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GSE58827: Dynamics of the Mouse Liver

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Results for Hdx

Z-value: 1.87

Motif logo

Transcription factors associated with Hdx

Gene Symbol Gene ID Gene Info
ENSMUSG00000034551.13 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hdxmm39_v1_chrX_-_110606766_110606834-0.626.6e-05Click!

Activity profile of Hdx motif

Sorted Z-values of Hdx motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_61437704 28.35 ENSMUST00000095051.6
ENSMUST00000107483.8
major urinary protein 16
chr4_-_62069046 21.34 ENSMUST00000077719.4
major urinary protein 21
chr19_+_20470056 17.76 ENSMUST00000225337.3
aldehyde dehydrogenase family 1, subfamily A1
chr15_+_4756657 14.48 ENSMUST00000162585.8
complement component 6
chr19_+_20470114 14.24 ENSMUST00000225313.2
aldehyde dehydrogenase family 1, subfamily A1
chr5_-_87240405 13.95 ENSMUST00000132667.2
ENSMUST00000145617.8
ENSMUST00000094649.11
UDP glucuronosyltransferase 2 family, polypeptide B36
chr15_+_4756684 13.88 ENSMUST00000161997.8
ENSMUST00000022788.15
complement component 6
chr17_-_34962823 12.32 ENSMUST00000069507.9
complement component 4B (Chido blood group)
chr19_-_46661501 11.65 ENSMUST00000236174.2
cytochrome P450, family 17, subfamily a, polypeptide 1
chr1_+_87998487 9.97 ENSMUST00000073772.5
UDP glucuronosyltransferase 1 family, polypeptide A9
chr15_+_10177709 9.30 ENSMUST00000124470.8
prolactin receptor
chr19_-_46661321 9.22 ENSMUST00000026012.8
cytochrome P450, family 17, subfamily a, polypeptide 1
chr13_-_56696310 9.22 ENSMUST00000062806.6
leukocyte cell-derived chemotaxin 2
chr13_-_56696222 8.66 ENSMUST00000225183.2
leukocyte cell-derived chemotaxin 2
chr15_+_10249646 7.35 ENSMUST00000134410.8
prolactin receptor
chr9_-_71075939 7.12 ENSMUST00000113570.8
aquaporin 9
chr6_-_3968365 7.03 ENSMUST00000031674.11
tissue factor pathway inhibitor 2
chr1_-_140111138 6.32 ENSMUST00000111976.9
ENSMUST00000066859.13
complement component factor h
chr1_-_140111018 5.95 ENSMUST00000192880.6
ENSMUST00000111977.8
complement component factor h
chr7_-_5128936 5.38 ENSMUST00000147835.4
RAS-like, family 2, locus 9
chr16_+_22769822 5.22 ENSMUST00000023590.9
histidine-rich glycoprotein
chr4_+_155666933 5.22 ENSMUST00000105612.2
NAD kinase
chr10_-_126956991 4.70 ENSMUST00000080975.6
ENSMUST00000164259.9
amplified in osteosarcoma
chr16_+_22769844 4.64 ENSMUST00000232422.2
histidine-rich glycoprotein
chr16_+_22926162 4.17 ENSMUST00000023599.13
ENSMUST00000168891.8
eukaryotic translation initiation factor 4A2
chr8_-_85500010 4.06 ENSMUST00000109764.8
nuclear factor I/X
chr17_+_31652073 3.92 ENSMUST00000237363.2
phosphodiesterase 9A
chr17_+_31652029 3.89 ENSMUST00000136384.9
phosphodiesterase 9A
chr14_-_45715308 3.81 ENSMUST00000141424.2
fermitin family member 2
chr13_+_24511387 3.81 ENSMUST00000224953.2
ENSMUST00000050859.13
ENSMUST00000167746.8
ENSMUST00000224819.2
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr1_+_13738967 3.78 ENSMUST00000088542.4
X-linked Kx blood group related 9
chr1_-_184543367 3.73 ENSMUST00000048462.13
ENSMUST00000110992.9
mitochondrial amidoxime reducing component 1
chr17_-_45997823 3.43 ENSMUST00000156254.8
transmembrane protein 63b
chr13_-_96028412 3.40 ENSMUST00000068603.8
IQ motif containing GTPase activating protein 2
chr7_-_29935150 3.35 ENSMUST00000189482.2
ovo like zinc finger 3
chr1_+_182392559 3.11 ENSMUST00000168514.7
calpain 8
chr3_-_154036180 3.06 ENSMUST00000177846.8
LIM homeobox protein 8
chr17_+_3447465 3.05 ENSMUST00000072156.7
T cell lymphoma invasion and metastasis 2
chr6_-_87327885 3.03 ENSMUST00000032129.3
gastrokine 1
chr2_+_69210775 2.99 ENSMUST00000063690.4
dehydrogenase/reductase (SDR family) member 9
chr1_-_171122509 2.82 ENSMUST00000111302.4
ENSMUST00000080001.9
ubiquitin-fold modifier conjugating enzyme 1
chr6_+_54244116 2.81 ENSMUST00000114402.9
chimerin 2
chr6_-_4086914 2.79 ENSMUST00000049166.5
Bet1 golgi vesicular membrane trafficking protein
chr18_-_35631914 2.78 ENSMUST00000236007.2
ENSMUST00000237896.2
ENSMUST00000235778.2
ENSMUST00000235524.2
ENSMUST00000235691.2
ENSMUST00000235619.2
ENSMUST00000025215.10
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr14_+_53743184 2.75 ENSMUST00000103583.5
T cell receptor alpha variable 10
chr9_-_39918243 2.61 ENSMUST00000073932.4
olfactory receptor 980
chr9_+_14187597 2.58 ENSMUST00000208222.2
sestrin 3
chr2_-_121637505 2.51 ENSMUST00000138157.8
FERM domain containing 5
chr3_+_62327089 2.49 ENSMUST00000161057.2
Rho guanine nucleotide exchange factor (GEF) 26
chr4_+_89055359 2.32 ENSMUST00000058030.10
methylthioadenosine phosphorylase
chr1_+_182392577 2.32 ENSMUST00000048941.14
calpain 8
chr2_-_121637469 2.28 ENSMUST00000110592.2
FERM domain containing 5
chr13_+_41403317 2.21 ENSMUST00000165561.4
small integral membrane protein 13
chr6_+_41107047 2.20 ENSMUST00000103271.2
T cell receptor beta, variable 13-3
chr3_+_122305819 2.17 ENSMUST00000199344.2
breast cancer anti-estrogen resistance 3
chr3_-_89152320 2.08 ENSMUST00000107464.8
ENSMUST00000090924.13
tripartite motif-containing 46
chr4_-_57300361 2.05 ENSMUST00000153926.8
protein tyrosine phosphatase, non-receptor type 3
chr14_+_53995108 2.05 ENSMUST00000184905.2
T cell receptor alpha variable 13-4-DV7
chr11_+_97692738 2.04 ENSMUST00000127033.9
LIM and SH3 protein 1
chr12_-_81615248 2.03 ENSMUST00000008582.4
a disintegrin and metallopeptidase domain 21
chr11_+_98337655 1.94 ENSMUST00000019456.5
growth factor receptor bound protein 7
chr14_-_36690636 1.84 ENSMUST00000067700.13
coiled-coil serine rich 2
chr18_-_39622295 1.79 ENSMUST00000131885.2
nuclear receptor subfamily 3, group C, member 1
chr3_+_115801869 1.77 ENSMUST00000106502.2
exostosin-like glycosyltransferase 2
chr5_-_146900548 1.72 ENSMUST00000125217.2
ENSMUST00000110564.8
ENSMUST00000066675.10
ENSMUST00000016654.9
ENSMUST00000110566.2
ENSMUST00000140526.2
mitochondrial translational initiation factor 3
chr14_-_68893253 1.68 ENSMUST00000225767.3
ENSMUST00000111072.8
ENSMUST00000022642.6
ENSMUST00000224039.2
a disintegrin and metallopeptidase domain 28
chr14_+_62901114 1.64 ENSMUST00000171692.2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
chr8_-_23196523 1.54 ENSMUST00000033939.13
ENSMUST00000063401.10
inhibitor of kappaB kinase beta
chr9_+_27210500 1.52 ENSMUST00000214357.2
ENSMUST00000115247.8
ENSMUST00000133213.3
immunoglobulin superfamily, member 9B
chr11_-_69576363 1.52 ENSMUST00000018896.14
tumor necrosis factor (ligand) superfamily, member 13
chr2_-_155571279 1.48 ENSMUST00000040833.5
ER degradation enhancer, mannosidase alpha-like 2
chr18_-_61533434 1.45 ENSMUST00000063307.6
ENSMUST00000075299.13
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
chr11_-_50778270 1.43 ENSMUST00000050595.13
ENSMUST00000163301.8
ENSMUST00000109131.8
ENSMUST00000125749.2
zinc finger protein 454
chr11_+_49176109 1.43 ENSMUST00000217275.2
ENSMUST00000214598.2
ENSMUST00000215861.2
ENSMUST00000214170.2
olfactory receptor 1392
chr15_-_98985698 1.42 ENSMUST00000064462.5
complement component 1, q subcomponent-like 4
chr11_+_102175985 1.40 ENSMUST00000156326.2
transmembrane and ubiquitin-like domain containing 2
chr18_-_72484126 1.40 ENSMUST00000114943.11
deleted in colorectal carcinoma
chrX_+_106193060 1.39 ENSMUST00000125676.8
ENSMUST00000180182.2
purinergic receptor P2Y, G-protein coupled 10B
chr16_+_14523696 1.35 ENSMUST00000023356.8
snail family zinc finger 2
chr17_-_45970238 1.34 ENSMUST00000120717.8
calpain 11
chr7_+_86564302 1.33 ENSMUST00000233033.2
ENSMUST00000170835.4
vomeronasal 2, receptor 78
chr13_-_40882417 1.32 ENSMUST00000225180.2
transcription factor AP-2, alpha
chr11_-_69686756 1.31 ENSMUST00000045971.9
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
chr5_+_107585774 1.27 ENSMUST00000162298.4
ENSMUST00000094541.4
ENSMUST00000211896.2
BTB (POZ) domain containing 8
chr15_+_100659622 1.25 ENSMUST00000023776.13
solute carrier family 4 (anion exchanger), member 8
chr11_+_43046476 1.25 ENSMUST00000238415.2
ATPase, class V, type 10B
chr5_+_107745562 1.24 ENSMUST00000112651.8
ENSMUST00000112654.8
ENSMUST00000065422.12
RNA polymerase II associated protein 2
chr16_-_50252703 1.23 ENSMUST00000066037.13
ENSMUST00000089399.11
ENSMUST00000089404.10
ENSMUST00000138166.8
bobby sox HMG box containing
chr8_-_43760017 1.22 ENSMUST00000082120.5
zinc finger protein 42
chr2_+_36575800 1.18 ENSMUST00000213258.2
olfactory receptor 346
chr11_+_117123107 1.14 ENSMUST00000106354.9
septin 9
chr9_-_45115381 1.13 ENSMUST00000034599.15
transmembrane protease, serine 4
chr14_+_53872276 1.13 ENSMUST00000103658.4
T cell receptor alpha variable 13-2
chr18_+_77877611 1.12 ENSMUST00000238172.2
proline-serine-threonine phosphatase-interacting protein 2
chr5_+_107745626 1.10 ENSMUST00000112655.8
RNA polymerase II associated protein 2
chrX_+_106193167 1.10 ENSMUST00000137107.2
ENSMUST00000067249.3
purinergic receptor P2Y, G-protein coupled 10B
chr1_+_37068387 1.05 ENSMUST00000067178.14
ENSMUST00000238500.2
von Willebrand factor A domain containing 3B
chr17_-_40553176 1.04 ENSMUST00000026499.6
cysteine-rich secretory protein 3
chr12_+_89779178 1.03 ENSMUST00000238943.2
neurexin III
chr7_+_19093665 1.03 ENSMUST00000140836.8
protein phosphatase 1, regulatory subunit 13 like
chrX_-_111315519 1.02 ENSMUST00000124335.8
spermidine/spermine N1-acetyl transferase-like 1
chr9_+_67666705 1.01 ENSMUST00000171652.3
C2 calcium-dependent domain containing 4B
chr4_-_114991174 1.01 ENSMUST00000051400.8
cytochrome P450, family 4, subfamily x, polypeptide 1
chr1_+_37068429 1.01 ENSMUST00000162449.7
von Willebrand factor A domain containing 3B
chr11_+_67477501 1.00 ENSMUST00000108680.2
growth arrest specific 7
chr11_-_99941369 1.00 ENSMUST00000007318.2
keratin 31
chr7_-_9575286 0.97 ENSMUST00000174433.2
predicted gene 10302
chrX_-_20955370 0.97 ENSMUST00000040667.13
zinc finger protein 300
chr2_-_17465410 0.96 ENSMUST00000145492.2
nebulette
chr8_+_110220614 0.94 ENSMUST00000034162.8
polyamine modulated factor 1 binding protein 1
chr12_+_89779237 0.93 ENSMUST00000110133.9
ENSMUST00000110130.4
neurexin III
chr2_+_86655007 0.92 ENSMUST00000217509.2
olfactory receptor 1094
chr1_-_179527845 0.91 ENSMUST00000223392.2
kinesin family member 28
chr18_-_72484082 0.90 ENSMUST00000073379.6
deleted in colorectal carcinoma
chrX_+_142301666 0.90 ENSMUST00000134402.8
p21 (RAC1) activated kinase 3
chr9_+_3015654 0.88 ENSMUST00000099050.4
predicted gene 10720
chr5_-_129907878 0.87 ENSMUST00000026617.13
phosphorylase kinase gamma 1
chr2_-_37249247 0.85 ENSMUST00000112940.8
ENSMUST00000009174.15
phosducin-like
chr13_+_13357291 0.85 ENSMUST00000021778.14
ENSMUST00000126540.8
ENSMUST00000151144.2
prolactin family 2, subfamily c, member 5
chr6_-_129308748 0.84 ENSMUST00000051283.8
C-type lectin domain family 2, member m
chr6_-_78355834 0.84 ENSMUST00000089667.8
ENSMUST00000167492.4
regenerating islet-derived 3 delta
chr2_+_101716577 0.83 ENSMUST00000028584.8
COMM domain containing 9
chr4_-_57300750 0.75 ENSMUST00000151964.2
protein tyrosine phosphatase, non-receptor type 3
chr4_+_3938903 0.75 ENSMUST00000121210.8
ENSMUST00000121651.8
ENSMUST00000041122.11
ENSMUST00000120732.8
ENSMUST00000119307.8
ENSMUST00000123769.8
coiled-coil-helix-coiled-coil-helix domain containing 7
chr9_+_3025417 0.75 ENSMUST00000075573.7
predicted gene 10717
chr6_-_143892814 0.71 ENSMUST00000124233.7
ENSMUST00000144289.4
ENSMUST00000111748.8
SRY (sex determining region Y)-box 5
chr17_-_44416665 0.70 ENSMUST00000024757.14
ectonucleotide pyrophosphatase/phosphodiesterase 4
chr5_-_26177661 0.70 ENSMUST00000200447.2
predicted gene, 21680
chr5_-_86666408 0.70 ENSMUST00000140095.2
ENSMUST00000134179.8
transmembrane protease, serine 11g
chr5_-_107745404 0.69 ENSMUST00000124140.2
glomulin, FKBP associated protein
chr5_-_109340065 0.69 ENSMUST00000053253.10
vomeronasal 2, receptor 13
chr4_-_97472844 0.68 ENSMUST00000107067.8
ENSMUST00000107068.9
RIKEN cDNA E130114P18 gene
chr6_-_130170075 0.68 ENSMUST00000112032.8
ENSMUST00000071554.3
killer cell lectin-like receptor subfamily A, member 9
chr5_+_15824062 0.67 ENSMUST00000095006.9
spermatogenesis associated glutamate (E)-rich protein 4D
chr19_-_32038838 0.65 ENSMUST00000096119.5
N-acylsphingosine amidohydrolase 2
chr3_-_64417263 0.65 ENSMUST00000177184.9
vomeronasal 2, receptor 5
chr11_-_67856457 0.64 ENSMUST00000021287.12
ENSMUST00000126766.2
cilia and flagella associated protein 52
chr1_+_87254729 0.64 ENSMUST00000172794.8
ENSMUST00000164992.9
ENSMUST00000173173.8
GRB10 interacting GYF protein 2
chr15_+_102862862 0.64 ENSMUST00000001701.4
homeobox C11
chr16_-_50151350 0.63 ENSMUST00000114488.8
bobby sox HMG box containing
chr2_-_151528259 0.63 ENSMUST00000149319.2
transmembrane 74B, opposite strand
chrX_+_106192510 0.63 ENSMUST00000147521.8
ENSMUST00000167673.2
purinergic receptor P2Y, G-protein coupled 10B
chr13_-_67877228 0.61 ENSMUST00000073157.15
zinc finger protein 65
chr1_+_179928709 0.61 ENSMUST00000133890.8
CDC42 binding protein kinase alpha
chr7_+_66489500 0.60 ENSMUST00000107478.9
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chrX_+_142301572 0.60 ENSMUST00000033640.14
p21 (RAC1) activated kinase 3
chr9_+_3004457 0.59 ENSMUST00000178348.2
predicted gene 11168
chr18_-_32082624 0.59 ENSMUST00000064016.6
G protein-coupled receptor 17
chr17_+_38032699 0.59 ENSMUST00000207771.3
olfactory receptor 120
chr3_-_144804784 0.58 ENSMUST00000040465.11
ENSMUST00000198993.2
chloride channel accessory 2
chr5_-_26310360 0.58 ENSMUST00000063524.3
RIKEN cDNA 5031410I06 gene
chr5_-_26326419 0.58 ENSMUST00000088236.5
predicted gene 10220
chr3_-_34135408 0.58 ENSMUST00000117223.4
ENSMUST00000120805.8
ENSMUST00000011029.12
ENSMUST00000108195.10
DnaJ heat shock protein family (Hsp40) member C19
chr5_-_26227914 0.58 ENSMUST00000072286.7
predicted gene 5862
chr12_-_87742525 0.58 ENSMUST00000164517.3
eukaryotic translation initiation factor 1A domain containing 19
chr5_-_26147379 0.57 ENSMUST00000196214.2
predicted gene, 21663
chr5_-_26263579 0.57 ENSMUST00000095004.4
predicted gene 7347
chr9_+_3037111 0.56 ENSMUST00000177969.2
predicted gene 10715
chr6_+_30568366 0.56 ENSMUST00000049251.6
carboxypeptidase A4
chr17_+_33651864 0.56 ENSMUST00000174088.3
actin-like 9
chr5_-_15681521 0.56 ENSMUST00000197995.2
predicted gene, 21149
chr5_+_15782286 0.56 ENSMUST00000188807.4
predicted gene, 21083
chr5_-_15919234 0.55 ENSMUST00000095005.12
ENSMUST00000179506.2
spermatogenesis associated glutamate (E)-rich protein 4C
chr11_+_81992662 0.54 ENSMUST00000000194.4
chemokine (C-C motif) ligand 12
chr13_+_22737368 0.54 ENSMUST00000228195.2
vomeronasal 1 receptor 204
chr13_-_67417132 0.54 ENSMUST00000045969.8
zinc finger protein 458
chrX_-_8455485 0.54 ENSMUST00000089379.5
synovial sarcoma, X member B3
chrX_+_133088238 0.54 ENSMUST00000064476.5
ADP-ribosylation factor-like 13A
chr9_+_3018753 0.53 ENSMUST00000179272.2
predicted gene 10719
chr5_+_26462689 0.52 ENSMUST00000074148.7
predicted gene 7361
chr7_-_9687512 0.52 ENSMUST00000165611.2
vomeronasal 2, receptor 48
chr5_-_15028949 0.51 ENSMUST00000096953.5
predicted gene 10354
chr7_-_41708447 0.51 ENSMUST00000168489.3
ENSMUST00000233456.2
vomeronasal 2, receptor 59
chr8_-_84169071 0.51 ENSMUST00000212449.2
short coiled-coil protein
chr5_-_26244556 0.50 ENSMUST00000079447.4
spermatogenesis associated glutamate (E)-rich protein 4A
chr16_-_37360097 0.50 ENSMUST00000023525.9
general transcription factor II E, polypeptide 1 (alpha subunit)
chr14_+_54082691 0.50 ENSMUST00000103674.6
T cell receptor alpha variable 19
chr4_-_149211145 0.49 ENSMUST00000030815.3
cortistatin
chr1_+_87254719 0.49 ENSMUST00000027475.15
GRB10 interacting GYF protein 2
chr14_+_53048391 0.47 ENSMUST00000103646.5
T cell receptor alpha variable 10D
chr4_-_133728168 0.46 ENSMUST00000105887.8
ENSMUST00000012262.12
ENSMUST00000144668.8
ENSMUST00000105889.4
dehydrodolichyl diphosphate synthase
chr6_+_34686543 0.46 ENSMUST00000031775.13
caldesmon 1
chr5_-_27706360 0.46 ENSMUST00000155721.2
ENSMUST00000053257.10
spermatogenesis associated glutamate (E)-rich protein 4B
chr7_+_13132040 0.46 ENSMUST00000005791.14
calcium binding protein 5
chr5_-_26193648 0.46 ENSMUST00000191203.7
predicted gene, 21698
chr5_-_26294289 0.46 ENSMUST00000094946.5
predicted gene 10471
chr13_-_21765822 0.45 ENSMUST00000206526.3
ENSMUST00000213912.2
olfactory receptor 1364
chr17_+_38231439 0.45 ENSMUST00000216440.2
olfactory receptor 128
chr12_+_65272495 0.45 ENSMUST00000221980.2
WD repeat domain 20, retrogene
chr9_-_121324705 0.44 ENSMUST00000216138.2
cholecystokinin
chr14_+_115329676 0.44 ENSMUST00000176912.8
ENSMUST00000175665.8
glypican 5
chr9_+_3036877 0.44 ENSMUST00000155807.3
predicted gene 10715
chr7_-_43906629 0.43 ENSMUST00000012921.9
acid phosphatase 4
chr14_-_72840373 0.43 ENSMUST00000162825.8
fibronectin type III domain containing 3A
chr6_+_40546421 0.42 ENSMUST00000216942.2
olfactory receptor 460
chr4_-_114991478 0.42 ENSMUST00000106545.8
cytochrome P450, family 4, subfamily x, polypeptide 1
chr8_-_106306477 0.41 ENSMUST00000194654.2
agouti related neuropeptide
chr7_+_44592628 0.41 ENSMUST00000207719.2
ENSMUST00000120929.9
testis-specific serine kinase substrate
chr17_+_38211328 0.41 ENSMUST00000217223.2
olfactory receptor 127
chr7_-_21750929 0.39 ENSMUST00000178209.2
predicted gene 6176

Network of associatons between targets according to the STRING database.

First level regulatory network of Hdx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 28.4 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
3.9 35.0 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
3.3 9.9 GO:0097037 heme export(GO:0097037)
2.8 16.7 GO:0038161 prolactin signaling pathway(GO:0038161)
1.8 7.1 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
1.4 12.3 GO:0045919 positive regulation of cytolysis(GO:0045919)
1.1 20.9 GO:0042448 progesterone metabolic process(GO:0042448)
1.0 3.8 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.8 10.0 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.7 4.7 GO:0006621 protein retention in ER lumen(GO:0006621)
0.6 5.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.6 2.8 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.5 1.5 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.5 1.5 GO:1904154 trimming of terminal mannose on B branch(GO:0036509) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.5 2.3 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.4 1.3 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.4 7.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.3 1.8 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3 1.8 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.3 2.3 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.3 2.6 GO:0038203 TORC2 signaling(GO:0038203)
0.3 1.3 GO:0003409 optic cup structural organization(GO:0003409)
0.3 1.5 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.2 2.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.2 1.7 GO:0032790 ribosome disassembly(GO:0032790)
0.2 2.3 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 3.4 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.2 1.0 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.2 2.8 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 3.5 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 1.2 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.1 2.9 GO:0000054 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.1 0.9 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 0.5 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.1 1.5 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.1 3.8 GO:0033622 integrin activation(GO:0033622)
0.1 2.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 1.3 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.7 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 1.9 GO:0034063 stress granule assembly(GO:0034063)
0.1 2.1 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 2.0 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 4.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.2 GO:0070318 enucleate erythrocyte development(GO:0048822) positive regulation of G0 to G1 transition(GO:0070318)
0.1 0.3 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.1 9.4 GO:0006956 complement activation(GO:0006956)
0.1 0.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.1 0.5 GO:0016093 polyprenol metabolic process(GO:0016093)
0.1 0.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 2.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 3.1 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.5 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 1.5 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 1.0 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 1.1 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 0.3 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 7.7 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.6 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 5.4 GO:0007586 digestion(GO:0007586)
0.0 0.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 1.4 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.0 0.7 GO:0006152 purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0 0.6 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 0.7 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 4.8 GO:0007596 blood coagulation(GO:0007596)
0.0 0.7 GO:0001562 response to protozoan(GO:0001562)
0.0 1.5 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.4 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 4.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.3 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.9 GO:0072384 organelle transport along microtubule(GO:0072384)
0.0 1.3 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 0.4 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.9 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.6 GO:0048806 genitalia development(GO:0048806)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:0061474 phagolysosome membrane(GO:0061474)
3.2 28.4 GO:0005579 membrane attack complex(GO:0005579)
0.6 4.7 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.5 2.1 GO:1990769 proximal neuron projection(GO:1990769)
0.3 3.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 11.1 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.2 2.6 GO:0061700 GATOR2 complex(GO:0061700)
0.2 2.3 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 7.2 GO:0031941 filamentous actin(GO:0031941)
0.1 1.1 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 1.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.6 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 2.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.5 GO:0030478 actin cap(GO:0030478)
0.0 2.8 GO:0031201 SNARE complex(GO:0031201)
0.0 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 7.1 GO:0043204 perikaryon(GO:0043204)
0.0 9.3 GO:0072562 blood microparticle(GO:0072562)
0.0 1.6 GO:0016592 mediator complex(GO:0016592)
0.0 1.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 22.9 GO:0030424 axon(GO:0030424)
0.0 1.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 7.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 1.4 GO:0005581 collagen trimer(GO:0005581)
0.0 1.8 GO:0043197 dendritic spine(GO:0043197)
0.0 1.0 GO:0005884 actin filament(GO:0005884)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 32.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
3.3 16.7 GO:0004925 prolactin receptor activity(GO:0004925)
1.8 12.3 GO:0001851 complement component C3b binding(GO:0001851)
1.5 12.3 GO:0001849 complement component C1q binding(GO:0001849)
1.4 7.1 GO:0015254 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
1.3 3.8 GO:0030338 CMP-N-acetylneuraminate monooxygenase activity(GO:0030338)
1.0 20.9 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.8 2.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.6 1.8 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888)
0.6 23.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.5 3.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 1.8 GO:0004883 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 2.3 GO:0005042 netrin receptor activity(GO:0005042)
0.3 7.8 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.3 1.5 GO:0008384 IkappaB kinase activity(GO:0008384)
0.3 1.0 GO:0019809 spermidine binding(GO:0019809)
0.2 3.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.2 2.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 0.6 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.2 5.2 GO:0003951 NAD+ kinase activity(GO:0003951)
0.2 0.7 GO:0047710 bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 1.7 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.9 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 18.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.9 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 0.7 GO:0017040 ceramidase activity(GO:0017040)
0.1 1.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)
0.1 1.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 4.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 3.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0036033 mediator complex binding(GO:0036033)
0.0 1.4 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 2.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.9 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 2.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.2 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.0 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.4 GO:0030546 receptor activator activity(GO:0030546)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.5 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 1.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.4 GO:0019905 syntaxin binding(GO:0019905)
0.0 1.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 16.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 17.9 PID CMYB PATHWAY C-MYB transcription factor network
0.1 9.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 1.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.5 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 2.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 6.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.8 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.7 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 32.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
1.4 20.9 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
1.3 40.6 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.9 10.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.6 16.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.5 7.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 7.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 2.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 2.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 4.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.5 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 9.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 2.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 2.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.5 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction