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GSE58827: Dynamics of the Mouse Liver

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Results for Gbx2

Z-value: 0.58

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Transcription factors associated with Gbx2

Gene Symbol Gene ID Gene Info
Gbx2
ENSMUSG00000034486.9 gastrulation brain homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gbx2mm39_v1_chr1_-_89858901_89858920-0.492.4e-03Click!

Activity profile of Gbx2 motif

Sorted Z-values of Gbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_38995463 2.90 ENSMUST00000025966.5
Cyp2c55
cytochrome P450, family 2, subfamily c, polypeptide 55
chr19_+_38121248 1.48 ENSMUST00000025956.13
Pde6c
phosphodiesterase 6C, cGMP specific, cone, alpha prime
chr17_-_36343573 1.36 ENSMUST00000102678.5
H2-T23
histocompatibility 2, T region locus 23
chr19_+_38121214 1.36 ENSMUST00000112329.3
Pde6c
phosphodiesterase 6C, cGMP specific, cone, alpha prime
chr7_-_141014477 1.27 ENSMUST00000106007.10
ENSMUST00000150026.2
ENSMUST00000202840.4
ENSMUST00000133206.9
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr3_+_94280101 1.05 ENSMUST00000029795.10
Rorc
RAR-related orphan receptor gamma
chr7_-_141014336 1.01 ENSMUST00000136354.8
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr7_-_141014445 0.98 ENSMUST00000133021.2
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr7_-_141014192 0.98 ENSMUST00000201127.5
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chrM_-_14061 0.96 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr3_-_113371392 0.92 ENSMUST00000067980.12
Amy1
amylase 1, salivary
chr11_-_21320452 0.88 ENSMUST00000102875.11
Ugp2
UDP-glucose pyrophosphorylase 2
chr5_-_31453206 0.87 ENSMUST00000041266.11
ENSMUST00000172435.8
ENSMUST00000201417.2
Fndc4
fibronectin type III domain containing 4
chrM_+_14138 0.82 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr11_-_46597885 0.79 ENSMUST00000055102.13
ENSMUST00000125008.2
Timd2
T cell immunoglobulin and mucin domain containing 2
chr9_+_106325860 0.78 ENSMUST00000185527.3
Abhd14b
abhydrolase domain containing 14b
chr11_+_97206542 0.75 ENSMUST00000019026.10
ENSMUST00000132168.2
Mrpl45
mitochondrial ribosomal protein L45
chr3_+_57332735 0.70 ENSMUST00000029377.8
Tm4sf4
transmembrane 4 superfamily member 4
chr2_+_26969384 0.64 ENSMUST00000091233.7
Adamtsl2
ADAMTS-like 2
chr9_+_50466127 0.59 ENSMUST00000213916.2
Il18
interleukin 18
chr1_-_175453117 0.58 ENSMUST00000027810.14
Fh1
fumarate hydratase 1
chr4_-_139695337 0.50 ENSMUST00000105031.4
Klhdc7a
kelch domain containing 7A
chr5_+_113873864 0.46 ENSMUST00000065698.7
Ficd
FIC domain containing
chr6_+_41118120 0.45 ENSMUST00000103273.3
Trbv15
T cell receptor beta, variable 15
chr14_+_69585036 0.44 ENSMUST00000064831.6
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr11_+_99748741 0.41 ENSMUST00000107434.2
Gm11568
predicted gene 11568
chr10_-_95337783 0.31 ENSMUST00000075829.3
ENSMUST00000217777.2
ENSMUST00000218893.2
Mrpl42
mitochondrial ribosomal protein L42
chr2_-_157408239 0.25 ENSMUST00000109528.9
ENSMUST00000088494.3
Blcap
bladder cancer associated protein
chr10_-_116732813 0.22 ENSMUST00000048229.9
Myrfl
myelin regulatory factor-like
chr2_-_17465410 0.21 ENSMUST00000145492.2
Nebl
nebulette
chr1_-_24044688 0.20 ENSMUST00000027338.4
Sdhaf4
succinate dehydrogenase complex assembly factor 4
chr1_-_128030148 0.19 ENSMUST00000086614.12
Zranb3
zinc finger, RAN-binding domain containing 3
chr4_-_129155185 0.18 ENSMUST00000145261.8
C77080
expressed sequence C77080
chr9_+_21634779 0.17 ENSMUST00000034713.9
Ldlr
low density lipoprotein receptor
chr16_-_26190578 0.16 ENSMUST00000023154.3
Cldn1
claudin 1
chr5_+_7354130 0.16 ENSMUST00000160634.2
ENSMUST00000159546.2
Tex47
testis expressed 47
chr5_+_117919082 0.14 ENSMUST00000138579.3
Nos1
nitric oxide synthase 1, neuronal
chr1_-_74932266 0.14 ENSMUST00000006721.3
Cryba2
crystallin, beta A2
chr7_-_78432774 0.12 ENSMUST00000032841.7
Mrpl46
mitochondrial ribosomal protein L46
chr5_-_5315968 0.12 ENSMUST00000115451.8
ENSMUST00000115452.8
ENSMUST00000131392.8
Cdk14
cyclin-dependent kinase 14
chr17_-_37974666 0.12 ENSMUST00000215414.2
ENSMUST00000213638.3
Olfr117
olfactory receptor 117
chr14_-_66315144 0.11 ENSMUST00000022618.6
Adam2
a disintegrin and metallopeptidase domain 2
chr19_+_17114108 0.10 ENSMUST00000223920.2
ENSMUST00000225351.2
Prune2
prune homolog 2
chr3_-_89905547 0.09 ENSMUST00000199740.2
ENSMUST00000198782.2
Hax1
HCLS1 associated X-1
chr17_-_71153283 0.09 ENSMUST00000156484.2
Tgif1
TGFB-induced factor homeobox 1
chr11_+_59197746 0.09 ENSMUST00000000128.10
ENSMUST00000108783.4
Wnt9a
wingless-type MMTV integration site family, member 9A
chr16_+_44215136 0.09 ENSMUST00000099742.9
Cfap44
cilia and flagella associated protein 44
chr19_-_39729431 0.09 ENSMUST00000099472.4
Cyp2c68
cytochrome P450, family 2, subfamily c, polypeptide 68
chr10_+_116013256 0.09 ENSMUST00000155606.8
ENSMUST00000128399.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr10_+_127919142 0.08 ENSMUST00000026459.6
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr6_-_130170075 0.08 ENSMUST00000112032.8
ENSMUST00000071554.3
Klra9
killer cell lectin-like receptor subfamily A, member 9
chr1_+_92533504 0.08 ENSMUST00000217316.2
ENSMUST00000216553.2
Olfr1410
olfactory receptor 1410
chr11_-_99742434 0.08 ENSMUST00000107437.2
Krtap4-16
keratin associated protein 4-16
chr3_-_10396418 0.08 ENSMUST00000191670.6
ENSMUST00000065938.15
ENSMUST00000118410.8
Impa1
inositol (myo)-1(or 4)-monophosphatase 1
chr9_+_108708939 0.08 ENSMUST00000192235.2
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
chr2_-_85632888 0.07 ENSMUST00000217410.3
ENSMUST00000216425.3
Olfr1016
olfactory receptor 1016
chr2_+_70392491 0.07 ENSMUST00000148210.8
Gad1
glutamate decarboxylase 1
chr18_-_78640066 0.07 ENSMUST00000235389.2
ENSMUST00000237674.2
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr11_-_58521327 0.07 ENSMUST00000214132.2
Olfr323
olfactory receptor 323
chr1_-_4855894 0.06 ENSMUST00000130201.8
ENSMUST00000156816.7
ENSMUST00000146665.3
Mrpl15
mitochondrial ribosomal protein L15
chr17_-_33028814 0.06 ENSMUST00000234594.2
Zfp811
zinc finger protein 811
chr10_+_116013122 0.05 ENSMUST00000148731.8
Ptprr
protein tyrosine phosphatase, receptor type, R
chr1_-_161807205 0.05 ENSMUST00000162676.2
4930558K02Rik
RIKEN cDNA 4930558K02 gene
chr17_+_38374812 0.05 ENSMUST00000215726.2
ENSMUST00000217390.2
Olfr130
olfactory receptor 130
chr4_+_52596266 0.05 ENSMUST00000029995.6
Toporsl
topoisomerase I binding, arginine/serine-rich like
chr14_+_45225641 0.04 ENSMUST00000046891.6
Ptger2
prostaglandin E receptor 2 (subtype EP2)
chr2_+_70392351 0.04 ENSMUST00000094934.11
Gad1
glutamate decarboxylase 1
chr2_-_111324108 0.03 ENSMUST00000208881.2
ENSMUST00000208695.2
ENSMUST00000217611.2
Olfr1290
olfactory receptor 1290
chr6_+_114435480 0.03 ENSMUST00000160780.2
Hrh1
histamine receptor H1
chr14_-_48904958 0.03 ENSMUST00000144465.8
ENSMUST00000133479.8
ENSMUST00000119070.8
ENSMUST00000226501.2
Otx2
orthodenticle homeobox 2
chr8_+_22329942 0.03 ENSMUST00000006745.4
Defb2
defensin beta 2
chrX_-_42256694 0.03 ENSMUST00000115058.8
ENSMUST00000115059.8
Tenm1
teneurin transmembrane protein 1
chr8_-_41494890 0.02 ENSMUST00000051379.14
Mtus1
mitochondrial tumor suppressor 1
chr7_+_28510310 0.01 ENSMUST00000038572.15
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr3_-_89905927 0.01 ENSMUST00000197725.5
ENSMUST00000197767.5
ENSMUST00000197786.5
ENSMUST00000079724.9
Hax1
HCLS1 associated X-1
chr1_+_179936757 0.01 ENSMUST00000143176.8
ENSMUST00000135056.8
Cdc42bpa
CDC42 binding protein kinase alpha
chr6_-_129077867 0.01 ENSMUST00000032258.8
Clec2e
C-type lectin domain family 2, member e
chr11_-_73707875 0.01 ENSMUST00000118463.4
ENSMUST00000144724.3
Olfr392
olfactory receptor 392
chr14_-_50390356 0.01 ENSMUST00000215451.2
ENSMUST00000213163.2
ENSMUST00000215327.2
Olfr729
olfactory receptor 729
chr2_-_73410632 0.01 ENSMUST00000028515.4
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr17_+_85264134 0.01 ENSMUST00000112305.10
Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
chr2_+_113116075 0.00 ENSMUST00000040856.3
Tmco5b
transmembrane and coiled-coil domains 5B
chr8_-_22396428 0.00 ENSMUST00000051965.5
Defb11
defensin beta 11

Network of associatons between targets according to the STRING database.

First level regulatory network of Gbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:2000566 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.3 0.9 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.2 2.9 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.2 0.6 GO:0006106 fumarate metabolic process(GO:0006106)
0.2 2.8 GO:0046549 retinal cone cell development(GO:0046549)
0.1 0.6 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.1 4.2 GO:0015813 L-glutamate transport(GO:0015813)
0.1 0.8 GO:0033762 response to glucagon(GO:0033762)
0.1 1.1 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.2 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.2 GO:0010899 regulation of phosphatidylcholine catabolic process(GO:0010899) receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 0.6 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.2 GO:0048478 replication fork protection(GO:0048478)
0.0 0.1 GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.8 GO:0097286 iron ion import(GO:0097286)
0.0 0.1 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 1.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.8 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 0.2 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.0 0.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 1.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.9 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
0.3 4.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 1.1 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.6 GO:0050436 microfibril binding(GO:0050436)
0.2 0.8 GO:0070287 ferritin receptor activity(GO:0070287)
0.1 0.9 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.9 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 2.8 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 1.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.4 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 1.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.1 GO:0052834 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.5 GO:0070566 adenylyltransferase activity(GO:0070566)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 PID IL27 PATHWAY IL27-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway