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GSE58827: Dynamics of the Mouse Liver

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Results for Gmeb1

Z-value: 0.53

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Transcription factors associated with Gmeb1

Gene Symbol Gene ID Gene Info
ENSMUSG00000028901.14 glucocorticoid modulatory element binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gmeb1mm39_v1_chr4_-_131988832_1319888820.316.6e-02Click!

Activity profile of Gmeb1 motif

Sorted Z-values of Gmeb1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_7163897 1.37 ENSMUST00000020702.11
ENSMUST00000135887.3
insulin-like growth factor binding protein 3
chr11_+_83193495 1.11 ENSMUST00000176430.8
ENSMUST00000065692.14
ENSMUST00000142680.2
adaptor-related protein complex 2, beta 1 subunit
chr1_-_91386976 0.92 ENSMUST00000069620.10
period circadian clock 2
chr15_-_79430742 0.91 ENSMUST00000231053.2
ENSMUST00000229431.2
DEAD box helicase 17
chr4_-_126096376 0.90 ENSMUST00000106142.8
ENSMUST00000169403.8
ENSMUST00000130334.2
thyroid hormone receptor associated protein 3
chr8_-_124675939 0.84 ENSMUST00000044795.8
nucleoporin 133
chr4_-_135080437 0.83 ENSMUST00000030613.11
ENSMUST00000131373.8
serine/arginine repetitive matrix 1
chr15_+_81284333 0.79 ENSMUST00000163754.9
ENSMUST00000041609.11
X-prolyl aminopeptidase 3, mitochondrial
chr2_-_156848923 0.78 ENSMUST00000146413.8
ENSMUST00000103129.9
ENSMUST00000103130.8
DSN1 homolog, MIS12 kinetochore complex component
chr16_-_87229367 0.74 ENSMUST00000232095.2
listerin E3 ubiquitin protein ligase 1
chr11_+_68986043 0.69 ENSMUST00000101004.9
period circadian clock 1
chr5_-_93354287 0.63 ENSMUST00000144514.3
cyclin I
chr10_-_112764879 0.61 ENSMUST00000099276.4
ataxin 7-like 3B
chr3_+_95341698 0.58 ENSMUST00000102749.11
ENSMUST00000090804.12
ENSMUST00000107161.8
ENSMUST00000107160.8
ENSMUST00000015666.17
aryl hydrocarbon receptor nuclear translocator
chr7_+_46495521 0.57 ENSMUST00000133062.2
lactate dehydrogenase A
chr15_+_81756671 0.55 ENSMUST00000135198.2
ENSMUST00000157003.8
ENSMUST00000229068.2
aconitase 2, mitochondrial
chr7_-_110682204 0.54 ENSMUST00000161051.8
ENSMUST00000160132.8
ENSMUST00000162415.9
eukaryotic translation initiation factor 4, gamma 2
chr12_+_31704853 0.52 ENSMUST00000036862.5
component of oligomeric golgi complex 5
chr17_+_83658354 0.48 ENSMUST00000096766.12
ENSMUST00000049503.10
ENSMUST00000112363.10
ENSMUST00000234460.2
echinoderm microtubule associated protein like 4
chr4_+_40970906 0.47 ENSMUST00000091614.7
ENSMUST00000030133.15
ENSMUST00000098143.11
nuclear transcription factor, X-box binding 1
chr14_-_57015748 0.47 ENSMUST00000022507.13
ENSMUST00000163924.2
paraspeckle protein 1
chr15_-_81283795 0.46 ENSMUST00000023039.15
suppression of tumorigenicity 13
chr18_+_36693024 0.44 ENSMUST00000134146.8
ankyrin repeat and KH domain containing 1
chr5_-_31448370 0.44 ENSMUST00000041565.11
ENSMUST00000201809.2
intraflagellar transport 172
chr11_+_53661251 0.43 ENSMUST00000138913.8
ENSMUST00000123376.8
ENSMUST00000019043.13
ENSMUST00000133291.3
interferon regulatory factor 1
chr9_+_107879700 0.43 ENSMUST00000035214.11
ENSMUST00000176854.7
ENSMUST00000175874.2
inositol hexaphosphate kinase 1
chr7_+_44146029 0.39 ENSMUST00000205359.2
family with sequence similarity 71, member E1
chr18_+_24087725 0.39 ENSMUST00000225682.2
ENSMUST00000060762.6
zinc finger protein 397
chr14_+_20745024 0.36 ENSMUST00000048016.3
fucosyltransferase 11
chr4_+_43441939 0.36 ENSMUST00000060864.13
testis specific protein kinase 1
chr17_+_23898223 0.36 ENSMUST00000024699.4
ENSMUST00000232719.2
claudin 6
chr2_+_26899935 0.36 ENSMUST00000114005.9
ENSMUST00000114004.8
ENSMUST00000114006.8
ENSMUST00000114007.8
ENSMUST00000133807.2
calcium channel flower domain containing 1
chr2_+_75489596 0.35 ENSMUST00000111964.8
ENSMUST00000111962.8
ENSMUST00000111961.8
ENSMUST00000164947.9
ENSMUST00000090792.11
heterogeneous nuclear ribonucleoprotein A3
chr15_+_101982208 0.35 ENSMUST00000169681.3
ENSMUST00000229400.2
eukaryotic translation initiation factor 4B
chr11_-_63813083 0.34 ENSMUST00000094103.4
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr13_-_69682696 0.33 ENSMUST00000198607.5
terminal nucleotidyltransferase 4A
chr6_+_29348068 0.31 ENSMUST00000173216.8
ENSMUST00000173694.5
ENSMUST00000172974.8
ENSMUST00000031779.17
ENSMUST00000090481.14
calumenin
chr7_+_46495256 0.30 ENSMUST00000048209.16
ENSMUST00000210815.2
ENSMUST00000125862.8
ENSMUST00000210968.2
ENSMUST00000092621.12
ENSMUST00000210467.2
lactate dehydrogenase A
chr16_+_36695479 0.28 ENSMUST00000023534.7
ENSMUST00000114812.9
ENSMUST00000134616.8
golgi autoantigen, golgin subfamily b, macrogolgin 1
chr11_+_97206542 0.26 ENSMUST00000019026.10
ENSMUST00000132168.2
mitochondrial ribosomal protein L45
chr1_+_175708341 0.25 ENSMUST00000195196.6
ENSMUST00000194306.6
ENSMUST00000193822.6
exonuclease 1
chr4_-_126096551 0.23 ENSMUST00000080919.12
thyroid hormone receptor associated protein 3
chr7_+_44145987 0.23 ENSMUST00000107927.5
family with sequence similarity 71, member E1
chr11_-_113641980 0.23 ENSMUST00000153453.2
CDC42 effector protein (Rho GTPase binding) 4
chr18_-_53877579 0.23 ENSMUST00000049811.8
ENSMUST00000237062.2
centrosomal protein 120
chr2_-_26012751 0.22 ENSMUST00000140993.2
ENSMUST00000028300.6
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr16_-_87229485 0.22 ENSMUST00000039449.9
listerin E3 ubiquitin protein ligase 1
chr15_-_81284244 0.22 ENSMUST00000172107.8
ENSMUST00000169204.2
ENSMUST00000163382.2
suppression of tumorigenicity 13
chr17_+_29768757 0.22 ENSMUST00000048677.9
ENSMUST00000150388.3
TBC1 domain family, member 22B
predicted gene, 28052
chr5_-_122917341 0.21 ENSMUST00000198257.5
ENSMUST00000199599.2
ENSMUST00000196742.2
ENSMUST00000200109.5
ENSMUST00000111668.8
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr14_+_31807760 0.21 ENSMUST00000170600.8
ENSMUST00000168986.7
ENSMUST00000169649.2
oxidoreductase NAD-binding domain containing 1
chr15_-_79430942 0.20 ENSMUST00000054014.9
ENSMUST00000229877.2
DEAD box helicase 17
chr19_+_46064409 0.20 ENSMUST00000223728.2
ENSMUST00000235620.2
nucleolar and coiled-body phosphoprotein 1
chr7_+_5023552 0.20 ENSMUST00000208728.2
ENSMUST00000085427.6
coiled-coil domain containing 106
zinc finger protein 865
chr16_+_49519561 0.20 ENSMUST00000046777.11
ENSMUST00000142682.9
intraflagellar transport 57
chrX_+_149371219 0.19 ENSMUST00000153221.8
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr9_-_48406564 0.17 ENSMUST00000213276.2
ENSMUST00000170000.4
RNA binding motif protein 7
chr11_+_22940599 0.17 ENSMUST00000020562.5
chaperonin containing Tcp1, subunit 4 (delta)
chr19_+_46064302 0.16 ENSMUST00000165017.2
ENSMUST00000223741.2
ENSMUST00000225780.2
nucleolar and coiled-body phosphoprotein 1
chr9_+_48406706 0.16 ENSMUST00000048824.9
predicted gene 5617
chr7_+_44146012 0.16 ENSMUST00000205422.2
family with sequence similarity 71, member E1
chr17_+_84819260 0.16 ENSMUST00000047206.7
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr5_-_113910571 0.15 ENSMUST00000019118.8
squamous cell carcinoma antigen recognized by T cells 3
chr2_+_30127692 0.15 ENSMUST00000113654.8
ENSMUST00000095078.3
leucine rich repeat containing 8A VRAC subunit A
chr11_+_22940519 0.15 ENSMUST00000173867.8
chaperonin containing Tcp1, subunit 4 (delta)
chr5_-_130053120 0.15 ENSMUST00000161640.8
ENSMUST00000161884.2
ENSMUST00000161094.8
argininosuccinate lyase
chr15_+_98972850 0.14 ENSMUST00000039665.8
trophinin associated protein
chr15_+_86098660 0.13 ENSMUST00000063414.9
TBC1 domain family, member 22a
chr8_-_25506916 0.12 ENSMUST00000084035.12
ENSMUST00000208247.3
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr19_+_46064437 0.12 ENSMUST00000223683.2
nucleolar and coiled-body phosphoprotein 1
chr7_+_30021165 0.11 ENSMUST00000098585.4
RIKEN cDNA E130208F15 gene
chr17_-_56933872 0.11 ENSMUST00000047226.10
lon peptidase 1, mitochondrial
chr10_-_78248771 0.11 ENSMUST00000062678.11
ribosomal RNA processing 1
chr11_-_86435579 0.10 ENSMUST00000138810.3
ENSMUST00000058286.9
ENSMUST00000154617.8
ribosomal protein S6 kinase, polypeptide 1
chr11_-_85125889 0.10 ENSMUST00000018625.10
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr5_-_93354348 0.10 ENSMUST00000058550.15
cyclin I
chr8_-_25506756 0.10 ENSMUST00000084032.6
ENSMUST00000207132.2
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr6_-_128401832 0.09 ENSMUST00000203374.3
ENSMUST00000142615.4
ENSMUST00000001559.11
integrin alpha FG-GAP repeat containing 2
chr17_+_23898633 0.09 ENSMUST00000233364.2
claudin 6
chr19_-_24454720 0.09 ENSMUST00000099556.2
family with sequence similarity 122, member A
chrX_+_111221031 0.09 ENSMUST00000026599.10
ENSMUST00000113415.2
apolipoprotein O-like
chr16_+_34842764 0.08 ENSMUST00000061156.10
3-hydroxyacyl-CoA dehydratase 2
chr7_+_5023375 0.08 ENSMUST00000076251.7
zinc finger protein 865
chr11_-_113642135 0.08 ENSMUST00000106616.2
CDC42 effector protein (Rho GTPase binding) 4
chr19_-_44124252 0.06 ENSMUST00000026218.7
CWF19-like 1, cell cycle control (S. pombe)
chr17_+_85397980 0.06 ENSMUST00000095188.7
calmodulin-lysine N-methyltransferase
chr7_+_101859542 0.05 ENSMUST00000140631.2
ENSMUST00000120879.8
ENSMUST00000146996.8
post-GPI attachment to proteins 2
chr11_-_6576030 0.05 ENSMUST00000000394.14
ENSMUST00000189268.7
ENSMUST00000136682.8
transforming growth factor beta regulated gene 4
chr17_+_21165573 0.04 ENSMUST00000007708.14
protein phosphatase 2, regulatory subunit A, alpha
chr11_+_51153941 0.02 ENSMUST00000093132.13
ENSMUST00000109113.8
CDC like kinase 4
chr12_+_113104085 0.01 ENSMUST00000200380.5
cysteine rich protein 2
chr7_-_83533497 0.00 ENSMUST00000094216.5
talin rod domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Gmeb1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:2000843 testosterone secretion(GO:0035936) negative regulation of steroid hormone secretion(GO:2000832) regulation of testosterone secretion(GO:2000843)
0.3 0.9 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.2 0.8 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.2 1.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 0.7 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.7 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.1 0.5 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 0.4 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.1 0.9 GO:0019659 glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 0.2 GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477)
0.1 0.2 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 0.8 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 1.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.1 0.5 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.2 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.0 0.1 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.0 0.3 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.5 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 1.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.6 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.3 GO:0006477 protein sulfation(GO:0006477)
0.0 0.8 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.4 GO:0061525 hindgut development(GO:0061525) left/right axis specification(GO:0070986)
0.0 0.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.2 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.1 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0 0.2 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.3 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.0 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.0 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 1.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.4 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 0.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.2 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.5 GO:0042382 paraspeckles(GO:0042382)
0.0 0.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.2 0.5 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.1 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.7 GO:0032564 dATP binding(GO:0032564)
0.1 0.4 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.4 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.3 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.9 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.3 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 0.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
0.0 0.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 1.1 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.1 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.9 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 1.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 2.2 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes