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GSE58827: Dynamics of the Mouse Liver

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Results for Foxo4

Z-value: 0.66

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Transcription factors associated with Foxo4

Gene Symbol Gene ID Gene Info
Foxo4
ENSMUSG00000042903.9 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo4mm39_v1_chrX_+_100298134_1002981860.642.2e-05Click!

Activity profile of Foxo4 motif

Sorted Z-values of Foxo4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_102255999 9.82 ENSMUST00000006749.10
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr7_-_103463120 4.64 ENSMUST00000098192.4
Hbb-bt
hemoglobin, beta adult t chain
chr17_+_37180437 4.47 ENSMUST00000060524.11
Trim10
tripartite motif-containing 10
chr4_-_131664478 2.13 ENSMUST00000155990.8
Epb41
erythrocyte membrane protein band 4.1
chrX_+_84617624 2.12 ENSMUST00000048250.10
ENSMUST00000137438.2
ENSMUST00000146063.2
Tab3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr19_-_53577499 2.09 ENSMUST00000095978.5
Nutf2-ps1
nuclear transport factor 2, pseudogene 1
chr3_+_107803225 2.05 ENSMUST00000172247.8
ENSMUST00000167387.8
Gstm5
glutathione S-transferase, mu 5
chr3_+_107803563 2.02 ENSMUST00000169365.2
Gstm5
glutathione S-transferase, mu 5
chr17_+_56259617 1.78 ENSMUST00000003274.8
Ebi3
Epstein-Barr virus induced gene 3
chr11_-_33113071 1.76 ENSMUST00000093201.13
ENSMUST00000101375.5
ENSMUST00000109354.10
ENSMUST00000075641.10
Npm1
nucleophosmin 1
chr11_+_3240439 1.73 ENSMUST00000057089.13
ENSMUST00000093402.12
Patz1
POZ (BTB) and AT hook containing zinc finger 1
chrX_+_133501928 1.72 ENSMUST00000074950.11
ENSMUST00000113203.2
ENSMUST00000113202.8
ENSMUST00000050331.13
ENSMUST00000059297.6
Hnrnph2
heterogeneous nuclear ribonucleoprotein H2
chr1_-_153363354 1.63 ENSMUST00000186380.7
ENSMUST00000188345.2
ENSMUST00000042141.12
Dhx9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr11_-_85030761 1.54 ENSMUST00000108075.9
Usp32
ubiquitin specific peptidase 32
chr12_-_69939762 1.50 ENSMUST00000110567.8
ENSMUST00000171211.8
Map4k5
mitogen-activated protein kinase kinase kinase kinase 5
chr12_-_69939931 1.11 ENSMUST00000049239.8
ENSMUST00000110570.8
Map4k5
mitogen-activated protein kinase kinase kinase kinase 5
chr18_+_46874920 1.08 ENSMUST00000025357.9
ENSMUST00000225520.2
Ap3s1
adaptor-related protein complex 3, sigma 1 subunit
chr7_+_3632982 0.99 ENSMUST00000179769.8
ENSMUST00000008517.13
Prpf31
pre-mRNA processing factor 31
chr4_+_130253925 0.97 ENSMUST00000105994.4
Snrnp40
small nuclear ribonucleoprotein 40 (U5)
chr11_+_43572825 0.94 ENSMUST00000061070.6
ENSMUST00000094294.5
Pwwp2a
PWWP domain containing 2A
chr15_-_77527470 0.86 ENSMUST00000181154.2
ENSMUST00000180949.8
ENSMUST00000166623.10
Apol11b
apolipoprotein L 11b
chr18_+_46874970 0.81 ENSMUST00000224622.2
Ap3s1
adaptor-related protein complex 3, sigma 1 subunit
chr17_-_43813664 0.77 ENSMUST00000024707.9
ENSMUST00000117137.8
Mep1a
meprin 1 alpha
chrX_+_134786600 0.75 ENSMUST00000180025.8
ENSMUST00000148374.8
ENSMUST00000068755.14
Bhlhb9
basic helix-loop-helix domain containing, class B9
chr5_-_123126550 0.68 ENSMUST00000086200.11
ENSMUST00000156474.8
Kdm2b
lysine (K)-specific demethylase 2B
chr2_-_175179990 0.67 ENSMUST00000121393.9
Gm4631
predicted gene 4631
chr13_-_117161921 0.61 ENSMUST00000223949.2
Parp8
poly (ADP-ribose) polymerase family, member 8
chr18_-_6490808 0.57 ENSMUST00000028100.13
ENSMUST00000050542.6
Epc1
enhancer of polycomb homolog 1
chr13_-_117162041 0.57 ENSMUST00000022239.8
Parp8
poly (ADP-ribose) polymerase family, member 8
chr11_-_101998648 0.57 ENSMUST00000177304.8
ENSMUST00000017455.15
Pyy
peptide YY
chr11_+_96820220 0.55 ENSMUST00000062172.6
Prr15l
proline rich 15-like
chr4_-_82777746 0.54 ENSMUST00000156055.2
ENSMUST00000030110.15
Zdhhc21
zinc finger, DHHC domain containing 21
chr7_-_27055405 0.53 ENSMUST00000003857.7
Shkbp1
Sh3kbp1 binding protein 1
chrX_+_93012255 0.52 ENSMUST00000121565.8
AU015836
expressed sequence AU015836
chr2_+_26800757 0.51 ENSMUST00000102898.5
Rpl7a
ribosomal protein L7A
chr2_-_177599032 0.50 ENSMUST00000108928.2
ENSMUST00000108932.8
ENSMUST00000108930.9
Gm14326
predicted gene 14326
chr2_-_45000389 0.49 ENSMUST00000201804.4
ENSMUST00000028229.13
ENSMUST00000202187.4
ENSMUST00000153561.6
ENSMUST00000201490.2
Zeb2
zinc finger E-box binding homeobox 2
chr11_+_96820091 0.42 ENSMUST00000054311.6
ENSMUST00000107636.4
Prr15l
proline rich 15-like
chr9_-_119151428 0.42 ENSMUST00000040853.11
Oxsr1
oxidative-stress responsive 1
chr2_-_164585102 0.40 ENSMUST00000103096.10
Wfdc3
WAP four-disulfide core domain 3
chr11_+_98700613 0.40 ENSMUST00000169695.2
Casc3
cancer susceptibility candidate 3
chr9_+_37450551 0.40 ENSMUST00000002008.7
ENSMUST00000215957.2
ENSMUST00000215271.2
Vsig2
V-set and immunoglobulin domain containing 2
chr15_-_35938155 0.39 ENSMUST00000156915.3
Cox6c
cytochrome c oxidase subunit 6C
chr6_-_128401832 0.38 ENSMUST00000203374.3
ENSMUST00000142615.4
ENSMUST00000001559.11
Itfg2
integrin alpha FG-GAP repeat containing 2
chr5_-_149559636 0.38 ENSMUST00000201452.4
Hsph1
heat shock 105kDa/110kDa protein 1
chr12_+_3945467 0.35 ENSMUST00000172749.2
Dnmt3a
DNA methyltransferase 3A
chr5_-_135573962 0.34 ENSMUST00000060311.12
Hip1
huntingtin interacting protein 1
chr15_-_77037756 0.34 ENSMUST00000227314.2
ENSMUST00000227930.2
ENSMUST00000227533.2
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr9_+_56983679 0.34 ENSMUST00000168177.8
Sin3a
transcriptional regulator, SIN3A (yeast)
chr12_-_12990584 0.33 ENSMUST00000130990.2
Mycn
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
chr9_+_56983627 0.33 ENSMUST00000168678.8
Sin3a
transcriptional regulator, SIN3A (yeast)
chr3_+_88439616 0.31 ENSMUST00000172699.2
Mex3a
mex3 RNA binding family member A
chr2_-_175048692 0.31 ENSMUST00000109055.2
ENSMUST00000099028.10
ENSMUST00000109056.8
ENSMUST00000109058.9
Gm14391
predicted gene 14391
chr2_-_176328111 0.31 ENSMUST00000108990.9
ENSMUST00000119149.8
ENSMUST00000117267.2
Gm14308
predicted gene 14308
chr2_-_177482111 0.30 ENSMUST00000108939.9
ENSMUST00000150650.2
Gm14325
predicted gene 14325
chr4_-_130253703 0.30 ENSMUST00000134159.3
Zcchc17
zinc finger, CCHC domain containing 17
chr5_-_149559667 0.29 ENSMUST00000074846.14
Hsph1
heat shock 105kDa/110kDa protein 1
chr11_-_72097821 0.27 ENSMUST00000204457.3
Gm43951
predicted gene, 43951
chr2_+_176400121 0.26 ENSMUST00000108981.9
ENSMUST00000108980.9
Gm14305
predicted gene 14305
chr7_+_30215124 0.25 ENSMUST00000238768.2
Arhgap33os
Rho GTPase activating protein 33, opposite strand
chr2_+_176490405 0.24 ENSMUST00000118012.9
Gm14295
predicted gene 14295
chrX_-_165368675 0.24 ENSMUST00000000412.3
Egfl6
EGF-like-domain, multiple 6
chr15_-_35938328 0.24 ENSMUST00000014457.15
Cox6c
cytochrome c oxidase subunit 6C
chr2_+_176692749 0.23 ENSMUST00000108975.9
ENSMUST00000156844.8
Gm14419
predicted gene 14419
chr2_-_176178566 0.22 ENSMUST00000120959.8
ENSMUST00000120521.2
Gm14434
predicted gene 14434
chr2_+_175661012 0.21 ENSMUST00000109011.8
Gm6710
predicted gene 6710
chr2_+_177665068 0.21 ENSMUST00000108925.10
ENSMUST00000108926.3
Zfp971
zinc finger protein 971
chr6_-_38101503 0.20 ENSMUST00000040259.8
Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr2_-_175277575 0.20 ENSMUST00000152941.2
ENSMUST00000109045.9
Gm4724
predicted gene 4724
chr8_-_45863335 0.19 ENSMUST00000210996.2
ENSMUST00000209772.2
Tlr3
toll-like receptor 3
chr7_-_19307268 0.18 ENSMUST00000051364.4
Gemin7
gem nuclear organelle associated protein 7
chr4_+_136011969 0.18 ENSMUST00000144217.8
Zfp46
zinc finger protein 46
chr2_-_175722844 0.17 ENSMUST00000108949.3
ENSMUST00000109018.3
Zfp966
zinc finger protein 966
chr14_-_31807552 0.17 ENSMUST00000022461.11
ENSMUST00000067955.12
ENSMUST00000124303.9
Dph3
diphthamine biosynthesis 3
chr7_-_3632826 0.16 ENSMUST00000205596.2
ENSMUST00000155592.8
ENSMUST00000108641.10
Tfpt
TCF3 (E2A) fusion partner
chr6_-_70364222 0.16 ENSMUST00000103392.3
ENSMUST00000195945.2
Igkv8-16
immunoglobulin kappa variable 8-16
chr2_-_45001141 0.16 ENSMUST00000201969.4
ENSMUST00000201623.4
Zeb2
zinc finger E-box binding homeobox 2
chr12_-_115031622 0.14 ENSMUST00000194257.2
Ighv8-5
immunoglobulin heavy variable V8-5
chr17_+_78815493 0.14 ENSMUST00000024880.11
ENSMUST00000232859.2
Vit
vitrin
chr7_-_19307290 0.13 ENSMUST00000119912.2
Gemin7
gem nuclear organelle associated protein 7
chr2_-_176898214 0.12 ENSMUST00000108964.2
Gm14410
predicted gene 14410
chr6_-_23650205 0.12 ENSMUST00000115354.2
Rnf133
ring finger protein 133
chr2_+_175311778 0.12 ENSMUST00000109042.10
ENSMUST00000109002.9
ENSMUST00000109043.9
ENSMUST00000143490.2
Zfp965
zinc finger protein 965
chr2_-_174983792 0.11 ENSMUST00000109062.8
ENSMUST00000109059.8
ENSMUST00000109060.8
Gm14399
predicted gene 14399
chr2_+_176362315 0.10 ENSMUST00000121956.8
ENSMUST00000108985.9
Zfp973
zinc finger protein 973
chr12_+_52551092 0.10 ENSMUST00000217820.2
Arhgap5
Rho GTPase activating protein 5
chr19_-_24178000 0.09 ENSMUST00000233658.3
Tjp2
tight junction protein 2
chr2_-_119060366 0.09 ENSMUST00000076084.6
Ppp1r14d
protein phosphatase 1, regulatory inhibitor subunit 14D
chr2_+_175968362 0.08 ENSMUST00000099009.9
ENSMUST00000136719.2
2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr1_+_36107452 0.07 ENSMUST00000088174.4
Hs6st1
heparan sulfate 6-O-sulfotransferase 1
chr6_+_42263644 0.07 ENSMUST00000163936.8
Clcn1
chloride channel, voltage-sensitive 1
chr16_-_97564910 0.07 ENSMUST00000019386.10
Ripk4
receptor-interacting serine-threonine kinase 4
chr12_-_115129697 0.06 ENSMUST00000103524.2
ENSMUST00000193145.2
Ighv8-6
immunoglobulin heavy variable V8-6
chr9_+_107784065 0.06 ENSMUST00000035203.9
Mst1r
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
chr15_+_102378966 0.05 ENSMUST00000077037.13
ENSMUST00000229102.2
ENSMUST00000229618.2
ENSMUST00000229275.2
ENSMUST00000231089.2
ENSMUST00000229802.2
ENSMUST00000229854.2
ENSMUST00000108838.5
Pcbp2
poly(rC) binding protein 2
chr4_-_32950812 0.04 ENSMUST00000084750.8
ENSMUST00000084748.9
Ankrd6
ankyrin repeat domain 6
chr11_+_105480796 0.04 ENSMUST00000168598.8
ENSMUST00000100330.10
Tanc2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chrX_+_93012288 0.03 ENSMUST00000163458.2
AU015836
expressed sequence AU015836
chr15_-_77037926 0.03 ENSMUST00000228087.2
Rbfox2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_-_72080709 0.03 ENSMUST00000114540.4
ENSMUST00000051569.7
Pnma5
paraneoplastic antigen family 5
chr2_+_129854256 0.03 ENSMUST00000110299.3
Tgm3
transglutaminase 3, E polypeptide
chr2_+_175757124 0.02 ENSMUST00000109007.8
ENSMUST00000174416.8
Gm2026
predicted gene 2026
chr1_+_131678223 0.02 ENSMUST00000147800.2
Slc26a9
solute carrier family 26, member 9
chr2_-_176619602 0.02 ENSMUST00000099007.3
Gm14296
predicted gene 14296
chr4_-_82778066 0.01 ENSMUST00000107239.8
Zdhhc21
zinc finger, DHHC domain containing 21

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.1 GO:0051410 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.6 1.8 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) rRNA export from nucleus(GO:0006407)
0.4 9.8 GO:0015701 bicarbonate transport(GO:0015701)
0.3 1.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 4.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.2 0.7 GO:0021993 initiation of neural tube closure(GO:0021993)
0.2 0.7 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.4 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 2.1 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.3 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.1 1.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 1.9 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.6 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
0.0 0.6 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.6 GO:0032096 negative regulation of response to food(GO:0032096)
0.0 0.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.3 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.4 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.2 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.1 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.0 0.5 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.3 GO:0000387 spliceosomal snRNP assembly(GO:0000387)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 1.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 1.8 GO:0001652 granular component(GO:0001652)
0.2 4.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.9 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 1.0 GO:0005687 U4 snRNP(GO:0005687)
0.1 9.8 GO:0014704 intercalated disc(GO:0014704)
0.1 0.3 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.0 1.0 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.7 GO:0016580 Sin3 complex(GO:0016580)
0.0 2.1 GO:0099738 cell cortex region(GO:0099738)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.5 1.6 GO:0045142 ATP-dependent DNA/RNA helicase activity(GO:0033680) triplex DNA binding(GO:0045142)
0.4 9.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 1.0 GO:0030622 U4atac snRNA binding(GO:0030622)
0.2 1.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 2.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 4.1 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 2.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 1.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.7 GO:0033558 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.4 GO:0004896 cytokine receptor activity(GO:0004896)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID IL27 PATHWAY IL27-mediated signaling events
0.0 2.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.8 PID BARD1 PATHWAY BARD1 signaling events
0.0 2.5 PID TNF PATHWAY TNF receptor signaling pathway
0.0 2.1 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 4.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 9.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 4.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation