_-_89940652 0.30 ENSMUST00000114124.9
T cell lymphoma invasion and metastasis 1
chr7_+_90075762 0.30 ENSMUST00000061391.9
coiled-coil domain containing 89
chr2_-_86944911 0.29 ENSMUST00000216088.3
olfactory receptor 259
chr19_-_11291805 0.29 ENSMUST00000187467.2
membrane-spanning 4-domains, subfamily A, member 14
chr16_-_45313324 0.28 ENSMUST00000114585.3
predicted gene 609
chr8_+_66838927 0.28 ENSMUST00000039540.12
ENSMUST00000110253.3
membrane associated ring-CH-type finger 1
chr18_+_69652837 0.27 ENSMUST00000201410.4
ENSMUST00000202937.4
transcription factor 4
chr4_-_55532453 0.26 ENSMUST00000132746.2
ENSMUST00000107619.3
Kruppel-like factor 4 (gut)
chr13_-_78344492 0.26 ENSMUST00000125176.3
nuclear receptor subfamily 2, group F, member 1
chr11_+_54517164 0.25 ENSMUST00000239168.2
Rap guanine nucleotide exchange factor (GEF) 6
chr3_+_68491487 0.24 ENSMUST00000182997.3
schwannomin interacting protein 1
chr5_-_87630117 0.24 ENSMUST00000079811.13
ENSMUST00000144144.3
UDP glucuronosyltransferase 2 family, polypeptide A2
chr5_+_16758777 0.24 ENSMUST00000030683.8
hepatocyte growth factor
chr5_+_16758897 0.23 ENSMUST00000196645.2
hepatocyte growth factor
chr11_+_31950452 0.23 ENSMUST00000109409.8
ENSMUST00000020537.9
neuron specific gene family member 2
chr4_+_52607204 0.22 ENSMUST00000107671.2
topoisomerase I binding, arginine/serine-rich like
chr3_-_123483772 0.21 ENSMUST00000172537.3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr3_-_154760978 0.21 ENSMUST00000064076.6
TNNI3 interacting kinase
chr14_-_61495934 0.20 ENSMUST00000077954.13
sarcoglycan, gamma (dystrophin-associated glycoprotein)
chr11_+_77656414 0.20 ENSMUST00000164315.2
myosin XVIIIA
chr14_+_61844899 0.20 ENSMUST00000225582.2
ENSMUST00000051184.10
potassium channel regulator
chr18_+_69652550 0.20 ENSMUST00000201205.4
transcription factor 4
chr5_+_16758538 0.19 ENSMUST00000199581.5
hepatocyte growth factor
chr18_+_34892599 0.19 ENSMUST00000097622.4
family with sequence similarity 53, member C
chr16_-_22475915 0.19 ENSMUST00000089925.10
diacylglycerol kinase, gamma
chr18_+_69652880 0.18 ENSMUST00000200813.4
transcription factor 4
chr2_+_109522781 0.18 ENSMUST00000111050.10
brain derived neurotrophic factor
chr6_+_34840057 0.17 ENSMUST00000074949.4
transmembrane protein 140
chr9_-_99592116 0.17 ENSMUST00000035048.12
claudin 18
chr18_+_69652751 0.17 ENSMUST00000200966.4
transcription factor 4
chr9_+_43983493 0.17 ENSMUST00000176671.2
ubiquitin specific peptidase 2
chr3_-_102690026 0.17 ENSMUST00000172026.8
ENSMUST00000170856.6
thyroid stimulating hormone, beta subunit
chrX_+_56257374 0.17 ENSMUST00000033466.2
CD40 ligand
chr17_-_71158703 0.16 ENSMUST00000166395.9
TGFB-induced factor homeobox 1
chr17_+_46472037 0.15 ENSMUST00000166563.2
GTP binding protein 2
chr4_-_102883905 0.15 ENSMUST00000084382.6
ENSMUST00000106869.3
insulin-like 5
chr2_-_87570322 0.15 ENSMUST00000214573.2
olfactory receptor 1138
chr12_-_32258331 0.15 ENSMUST00000220366.2
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
chr2_-_45000389 0.14 ENSMUST00000201804.4
ENSMUST00000028229.13
ENSMUST00000202187.4
ENSMUST00000153561.6
ENSMUST00000201490.2
zinc finger E-box binding homeobox 2
chr6_-_23650205 0.14 ENSMUST00000115354.2
ring finger protein 133
chr13_-_43632368 0.14 ENSMUST00000222651.2
RAN binding protein 9
chr4_-_118266416 0.14 ENSMUST00000075406.12
SZT2 subunit of KICSTOR complex
chr1_+_156666485 0.13 ENSMUST00000111720.2
angiopoietin-like 1
chr11_+_99748741 0.13 ENSMUST00000107434.2
predicted gene 11568
chr3_-_9029097 0.12 ENSMUST00000091354.12
ENSMUST00000094381.11
tumor protein D52
chr3_-_64252048 0.12 ENSMUST00000234658.2
vomeronasal 2 receptor 128
chr10_+_38841511 0.11 ENSMUST00000019992.6
laminin, alpha 4
chr9_-_99592058 0.11 ENSMUST00000136429.8
claudin 18
chr4_-_120966396 0.10 ENSMUST00000106268.4
transmembrane and coiled-coil domains 2
chr9_+_35819708 0.10 ENSMUST00000176049.2
ENSMUST00000176153.2
prostate and testis expressed 13
chr19_+_5091365 0.10 ENSMUST00000116567.4
ENSMUST00000235918.2
breast cancer metastasis-suppressor 1
chr7_-_44498305 0.10 ENSMUST00000207293.2
ENSMUST00000207532.2
TBC1 domain family, member 17
chr12_-_32258604 0.09 ENSMUST00000053215.14
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
chr12_-_32258469 0.08 ENSMUST00000085469.6
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
chr2_+_4305273 0.08 ENSMUST00000175669.8
FERM domain containing 4A
chr5_+_43672856 0.08 ENSMUST00000076939.10
C1q and tumor necrosis factor related protein 7
chr14_-_110992533 0.05 ENSMUST00000078386.4
SLIT and NTRK-like family, member 6
chr18_+_37827413 0.05 ENSMUST00000193414.2
protocadherin gamma subfamily A, 5
chr4_+_32238950 0.05 ENSMUST00000037416.13
BTB and CNC homology, basic leucine zipper transcription factor 2
chr12_+_119291343 0.05 ENSMUST00000221917.2
metastasis associated in colon cancer 1
chr4_-_82803384 0.04 ENSMUST00000048430.4
cerberus 1, DAN family BMP antagonist
chr14_+_53478202 0.04 ENSMUST00000179583.3
T cell receptor alpha variable 12N-3
chr12_+_113038376 0.04 ENSMUST00000109729.3
testis expressed gene 22
chr5_-_5714196 0.04 ENSMUST00000196165.5
ENSMUST00000061008.10
ENSMUST00000135252.3
ENSMUST00000054865.13
cilia and flagella associated protein 69
chr14_-_50538979 0.04 ENSMUST00000216195.2
ENSMUST00000214372.2
ENSMUST00000214756.2
olfactory receptor 733
chr2_+_67004178 0.04 ENSMUST00000239009.2
ENSMUST00000238912.2
xin actin-binding repeat containing 2
chr19_+_56414114 0.03 ENSMUST00000238892.2
caspase 7
chr7_-_141009346 0.03 ENSMUST00000124444.2
cell cycle exit and neuronal differentiation 1
chr8_+_112262729 0.03 ENSMUST00000172856.8
zinc and ring finger 1
chr14_+_33193765 0.03 ENSMUST00000208577.2
FERM and PDZ domain containing 2
chr19_+_12834647 0.03 ENSMUST00000213606.2
olfactory receptor 1444
chr18_+_34891941 0.03 ENSMUST00000049281.12
family with sequence similarity 53, member C
chr7_-_85895409 0.03 ENSMUST00000165771.2
ENSMUST00000233075.2
ENSMUST00000233317.2
ENSMUST00000233312.2
ENSMUST00000233928.2
ENSMUST00000232799.2
ENSMUST00000233744.2
vomeronasal 2, receptor 76
chr16_-_34083549 0.03 ENSMUST00000114949.8
ENSMUST00000114954.8
kalirin, RhoGEF kinase
chr14_+_50618620 0.02 ENSMUST00000215263.2
ENSMUST00000213402.2
ENSMUST00000213755.2
ENSMUST00000215227.2
olfactory receptor 736
chr6_+_146934082 0.02 ENSMUST00000036194.6
RAB15 effector protein
chr3_+_125197722 0.02 ENSMUST00000173932.8
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr6_+_34686543 0.01 ENSMUST00000031775.13
caldesmon 1
chr6_-_142268692 0.01 ENSMUST00000081380.10
solute carrier organic anion transporter family, member 1a5
chr4_-_58499398 0.01 ENSMUST00000107570.2
lysophosphatidic acid receptor 1
chr7_-_141009264 0.01 ENSMUST00000164387.2
ENSMUST00000137488.2
ENSMUST00000084436.10
cell cycle exit and neuronal differentiation 1
chr11_+_29413734 0.01 ENSMUST00000155854.8
coiled coil domain containing 88A
chr11_+_31950496 0.00 ENSMUST00000093219.4
neuron specific gene family member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxc2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0060305 regulation of inositol-polyphosphate 5-phosphatase activity(GO:0010924) positive regulation of inositol-polyphosphate 5-phosphatase activity(GO:0010925) phospholipase C-inhibiting G-protein coupled receptor signaling pathway(GO:0030845) regulation of cell diameter(GO:0060305)
0.5 10.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.5 3.2 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.4 10.8 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.4 1.9 GO:0009597 detection of virus(GO:0009597)
0.4 1.2 GO:0035638 patched ligand maturation(GO:0007225) signal maturation(GO:0035638)
0.4 5.7 GO:0048102 autophagic cell death(GO:0048102)
0.4 1.5 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.3 2.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 5.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 2.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.3 1.4 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.2 1.4 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.2 2.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 2.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 1.6 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.2 1.0 GO:0070543 response to linoleic acid(GO:0070543)
0.2 0.8 GO:0021993 initiation of neural tube closure(GO:0021993)
0.2 1.5 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.2 0.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 3.0 GO:0001778 plasma membrane repair(GO:0001778)
0.1 2.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.6 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 1.0 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 3.8 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.5 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 1.4 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.1 0.8 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.1 0.3 GO:1904268 regulation of Schwann cell chemotaxis(GO:1904266) positive regulation of Schwann cell chemotaxis(GO:1904268) Schwann cell chemotaxis(GO:1990751)
0.1 0.6 GO:0031179 peptide modification(GO:0031179)
0.1 2.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 1.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.1 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 0.2 GO:1903027 regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028)
0.1 0.3 GO:0045415 negative regulation of interleukin-8 biosynthetic process(GO:0045415)
0.1 0.4 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 0.2 GO:0061193 taste bud development(GO:0061193)
0.1 0.6 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 0.2 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.1 5.1 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 1.8 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.7 GO:1902947 regulation of tau-protein kinase activity(GO:1902947)
0.0 0.5 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.3 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
0.0 0.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.8 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 1.2 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.9 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.6 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 2.4 GO:0045576 mast cell activation(GO:0045576)
0.0 0.0 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.0 1.7 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.2 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 0.5 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.0 GO:1900175 regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900175)
0.0 0.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.4 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.7 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 1.3 GO:1904888 cranial skeletal system development(GO:1904888)
0.0 0.2 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.7 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.2 GO:0001553 luteinization(GO:0001553)
0.0 0.2 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.4 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0036398 TCR signalosome(GO:0036398)
0.7 5.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.7 2.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.4 1.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.3 0.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 10.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 2.8 GO:0042555 MCM complex(GO:0042555)
0.2 10.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.3 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 5.1 GO:0005643 nuclear pore(GO:0005643)
0.0 0.4 GO:0033010 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.0 0.6 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.6 GO:0030061 mitochondrial crista(GO:0030061)
0.0 2.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 3.9 GO:0005882 intermediate filament(GO:0005882)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 4.5 GO:0005901 caveola(GO:0005901)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.5 GO:0032426 stereocilium tip(GO:0032426)
0.0 2.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 5.2 GO:0072562 blood microparticle(GO:0072562)
0.0 2.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.8 GO:0031519 PcG protein complex(GO:0031519)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 21.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.5 1.4 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.4 5.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 6.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.3 1.0 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.3 5.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 3.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 10.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 2.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 1.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 1.9 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.6 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.5 GO:0045183 translation factor activity, non-nucleic acid binding(GO:0045183)
0.1 0.8 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 2.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.4 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386)
0.1 0.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.5 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 1.0 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.1 2.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.9 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 0.9 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.2 GO:0015197 peptide transporter activity(GO:0015197)
0.1 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.4 GO:0005537 mannose binding(GO:0005537)
0.1 0.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.3 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.6 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.8 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 2.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.8 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.2 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 3.3 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 0.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 3.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 1.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0016015 morphogen activity(GO:0016015)
0.0 0.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.2 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 2.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 8.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 0.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 2.8 PID ATR PATHWAY ATR signaling pathway
0.1 2.1 PID AURORA A PATHWAY Aurora A signaling
0.1 2.9 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 3.5 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 2.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.3 17.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.2 2.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 2.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 1.6 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 8.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.8 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 2.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 2.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 1.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 0.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 2.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.0 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.9 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME G PROTEIN BETA GAMMA SIGNALLING Genes involved in G-protein beta:gamma signalling
0.0 1.0 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.5 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation