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GSE58827: Dynamics of the Mouse Liver

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Results for Gcm1

Z-value: 0.35

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Transcription factors associated with Gcm1

Gene Symbol Gene ID Gene Info
Gcm1
ENSMUSG00000023333.9 glial cells missing homolog 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gcm1mm39_v1_chr9_+_77959206_77959231-0.067.3e-01Click!

Activity profile of Gcm1 motif

Sorted Z-values of Gcm1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_4573312 3.19 ENSMUST00000221564.2
ENSMUST00000078239.5
ENSMUST00000080361.13
Akr1c20
aldo-keto reductase family 1, member C20
chr15_+_10249646 2.04 ENSMUST00000134410.8
Prlr
prolactin receptor
chr8_-_45811774 1.60 ENSMUST00000155230.2
ENSMUST00000135912.8
Fam149a
family with sequence similarity 149, member A
chr12_-_30423356 1.45 ENSMUST00000021004.14
Sntg2
syntrophin, gamma 2
chr8_-_3770642 1.33 ENSMUST00000062037.7
Clec4g
C-type lectin domain family 4, member g
chr7_+_119499322 1.26 ENSMUST00000106516.2
Lyrm1
LYR motif containing 1
chr7_-_105249308 1.21 ENSMUST00000210531.2
ENSMUST00000033185.10
Hpx
hemopexin
chr7_-_98831916 1.15 ENSMUST00000033001.6
Dgat2
diacylglycerol O-acyltransferase 2
chr6_-_124613044 1.01 ENSMUST00000068797.3
ENSMUST00000218020.2
C1s2
complement component 1, s subcomponent 2
chr3_+_89366632 0.94 ENSMUST00000107410.8
Pmvk
phosphomevalonate kinase
chr19_+_46750016 0.81 ENSMUST00000099373.12
ENSMUST00000077666.6
Cnnm2
cyclin M2
chr11_-_121245251 0.78 ENSMUST00000026173.13
Wdr45b
WD repeat domain 45B
chr6_-_84564623 0.75 ENSMUST00000205228.3
Cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr4_-_42661893 0.73 ENSMUST00000108006.4
Il11ra2
interleukin 11 receptor, alpha chain 2
chr2_-_34951443 0.65 ENSMUST00000028233.7
Hc
hemolytic complement
chr11_+_120382666 0.62 ENSMUST00000026899.4
Slc25a10
solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
chr11_-_121245163 0.60 ENSMUST00000106110.10
ENSMUST00000136797.3
Wdr45b
WD repeat domain 45B
chr3_+_137923521 0.52 ENSMUST00000090171.7
Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr16_+_38722666 0.51 ENSMUST00000023478.8
Igsf11
immunoglobulin superfamily, member 11
chr5_+_102872838 0.49 ENSMUST00000112853.8
Arhgap24
Rho GTPase activating protein 24
chr7_+_44647072 0.47 ENSMUST00000003284.16
ENSMUST00000209066.2
Irf3
interferon regulatory factor 3
chr14_-_78970160 0.47 ENSMUST00000226342.3
Dgkh
diacylglycerol kinase, eta
chr3_+_107137924 0.46 ENSMUST00000179399.3
A630076J17Rik
RIKEN cDNA A630076J17 gene
chr6_+_86342622 0.46 ENSMUST00000071492.9
Fam136a
family with sequence similarity 136, member A
chr17_-_7215682 0.42 ENSMUST00000024572.10
Rsph3b
radial spoke 3B homolog (Chlamydomonas)
chr17_+_64907697 0.41 ENSMUST00000086723.10
Man2a1
mannosidase 2, alpha 1
chr17_+_8529932 0.34 ENSMUST00000154553.2
ENSMUST00000140890.3
Sft2d1
Gm49987
SFT2 domain containing 1
predicted gene, 49987
chr1_+_53352780 0.33 ENSMUST00000027265.10
ENSMUST00000114484.8
Osgepl1
O-sialoglycoprotein endopeptidase-like 1
chr7_-_44785815 0.33 ENSMUST00000146760.7
Flt3l
FMS-like tyrosine kinase 3 ligand
chr6_-_52160816 0.30 ENSMUST00000134831.2
Hoxa3
homeobox A3
chr12_-_73160181 0.28 ENSMUST00000043208.8
ENSMUST00000175693.3
Six4
sine oculis-related homeobox 4
chr2_+_169475436 0.27 ENSMUST00000109157.2
Tshz2
teashirt zinc finger family member 2
chr5_+_107551362 0.26 ENSMUST00000049146.12
Ephx4
epoxide hydrolase 4
chr1_-_190897012 0.26 ENSMUST00000171798.2
Fam71a
family with sequence similarity 71, member A
chr7_-_45343785 0.25 ENSMUST00000040636.9
Sec1
secretory blood group 1
chr17_-_32408431 0.25 ENSMUST00000087721.10
ENSMUST00000162117.3
Ephx3
epoxide hydrolase 3
chr9_-_99302205 0.25 ENSMUST00000123771.2
Mras
muscle and microspikes RAS
chr6_-_70313491 0.24 ENSMUST00000103388.4
Igkv6-20
immunoglobulin kappa variable 6-20
chr11_-_98040377 0.23 ENSMUST00000103143.10
Fbxl20
F-box and leucine-rich repeat protein 20
chr2_-_105734829 0.20 ENSMUST00000122965.8
Elp4
elongator acetyltransferase complex subunit 4
chr14_-_66451001 0.20 ENSMUST00000178730.8
Ptk2b
PTK2 protein tyrosine kinase 2 beta
chr1_-_43131598 0.19 ENSMUST00000188728.2
Tgfbrap1
transforming growth factor, beta receptor associated protein 1
chr8_-_13304096 0.19 ENSMUST00000171619.2
Adprhl1
ADP-ribosylhydrolase like 1
chr4_-_9669068 0.19 ENSMUST00000078139.13
ENSMUST00000108340.9
ENSMUST00000084915.11
ENSMUST00000108337.8
ENSMUST00000084912.12
ENSMUST00000038564.13
ENSMUST00000146441.8
ENSMUST00000098275.9
Asph
aspartate-beta-hydroxylase
chr7_-_44785709 0.18 ENSMUST00000211429.2
Flt3l
FMS-like tyrosine kinase 3 ligand
chr11_+_43046476 0.18 ENSMUST00000238415.2
Atp10b
ATPase, class V, type 10B
chr2_+_105734975 0.17 ENSMUST00000037499.6
Immp1l
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr7_-_29605949 0.17 ENSMUST00000159920.2
ENSMUST00000162592.8
Zfp27
zinc finger protein 27
chr5_+_148239975 0.16 ENSMUST00000152105.8
ENSMUST00000085554.5
Mtus2
microtubule associated tumor suppressor candidate 2
chr9_-_107482462 0.15 ENSMUST00000194433.6
Sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr14_+_32321341 0.15 ENSMUST00000187377.7
ENSMUST00000189022.8
ENSMUST00000186452.7
Prrxl1
paired related homeobox protein-like 1
chr6_-_113478779 0.15 ENSMUST00000101059.4
ENSMUST00000204268.3
ENSMUST00000205170.2
ENSMUST00000205075.2
ENSMUST00000204134.3
Prrt3
proline-rich transmembrane protein 3
chr12_-_119202527 0.15 ENSMUST00000026360.9
Itgb8
integrin beta 8
chr8_+_91796680 0.15 ENSMUST00000034091.8
ENSMUST00000211136.2
Rbl2
RB transcriptional corepressor like 2
chr6_+_70565173 0.14 ENSMUST00000103398.2
Igkv3-9
immunoglobulin kappa variable 3-9
chr8_-_13304068 0.14 ENSMUST00000168498.8
Adprhl1
ADP-ribosylhydrolase like 1
chr14_+_35816874 0.14 ENSMUST00000226305.2
4930474N05Rik
RIKEN cDNA 4930474N05 gene
chr16_+_65612394 0.14 ENSMUST00000227997.2
Vgll3
vestigial like family member 3
chr16_-_36695166 0.13 ENSMUST00000075946.12
Eaf2
ELL associated factor 2
chr9_+_107457316 0.13 ENSMUST00000093785.6
Naa80
N(alpha)-acetyltransferase 80, NatH catalytic subunit
chr17_-_33007238 0.12 ENSMUST00000159086.10
Zfp871
zinc finger protein 871
chrX_+_92330102 0.12 ENSMUST00000046565.13
ENSMUST00000113947.6
Arx
aristaless related homeobox
chr13_+_8252957 0.12 ENSMUST00000123187.2
Adarb2
adenosine deaminase, RNA-specific, B2
chr8_+_91796767 0.12 ENSMUST00000209518.2
Rbl2
RB transcriptional corepressor like 2
chr2_+_96148418 0.12 ENSMUST00000135431.8
ENSMUST00000162807.9
Lrrc4c
leucine rich repeat containing 4C
chr4_+_120389415 0.12 ENSMUST00000062990.4
Slfnl1
schlafen like 1
chr16_+_36695479 0.12 ENSMUST00000023534.7
ENSMUST00000114812.9
ENSMUST00000134616.8
Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1
chr7_-_30560989 0.12 ENSMUST00000052700.6
Ffar1
free fatty acid receptor 1
chr7_+_75879603 0.12 ENSMUST00000156166.8
Agbl1
ATP/GTP binding protein-like 1
chr5_-_110490821 0.11 ENSMUST00000112478.8
ENSMUST00000200037.5
ENSMUST00000058016.16
ENSMUST00000200214.2
ENSMUST00000195985.5
P2rx2
purinergic receptor P2X, ligand-gated ion channel, 2
chr11_-_97466035 0.11 ENSMUST00000107596.9
ENSMUST00000238314.2
ENSMUST00000238597.2
ENSMUST00000238342.2
Srcin1
SRC kinase signaling inhibitor 1
chr8_-_106706035 0.11 ENSMUST00000034371.9
Dpep3
dipeptidase 3
chr14_+_55747902 0.11 ENSMUST00000165262.8
ENSMUST00000074225.11
Cpne6
copine VI
chr9_-_107482494 0.11 ENSMUST00000102529.10
Sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr2_-_155676765 0.11 ENSMUST00000029143.7
ENSMUST00000239423.2
Fam83c
family with sequence similarity 83, member C
chr10_-_71121083 0.11 ENSMUST00000020085.7
Ube2d1
ubiquitin-conjugating enzyme E2D 1
chrX_-_59224449 0.10 ENSMUST00000063507.11
Mcf2
mcf.2 transforming sequence
chr12_+_8724220 0.10 ENSMUST00000111122.9
Pum2
pumilio RNA-binding family member 2
chr8_-_13304154 0.09 ENSMUST00000204916.3
ENSMUST00000033825.11
Adprhl1
ADP-ribosylhydrolase like 1
chr13_+_8252895 0.09 ENSMUST00000064473.13
Adarb2
adenosine deaminase, RNA-specific, B2
chrX_-_149224054 0.09 ENSMUST00000059256.8
Tmem29
transmembrane protein 29
chr6_-_69394425 0.08 ENSMUST00000199160.2
Igkv4-61
immunoglobulin kappa chain variable 4-61
chr10_-_74868360 0.08 ENSMUST00000159994.2
ENSMUST00000179546.8
ENSMUST00000160450.8
ENSMUST00000160072.8
ENSMUST00000009214.10
ENSMUST00000166088.8
Rsph14
radial spoke head homolog 14 (Chlamydomonas)
chr11_-_75345482 0.08 ENSMUST00000173320.8
Wdr81
WD repeat domain 81
chr11_-_73089837 0.08 ENSMUST00000006103.9
ENSMUST00000108476.8
Ctns
cystinosis, nephropathic
chr7_-_44646960 0.07 ENSMUST00000207443.2
ENSMUST00000207755.2
ENSMUST00000003290.12
Bcl2l12
BCL2-like 12 (proline rich)
chr6_+_67532481 0.07 ENSMUST00000103302.3
Igkv2-137
immunoglobulin kappa chain variable 2-137
chr7_-_44785480 0.06 ENSMUST00000211246.2
ENSMUST00000210197.2
Flt3l
FMS-like tyrosine kinase 3 ligand
chr5_-_35263035 0.06 ENSMUST00000030986.15
Lrpap1
low density lipoprotein receptor-related protein associated protein 1
chr2_-_39116044 0.06 ENSMUST00000204368.2
Ppp6c
protein phosphatase 6, catalytic subunit
chr7_+_131568167 0.05 ENSMUST00000045840.5
Gpr26
G protein-coupled receptor 26
chr6_-_70120881 0.04 ENSMUST00000103380.3
Igkv8-28
immunoglobulin kappa variable 8-28
chr10_+_52265049 0.04 ENSMUST00000219730.2
Nepn
nephrocan
chr11_-_77079794 0.04 ENSMUST00000108400.8
Efcab5
EF-hand calcium binding domain 5
chr13_+_100244663 0.02 ENSMUST00000129014.2
Serf1
small EDRK-rich factor 1
chr11_-_99433984 0.02 ENSMUST00000107443.8
ENSMUST00000074253.4
Krt40
keratin 40
chr18_-_39620115 0.01 ENSMUST00000097592.9
ENSMUST00000115571.8
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr2_+_48704121 0.01 ENSMUST00000063886.4
Acvr2a
activin receptor IIA
chrX_+_72546680 0.00 ENSMUST00000033744.12
ENSMUST00000088429.8
ENSMUST00000114479.2
Atp2b3
ATPase, Ca++ transporting, plasma membrane 3
chr5_+_114427227 0.00 ENSMUST00000169347.6
Myo1h
myosin 1H

Network of associatons between targets according to the STRING database.

First level regulatory network of Gcm1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0034201 response to oleic acid(GO:0034201)
0.3 2.0 GO:0038161 prolactin signaling pathway(GO:0038161)
0.2 0.9 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 1.2 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) heme transport(GO:0015886) positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.2 0.6 GO:0015744 succinate transport(GO:0015744)
0.1 0.6 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.1 0.5 GO:0006069 ethanol oxidation(GO:0006069)
0.1 0.6 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 0.8 GO:1902811 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 0.5 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.1 0.3 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.1 0.3 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 1.0 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 1.3 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.2 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.3 GO:0021615 specification of organ position(GO:0010159) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.8 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.5 GO:0046339 diacylglycerol metabolic process(GO:0046339) phosphatidic acid metabolic process(GO:0046473)
0.0 0.1 GO:0015811 L-cystine transport(GO:0015811)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 3.2 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 0.1 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.6 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.6 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0004925 prolactin receptor activity(GO:0004925)
0.3 1.2 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.2 0.6 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.2 1.2 GO:0015232 heme transporter activity(GO:0015232)
0.2 0.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.4 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.1 0.8 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 3.2 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 0.3 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 1.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.4 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.1 0.3 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 1.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.9 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.2 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi