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GSE58827: Dynamics of the Mouse Liver

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Results for Foxd3

Z-value: 0.56

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Transcription factors associated with Foxd3

Gene Symbol Gene ID Gene Info
Foxd3
ENSMUSG00000067261.5 forkhead box D3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxd3mm39_v1_chr4_+_99544536_995445770.038.7e-01Click!

Activity profile of Foxd3 motif

Sorted Z-values of Foxd3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_103739847 4.54 ENSMUST00000078869.6
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr10_+_93324624 4.07 ENSMUST00000129421.8
Hal
histidine ammonia lyase
chr12_-_103871146 3.62 ENSMUST00000074051.6
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr10_-_95678786 3.04 ENSMUST00000211096.2
Gm33543
predicted gene, 33543
chr3_+_146302832 3.00 ENSMUST00000029837.14
ENSMUST00000147409.2
ENSMUST00000121133.2
Uox
urate oxidase
chr10_-_95678748 2.99 ENSMUST00000210336.2
Gm33543
predicted gene, 33543
chr5_-_31453206 2.96 ENSMUST00000041266.11
ENSMUST00000172435.8
ENSMUST00000201417.2
Fndc4
fibronectin type III domain containing 4
chr1_+_88066086 2.92 ENSMUST00000014263.6
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr13_-_56696310 2.85 ENSMUST00000062806.6
Lect2
leukocyte cell-derived chemotaxin 2
chr13_-_56696222 2.68 ENSMUST00000225183.2
Lect2
leukocyte cell-derived chemotaxin 2
chr9_-_71070506 2.46 ENSMUST00000074465.9
Aqp9
aquaporin 9
chr12_-_103923145 2.30 ENSMUST00000085054.5
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chr19_-_38113696 2.07 ENSMUST00000025951.14
ENSMUST00000237287.2
Rbp4
retinol binding protein 4, plasma
chr9_-_50466470 1.93 ENSMUST00000119103.2
Bco2
beta-carotene oxygenase 2
chr6_-_21851827 1.83 ENSMUST00000202353.2
ENSMUST00000134635.2
ENSMUST00000123116.8
ENSMUST00000120965.8
ENSMUST00000143531.2
Tspan12
tetraspanin 12
chr7_+_67305162 1.68 ENSMUST00000107470.2
Ttc23
tetratricopeptide repeat domain 23
chr17_-_31855605 1.61 ENSMUST00000151718.3
ENSMUST00000135425.9
ENSMUST00000155814.8
Cbs
cystathionine beta-synthase
chr14_-_45626237 1.17 ENSMUST00000227865.2
ENSMUST00000226856.2
ENSMUST00000226276.2
ENSMUST00000046191.9
Gnpnat1
glucosamine-phosphate N-acetyltransferase 1
chr9_+_50466127 1.07 ENSMUST00000213916.2
Il18
interleukin 18
chr2_+_152511381 1.06 ENSMUST00000125366.8
ENSMUST00000109825.8
ENSMUST00000089059.9
ENSMUST00000079247.4
H13
histocompatibility 13
chr3_-_146302343 0.99 ENSMUST00000029836.9
Dnase2b
deoxyribonuclease II beta
chr9_-_20791012 0.87 ENSMUST00000043726.8
Angptl6
angiopoietin-like 6
chr13_+_41040657 0.85 ENSMUST00000069958.15
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr1_+_88334678 0.83 ENSMUST00000027518.12
Spp2
secreted phosphoprotein 2
chr3_-_82957104 0.71 ENSMUST00000048246.5
Fgb
fibrinogen beta chain
chr7_-_99629637 0.70 ENSMUST00000080817.6
Rnf169
ring finger protein 169
chr18_+_44467133 0.67 ENSMUST00000025349.12
ENSMUST00000115498.2
Myot
myotilin
chr17_+_29309942 0.63 ENSMUST00000119901.9
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr12_-_103597663 0.63 ENSMUST00000121625.2
ENSMUST00000044231.12
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr12_-_110807330 0.60 ENSMUST00000177224.2
ENSMUST00000084974.11
ENSMUST00000070565.15
Mok
MOK protein kinase
chr16_-_4698148 0.59 ENSMUST00000037843.7
Ubald1
UBA-like domain containing 1
chr2_-_18397547 0.56 ENSMUST00000091418.12
ENSMUST00000166495.8
Dnajc1
DnaJ heat shock protein family (Hsp40) member C1
chr17_-_35265702 0.55 ENSMUST00000097338.11
Msh5
mutS homolog 5
chr8_-_45715049 0.51 ENSMUST00000034064.5
F11
coagulation factor XI
chr17_+_28910393 0.50 ENSMUST00000124886.9
ENSMUST00000114758.9
Mapk14
mitogen-activated protein kinase 14
chr11_-_34048538 0.48 ENSMUST00000223852.2
4930469K13Rik
RIKEN cDNA 4930469K13 gene
chr18_+_37646674 0.48 ENSMUST00000061405.6
Pcdhb21
protocadherin beta 21
chr15_-_6904450 0.45 ENSMUST00000022746.13
ENSMUST00000176826.2
Osmr
oncostatin M receptor
chr6_-_131224305 0.42 ENSMUST00000032306.15
ENSMUST00000088867.7
Klra2
killer cell lectin-like receptor, subfamily A, member 2
chr17_+_28910302 0.37 ENSMUST00000004990.14
ENSMUST00000114754.8
ENSMUST00000062694.16
Mapk14
mitogen-activated protein kinase 14
chr15_+_92495007 0.35 ENSMUST00000035399.10
Pdzrn4
PDZ domain containing RING finger 4
chr6_+_142244145 0.31 ENSMUST00000041993.3
Iapp
islet amyloid polypeptide
chr5_+_148202011 0.31 ENSMUST00000110515.9
Mtus2
microtubule associated tumor suppressor candidate 2
chr2_-_17465410 0.30 ENSMUST00000145492.2
Nebl
nebulette
chr11_-_75330302 0.28 ENSMUST00000043696.9
Serpinf2
serine (or cysteine) peptidase inhibitor, clade F, member 2
chr5_+_148202117 0.27 ENSMUST00000110514.8
Mtus2
microtubule associated tumor suppressor candidate 2
chr10_-_89457115 0.24 ENSMUST00000020102.14
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr17_+_93506435 0.24 ENSMUST00000234646.2
ENSMUST00000234081.2
Adcyap1
adenylate cyclase activating polypeptide 1
chr10_-_88440869 0.24 ENSMUST00000119185.8
ENSMUST00000238199.2
Mybpc1
myosin binding protein C, slow-type
chr18_+_37858753 0.23 ENSMUST00000066149.9
Pcdhga8
protocadherin gamma subfamily A, 8
chr8_-_88686188 0.22 ENSMUST00000109655.9
Zfp423
zinc finger protein 423
chr12_+_111937978 0.22 ENSMUST00000079009.11
Tdrd9
tudor domain containing 9
chr17_+_93506590 0.22 ENSMUST00000064775.8
Adcyap1
adenylate cyclase activating polypeptide 1
chr13_+_23715220 0.21 ENSMUST00000102972.6
H4c8
H4 clustered histone 8
chr6_+_77219698 0.19 ENSMUST00000161677.2
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chrX_+_163156359 0.18 ENSMUST00000033751.8
Vegfd
vascular endothelial growth factor D
chr1_+_6805048 0.18 ENSMUST00000139838.8
St18
suppression of tumorigenicity 18
chr11_-_75330415 0.17 ENSMUST00000128330.8
Serpinf2
serine (or cysteine) peptidase inhibitor, clade F, member 2
chr2_+_124978518 0.17 ENSMUST00000238754.2
Ctxn2
cortexin 2
chr5_+_148202075 0.16 ENSMUST00000071878.12
Mtus2
microtubule associated tumor suppressor candidate 2
chr2_+_181408833 0.15 ENSMUST00000108756.8
Myt1
myelin transcription factor 1
chrX_-_156198282 0.14 ENSMUST00000079945.11
ENSMUST00000138396.3
Phex
phosphate regulating endopeptidase homolog, X-linked
chr6_+_77219627 0.14 ENSMUST00000159616.2
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr2_+_131792774 0.13 ENSMUST00000110170.8
ENSMUST00000110172.9
ENSMUST00000110171.9
Prnd
prion like protein doppel
chr14_-_45626198 0.13 ENSMUST00000226590.2
Gnpnat1
glucosamine-phosphate N-acetyltransferase 1
chr6_-_141957140 0.13 ENSMUST00000181791.8
ENSMUST00000181628.8
Gm6614
predicted gene 6614
chr2_+_51928017 0.12 ENSMUST00000065927.6
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr12_+_103564479 0.12 ENSMUST00000190151.2
Ppp4r4
protein phosphatase 4, regulatory subunit 4
chrX_+_132751729 0.11 ENSMUST00000033602.9
Tnmd
tenomodulin
chr2_+_14393127 0.11 ENSMUST00000114731.8
ENSMUST00000082290.8
Slc39a12
solute carrier family 39 (zinc transporter), member 12
chr2_+_131792931 0.11 ENSMUST00000110169.2
Prnd
prion like protein doppel
chr15_-_99185050 0.10 ENSMUST00000109100.2
Fam186b
family with sequence similarity 186, member B
chr11_-_99884818 0.10 ENSMUST00000105049.2
Krtap17-1
keratin associated protein 17-1
chr7_+_91321694 0.09 ENSMUST00000238608.2
Dlg2
discs large MAGUK scaffold protein 2
chr10_-_88440996 0.09 ENSMUST00000121629.8
Mybpc1
myosin binding protein C, slow-type
chr9_+_37995368 0.09 ENSMUST00000212502.4
Olfr887
olfactory receptor 887
chr10_+_66932235 0.09 ENSMUST00000174317.8
Jmjd1c
jumonji domain containing 1C
chr2_+_181409075 0.08 ENSMUST00000108757.9
Myt1
myelin transcription factor 1
chr10_-_128579879 0.08 ENSMUST00000026414.9
Dgka
diacylglycerol kinase, alpha
chr1_+_53100796 0.07 ENSMUST00000027269.7
ENSMUST00000191197.2
Mstn
myostatin
chr2_+_124978612 0.07 ENSMUST00000099452.3
ENSMUST00000238377.2
Ctxn2
cortexin 2
chr5_-_86475595 0.07 ENSMUST00000122377.2
Tmprss11d
transmembrane protease, serine 11d
chr15_-_101833160 0.06 ENSMUST00000023797.8
Krt4
keratin 4
chr2_+_9887427 0.03 ENSMUST00000114919.2
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr10_-_10956700 0.03 ENSMUST00000105560.2
Grm1
glutamate receptor, metabotropic 1
chr18_+_37637317 0.02 ENSMUST00000052179.8
Pcdhb20
protocadherin beta 20
chr17_-_37334091 0.02 ENSMUST00000167275.3
Mog
myelin oligodendrocyte glycoprotein
chr15_+_8997480 0.02 ENSMUST00000227191.3
Ranbp3l
RAN binding protein 3-like
chr6_-_3494587 0.02 ENSMUST00000049985.15
Hepacam2
HEPACAM family member 2
chr4_-_82768958 0.01 ENSMUST00000139401.2
Zdhhc21
zinc finger, DHHC domain containing 21
chr19_+_8931187 0.01 ENSMUST00000096239.7
Tut1
terminal uridylyl transferase 1, U6 snRNA-specific

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxd3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0006548 histidine catabolic process(GO:0006548)
0.6 2.5 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.5 1.6 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.4 2.1 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.4 1.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.3 1.1 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.3 1.3 GO:0006041 glucosamine metabolic process(GO:0006041)
0.2 2.9 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 0.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 1.9 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.1 3.0 GO:0046415 urate metabolic process(GO:0046415)
0.1 0.9 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.9 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.1 0.5 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.1 0.5 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.1 0.5 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.1 0.5 GO:0003072 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.0 1.8 GO:0010842 retina layer formation(GO:0010842)
0.0 1.0 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 0.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.1 GO:0014732 skeletal muscle atrophy(GO:0014732)
0.0 0.6 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.7 GO:2000780 negative regulation of double-strand break repair(GO:2000780)
0.0 0.1 GO:0080163 regulation of protein serine/threonine phosphatase activity(GO:0080163)
0.0 5.5 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.2 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 6.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.0 GO:0038042 dimeric G-protein coupled receptor signaling pathway(GO:0038042)
0.0 0.2 GO:2001269 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001267) positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.2 GO:0006878 cellular copper ion homeostasis(GO:0006878)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 1.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 0.5 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0071547 piP-body(GO:0071547)
0.0 0.2 GO:0097441 basilar dendrite(GO:0097441)
0.0 1.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.7 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)
0.0 0.3 GO:0005859 muscle myosin complex(GO:0005859)
0.0 2.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0034632 retinol transporter activity(GO:0034632)
0.6 4.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.5 1.6 GO:0004122 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitric oxide binding(GO:0070026)
0.5 2.5 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.3 3.0 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 0.9 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 0.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 1.0 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 1.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 1.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.5 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.1 11.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.9 GO:0051525 NFAT protein binding(GO:0051525)
0.1 1.9 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.5 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0 0.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 1.3 GO:0048029 monosaccharide binding(GO:0048029)
0.0 0.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 5.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 3.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.3 REACTOME AMYLOIDS Genes involved in Amyloids