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GSE58827: Dynamics of the Mouse Liver

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Results for Foxo3

Z-value: 0.70

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Transcription factors associated with Foxo3

Gene Symbol Gene ID Gene Info
Foxo3
ENSMUSG00000048756.12 forkhead box O3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo3mm39_v1_chr10_-_42152684_42152759-0.803.4e-09Click!

Activity profile of Foxo3 motif

Sorted Z-values of Foxo3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_51333816 7.69 ENSMUST00000169895.3
Rnase4
ribonuclease, RNase A family 4
chr14_-_52150804 6.63 ENSMUST00000004673.15
ENSMUST00000111632.5
Ndrg2
N-myc downstream regulated gene 2
chr14_-_52151026 5.61 ENSMUST00000228164.2
Ndrg2
N-myc downstream regulated gene 2
chr1_-_180023518 5.53 ENSMUST00000162769.8
ENSMUST00000161379.2
ENSMUST00000027766.13
ENSMUST00000161814.8
Coq8a
coenzyme Q8A
chr1_-_180023467 5.52 ENSMUST00000161746.2
ENSMUST00000160879.7
Coq8a
coenzyme Q8A
chr15_-_78352801 5.33 ENSMUST00000229124.2
ENSMUST00000230226.2
ENSMUST00000017086.5
Tmprss6
transmembrane serine protease 6
chr11_+_101258368 4.49 ENSMUST00000019469.3
G6pc
glucose-6-phosphatase, catalytic
chr4_-_49549489 4.08 ENSMUST00000029987.10
Aldob
aldolase B, fructose-bisphosphate
chr9_-_71070506 3.95 ENSMUST00000074465.9
Aqp9
aquaporin 9
chr8_+_105996419 3.33 ENSMUST00000036127.9
ENSMUST00000163734.9
Hsf4
heat shock transcription factor 4
chr1_-_140111138 3.06 ENSMUST00000111976.9
ENSMUST00000066859.13
Cfh
complement component factor h
chr1_-_140111018 2.94 ENSMUST00000192880.6
ENSMUST00000111977.8
Cfh
complement component factor h
chr2_+_155360015 2.83 ENSMUST00000103142.12
Acss2
acyl-CoA synthetase short-chain family member 2
chr3_+_85946145 2.71 ENSMUST00000238331.2
Sh3d19
SH3 domain protein D19
chr2_+_155359868 2.66 ENSMUST00000029135.15
ENSMUST00000065973.9
Acss2
acyl-CoA synthetase short-chain family member 2
chr1_+_172525613 2.64 ENSMUST00000038495.5
Crp
C-reactive protein, pentraxin-related
chr4_+_105014536 2.50 ENSMUST00000064139.8
Plpp3
phospholipid phosphatase 3
chr11_-_86884507 2.45 ENSMUST00000018571.5
Ypel2
yippee like 2
chr19_-_7780025 2.31 ENSMUST00000065634.8
Slc22a26
solute carrier family 22 (organic cation transporter), member 26
chr9_+_114560235 2.27 ENSMUST00000035007.10
Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
chr8_-_45835234 2.16 ENSMUST00000093526.13
Fam149a
family with sequence similarity 149, member A
chr1_+_171052623 2.02 ENSMUST00000111321.8
ENSMUST00000005824.12
ENSMUST00000111320.8
ENSMUST00000111319.2
Apoa2
apolipoprotein A-II
chr2_+_76505619 1.97 ENSMUST00000111920.2
Plekha3
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
chr11_-_60243695 1.95 ENSMUST00000095254.12
ENSMUST00000102683.11
ENSMUST00000093048.13
ENSMUST00000093046.13
ENSMUST00000064019.15
ENSMUST00000102682.5
Tom1l2
target of myb1-like 2 (chicken)
chr8_-_64659004 1.92 ENSMUST00000066166.6
Tll1
tolloid-like
chr3_+_63203516 1.88 ENSMUST00000029400.7
Mme
membrane metallo endopeptidase
chr8_-_26275182 1.85 ENSMUST00000038498.10
Bag4
BCL2-associated athanogene 4
chr2_+_4722956 1.82 ENSMUST00000056914.7
Bend7
BEN domain containing 7
chr5_-_151113619 1.74 ENSMUST00000062015.15
ENSMUST00000110483.9
Stard13
StAR-related lipid transfer (START) domain containing 13
chr14_+_30601157 1.73 ENSMUST00000040715.8
Mustn1
musculoskeletal, embryonic nuclear protein 1
chr5_+_65288418 1.73 ENSMUST00000101191.10
ENSMUST00000204348.3
Klhl5
kelch-like 5
chr4_-_155430153 1.65 ENSMUST00000103178.11
Prkcz
protein kinase C, zeta
chr3_+_107137924 1.63 ENSMUST00000179399.3
A630076J17Rik
RIKEN cDNA A630076J17 gene
chr1_+_75119419 1.62 ENSMUST00000097694.11
ENSMUST00000190240.7
Retreg2
reticulophagy regulator family member 2
chr17_+_25059079 1.57 ENSMUST00000164251.8
Hagh
hydroxyacyl glutathione hydrolase
chr19_+_5927821 1.53 ENSMUST00000145200.8
ENSMUST00000025732.14
ENSMUST00000125114.8
ENSMUST00000155697.8
Slc25a45
solute carrier family 25, member 45
chr19_+_34268071 1.53 ENSMUST00000112472.4
ENSMUST00000235232.2
Fas
Fas (TNF receptor superfamily member 6)
chr19_-_34856853 1.43 ENSMUST00000036584.13
Pank1
pantothenate kinase 1
chrX_-_47297746 1.40 ENSMUST00000088935.4
Zdhhc9
zinc finger, DHHC domain containing 9
chr18_-_75094323 1.38 ENSMUST00000066532.5
Lipg
lipase, endothelial
chr2_-_51862941 1.38 ENSMUST00000145481.8
ENSMUST00000112705.9
Nmi
N-myc (and STAT) interactor
chr3_+_63203235 1.37 ENSMUST00000194134.6
Mme
membrane metallo endopeptidase
chr11_-_68277631 1.36 ENSMUST00000021284.4
Ntn1
netrin 1
chr19_+_5927876 1.32 ENSMUST00000235340.2
Slc25a45
solute carrier family 25, member 45
chr2_-_104324035 1.31 ENSMUST00000111124.8
Hipk3
homeodomain interacting protein kinase 3
chr1_+_75119472 1.21 ENSMUST00000189650.7
Retreg2
reticulophagy regulator family member 2
chr13_+_60749995 1.17 ENSMUST00000044083.9
Dapk1
death associated protein kinase 1
chr12_-_25147139 1.11 ENSMUST00000221761.2
Id2
inhibitor of DNA binding 2
chr7_-_65020955 1.08 ENSMUST00000102592.10
Tjp1
tight junction protein 1
chr2_+_3514071 1.08 ENSMUST00000036350.3
Cdnf
cerebral dopamine neurotrophic factor
chr2_-_91540864 1.04 ENSMUST00000028678.9
ENSMUST00000076803.12
Atg13
autophagy related 13
chr2_+_91541245 1.00 ENSMUST00000142692.2
ENSMUST00000090608.6
Harbi1
harbinger transposase derived 1
chr17_+_43700327 0.99 ENSMUST00000113599.2
ENSMUST00000224278.2
ENSMUST00000225466.2
Adgrf5
adhesion G protein-coupled receptor F5
chr7_-_70010341 0.92 ENSMUST00000032768.15
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr6_-_83808717 0.90 ENSMUST00000058383.9
Paip2b
poly(A) binding protein interacting protein 2B
chr11_-_68277799 0.86 ENSMUST00000135141.2
Ntn1
netrin 1
chr9_-_48747232 0.86 ENSMUST00000093852.5
Zbtb16
zinc finger and BTB domain containing 16
chr18_-_39622829 0.85 ENSMUST00000025300.13
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr14_+_45457168 0.83 ENSMUST00000227086.2
ENSMUST00000147957.2
Gpr137c
G protein-coupled receptor 137C
chr6_+_14901343 0.82 ENSMUST00000115477.8
Foxp2
forkhead box P2
chr18_-_39622932 0.79 ENSMUST00000152853.2
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr10_+_88036947 0.78 ENSMUST00000020248.16
ENSMUST00000182183.8
ENSMUST00000171151.9
ENSMUST00000182619.2
Washc3
WASH complex subunit 3
chr4_-_119272690 0.75 ENSMUST00000238287.2
ENSMUST00000238759.2
ENSMUST00000063642.10
Ccdc30
coiled-coil domain containing 30
chr4_-_91264670 0.75 ENSMUST00000107109.9
ENSMUST00000107111.9
ENSMUST00000107120.8
Elavl2
ELAV like RNA binding protein 1
chr2_+_91541197 0.74 ENSMUST00000128140.2
ENSMUST00000140183.2
Harbi1
harbinger transposase derived 1
chr2_-_51863203 0.72 ENSMUST00000028314.9
Nmi
N-myc (and STAT) interactor
chr4_+_135455427 0.71 ENSMUST00000102546.4
Il22ra1
interleukin 22 receptor, alpha 1
chr11_+_96024612 0.69 ENSMUST00000167258.8
Ttll6
tubulin tyrosine ligase-like family, member 6
chr18_-_39622295 0.67 ENSMUST00000131885.2
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr14_-_121935829 0.66 ENSMUST00000040700.9
ENSMUST00000212181.2
Dock9
dedicator of cytokinesis 9
chr1_-_20854490 0.66 ENSMUST00000039046.10
Il17f
interleukin 17F
chr2_-_27365633 0.65 ENSMUST00000138693.8
ENSMUST00000113941.9
ENSMUST00000077737.13
Brd3
bromodomain containing 3
chr8_-_41469786 0.65 ENSMUST00000117735.8
Mtus1
mitochondrial tumor suppressor 1
chr4_-_91264727 0.64 ENSMUST00000107124.10
Elavl2
ELAV like RNA binding protein 1
chr6_+_14901439 0.63 ENSMUST00000128567.8
Foxp2
forkhead box P2
chr7_+_107264518 0.57 ENSMUST00000239294.2
Ppfibp2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr8_-_13939964 0.57 ENSMUST00000209371.2
Coprs
coordinator of PRMT5, differentiation stimulator
chr10_+_103203552 0.51 ENSMUST00000179636.3
ENSMUST00000217905.2
ENSMUST00000074204.12
Slc6a15
solute carrier family 6 (neurotransmitter transporter), member 15
chr7_-_65020655 0.51 ENSMUST00000032729.8
Tjp1
tight junction protein 1
chr4_-_119272640 0.50 ENSMUST00000238293.2
Ccdc30
coiled-coil domain containing 30
chr19_+_56414114 0.50 ENSMUST00000238892.2
Casp7
caspase 7
chr11_+_60244132 0.49 ENSMUST00000070805.13
ENSMUST00000094140.9
ENSMUST00000108723.9
ENSMUST00000108722.5
Drc3
dynein regulatory complex subunit 3
chr10_+_128540049 0.48 ENSMUST00000217836.2
Pmel
premelanosome protein
chr12_-_85317359 0.47 ENSMUST00000166821.8
ENSMUST00000019378.8
ENSMUST00000220854.2
Mlh3
mutL homolog 3
chr11_-_101676076 0.47 ENSMUST00000164750.8
ENSMUST00000107176.8
ENSMUST00000017868.7
Etv4
ets variant 4
chr11_+_82802079 0.45 ENSMUST00000018989.14
ENSMUST00000164945.3
Unc45b
unc-45 myosin chaperone B
chr7_+_141056305 0.43 ENSMUST00000117634.2
Tspan4
tetraspanin 4
chr4_-_119272667 0.42 ENSMUST00000238609.2
Ccdc30
coiled-coil domain containing 30
chr3_-_145355725 0.41 ENSMUST00000029846.5
Ccn1
cellular communication network factor 1
chr2_+_164328375 0.40 ENSMUST00000069385.15
ENSMUST00000143690.8
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr11_-_100244866 0.39 ENSMUST00000173630.8
Hap1
huntingtin-associated protein 1
chr17_+_31783708 0.39 ENSMUST00000097352.11
ENSMUST00000237248.2
ENSMUST00000235869.2
ENSMUST00000175806.9
Pknox1
Pbx/knotted 1 homeobox
chr10_-_5019044 0.39 ENSMUST00000095899.5
Syne1
spectrin repeat containing, nuclear envelope 1
chr4_+_130001349 0.39 ENSMUST00000030563.6
Pef1
penta-EF hand domain containing 1
chr9_+_40092216 0.37 ENSMUST00000218134.2
ENSMUST00000216720.2
ENSMUST00000214763.2
Olfr986
olfactory receptor 986
chr15_+_102875229 0.37 ENSMUST00000001699.8
Hoxc10
homeobox C10
chr10_+_102348076 0.37 ENSMUST00000219445.2
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr11_-_99313078 0.36 ENSMUST00000017741.4
Krt12
keratin 12
chr3_+_53396120 0.35 ENSMUST00000029307.4
Stoml3
stomatin (Epb7.2)-like 3
chr13_+_83720484 0.34 ENSMUST00000196207.5
Mef2c
myocyte enhancer factor 2C
chr15_-_77129706 0.32 ENSMUST00000228361.2
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr18_-_66155651 0.30 ENSMUST00000143990.2
Lman1
lectin, mannose-binding, 1
chr9_+_65268304 0.30 ENSMUST00000147185.3
Ubap1l
ubiquitin-associated protein 1-like
chr1_+_66360865 0.29 ENSMUST00000114013.8
Map2
microtubule-associated protein 2
chr19_-_27988534 0.28 ENSMUST00000174850.8
Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr8_+_72021510 0.28 ENSMUST00000212889.2
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr19_+_25649767 0.26 ENSMUST00000053068.7
Dmrt2
doublesex and mab-3 related transcription factor 2
chr11_+_3282424 0.26 ENSMUST00000136474.2
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr1_+_17672117 0.25 ENSMUST00000088476.4
Pi15
peptidase inhibitor 15
chr8_+_72021567 0.24 ENSMUST00000034267.5
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr2_+_164328763 0.24 ENSMUST00000109349.9
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr2_+_127696548 0.23 ENSMUST00000028859.8
Acoxl
acyl-Coenzyme A oxidase-like
chr1_-_58735106 0.23 ENSMUST00000055313.14
ENSMUST00000188772.7
Flacc1
flagellum associated containing coiled-coil domains 1
chrX_+_7744535 0.22 ENSMUST00000033495.15
Pim2
proviral integration site 2
chr3_-_146475974 0.20 ENSMUST00000106137.8
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr16_-_34083315 0.20 ENSMUST00000114953.8
Kalrn
kalirin, RhoGEF kinase
chr4_-_134642286 0.20 ENSMUST00000105863.2
ENSMUST00000030626.12
Tmem50a
transmembrane protein 50A
chr10_+_25308466 0.19 ENSMUST00000219224.2
ENSMUST00000219166.2
Epb41l2
erythrocyte membrane protein band 4.1 like 2
chr13_+_108180957 0.19 ENSMUST00000095458.6
ENSMUST00000223808.2
ENSMUST00000226042.2
ENSMUST00000225972.2
Smim15
small integral membrane protein 15
chr15_+_25752963 0.18 ENSMUST00000022882.12
ENSMUST00000135173.8
Myo10
myosin X
chr13_+_83720457 0.16 ENSMUST00000196730.5
Mef2c
myocyte enhancer factor 2C
chr3_+_5283606 0.15 ENSMUST00000026284.13
Zfhx4
zinc finger homeodomain 4
chr1_+_36550948 0.15 ENSMUST00000001166.14
ENSMUST00000097776.4
Cnnm3
cyclin M3
chr2_+_154855350 0.13 ENSMUST00000148402.8
a
nonagouti
chr14_-_52011035 0.12 ENSMUST00000073860.6
Ang4
angiogenin, ribonuclease A family, member 4
chr2_-_7086066 0.12 ENSMUST00000183209.8
Celf2
CUGBP, Elav-like family member 2
chr7_-_119461027 0.11 ENSMUST00000137888.2
ENSMUST00000142120.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr1_-_172958803 0.11 ENSMUST00000073663.3
Olfr1408
olfactory receptor 1408
chr3_+_5283577 0.11 ENSMUST00000175866.8
Zfhx4
zinc finger homeodomain 4
chr10_+_112107026 0.11 ENSMUST00000219301.2
ENSMUST00000092175.4
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr2_-_51039112 0.11 ENSMUST00000154545.2
ENSMUST00000017288.9
Rnd3
Rho family GTPase 3
chr6_+_55813862 0.10 ENSMUST00000044729.7
Itprid1
ITPR interacting domain containing 1
chr12_-_31549538 0.09 ENSMUST00000064240.14
ENSMUST00000185739.8
ENSMUST00000188326.3
ENSMUST00000101499.10
ENSMUST00000085487.12
Cbll1
Casitas B-lineage lymphoma-like 1
chr16_+_93480061 0.08 ENSMUST00000039620.7
Cbr3
carbonyl reductase 3
chr11_+_19874403 0.08 ENSMUST00000093298.12
Spred2
sprouty-related EVH1 domain containing 2
chr6_+_34840151 0.07 ENSMUST00000202010.2
Tmem140
transmembrane protein 140
chr9_+_78020554 0.06 ENSMUST00000009972.6
ENSMUST00000117330.8
ENSMUST00000044551.8
Cilk1
ciliogenesis associated kinase 1
chr1_-_163231196 0.04 ENSMUST00000045138.6
Gorab
golgin, RAB6-interacting
chr14_-_7750938 0.03 ENSMUST00000223740.3
ENSMUST00000224049.3
ENSMUST00000224672.3
ENSMUST00000224752.3
ENSMUST00000223695.3
ENSMUST00000224333.3
ENSMUST00000224952.3
Slc4a7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr6_-_69741999 0.03 ENSMUST00000103365.3
Igkv12-46
immunoglobulin kappa variable 12-46
chr7_-_109215754 0.03 ENSMUST00000084738.5
Denn2b
DENN domain containing 2B
chr2_-_85675827 0.02 ENSMUST00000213515.2
Olfr1019
olfactory receptor 1019
chr7_+_29991366 0.02 ENSMUST00000144508.2
Clip3
CAP-GLY domain containing linker protein 3
chr14_-_57371041 0.02 ENSMUST00000039380.9
Gjb6
gap junction protein, beta 6
chr19_-_19088543 0.02 ENSMUST00000112832.8
Rorb
RAR-related orphan receptor beta
chr1_+_63655127 0.01 ENSMUST00000226288.2
Gm39653
predicted gene, 39653

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 12.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
1.8 5.5 GO:0019413 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate biosynthetic process(GO:0019542)
1.0 3.9 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.7 2.1 GO:1902524 positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.7 4.1 GO:0006116 NADH oxidation(GO:0006116)
0.7 6.0 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.6 1.8 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.5 1.5 GO:0031104 dendrite regeneration(GO:0031104)
0.5 2.0 GO:0046340 regulation of very-low-density lipoprotein particle remodeling(GO:0010901) diacylglycerol catabolic process(GO:0046340)
0.5 2.5 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330)
0.5 4.5 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.5 3.2 GO:0071492 cellular response to UV-A(GO:0071492)
0.5 1.4 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.5 11.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.4 1.1 GO:0001966 thigmotaxis(GO:0001966)
0.3 1.7 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.3 2.3 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3 2.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 5.3 GO:0097264 self proteolysis(GO:0097264)
0.2 1.7 GO:2000667 positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.2 0.9 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.2 1.7 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.2 2.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488) anterior/posterior axon guidance(GO:0033564)
0.2 0.4 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.2 1.6 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 2.3 GO:0015747 urate transport(GO:0015747)
0.1 3.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.7 GO:0045423 granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253) regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423)
0.1 0.5 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.1 2.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.5 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1 0.7 GO:0051013 microtubule severing(GO:0051013)
0.1 0.9 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 1.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.6 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.1 1.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.4 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.1 1.0 GO:0071073 positive regulation of phospholipid biosynthetic process(GO:0071073)
0.1 1.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 1.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.5 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 0.3 GO:0061055 myotome development(GO:0061055)
0.1 0.5 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 0.4 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.5 GO:0007144 female meiosis I(GO:0007144)
0.0 0.9 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 1.0 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.0 0.6 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 7.0 GO:0009267 cellular response to starvation(GO:0009267)
0.0 0.4 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 2.0 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.1 GO:0042374 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.0 0.2 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 1.2 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.4 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.2 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.6 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.2 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.7 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 1.5 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.2 0.5 GO:0005712 chiasma(GO:0005712)
0.2 1.7 GO:0045179 apical cortex(GO:0045179)
0.1 2.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 1.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.8 GO:0071203 WASH complex(GO:0071203)
0.0 0.4 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 4.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.4 GO:0030118 clathrin coat(GO:0030118)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 2.8 GO:0030175 filopodium(GO:0030175)
0.0 2.2 GO:0016605 PML body(GO:0016605)
0.0 2.2 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 3.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.1 5.5 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.9 6.0 GO:0001851 complement component C3b binding(GO:0001851)
0.8 3.9 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.6 2.5 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.5 2.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.4 4.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 2.3 GO:0038051 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.4 1.5 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.3 2.6 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 0.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 1.4 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 1.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 11.1 GO:0043531 ADP binding(GO:0043531)
0.2 0.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 2.3 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 1.6 GO:0071253 connexin binding(GO:0071253)
0.1 1.7 GO:0004697 protein kinase C activity(GO:0004697)
0.1 2.7 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.3 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.7 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.1 0.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 0.9 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 2.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 6.6 GO:0004540 ribonuclease activity(GO:0004540)
0.0 0.9 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.9 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.4 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 3.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.1 GO:0031782 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 2.0 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.3 GO:0005537 mannose binding(GO:0005537)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 1.8 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 3.3 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 2.9 GO:0005125 cytokine activity(GO:0005125)
0.0 1.7 GO:0004518 nuclease activity(GO:0004518)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 13.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 5.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.6 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 3.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.3 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 2.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.8 PID P73PATHWAY p73 transcription factor network
0.0 0.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 6.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.3 2.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 3.9 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 2.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 4.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 4.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 1.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 2.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 2.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules