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GSE58827: Dynamics of the Mouse Liver

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Results for Hmx1

Z-value: 1.95

Motif logo

Transcription factors associated with Hmx1

Gene Symbol Gene ID Gene Info
ENSMUSG00000067438.6 H6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hmx1mm39_v1_chr5_+_35546363_35546461-0.192.7e-01Click!

Activity profile of Hmx1 motif

Sorted Z-values of Hmx1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_79539063 23.90 ENSMUST00000022595.8
regulator of cell cycle
chr14_-_56339915 23.77 ENSMUST00000015583.2
cathepsin G
chr7_+_18618605 22.18 ENSMUST00000032573.8
peptidoglycan recognition protein 1
chr2_+_162916551 21.94 ENSMUST00000142729.3
myeloblastosis oncogene-like 2
chr4_+_120523758 21.28 ENSMUST00000094814.6
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr13_+_91609169 20.75 ENSMUST00000004094.15
ENSMUST00000042122.15
single-stranded DNA binding protein 2
chr11_+_11636213 20.56 ENSMUST00000076700.11
ENSMUST00000048122.13
IKAROS family zinc finger 1
chr12_+_109425769 17.89 ENSMUST00000173812.2
delta like non-canonical Notch ligand 1
chr6_+_30738043 16.89 ENSMUST00000163949.9
ENSMUST00000124665.3
mesoderm specific transcript
chr13_+_91609264 14.58 ENSMUST00000231481.2
single-stranded DNA binding protein 2
chr13_+_45660905 13.72 ENSMUST00000000260.13
guanosine monophosphate reductase
chrX_-_7537580 13.62 ENSMUST00000033486.6
proteolipid protein 2
chr17_-_34109513 13.59 ENSMUST00000173386.2
ENSMUST00000114361.9
ENSMUST00000173492.9
kinesin family member C1
chr11_-_46203047 12.93 ENSMUST00000129474.2
ENSMUST00000093166.11
ENSMUST00000165599.9
cytoplasmic FMR1 interacting protein 2
chr9_+_108437485 12.80 ENSMUST00000081111.14
ENSMUST00000193421.2
inosine monophosphate dehydrogenase 2
chr8_+_106024294 11.19 ENSMUST00000015003.10
E2F transcription factor 4
chr1_-_75482975 10.47 ENSMUST00000113567.10
ENSMUST00000113565.3
obscurin-like 1
chr11_+_61847589 10.18 ENSMUST00000201671.4
ENSMUST00000202178.4
sperm antigen with calponin homology and coiled-coil domains 1
chr6_+_34453142 9.74 ENSMUST00000045372.6
ENSMUST00000138668.2
ENSMUST00000139067.2
2,3-bisphosphoglycerate mutase
chr4_-_152561896 9.57 ENSMUST00000238738.2
ENSMUST00000162017.3
ENSMUST00000030768.10
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chrX_-_133709733 9.55 ENSMUST00000035559.11
armadillo repeat containing, X-linked 2
chr1_+_135656885 9.22 ENSMUST00000027677.8
cysteine and glycine-rich protein 1
chr15_-_78456898 8.99 ENSMUST00000043214.8
Rac family small GTPase 2
chrX_-_73290140 8.96 ENSMUST00000101454.9
ENSMUST00000033699.13
filamin, alpha
chr6_+_90596123 8.72 ENSMUST00000032177.10
solute carrier family 41, member 3
chr2_+_129040677 8.59 ENSMUST00000028880.10
solute carrier family 20, member 1
chrX_+_9138995 8.48 ENSMUST00000015486.7
X-linked Kx blood group
chr7_-_125968653 8.32 ENSMUST00000205642.2
ENSMUST00000032997.8
ENSMUST00000206793.2
linker for activation of T cells
chr5_+_121358254 8.06 ENSMUST00000042614.13
HECT domain E3 ubiquitin protein ligase 4
chr11_+_69856222 8.04 ENSMUST00000018713.13
claudin 7
chrX_-_73289970 7.92 ENSMUST00000130007.8
filamin, alpha
chr1_-_181669891 7.61 ENSMUST00000193028.2
ENSMUST00000191878.6
ENSMUST00000005003.12
lamin B receptor
chr11_+_61847622 7.59 ENSMUST00000202389.4
sperm antigen with calponin homology and coiled-coil domains 1
chr4_+_134195631 7.16 ENSMUST00000030636.11
ENSMUST00000127279.8
ENSMUST00000105867.8
stathmin 1
chr17_+_27136065 7.04 ENSMUST00000078961.6
kinesin family member C5B
chr7_-_48530777 6.94 ENSMUST00000058745.15
E2F transcription factor 8
chr6_-_91093766 6.61 ENSMUST00000113509.2
ENSMUST00000032179.14
nucleoporin 210
chr18_-_62313019 6.41 ENSMUST00000053640.5
adrenergic receptor, beta 2
chr2_+_130116344 6.16 ENSMUST00000103198.11
NOP56 ribonucleoprotein
chr17_+_34811217 6.11 ENSMUST00000038149.13
pre B cell leukemia homeobox 2
chr3_-_89325594 6.09 ENSMUST00000029679.4
CDC28 protein kinase 1b
chr2_+_152950388 6.02 ENSMUST00000189688.2
ENSMUST00000109799.8
ENSMUST00000003370.14
hemopoietic cell kinase
chr2_+_130116357 5.69 ENSMUST00000136621.9
ENSMUST00000141872.2
NOP56 ribonucleoprotein
chr15_-_79718423 5.57 ENSMUST00000109623.8
ENSMUST00000109625.8
ENSMUST00000023060.13
ENSMUST00000089299.6
chromobox 6
neuronal pentraxin chromo domain
chr11_-_102210568 5.39 ENSMUST00000173870.8
upstream binding transcription factor, RNA polymerase I
chr11_-_109364424 5.30 ENSMUST00000070152.12
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr13_-_32522548 5.15 ENSMUST00000041859.9
GDP-mannose 4, 6-dehydratase
chr6_-_127128007 5.10 ENSMUST00000000188.12
cyclin D2
chr2_+_32766126 5.09 ENSMUST00000028135.15
niban apoptosis regulator 2
chr9_-_107474221 4.95 ENSMUST00000238519.2
leucine-rich single-pass membrane protein 2
chr8_+_121262528 4.47 ENSMUST00000120493.8
genetic suppressor element 1, coiled-coil protein
chrX_+_49930311 4.44 ENSMUST00000114887.9
serine/threonine kinase 26
chr11_-_102209767 4.33 ENSMUST00000174302.8
ENSMUST00000178839.8
ENSMUST00000006754.14
upstream binding transcription factor, RNA polymerase I
chr10_-_76797622 4.26 ENSMUST00000001148.11
ENSMUST00000105411.9
poly(rC) binding protein 3
chr3_-_107992662 4.03 ENSMUST00000078912.7
adenosine monophosphate deaminase 2
chr2_-_92201342 3.91 ENSMUST00000176810.8
ENSMUST00000090582.11
ENSMUST00000068586.13
LARGE xylosyl- and glucuronyltransferase 2
chr11_+_44409775 3.89 ENSMUST00000019333.10
ring finger protein 145
chr11_+_68582731 3.87 ENSMUST00000102611.10
myosin, heavy polypeptide 10, non-muscle
chr6_-_127127959 3.85 ENSMUST00000201637.2
cyclin D2
chr15_-_79571977 3.84 ENSMUST00000023061.7
Josephin domain containing 1
chr14_-_56499690 3.82 ENSMUST00000015581.6
granzyme B
chr2_-_156833932 3.80 ENSMUST00000109558.2
ENSMUST00000069600.13
ENSMUST00000072298.13
N-myc downstream regulated gene 3
chr13_-_38842967 3.78 ENSMUST00000001757.9
eukaryotic translation elongation factor 1 epsilon 1
chr8_+_121264161 3.70 ENSMUST00000118136.2
genetic suppressor element 1, coiled-coil protein
chr13_-_55477535 3.69 ENSMUST00000021941.8
Max dimerization protein 3
chr14_-_54924382 3.67 ENSMUST00000022793.15
ENSMUST00000111484.9
apoptotic chromatin condensation inducer 1
chr11_+_68582923 3.66 ENSMUST00000018887.15
myosin, heavy polypeptide 10, non-muscle
chr15_-_98507913 3.59 ENSMUST00000226500.2
ENSMUST00000227501.2
adenylate cyclase 6
chr15_+_59246134 3.58 ENSMUST00000227173.2
ENSMUST00000079703.11
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
chr9_-_42035560 3.53 ENSMUST00000060989.9
sortilin-related receptor, LDLR class A repeats-containing
chr7_-_83384711 3.51 ENSMUST00000001792.12
interleukin 16
chr13_+_55517545 3.44 ENSMUST00000063771.14
regulator of G-protein signaling 14
chr7_-_125760164 3.42 ENSMUST00000164741.2
exportin 6
chr4_+_129407374 3.42 ENSMUST00000062356.7
MARCKS-like 1
chr11_-_116001037 3.35 ENSMUST00000106441.8
ENSMUST00000021120.6
tripartite motif-containing 47
chr11_-_61384998 3.30 ENSMUST00000101085.9
ENSMUST00000079080.13
ENSMUST00000108714.2
mitogen-activated protein kinase 7
chr17_+_35413415 3.29 ENSMUST00000025262.6
ENSMUST00000173600.2
lymphotoxin B
chr11_+_23234644 3.27 ENSMUST00000150750.3
exportin 1
chr6_-_124710030 3.22 ENSMUST00000173647.2
protein tyrosine phosphatase, non-receptor type 6
chr18_+_75953244 3.17 ENSMUST00000058997.15
zinc finger and BTB domain containing 7C
chr5_-_134643805 3.11 ENSMUST00000202085.2
ENSMUST00000036362.13
ENSMUST00000077636.8
linker for activation of T cells family, member 2
chr17_-_34043320 2.96 ENSMUST00000173879.8
ENSMUST00000166693.3
ENSMUST00000173019.8
ribosomal protein S28
chr12_+_112978051 2.94 ENSMUST00000223502.2
ENSMUST00000084891.5
ENSMUST00000220541.2
phosphofurin acidic cluster sorting protein 2
chr6_-_127127993 2.92 ENSMUST00000201066.2
cyclin D2
chr9_-_110483210 2.91 ENSMUST00000196488.5
ENSMUST00000133191.8
ENSMUST00000167320.8
neurobeachin-like 2
chr16_+_18695787 2.90 ENSMUST00000120532.9
ENSMUST00000004222.14
histone cell cycle regulator
chr17_-_48144094 2.89 ENSMUST00000131971.2
ENSMUST00000129360.2
ENSMUST00000113280.8
ENSMUST00000132125.8
MyoD family inhibitor
chr16_+_49519561 2.83 ENSMUST00000046777.11
ENSMUST00000142682.9
intraflagellar transport 57
chr17_-_48144181 2.82 ENSMUST00000152455.8
ENSMUST00000035375.14
MyoD family inhibitor
chr16_+_10652910 2.75 ENSMUST00000037913.9
RecQ mediated genome instability 2
chr9_-_21223551 2.69 ENSMUST00000003397.9
ENSMUST00000213250.2
adaptor protein complex AP-1, mu 2 subunit
chr17_-_12988492 2.64 ENSMUST00000024599.14
insulin-like growth factor 2 receptor
chr5_-_38719025 2.59 ENSMUST00000005234.13
WD repeat domain 1
chr2_+_118756973 2.50 ENSMUST00000099546.6
ENSMUST00000110837.2
carbohydrate sulfotransferase 14
chr6_-_124710084 2.47 ENSMUST00000112484.10
protein tyrosine phosphatase, non-receptor type 6
chr11_-_115024807 2.47 ENSMUST00000106561.8
ENSMUST00000051264.14
ENSMUST00000106562.3
CD300 molecule like family member F
chr5_+_100666278 2.46 ENSMUST00000151414.8
COP9 signalosome subunit 4
chr5_+_100666175 2.44 ENSMUST00000045993.15
COP9 signalosome subunit 4
chr15_+_79025523 2.42 ENSMUST00000040077.8
polymerase (RNA) II (DNA directed) polypeptide F
chr19_-_4665668 2.42 ENSMUST00000113822.3
leucine rich repeat and fibronectin type III domain containing 4
chr19_-_4665509 2.41 ENSMUST00000053597.3
leucine rich repeat and fibronectin type III domain containing 4
chr6_+_29433247 2.40 ENSMUST00000101617.9
ENSMUST00000065090.8
filamin C, gamma
chr2_-_25162347 2.37 ENSMUST00000028342.7
SS nuclear autoantigen 1
chr6_-_137146708 2.22 ENSMUST00000117919.8
RAS-like, estrogen-regulated, growth-inhibitor
chrX_+_20291927 2.18 ENSMUST00000115384.9
jade family PHD finger 3
chr14_-_54924062 2.14 ENSMUST00000147714.8
apoptotic chromatin condensation inducer 1
chr9_+_32607301 2.12 ENSMUST00000034534.13
ENSMUST00000050797.14
ENSMUST00000184887.2
E26 avian leukemia oncogene 1, 5' domain
chrX_-_73416824 2.11 ENSMUST00000178691.2
ENSMUST00000114146.8
ubiquitin-like 4A
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr9_+_106048116 2.10 ENSMUST00000020490.13
WD repeat domain containing 82
chrX_-_73416869 2.08 ENSMUST00000073067.11
ENSMUST00000037967.6
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr4_-_94444975 2.06 ENSMUST00000030313.9
caspase activity and apoptosis inhibitor 1
chr10_+_77095052 2.05 ENSMUST00000020493.9
protein O-fucosyltransferase 2
chr7_+_118311740 2.04 ENSMUST00000106557.8
centriolar coiled coil protein 110
chr2_-_73284262 2.02 ENSMUST00000102679.8
WAS/WASL interacting protein family, member 1
chr11_-_116734275 1.96 ENSMUST00000047616.10
jumonji domain containing 6
chr11_+_77873535 1.95 ENSMUST00000108360.8
ENSMUST00000049167.14
PHD finger protein 12
chr1_-_156546600 1.93 ENSMUST00000122424.8
ENSMUST00000086153.8
FAM20B, glycosaminoglycan xylosylkinase
chr18_-_24736848 1.93 ENSMUST00000070726.10
solute carrier family 39 (metal ion transporter), member 6
chr6_-_87312743 1.92 ENSMUST00000042025.12
ENSMUST00000205033.2
anthrax toxin receptor 1
chr15_+_8138805 1.91 ENSMUST00000230017.2
nucleoporin 155
chr10_-_61109188 1.88 ENSMUST00000092486.11
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14
chr3_+_102965601 1.87 ENSMUST00000029445.13
ENSMUST00000200069.5
neuroblastoma ras oncogene
chr11_-_69749549 1.83 ENSMUST00000001626.10
ENSMUST00000108626.8
tyrosine kinase, non-receptor, 1
chr6_-_137146677 1.81 ENSMUST00000119610.4
ENSMUST00000149100.3
RAS-like, estrogen-regulated, growth-inhibitor
chr12_+_70984631 1.75 ENSMUST00000021479.6
ARP10 actin-related protein 10
chr14_-_56812839 1.69 ENSMUST00000225951.2
centromere protein J
chr9_-_21223631 1.69 ENSMUST00000115433.11
adaptor protein complex AP-1, mu 2 subunit
chr11_-_5015275 1.66 ENSMUST00000109895.2
ENSMUST00000152257.2
ENSMUST00000037146.10
ENSMUST00000056649.13
growth arrest-specific 2 like 1
chr14_-_56472102 1.52 ENSMUST00000015585.4
granzyme C
chr15_-_74581384 1.52 ENSMUST00000050234.4
jerky
chrX_-_99670174 1.48 ENSMUST00000015812.12
PDZ domain containing 11
chrX_+_158038778 1.48 ENSMUST00000126686.8
ENSMUST00000033671.13
ribosomal protein S6 kinase polypeptide 3
chr3_-_92393193 1.48 ENSMUST00000054599.8
small proline-rich protein 1A
chr1_-_152642073 1.46 ENSMUST00000111857.3
ral guanine nucleotide dissociation stimulator,-like 1
chr15_+_59246080 1.45 ENSMUST00000168722.3
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
chr15_+_78312851 1.44 ENSMUST00000159771.8
potassium channel tetramerisation domain containing 17
chr1_-_127605660 1.41 ENSMUST00000160616.8
transmembrane protein 163
chr3_-_88455556 1.37 ENSMUST00000131775.2
ENSMUST00000008745.13
RAB25, member RAS oncogene family
chr3_-_107993906 1.36 ENSMUST00000102638.8
ENSMUST00000102637.8
adenosine monophosphate deaminase 2
chr7_-_117842787 1.33 ENSMUST00000032891.15
SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
chr2_+_25162487 1.31 ENSMUST00000028341.11
anaphase promoting complex subunit 2
chr11_+_88864753 1.31 ENSMUST00000036649.8
coilin
chr6_-_40413056 1.27 ENSMUST00000039008.10
ENSMUST00000101492.10
DENN domain containing 11
chr1_-_152642032 1.26 ENSMUST00000111859.8
ral guanine nucleotide dissociation stimulator,-like 1
chr8_+_108162985 1.24 ENSMUST00000166615.3
ENSMUST00000213097.2
ENSMUST00000212205.2
WW domain containing E3 ubiquitin protein ligase 2
chr15_+_78312764 1.22 ENSMUST00000162517.8
ENSMUST00000166142.10
ENSMUST00000089414.11
potassium channel tetramerisation domain containing 17
chr1_-_143578542 1.21 ENSMUST00000018337.9
cell division cycle 73, Paf1/RNA polymerase II complex component
chr5_+_124583524 1.19 ENSMUST00000100709.7
lysine methyltransferase 5A
chr12_-_46767619 1.18 ENSMUST00000219886.2
NOVA alternative splicing regulator 1
chr7_+_100021425 1.16 ENSMUST00000098259.11
ENSMUST00000051777.15
C2 calcium-dependent domain containing 3
chr2_+_174169351 1.14 ENSMUST00000124935.8
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr15_+_8138757 1.11 ENSMUST00000163765.3
nucleoporin 155
chr1_-_160134873 1.10 ENSMUST00000193185.6
RAB GTPase activating protein 1-like
chr1_+_180468895 1.05 ENSMUST00000192725.6
lin-9 homolog (C. elegans)
chrX_-_73436293 1.04 ENSMUST00000114138.8
family with sequence similarity 3, member A
chrX_-_73436609 1.04 ENSMUST00000015427.13
family with sequence similarity 3, member A
chr19_-_5345423 1.04 ENSMUST00000235182.2
ENSMUST00000025774.11
splicing factor 3b, subunit 2
chr1_+_39574829 1.03 ENSMUST00000003219.14
CCR4-NOT transcription complex, subunit 11
chr4_+_109533753 0.98 ENSMUST00000102724.5
Fas-associated factor 1
chr2_-_181234526 0.98 ENSMUST00000108789.9
ENSMUST00000153998.2
zinc finger protein 512B
chr9_-_44646487 0.96 ENSMUST00000034611.15
pleckstrin homology like domain, family B, member 1
chr11_+_62711057 0.95 ENSMUST00000055006.12
ENSMUST00000072639.10
tripartite motif-containing 16
chr2_-_34716083 0.93 ENSMUST00000113077.8
ENSMUST00000028220.10
F-box and WD-40 domain protein 2
chr1_+_61017057 0.92 ENSMUST00000027162.12
ENSMUST00000102827.4
inducible T cell co-stimulator
chr11_-_94133527 0.90 ENSMUST00000061469.4
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr19_-_14575395 0.89 ENSMUST00000052011.15
ENSMUST00000167776.3
transducin-like enhancer of split 4
chr15_+_78294154 0.87 ENSMUST00000229739.2
mercaptopyruvate sulfurtransferase
chr16_-_97564910 0.87 ENSMUST00000019386.10
receptor-interacting serine-threonine kinase 4
chr1_+_52047368 0.86 ENSMUST00000027277.7
signal transducer and activator of transcription 4
chr2_-_92201311 0.84 ENSMUST00000176774.8
LARGE xylosyl- and glucuronyltransferase 2
chr17_-_36291087 0.83 ENSMUST00000055454.14
proline-rich polypeptide 3
chr11_-_32217547 0.82 ENSMUST00000109389.9
ENSMUST00000129010.2
ENSMUST00000020530.12
nitrogen permease regulator-like 3
chr5_-_143513732 0.81 ENSMUST00000100489.4
ENSMUST00000080537.14
Rac family small GTPase 1
chr15_-_79025387 0.78 ENSMUST00000187550.7
ENSMUST00000188562.7
ENSMUST00000190509.7
ENSMUST00000190730.7
ENSMUST00000190959.7
ENSMUST00000169604.8
ENSMUST00000186053.7
RIKEN cDNA 1700088E04 gene
chrX_-_73436709 0.77 ENSMUST00000114142.8
ENSMUST00000114139.8
family with sequence similarity 3, member A
chr4_+_59626185 0.76 ENSMUST00000070150.11
ENSMUST00000052420.7
RIKEN cDNA E130308A19 gene
chr2_+_28083105 0.75 ENSMUST00000100244.10
olfactomedin 1
chr2_-_130471891 0.75 ENSMUST00000110262.3
ENSMUST00000028761.5
FAST kinase domains 5
U box domain containing 5
chr19_+_8713156 0.72 ENSMUST00000210512.2
ENSMUST00000049424.11
WD repeat domain 74
chr15_+_55171138 0.70 ENSMUST00000023053.12
ENSMUST00000110217.10
collagen, type XIV, alpha 1
chr19_-_32365862 0.69 ENSMUST00000099514.10
sphingomyelin synthase 1
chr7_+_48438751 0.69 ENSMUST00000118927.8
ENSMUST00000125280.8
zinc finger, DHHC domain containing 13
chr19_-_41969558 0.69 ENSMUST00000026168.9
ENSMUST00000171561.8
MMS19 cytosolic iron-sulfur assembly component
chr1_+_43769750 0.68 ENSMUST00000027217.9
ECRG4 augurin precursor
chr10_+_79500387 0.68 ENSMUST00000020554.8
mucosal vascular addressin cell adhesion molecule 1
chr4_+_115595610 0.67 ENSMUST00000106524.4
EF-hand calcium binding domain 14
chr15_+_86098660 0.64 ENSMUST00000063414.9
TBC1 domain family, member 22a
chr2_+_174169492 0.63 ENSMUST00000156623.8
ENSMUST00000149016.9
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr4_+_62537750 0.62 ENSMUST00000084521.11
ENSMUST00000107424.2
regulator of G-protein signaling 3
chr16_-_97412169 0.61 ENSMUST00000232141.2
ENSMUST00000000395.8
transmembrane protease, serine 2
chr17_-_37178079 0.60 ENSMUST00000025329.13
ENSMUST00000174195.8
tripartite motif-containing 15
chr4_+_129878890 0.60 ENSMUST00000106017.8
ENSMUST00000121049.8
adhesion G protein-coupled receptor B2
chr11_-_48836975 0.59 ENSMUST00000104958.2
protease (prosome, macropain) activator subunit 2B
chr2_-_39116284 0.57 ENSMUST00000204701.3
protein phosphatase 6, catalytic subunit
chr2_+_174169539 0.56 ENSMUST00000133356.8
ENSMUST00000087871.11
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
chr6_-_67512768 0.53 ENSMUST00000058178.6
tumor-associated calcium signal transducer 2
chr9_+_95836797 0.52 ENSMUST00000034981.14
ENSMUST00000185633.7
5'-3' exoribonuclease 1
chr1_+_152642291 0.52 ENSMUST00000077755.11
ENSMUST00000097536.6
actin related protein 2/3 complex, subunit 5
chr6_+_108637816 0.51 ENSMUST00000163617.2
basic helix-loop-helix family, member e40
chr15_-_59245998 0.50 ENSMUST00000022976.6
WASH complex subunit 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Hmx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 23.9 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
7.4 22.2 GO:0051714 regulation of cytolysis in other organism(GO:0051710) positive regulation of cytolysis in other organism(GO:0051714)
6.9 20.6 GO:0045660 positive regulation of neutrophil differentiation(GO:0045660)
5.6 16.9 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
3.4 13.6 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
2.4 23.8 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
2.3 6.9 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.8 12.8 GO:0006177 GMP biosynthetic process(GO:0006177)
1.8 7.3 GO:0070650 actin filament bundle distribution(GO:0070650)
1.6 6.4 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
1.4 8.5 GO:0031133 regulation of axon diameter(GO:0031133)
1.3 12.7 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
1.2 3.6 GO:1904117 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
1.1 3.3 GO:0070376 regulation of ERK5 cascade(GO:0070376)
1.1 5.3 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
1.0 7.2 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.0 9.7 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.9 5.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.9 3.5 GO:0045053 protein retention in Golgi apparatus(GO:0045053) positive regulation of endocytic recycling(GO:2001137)
0.8 5.0 GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.8 2.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.8 7.9 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.8 3.0 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.7 11.9 GO:0071481 cellular response to X-ray(GO:0071481)
0.7 5.8 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.7 5.7 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.7 10.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.6 2.5 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666) interleukin-4-mediated signaling pathway(GO:0035771) response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) negative regulation of apoptotic cell clearance(GO:2000426)
0.6 2.4 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.6 5.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.6 2.9 GO:1905035 regulation of antifungal innate immune response(GO:1905034) negative regulation of antifungal innate immune response(GO:1905035)
0.6 10.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.5 5.4 GO:0032264 IMP salvage(GO:0032264)
0.5 9.6 GO:0070995 NADPH oxidation(GO:0070995)
0.5 2.9 GO:0061511 centriole elongation(GO:0061511)
0.5 4.8 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.5 3.3 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.4 16.1 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.4 8.1 GO:0006968 cellular defense response(GO:0006968)
0.4 2.6 GO:0030043 actin filament fragmentation(GO:0030043)
0.4 13.7 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.4 2.9 GO:0070889 platelet alpha granule organization(GO:0070889)
0.4 2.0 GO:0032053 ciliary basal body organization(GO:0032053)
0.4 8.0 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.4 2.1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.3 2.1 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.3 3.4 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.3 2.0 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.3 3.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 21.9 GO:0090307 mitotic spindle assembly(GO:0090307)
0.3 1.7 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.3 11.9 GO:0000154 rRNA modification(GO:0000154)
0.3 3.2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.3 8.6 GO:0006817 phosphate ion transport(GO:0006817)
0.3 5.7 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.3 2.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.3 4.9 GO:0000338 protein deneddylation(GO:0000338)
0.3 16.9 GO:0010883 regulation of lipid storage(GO:0010883)
0.2 1.5 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 3.4 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 2.1 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.2 6.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 1.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.2 2.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.2 2.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.2 0.8 GO:0002551 mast cell chemotaxis(GO:0002551)
0.2 2.9 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 1.0 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 1.9 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.1 1.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 4.4 GO:0030033 microvillus assembly(GO:0030033)
0.1 2.9 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 0.9 GO:0009092 homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.1 2.8 GO:0044458 motile cilium assembly(GO:0044458)
0.1 16.5 GO:0043627 response to estrogen(GO:0043627)
0.1 0.6 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.1 9.2 GO:0070527 platelet aggregation(GO:0070527)
0.1 6.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 3.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.4 GO:0031268 pseudopodium organization(GO:0031268)
0.1 0.4 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 1.9 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 1.3 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 1.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 2.7 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 0.5 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
0.1 0.4 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.1 1.4 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 1.2 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.1 0.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.7 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.1 2.0 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 3.2 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 3.4 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.0 GO:1904261 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.1 0.6 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 3.1 GO:0002279 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.1 1.1 GO:0035855 megakaryocyte development(GO:0035855)
0.1 6.5 GO:0051028 mRNA transport(GO:0051028)
0.1 2.6 GO:0030199 collagen fibril organization(GO:0030199)
0.0 1.5 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.0 0.4 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.4 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.9 GO:0031295 T cell tolerance induction(GO:0002517) T cell costimulation(GO:0031295)
0.0 1.2 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516)
0.0 0.3 GO:0036006 response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006)
0.0 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 2.8 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.0 0.7 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.3 GO:0043545 molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.4 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.0 0.2 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 5.3 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 7.3 GO:0006006 glucose metabolic process(GO:0006006)
0.0 0.4 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.5 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 1.2 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.8 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.7 GO:0001825 blastocyst formation(GO:0001825)
0.0 3.8 GO:0007018 microtubule-based movement(GO:0007018)
0.0 2.5 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 1.0 GO:0031047 gene silencing by RNA(GO:0031047)
0.0 0.3 GO:0046039 GTP metabolic process(GO:0046039)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 38.8 GO:0031523 Myb complex(GO:0031523)
4.6 13.7 GO:1902560 GMP reductase complex(GO:1902560)
3.2 9.6 GO:1990031 pinceau fiber(GO:1990031)
1.5 11.9 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
1.3 11.9 GO:0031428 box C/D snoRNP complex(GO:0031428)
1.0 7.3 GO:0097513 myosin II filament(GO:0097513)
1.0 20.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.9 2.6 GO:0042643 actomyosin, actin portion(GO:0042643)
0.8 3.8 GO:0044194 cytolytic granule(GO:0044194)
0.6 5.8 GO:0061574 ASAP complex(GO:0061574)
0.5 13.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.5 5.0 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.5 5.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.4 3.0 GO:0044611 nuclear pore inner ring(GO:0044611)
0.4 10.5 GO:0005859 muscle myosin complex(GO:0005859)
0.4 7.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) nuclear lamina(GO:0005652) intrinsic component of nuclear inner membrane(GO:0031229)
0.4 6.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.3 22.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 3.3 GO:0005642 annulate lamellae(GO:0005642)
0.2 8.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 3.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 2.1 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2 2.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 0.7 GO:0097361 CIA complex(GO:0097361)
0.2 13.2 GO:0008180 COP9 signalosome(GO:0008180)
0.2 1.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 3.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 2.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.8 GO:1990130 Iml1 complex(GO:1990130)
0.2 4.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 1.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.4 GO:0002945 cyclin K-CDK12 complex(GO:0002944) cyclin K-CDK13 complex(GO:0002945)
0.1 12.8 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.7 GO:0005869 dynactin complex(GO:0005869)
0.1 2.8 GO:0044292 dendrite terminus(GO:0044292)
0.1 2.0 GO:0016580 Sin3 complex(GO:0016580)
0.1 5.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 4.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 1.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 6.6 GO:0005643 nuclear pore(GO:0005643)
0.1 3.7 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1 1.4 GO:0031143 pseudopodium(GO:0031143)
0.1 5.3 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.1 0.7 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 1.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.3 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.1 3.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.0 GO:0045180 basal cortex(GO:0045180)
0.0 1.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.4 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 1.0 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 4.6 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0001533 cornified envelope(GO:0001533)
0.0 8.3 GO:0001650 fibrillar center(GO:0001650)
0.0 24.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.2 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0000242 pericentriolar material(GO:0000242)
0.0 3.4 GO:0000922 spindle pole(GO:0000922)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 10.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.5 GO:0071203 WASH complex(GO:0071203)
0.0 3.7 GO:0005814 centriole(GO:0005814)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.2 GO:0044452 nucleolar part(GO:0044452)
0.0 0.3 GO:0034719 SMN-Sm protein complex(GO:0034719)
0.0 0.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 2.3 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 18.4 GO:0005730 nucleolus(GO:0005730)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 0.3 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.7 GO:0016528 sarcoplasm(GO:0016528)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.0 GO:0036064 ciliary basal body(GO:0036064)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
3.7 22.2 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
3.2 9.7 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
2.8 16.9 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
2.1 12.8 GO:0003938 IMP dehydrogenase activity(GO:0003938)
1.7 8.6 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
1.6 19.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.6 9.7 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
1.6 6.4 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
1.0 6.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.7 4.9 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.7 7.6 GO:0070087 chromo shadow domain binding(GO:0070087)
0.7 11.9 GO:1990226 histone methyltransferase binding(GO:1990226)
0.6 2.5 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.6 23.8 GO:0070412 R-SMAD binding(GO:0070412)
0.5 20.6 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.5 5.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.5 4.8 GO:0042285 xylosyltransferase activity(GO:0042285)
0.5 10.5 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.5 4.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.5 3.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.5 2.5 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.5 2.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.4 13.6 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.4 5.7 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.4 13.6 GO:0019956 chemokine binding(GO:0019956)
0.4 9.6 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.4 3.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.3 0.7 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.3 2.0 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.3 4.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.3 7.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 1.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.3 0.9 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.3 20.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 11.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 4.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.3 35.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.3 3.5 GO:0042609 CD4 receptor binding(GO:0042609)
0.3 2.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 3.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 2.4 GO:0001054 RNA polymerase I activity(GO:0001054) RNA polymerase II activity(GO:0001055)
0.2 2.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 1.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 2.1 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 5.0 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 8.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 3.3 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.3 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.7 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 3.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 2.7 GO:0097602 cullin family protein binding(GO:0097602)
0.1 3.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 5.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 0.8 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 3.1 GO:0042169 SH2 domain binding(GO:0042169)
0.1 6.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.8 GO:0043426 MRF binding(GO:0043426)
0.1 15.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 3.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 5.1 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 5.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 0.2 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.7 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 1.4 GO:0031489 myosin V binding(GO:0031489)
0.0 1.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.9 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.2 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 2.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.3 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 0.4 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0033691 sialic acid binding(GO:0033691)
0.0 1.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 10.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 2.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 1.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.4 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 3.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.9 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 3.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 8.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.4 7.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 24.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 16.9 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.3 21.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3 15.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 17.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 19.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 21.9 PID E2F PATHWAY E2F transcription factor network
0.2 12.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.2 6.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.2 3.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 3.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 3.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 6.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 1.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 3.3 ST GA12 PATHWAY G alpha 12 Pathway
0.1 5.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 2.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 0.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 2.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.4 ST GA13 PATHWAY G alpha 13 Pathway
0.0 1.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 34.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
1.1 23.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8 19.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.7 11.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.6 9.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.5 17.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4 13.6 REACTOME KINESINS Genes involved in Kinesins
0.4 17.8 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 6.0 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3 17.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 3.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.3 3.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 4.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 8.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.3 5.7 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.3 9.6 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 6.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 3.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 10.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 1.9 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 6.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 9.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 4.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.9 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 2.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 3.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 2.3 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 4.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 3.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.5 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 2.8 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 2.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 5.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.0 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.3 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling