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GSE58827: Dynamics of the Mouse Liver

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Results for Gata6

Z-value: 0.70

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Transcription factors associated with Gata6

Gene Symbol Gene ID Gene Info
Gata6
ENSMUSG00000005836.11 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata6mm39_v1_chr18_+_11052458_110524790.134.5e-01Click!

Activity profile of Gata6 motif

Sorted Z-values of Gata6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_30639217 8.44 ENSMUST00000031806.10
Cpa1
carboxypeptidase A1, pancreatic
chr11_-_102255999 8.03 ENSMUST00000006749.10
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr4_-_137157824 6.38 ENSMUST00000102522.5
Cela3b
chymotrypsin-like elastase family, member 3B
chr4_-_46404224 6.28 ENSMUST00000107764.9
Hemgn
hemogen
chr5_+_90920353 5.36 ENSMUST00000202625.2
Pf4
platelet factor 4
chr19_+_58658779 4.66 ENSMUST00000057270.9
Pnlip
pancreatic lipase
chr19_+_58658838 4.57 ENSMUST00000238108.2
Pnlip
pancreatic lipase
chr10_+_115653152 4.50 ENSMUST00000080630.11
ENSMUST00000179196.3
ENSMUST00000035563.15
Tspan8
tetraspanin 8
chr6_+_86055018 4.35 ENSMUST00000205034.3
ENSMUST00000203724.3
Add2
adducin 2 (beta)
chr15_-_103159892 4.25 ENSMUST00000133600.8
ENSMUST00000134554.2
ENSMUST00000156927.8
Nfe2
nuclear factor, erythroid derived 2
chr9_-_44253588 3.77 ENSMUST00000215091.2
Hmbs
hydroxymethylbilane synthase
chr10_-_62178453 3.73 ENSMUST00000143179.2
ENSMUST00000130422.8
Hk1
hexokinase 1
chr6_+_86055048 3.50 ENSMUST00000032069.8
Add2
adducin 2 (beta)
chr7_-_103502404 3.43 ENSMUST00000033229.5
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr8_-_86091946 2.71 ENSMUST00000034133.14
Mylk3
myosin light chain kinase 3
chr8_-_86091970 2.71 ENSMUST00000121972.8
Mylk3
myosin light chain kinase 3
chr9_-_44253630 2.42 ENSMUST00000097558.5
Hmbs
hydroxymethylbilane synthase
chr13_-_55676334 2.30 ENSMUST00000047877.5
Dok3
docking protein 3
chr2_-_172212426 2.03 ENSMUST00000109139.8
ENSMUST00000028997.8
ENSMUST00000109140.10
Aurka
aurora kinase A
chr4_-_137137088 2.02 ENSMUST00000024200.7
Cela3a
chymotrypsin-like elastase family, member 3A
chr19_+_45433899 1.89 ENSMUST00000224478.2
Btrc
beta-transducin repeat containing protein
chr3_-_75177378 1.73 ENSMUST00000039047.5
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr1_-_144651157 1.69 ENSMUST00000027603.4
Rgs18
regulator of G-protein signaling 18
chr2_+_72306503 1.57 ENSMUST00000102691.11
ENSMUST00000157019.2
Cdca7
cell division cycle associated 7
chr17_+_34823790 1.54 ENSMUST00000173242.8
Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr7_-_115445352 1.53 ENSMUST00000206369.2
Sox6
SRY (sex determining region Y)-box 6
chr5_+_76988444 1.37 ENSMUST00000120639.9
ENSMUST00000163347.8
ENSMUST00000121851.2
Cracd
capping protein inhibiting regulator of actin
chr11_-_115968373 1.21 ENSMUST00000174822.8
Unc13d
unc-13 homolog D
chr3_-_20296337 1.09 ENSMUST00000001921.3
Cpa3
carboxypeptidase A3, mast cell
chr3_+_108272205 1.06 ENSMUST00000090563.7
Mybphl
myosin binding protein H-like
chr11_-_70111796 1.01 ENSMUST00000060010.3
ENSMUST00000190533.2
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr11_+_97917520 0.84 ENSMUST00000092425.11
Rpl19
ribosomal protein L19
chr15_+_57849269 0.83 ENSMUST00000050374.3
Fam83a
family with sequence similarity 83, member A
chr11_-_115967873 0.81 ENSMUST00000153408.8
Unc13d
unc-13 homolog D
chr11_+_97917746 0.81 ENSMUST00000017548.7
Rpl19
ribosomal protein L19
chr16_+_78727829 0.72 ENSMUST00000114216.2
ENSMUST00000069148.13
ENSMUST00000023568.14
Chodl
chondrolectin
chr9_+_66257747 0.72 ENSMUST00000042824.13
Herc1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr11_-_99383938 0.62 ENSMUST00000006969.8
Krt23
keratin 23
chr15_-_38518458 0.60 ENSMUST00000127848.2
Azin1
antizyme inhibitor 1
chr13_+_19398273 0.59 ENSMUST00000103558.3
Trgc1
T cell receptor gamma, constant 1
chr2_+_110427643 0.56 ENSMUST00000045972.13
ENSMUST00000111026.3
Slc5a12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr4_+_34893772 0.54 ENSMUST00000029975.10
ENSMUST00000135871.8
ENSMUST00000108130.2
Cga
glycoprotein hormones, alpha subunit
chr8_+_57774010 0.43 ENSMUST00000040104.5
Hand2
heart and neural crest derivatives expressed 2
chr4_-_132649798 0.39 ENSMUST00000097856.10
ENSMUST00000030696.11
Fam76a
family with sequence similarity 76, member A
chr1_+_12762501 0.35 ENSMUST00000177608.8
ENSMUST00000180062.8
Sulf1
sulfatase 1
chr5_-_73349191 0.34 ENSMUST00000176910.3
Fryl
FRY like transcription coactivator
chrX_+_132751729 0.34 ENSMUST00000033602.9
Tnmd
tenomodulin
chr17_+_71511642 0.26 ENSMUST00000126681.8
Lpin2
lipin 2
chr2_+_109522781 0.26 ENSMUST00000111050.10
Bdnf
brain derived neurotrophic factor
chr3_+_90201388 0.25 ENSMUST00000199607.5
Gatad2b
GATA zinc finger domain containing 2B
chr2_+_172212577 0.24 ENSMUST00000151511.8
Cstf1
cleavage stimulation factor, 3' pre-RNA, subunit 1
chr1_-_160134873 0.18 ENSMUST00000193185.6
Rabgap1l
RAB GTPase activating protein 1-like
chr16_+_91444730 0.15 ENSMUST00000119368.8
ENSMUST00000114037.9
ENSMUST00000114036.9
ENSMUST00000122302.8
Son
Son DNA binding protein
chr10_+_101517348 0.15 ENSMUST00000179929.8
ENSMUST00000219195.2
ENSMUST00000127504.9
Mgat4c
MGAT4 family, member C
chr18_+_76192529 0.14 ENSMUST00000167921.2
Zbtb7c
zinc finger and BTB domain containing 7C
chr9_+_64939695 0.13 ENSMUST00000034960.14
Dpp8
dipeptidylpeptidase 8
chr5_-_30619246 0.13 ENSMUST00000114747.9
ENSMUST00000074171.10
Otof
otoferlin
chr7_+_100435548 0.12 ENSMUST00000216021.2
Fam168a
family with sequence similarity 168, member A
chr16_-_19334384 0.12 ENSMUST00000054606.2
Olfr167
olfactory receptor 167
chr2_-_59778560 0.11 ENSMUST00000153136.2
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chrX_-_111608339 0.10 ENSMUST00000039887.4
Pof1b
premature ovarian failure 1B
chr1_-_131161312 0.09 ENSMUST00000212202.2
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr2_-_125701059 0.08 ENSMUST00000110463.8
ENSMUST00000028635.6
Cops2
COP9 signalosome subunit 2
chr9_-_95697441 0.08 ENSMUST00000119760.2
Pls1
plastin 1 (I-isoform)
chr11_-_53598078 0.06 ENSMUST00000124352.2
ENSMUST00000020649.14
Rad50
RAD50 double strand break repair protein
chr13_-_22403990 0.02 ENSMUST00000057516.2
Vmn1r193
vomeronasal 1 receptor 193
chr13_-_103042554 0.01 ENSMUST00000171791.8
Mast4
microtubule associated serine/threonine kinase family member 4
chr15_-_73114855 0.01 ENSMUST00000227686.2
Ptk2
PTK2 protein tyrosine kinase 2
chr16_+_35861554 0.00 ENSMUST00000042203.10
Wdr5b
WD repeat domain 5B
chr2_-_7400690 0.00 ENSMUST00000182404.8
Celf2
CUGBP, Elav-like family member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
1.1 5.4 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.9 5.4 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.7 2.0 GO:1900195 positive regulation of oocyte maturation(GO:1900195)
0.5 3.7 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.4 7.4 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.4 3.4 GO:0015671 oxygen transport(GO:0015671)
0.3 8.0 GO:0015701 bicarbonate transport(GO:0015701)
0.3 4.3 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.3 2.0 GO:0002432 granuloma formation(GO:0002432)
0.2 7.9 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.6 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.1 1.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.5 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.1 0.3 GO:0061193 taste bud development(GO:0061193)
0.1 1.1 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 4.5 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 0.4 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 1.9 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 8.0 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.5 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.0 0.7 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.1 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 3.8 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.3 GO:0001886 endothelial cell morphogenesis(GO:0001886)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.4 3.4 GO:0005833 hemoglobin complex(GO:0005833)
0.4 5.4 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.3 2.0 GO:0042585 chromosome passenger complex(GO:0032133) germinal vesicle(GO:0042585)
0.2 2.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 3.7 GO:0097228 sperm principal piece(GO:0097228)
0.1 8.0 GO:0014704 intercalated disc(GO:0014704)
0.0 1.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 6.2 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.3 GO:0030061 mitochondrial crista(GO:0030061)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.9 5.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.9 3.4 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.6 5.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.5 3.7 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.5 9.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 1.6 GO:1990932 5.8S rRNA binding(GO:1990932)
0.4 8.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 9.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.6 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 2.0 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 7.9 GO:0030507 spectrin binding(GO:0030507)
0.1 0.3 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 4.3 GO:0050699 WW domain binding(GO:0050699)
0.1 1.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 8.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.8 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 2.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 4.2 GO:0005178 integrin binding(GO:0005178)
0.0 1.9 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 1.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0050733 RS domain binding(GO:0050733)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 2.0 PID AURORA A PATHWAY Aurora A signaling
0.0 9.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.9 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.3 6.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 9.8 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 0.6 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.9 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 3.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 8.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 2.0 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 1.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 2.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production