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GSE58827: Dynamics of the Mouse Liver

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Results for Gata5

Z-value: 2.33

Motif logo

Transcription factors associated with Gata5

Gene Symbol Gene ID Gene Info
ENSMUSG00000015627.6 GATA binding protein 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata5mm39_v1_chr2_-_179976458_1799765090.882.6e-12Click!

Activity profile of Gata5 motif

Sorted Z-values of Gata5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_84810802 46.48 ENSMUST00000028467.6
proteoglycan 2, bone marrow
chr17_+_41121979 38.24 ENSMUST00000024721.8
ENSMUST00000233740.2
Rhesus blood group-associated A glycoprotein
chr1_-_132295617 29.84 ENSMUST00000142609.8
transmembrane and coiled-coil domains 2
chr9_+_20940669 26.81 ENSMUST00000001040.7
ENSMUST00000215077.2
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr11_-_102360664 24.65 ENSMUST00000103086.4
integrin alpha 2b
chr4_-_119047202 24.25 ENSMUST00000239029.2
ENSMUST00000138395.9
ENSMUST00000156746.3
erythroblast membrane-associated protein
chr17_-_26417982 23.79 ENSMUST00000142410.2
ENSMUST00000120333.8
ENSMUST00000039113.14
protein disulfide isomerase associated 2
chr11_-_83177548 23.75 ENSMUST00000163961.3
schlafen 14
chr6_+_41498716 23.58 ENSMUST00000070380.5
protease, serine 2
chr15_-_103159892 23.51 ENSMUST00000133600.8
ENSMUST00000134554.2
ENSMUST00000156927.8
nuclear factor, erythroid derived 2
chr7_-_98887770 22.75 ENSMUST00000064231.8
monoacylglycerol O-acyltransferase 2
chr15_-_103160082 21.26 ENSMUST00000149111.8
ENSMUST00000132836.8
nuclear factor, erythroid derived 2
chr7_-_103477126 20.97 ENSMUST00000023934.8
hemoglobin, beta adult s chain
chr4_-_119047167 19.67 ENSMUST00000030396.15
erythroblast membrane-associated protein
chr2_+_84818538 19.35 ENSMUST00000028466.12
proteoglycan 3
chr11_+_70529944 17.71 ENSMUST00000055184.7
ENSMUST00000108551.3
glycoprotein 1b, alpha polypeptide
chr3_-_14873406 17.50 ENSMUST00000181860.8
ENSMUST00000144327.3
carbonic anhydrase 1
chr11_+_32233511 17.14 ENSMUST00000093209.4
hemoglobin alpha, adult chain 1
chr4_-_137157824 16.20 ENSMUST00000102522.5
chymotrypsin-like elastase family, member 3B
chr11_+_32246489 15.30 ENSMUST00000093207.4
hemoglobin alpha, adult chain 2
chr4_-_119047180 15.19 ENSMUST00000150864.3
ENSMUST00000141227.9
erythroblast membrane-associated protein
chr4_-_119047146 15.18 ENSMUST00000124626.9
erythroblast membrane-associated protein
chr13_+_108452866 14.95 ENSMUST00000051594.12
DEP domain containing 1B
chr7_-_103502404 14.63 ENSMUST00000033229.5
hemoglobin Y, beta-like embryonic chain
chr7_-_120673761 13.85 ENSMUST00000047194.4
immunoglobulin superfamily, member 6
chr6_+_41331039 13.76 ENSMUST00000072103.7
trypsin 10
chr3_-_14843512 13.63 ENSMUST00000094365.11
carbonic anhydrase 1
chr7_+_13011180 13.23 ENSMUST00000177588.10
ligase I, DNA, ATP-dependent
chr14_+_70694887 12.90 ENSMUST00000003561.10
phytanoyl-CoA hydroxylase interacting protein
chr15_-_78449172 12.90 ENSMUST00000230952.2
Rac family small GTPase 2
chr8_+_85428059 11.84 ENSMUST00000238364.2
ENSMUST00000238562.2
ENSMUST00000037165.6
lymphoblastomic leukemia 1
chrX_-_106446928 11.71 ENSMUST00000033591.6
integral membrane protein 2A
chr11_+_32226400 11.55 ENSMUST00000020531.9
hemoglobin X, alpha-like embryonic chain in Hba complex
chr6_+_41279199 10.74 ENSMUST00000031913.5
trypsin 4
chr17_+_35133435 10.52 ENSMUST00000007249.15
solute carrier family 44, member 4
chr10_+_45453907 10.51 ENSMUST00000037044.13
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
chr11_+_116423266 10.29 ENSMUST00000106386.8
ENSMUST00000145737.8
ENSMUST00000155102.8
ENSMUST00000063446.13
sphingosine kinase 1
chr11_+_58839716 9.32 ENSMUST00000078267.5
H2B.U histone 2
chr5_-_113968483 8.39 ENSMUST00000100874.6
selectin, platelet (p-selectin) ligand
chr13_+_108452930 8.39 ENSMUST00000171178.2
DEP domain containing 1B
chr14_-_51295099 8.30 ENSMUST00000227764.2
ribonuclease, RNase A family, 12 (non-active)
chr11_+_32226893 8.29 ENSMUST00000145569.2
hemoglobin X, alpha-like embryonic chain in Hba complex
chr3_-_107129038 8.15 ENSMUST00000029504.9
chymosin
chr11_+_94827050 7.87 ENSMUST00000001547.8
collagen, type I, alpha 1
chr2_+_72306503 7.86 ENSMUST00000102691.11
ENSMUST00000157019.2
cell division cycle associated 7
chr16_+_49675682 7.37 ENSMUST00000114496.3
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr6_+_38918327 7.31 ENSMUST00000160963.2
thromboxane A synthase 1, platelet
chr15_+_80507671 7.25 ENSMUST00000043149.9
GRB2-related adaptor protein 2
chr17_-_24746804 7.11 ENSMUST00000176353.8
ENSMUST00000176237.8
TNF receptor-associated factor 7
chr16_+_36755338 6.89 ENSMUST00000023531.15
hematopoietic cell specific Lyn substrate 1
chr15_+_89206923 6.49 ENSMUST00000066991.7
adrenomedullin 2
chr15_-_86070338 6.46 ENSMUST00000044332.16
ceramide kinase
chr12_+_83567240 6.42 ENSMUST00000021645.9
DDB1 and CUL4 associated factor 4
chr11_+_116422712 6.40 ENSMUST00000100201.10
sphingosine kinase 1
chr11_+_116422570 6.37 ENSMUST00000106387.9
sphingosine kinase 1
chr4_-_155012643 6.35 ENSMUST00000123514.8
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
chr17_-_24746911 5.97 ENSMUST00000176652.8
TNF receptor-associated factor 7
chr14_+_47605208 5.95 ENSMUST00000151405.9
lectin, galactose binding, soluble 3
chr1_-_170755136 5.30 ENSMUST00000046322.14
ENSMUST00000159171.2
Fc receptor-like A
chr2_-_25114660 5.24 ENSMUST00000043584.5
tubulin, beta 4B class IVB
chr1_+_85528392 5.18 ENSMUST00000080204.11
Sp140 nuclear body protein
chr6_-_68609426 4.77 ENSMUST00000103328.3
immunoglobulin kappa variable 10-96
chr8_+_85428391 4.63 ENSMUST00000238338.2
lymphoblastomic leukemia 1
chr14_+_61547202 4.59 ENSMUST00000055159.8
ADP-ribosylation factor-like 11
chr2_+_84867554 4.57 ENSMUST00000077798.13
structure specific recognition protein 1
chr6_-_40562700 4.53 ENSMUST00000177178.2
ENSMUST00000129948.9
ENSMUST00000101491.11
C-type lectin domain family 5, member a
chr1_+_51328265 4.51 ENSMUST00000051572.8
caveolae associated 2
chr17_-_50401305 4.30 ENSMUST00000113195.8
raftlin lipid raft linker 1
chr11_-_115967873 4.25 ENSMUST00000153408.8
unc-13 homolog D
chr6_+_34361153 4.19 ENSMUST00000038383.14
ENSMUST00000115051.8
aldo-keto reductase family 1, member B10 (aldose reductase)
chr16_+_58490625 4.19 ENSMUST00000060077.7
coproporphyrinogen oxidase
chr4_-_59438633 4.16 ENSMUST00000040166.14
ENSMUST00000107544.2
sushi domain containing 1
chr6_-_34294377 4.10 ENSMUST00000154655.2
ENSMUST00000102980.11
aldo-keto reductase family 1, member B3 (aldose reductase)
chr19_+_12647803 4.02 ENSMUST00000207341.3
ENSMUST00000208494.3
ENSMUST00000208657.3
olfactory receptor 1442
chr17_+_48653493 3.96 ENSMUST00000113237.4
triggering receptor expressed on myeloid cells 2
chr7_+_97480125 3.92 ENSMUST00000206351.2
p21 (RAC1) activated kinase 1
chr1_+_40468720 3.87 ENSMUST00000174335.8
interleukin 1 receptor-like 1
chr11_-_109886569 3.78 ENSMUST00000106669.3
ATP-binding cassette, sub-family A (ABC1), member 8b
chr2_+_84867783 3.68 ENSMUST00000168266.8
ENSMUST00000130729.3
structure specific recognition protein 1
chr11_-_109886601 3.63 ENSMUST00000020948.15
ATP-binding cassette, sub-family A (ABC1), member 8b
chr12_-_69939931 3.58 ENSMUST00000049239.8
ENSMUST00000110570.8
mitogen-activated protein kinase kinase kinase kinase 5
chr11_-_101442663 3.58 ENSMUST00000017290.11
breast cancer 1, early onset
chr2_+_4564553 3.56 ENSMUST00000176828.8
FERM domain containing 4A
chr6_-_36787096 3.49 ENSMUST00000201321.2
ENSMUST00000101534.5
pleiotrophin
chr16_+_14179421 3.49 ENSMUST00000100167.10
ENSMUST00000154748.8
ENSMUST00000134776.8
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
chr14_+_61547267 3.35 ENSMUST00000224727.2
ADP-ribosylation factor-like 11
chr12_-_112641260 3.23 ENSMUST00000144550.9
thymoma viral proto-oncogene 1
chr5_-_73349191 3.16 ENSMUST00000176910.3
FRY like transcription coactivator
chr1_-_136273436 3.09 ENSMUST00000192001.6
ENSMUST00000192314.2
calmodulin regulated spectrin-associated protein family, member 2
chr15_+_102391614 3.06 ENSMUST00000229432.2
poly(rC) binding protein 2
chr4_+_103000248 2.93 ENSMUST00000106855.2
MEIR1 treanscription regulator
chr3_+_107137924 2.79 ENSMUST00000179399.3
RIKEN cDNA A630076J17 gene
chr13_-_100338469 2.74 ENSMUST00000167986.3
ENSMUST00000117913.8
NLR family, apoptosis inhibitory protein 2
chr15_-_77037972 2.67 ENSMUST00000111581.4
ENSMUST00000166610.8
RNA binding protein, fox-1 homolog (C. elegans) 2
chr6_+_134988572 2.66 ENSMUST00000032326.11
ENSMUST00000130851.8
ENSMUST00000205244.3
ENSMUST00000205055.3
ENSMUST00000204646.3
ENSMUST00000154558.3
DEAD box helicase 47
chr12_-_103392039 2.61 ENSMUST00000110001.4
ENSMUST00000223233.2
ENSMUST00000044923.15
ENSMUST00000221211.2
DEAD box helicase 24
chr15_+_95698574 2.59 ENSMUST00000226793.2
anoctamin 6
chr12_+_59113659 2.56 ENSMUST00000021381.6
pinin
chr5_+_93241287 2.45 ENSMUST00000074733.11
ENSMUST00000201700.4
ENSMUST00000202196.4
ENSMUST00000202308.4
septin 11
chr9_+_117888124 2.41 ENSMUST00000123690.2
5-azacytidine induced gene 2
chr15_-_38518458 2.39 ENSMUST00000127848.2
antizyme inhibitor 1
chr7_-_44861235 2.33 ENSMUST00000210741.2
ENSMUST00000209466.2
dickkopf-like 1
chrX_+_52076998 2.23 ENSMUST00000026723.9
hypoxanthine guanine phosphoribosyl transferase
chr3_+_105778174 2.16 ENSMUST00000164730.2
ENSMUST00000010279.10
adenosine A3 receptor
transmembrane and immunoglobulin domain containing 3
chr3_-_97517472 2.16 ENSMUST00000029730.5
chromodomain helicase DNA binding protein 1-like
chr9_-_122016671 2.15 ENSMUST00000216738.2
anoctamin 10
chr10_+_74872898 2.09 ENSMUST00000147802.9
ENSMUST00000020391.13
ENSMUST00000234625.2
RAB36, member RAS oncogene family
chr11_+_59099147 2.08 ENSMUST00000020719.7
RIKEN cDNA 2310033P09 gene
chr12_+_83567303 2.02 ENSMUST00000222502.2
DDB1 and CUL4 associated factor 4
chr14_-_52273600 1.99 ENSMUST00000214342.2
olfactory receptor 221
chr15_-_60696790 1.97 ENSMUST00000100635.5
LRAT domain containing 1
chr11_-_45845992 1.94 ENSMUST00000109254.2
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr9_-_36678868 1.90 ENSMUST00000217599.2
ENSMUST00000120381.9
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
chr2_-_71198091 1.87 ENSMUST00000151937.8
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr4_-_3973586 1.86 ENSMUST00000089430.6
predicted gene 11808
chr3_-_35991548 1.78 ENSMUST00000199173.3
ENSMUST00000148465.8
DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
chr6_-_68887957 1.74 ENSMUST00000200454.2
immunoglobulin kappa variable 4-86
chr1_-_131025562 1.69 ENSMUST00000016672.11
MAP kinase-activated protein kinase 2
chr6_-_69584812 1.67 ENSMUST00000103359.3
immunoglobulin kappa variable 4-55
chr5_-_35897331 1.51 ENSMUST00000201511.2
SH3 domain and tetratricopeptide repeats 1
chr13_-_100454182 1.50 ENSMUST00000118574.8
NLR family, apoptosis inhibitory protein 6
chr15_-_76491758 1.48 ENSMUST00000071898.7
cleavage and polyadenylation specific factor 1
chr15_+_55171138 1.44 ENSMUST00000023053.12
ENSMUST00000110217.10
collagen, type XIV, alpha 1
chr6_+_68402550 1.43 ENSMUST00000103323.3
immunoglobulin kappa variable 16-104
chr4_+_6191084 1.41 ENSMUST00000029907.6
UBX domain protein 2B
chr9_+_38788422 1.39 ENSMUST00000078289.3
olfactory receptor 926
chr4_-_137137088 1.27 ENSMUST00000024200.7
chymotrypsin-like elastase family, member 3A
chr15_+_100052260 1.16 ENSMUST00000023768.14
disco interacting protein 2 homolog B
chr5_+_93241385 1.10 ENSMUST00000201421.4
ENSMUST00000202415.4
ENSMUST00000202217.3
septin 11
chr8_-_83128437 1.08 ENSMUST00000209573.3
interleukin 15
chr11_+_68979308 1.03 ENSMUST00000021273.13
vesicle-associated membrane protein 2
chr2_+_26473870 1.03 ENSMUST00000100290.13
ENSMUST00000238983.2
ENSMUST00000102907.13
EGF-like domain 7
chr12_-_108859123 1.02 ENSMUST00000161154.2
ENSMUST00000161410.8
tryptophanyl-tRNA synthetase
chr11_-_8900539 1.01 ENSMUST00000178195.2
polycystic kidney disease 1 like 1
chr11_+_68979332 1.01 ENSMUST00000117780.2
vesicle-associated membrane protein 2
chr5_+_32616187 0.98 ENSMUST00000015100.15
protein phosphatase 1 catalytic subunit beta
chr1_-_160134873 0.94 ENSMUST00000193185.6
RAB GTPase activating protein 1-like
chr2_+_109522781 0.93 ENSMUST00000111050.10
brain derived neurotrophic factor
chr7_+_45271229 0.93 ENSMUST00000033100.5
izumo sperm-egg fusion 1
chr16_-_19241884 0.92 ENSMUST00000206110.4
olfactory receptor 165
chr15_-_76491684 0.91 ENSMUST00000230157.2
cleavage and polyadenylation specific factor 1
chr1_-_136273811 0.89 ENSMUST00000048309.12
calmodulin regulated spectrin-associated protein family, member 2
chr3_-_95014218 0.87 ENSMUST00000107233.9
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr6_+_81900630 0.87 ENSMUST00000043195.11
GC-rich sequence DNA binding factor 2
chr1_-_173703424 0.84 ENSMUST00000186442.7
myeloid nuclear differentiation antigen like
chr15_-_77037926 0.73 ENSMUST00000228087.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_107288928 0.68 ENSMUST00000191425.7
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
chr9_+_23285228 0.68 ENSMUST00000214050.2
BMP-binding endothelial regulator
chr7_-_29772226 0.67 ENSMUST00000183115.8
ENSMUST00000182919.8
ENSMUST00000183190.2
ENSMUST00000080834.15
zinc finger protein 82
chr8_+_71047263 0.61 ENSMUST00000211501.2
myo-inositol 1-phosphate synthase A1
chr11_+_87744033 0.61 ENSMUST00000038196.7
MKS transition zone complex subunit 1
chr2_+_10375304 0.51 ENSMUST00000114862.8
ENSMUST00000114861.8
Scm-like with four mbt domains 2
chr6_+_137712076 0.51 ENSMUST00000064910.7
serine/threonine kinase receptor associated protein
chr2_+_85804239 0.45 ENSMUST00000217244.2
olfactory receptor 1029
chr10_+_58207229 0.44 ENSMUST00000238939.2
LIM and senescent cell antigen-like domains 1
chr12_+_102249294 0.43 ENSMUST00000056950.14
Ras and Rab interactor 3
chrX_-_133012600 0.42 ENSMUST00000033610.13
NADPH oxidase 1
chr2_-_153474695 0.39 ENSMUST00000071852.10
COMM domain containing 7
chrX_-_133012457 0.36 ENSMUST00000159259.3
ENSMUST00000113275.10
NADPH oxidase 1
chr17_+_37689924 0.34 ENSMUST00000215518.2
olfactory receptor 105, pseudogene
chr16_-_26810402 0.33 ENSMUST00000231299.2
geminin coiled-coil domain containing
chr14_-_63781381 0.31 ENSMUST00000058679.7
myotubularin related protein 9
chr1_+_172204109 0.31 ENSMUST00000052455.4
phosphatidylinositol glycan anchor biosynthesis, class M
chr19_-_32038838 0.27 ENSMUST00000096119.5
N-acylsphingosine amidohydrolase 2
chr16_-_58583539 0.26 ENSMUST00000214139.2
olfactory receptor 172
chr13_-_59890564 0.26 ENSMUST00000055343.3
RIKEN cDNA 1700014D04 gene
chr19_-_11852453 0.22 ENSMUST00000213954.2
ENSMUST00000217617.2
olfactory receptor 1419
chr7_-_18266150 0.21 ENSMUST00000094795.5
pregnancy-specific glycoprotein 25
chr9_+_39903409 0.19 ENSMUST00000217600.2
olfactory receptor 978
chr2_-_153474599 0.16 ENSMUST00000109782.2
COMM domain containing 7
chr14_+_52860023 0.16 ENSMUST00000103570.2
T cell receptor alpha variable 5-1
chr2_-_88581690 0.14 ENSMUST00000215179.3
ENSMUST00000215529.3
olfactory receptor 1198
chr16_+_17328924 0.14 ENSMUST00000232372.2
leucine-zipper-like transcriptional regulator, 1
chr4_+_126571423 0.12 ENSMUST00000030642.3
proteasome (prosome, macropain) subunit, beta type 2
chr10_-_128918779 0.12 ENSMUST00000213579.2
olfactory receptor 767
chrX_-_36368176 0.12 ENSMUST00000130324.2
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr6_-_128101275 0.12 ENSMUST00000127105.8
tetraspanin 9
chr7_+_16821858 0.11 ENSMUST00000152671.2
pregnancy specific glycoprotein 16
chr6_+_78347636 0.07 ENSMUST00000204873.3
regenerating islet-derived 3 beta
chr12_-_114793177 0.07 ENSMUST00000103511.2
ENSMUST00000195735.2
immunoglobulin heavy variable 1-31
chr9_-_40915895 0.06 ENSMUST00000180384.3
cytotoxic and regulatory T cell molecule
chr19_+_13477910 0.03 ENSMUST00000217001.2
olfactory receptor 1477

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.5 46.5 GO:0002215 defense response to nematode(GO:0002215)
9.6 38.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
7.6 22.8 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
4.8 19.4 GO:0045575 basophil activation(GO:0045575)
3.8 34.5 GO:0015671 oxygen transport(GO:0015671)
3.5 10.5 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
3.3 23.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
3.0 44.8 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
1.7 8.4 GO:0050902 leukocyte adhesive activation(GO:0050902)
1.7 11.7 GO:0002317 plasma cell differentiation(GO:0002317)
1.7 13.2 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
1.5 5.9 GO:2001188 negative regulation of immunological synapse formation(GO:2000521) regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001188) negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001189)
1.4 16.5 GO:0001955 blood vessel maturation(GO:0001955)
1.4 4.1 GO:0018931 hexitol metabolic process(GO:0006059) naphthalene metabolic process(GO:0018931) naphthalene-containing compound metabolic process(GO:0090420)
1.3 4.0 GO:0002588 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
1.3 12.9 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
1.1 23.7 GO:0016075 rRNA catabolic process(GO:0016075)
1.1 7.9 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
1.1 23.6 GO:0031000 response to caffeine(GO:0031000)
1.0 3.9 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.9 13.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.9 3.5 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.9 3.5 GO:0034635 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.9 2.6 GO:0097045 activation of blood coagulation via clotting cascade(GO:0002543) phosphatidylserine exposure on blood platelet(GO:0097045)
0.8 4.2 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.8 3.2 GO:0060709 glycogen cell differentiation involved in embryonic placenta development(GO:0060709)
0.7 2.2 GO:0046038 GMP catabolic process(GO:0046038) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.7 3.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.7 17.7 GO:0042730 fibrinolysis(GO:0042730)
0.6 1.9 GO:0043686 co-translational protein modification(GO:0043686)
0.6 2.4 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.6 6.4 GO:0008228 opsonization(GO:0008228)
0.6 31.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.5 32.4 GO:0048821 erythrocyte development(GO:0048821)
0.5 24.6 GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175)
0.5 4.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.5 4.3 GO:0002432 granuloma formation(GO:0002432)
0.5 2.4 GO:0044565 dendritic cell proliferation(GO:0044565)
0.4 6.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.4 7.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.4 29.8 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.4 1.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.4 6.3 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.3 3.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.3 1.0 GO:0003127 detection of nodal flow(GO:0003127) detection of endogenous stimulus(GO:0009726)
0.3 0.9 GO:0061193 taste bud development(GO:0061193)
0.3 0.6 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.3 4.2 GO:0070269 pyroptosis(GO:0070269)
0.3 2.7 GO:0002826 negative regulation of T-helper 1 type immune response(GO:0002826)
0.3 3.2 GO:0090527 actin filament reorganization(GO:0090527)
0.3 2.0 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.3 1.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 24.6 GO:0070527 platelet aggregation(GO:0070527)
0.2 2.2 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.2 2.9 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.2 4.5 GO:0033033 negative regulation of myeloid cell apoptotic process(GO:0033033)
0.2 0.6 GO:0006021 inositol biosynthetic process(GO:0006021)
0.2 1.1 GO:0071350 interleukin-15-mediated signaling pathway(GO:0035723) extrathymic T cell selection(GO:0045062) cellular response to interleukin-15(GO:0071350)
0.2 1.7 GO:0044351 macropinocytosis(GO:0044351)
0.2 25.2 GO:0007586 digestion(GO:0007586)
0.1 4.5 GO:0097320 membrane tubulation(GO:0097320)
0.1 3.1 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 23.3 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.1 10.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 1.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 5.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 3.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 1.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 2.4 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.4 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 0.9 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.1 1.8 GO:0045116 protein neddylation(GO:0045116)
0.0 0.7 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 4.7 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 4.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 6.6 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 1.4 GO:0061050 regulation of cell growth involved in cardiac muscle cell development(GO:0061050)
0.0 0.9 GO:0035855 megakaryocyte development(GO:0035855)
0.0 5.7 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 1.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 1.9 GO:0006400 tRNA modification(GO:0006400)
0.0 0.1 GO:0002355 detection of tumor cell(GO:0002355)
0.0 0.9 GO:0097178 ruffle assembly(GO:0097178)
0.0 5.6 GO:0006260 DNA replication(GO:0006260)
0.0 2.4 GO:0002377 immunoglobulin production(GO:0002377)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.0 87.9 GO:0005833 hemoglobin complex(GO:0005833)
2.6 7.9 GO:0005584 collagen type I trimer(GO:0005584)
0.8 4.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.7 17.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.6 4.2 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.6 5.2 GO:0045298 tubulin complex(GO:0045298)
0.5 8.4 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.5 24.6 GO:0008305 integrin complex(GO:0008305)
0.4 4.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 2.0 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.3 3.6 GO:0070531 BRCA1-A complex(GO:0070531)
0.3 4.0 GO:0036449 microtubule minus-end(GO:0036449)
0.3 8.4 GO:0005682 U5 snRNP(GO:0005682)
0.2 0.8 GO:0071438 invadopodium membrane(GO:0071438)
0.2 36.6 GO:0032993 protein-DNA complex(GO:0032993)
0.2 5.9 GO:0097386 glial cell projection(GO:0097386)
0.2 1.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 3.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.9 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 1.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 2.6 GO:0030057 desmosome(GO:0030057)
0.1 20.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.9 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 13.3 GO:0030027 lamellipodium(GO:0030027)
0.0 0.5 GO:0034719 SMN complex(GO:0032797) SMN-Sm protein complex(GO:0034719)
0.0 14.9 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 4.5 GO:0005901 caveola(GO:0005901)
0.0 41.3 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 3.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 66.9 GO:0005615 extracellular space(GO:0005615)
0.0 4.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 4.3 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.2 GO:0036064 ciliary basal body(GO:0036064)
0.0 6.4 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.2 GO:0030427 site of polarized growth(GO:0030427)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.0 2.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.0 GO:0034704 calcium channel complex(GO:0034704)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 16.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.0 3.5 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
13.4 53.4 GO:0031720 haptoglobin binding(GO:0031720)
7.3 14.6 GO:0031721 hemoglobin alpha binding(GO:0031721)
4.9 24.6 GO:0070051 fibrinogen binding(GO:0070051)
3.8 22.8 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
3.1 31.1 GO:0004064 arylesterase activity(GO:0004064)
2.8 19.8 GO:0005344 oxygen transporter activity(GO:0005344)
2.6 23.1 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
2.2 6.5 GO:0001729 ceramide kinase activity(GO:0001729)
2.0 23.8 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
2.0 5.9 GO:0050785 advanced glycation end-product receptor activity(GO:0050785)
1.8 10.5 GO:0015220 choline transmembrane transporter activity(GO:0015220)
1.7 38.2 GO:0022840 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
1.4 4.2 GO:0070401 NADP+ binding(GO:0070401)
1.3 13.2 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
1.3 3.9 GO:0002113 interleukin-33 binding(GO:0002113)
0.9 3.5 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.9 3.5 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.8 44.8 GO:0050699 WW domain binding(GO:0050699)
0.7 7.4 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.6 1.9 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.6 2.4 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.6 4.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.5 7.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 4.0 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.4 23.7 GO:0004521 endoribonuclease activity(GO:0004521)
0.4 1.9 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.3 4.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3 0.9 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.3 59.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 1.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 3.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 3.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.2 0.6 GO:0016872 inositol-3-phosphate synthase activity(GO:0004512) intramolecular lyase activity(GO:0016872)
0.2 4.0 GO:0051011 microtubule minus-end binding(GO:0051011)
0.2 1.9 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 6.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 65.4 GO:0030246 carbohydrate binding(GO:0030246)
0.2 2.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 3.2 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.2 26.8 GO:0005178 integrin binding(GO:0005178)
0.2 15.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 2.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 4.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 4.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 1.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 8.3 GO:0004540 ribonuclease activity(GO:0004540)
0.1 7.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.9 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.9 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 23.4 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 9.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 4.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 5.3 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.1 4.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.8 GO:0097602 cullin family protein binding(GO:0097602)
0.1 3.6 GO:0003684 damaged DNA binding(GO:0003684)
0.1 24.7 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 2.2 GO:0070035 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.1 4.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 6.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.0 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.0 4.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.6 GO:0030674 protein binding, bridging(GO:0030674)
0.0 3.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 6.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 11.6 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.1 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 5.6 GO:0005525 GTP binding(GO:0005525)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 3.5 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 65.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
1.3 44.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
1.1 62.9 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.4 7.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.3 16.1 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 27.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 3.9 PID S1P S1P2 PATHWAY S1P2 pathway
0.2 3.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 6.5 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2 3.5 PID S1P S1P1 PATHWAY S1P1 pathway
0.2 8.4 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.2 40.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.9 PID RAS PATHWAY Regulation of Ras family activation
0.1 7.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 1.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 3.6 PID TNF PATHWAY TNF receptor signaling pathway
0.1 7.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.4 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 3.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID SHP2 PATHWAY SHP2 signaling
0.0 1.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.8 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 23.5 REACTOME DEFENSINS Genes involved in Defensins
1.6 25.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
1.3 48.8 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
1.2 24.6 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.9 16.8 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.5 23.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 26.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4 7.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.4 12.9 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 11.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.3 7.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 5.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 5.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 8.3 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.2 3.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 2.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 29.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 4.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 4.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 6.3 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 2.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 20.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.7 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 2.2 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 3.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 6.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism