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GSE58827: Dynamics of the Mouse Liver

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Results for Hnf1a

Z-value: 2.22

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Transcription factors associated with Hnf1a

Gene Symbol Gene ID Gene Info
Hnf1a
ENSMUSG00000029556.13 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hnf1amm39_v1_chr5_-_115109118_1151091380.633.9e-05Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_51333816 33.41 ENSMUST00000169895.3
Rnase4
ribonuclease, RNase A family 4
chr7_+_140343652 32.22 ENSMUST00000026552.9
ENSMUST00000209253.2
ENSMUST00000210235.2
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr5_+_90666791 27.47 ENSMUST00000113179.9
ENSMUST00000128740.2
Afm
afamin
chr1_+_88139678 26.95 ENSMUST00000073049.7
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr11_+_101258368 26.28 ENSMUST00000019469.3
G6pc
glucose-6-phosphatase, catalytic
chr1_-_130589321 25.79 ENSMUST00000137276.3
C4bp
complement component 4 binding protein
chr1_-_130589349 25.50 ENSMUST00000027657.14
C4bp
complement component 4 binding protein
chr5_-_89605622 24.53 ENSMUST00000049209.13
Gc
vitamin D binding protein
chr12_-_103739847 21.79 ENSMUST00000078869.6
Serpina1d
serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr6_+_141575226 21.38 ENSMUST00000042812.9
Slco1b2
solute carrier organic anion transporter family, member 1b2
chr12_-_103871146 17.64 ENSMUST00000074051.6
Serpina1c
serine (or cysteine) peptidase inhibitor, clade A, member 1C
chr12_-_103704417 16.84 ENSMUST00000095450.11
ENSMUST00000187220.2
Serpina1b
serine (or cysteine) preptidase inhibitor, clade A, member 1B
chr12_-_103829810 16.46 ENSMUST00000085056.8
ENSMUST00000072876.12
ENSMUST00000124717.2
Serpina1a
serine (or cysteine) peptidase inhibitor, clade A, member 1A
chr9_-_71070506 16.44 ENSMUST00000074465.9
Aqp9
aquaporin 9
chr2_-_91466739 16.41 ENSMUST00000111335.2
ENSMUST00000028681.15
F2
coagulation factor II
chr17_+_12597490 15.59 ENSMUST00000014578.7
Plg
plasminogen
chr2_-_34990689 14.48 ENSMUST00000226631.2
ENSMUST00000045776.5
ENSMUST00000226972.2
AI182371
expressed sequence AI182371
chr10_+_87695117 14.27 ENSMUST00000105300.9
Igf1
insulin-like growth factor 1
chr5_+_90608751 14.22 ENSMUST00000031314.10
Alb
albumin
chr15_+_10216041 13.47 ENSMUST00000130720.8
Prlr
prolactin receptor
chr3_+_129630380 13.44 ENSMUST00000077918.7
Cfi
complement component factor i
chr10_+_87694924 12.94 ENSMUST00000095360.11
Igf1
insulin-like growth factor 1
chr19_+_42034231 12.15 ENSMUST00000172244.8
ENSMUST00000081714.5
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
chr2_-_34951443 11.64 ENSMUST00000028233.7
Hc
hemolytic complement
chr1_+_88066086 11.53 ENSMUST00000014263.6
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr1_+_87998487 11.03 ENSMUST00000073772.5
Ugt1a9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr2_-_134396268 10.96 ENSMUST00000028704.3
Hao1
hydroxyacid oxidase 1, liver
chr8_-_122671588 9.60 ENSMUST00000057653.8
Car5a
carbonic anhydrase 5a, mitochondrial
chr5_+_31454939 9.32 ENSMUST00000201675.3
Gckr
glucokinase regulatory protein
chr5_+_35198853 9.24 ENSMUST00000030985.10
ENSMUST00000202573.2
Hgfac
hepatocyte growth factor activator
chr4_+_150938376 9.12 ENSMUST00000073600.9
Errfi1
ERBB receptor feedback inhibitor 1
chr2_-_32314017 8.42 ENSMUST00000113307.9
Slc25a25
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr4_+_138694422 8.19 ENSMUST00000116094.5
ENSMUST00000239443.2
Rnf186
ring finger protein 186
chr7_+_51537645 8.03 ENSMUST00000208711.2
Gas2
growth arrest specific 2
chr11_-_84058292 7.74 ENSMUST00000050771.8
Gm11437
predicted gene 11437
chr16_-_38253507 7.72 ENSMUST00000002926.8
Pla1a
phospholipase A1 member A
chr2_+_163389068 7.71 ENSMUST00000109411.8
ENSMUST00000018094.13
Hnf4a
hepatic nuclear factor 4, alpha
chr19_+_56276375 7.65 ENSMUST00000166049.8
Habp2
hyaluronic acid binding protein 2
chr1_+_172525613 7.45 ENSMUST00000038495.5
Crp
C-reactive protein, pentraxin-related
chr9_-_70841881 7.18 ENSMUST00000214995.2
Lipc
lipase, hepatic
chr11_-_11848107 6.99 ENSMUST00000178704.8
Ddc
dopa decarboxylase
chr11_+_70410445 6.98 ENSMUST00000179000.2
Gltpd2
glycolipid transfer protein domain containing 2
chr19_+_56276343 6.82 ENSMUST00000095948.11
Habp2
hyaluronic acid binding protein 2
chr5_+_31454787 6.71 ENSMUST00000201166.4
ENSMUST00000072228.9
Gckr
glucokinase regulatory protein
chrX_-_137985960 6.32 ENSMUST00000033626.15
ENSMUST00000060824.4
Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chrX_+_100420873 6.14 ENSMUST00000052130.14
Gjb1
gap junction protein, beta 1
chr11_-_11848044 6.01 ENSMUST00000066237.10
Ddc
dopa decarboxylase
chr10_-_125164399 5.98 ENSMUST00000063318.10
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr7_-_79492091 5.62 ENSMUST00000049004.8
Anpep
alanyl (membrane) aminopeptidase
chr5_+_24633206 5.59 ENSMUST00000115049.9
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr18_+_56533389 5.56 ENSMUST00000237355.2
ENSMUST00000237422.2
Gramd3
GRAM domain containing 3
chr12_-_103923145 5.54 ENSMUST00000085054.5
Serpina1e
serine (or cysteine) peptidase inhibitor, clade A, member 1E
chrX_-_137985979 5.54 ENSMUST00000152457.2
Serpina7
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr2_+_162829250 5.52 ENSMUST00000018012.14
Sgk2
serum/glucocorticoid regulated kinase 2
chr4_-_140344373 5.23 ENSMUST00000154979.2
Arhgef10l
Rho guanine nucleotide exchange factor (GEF) 10-like
chr13_+_55300453 5.06 ENSMUST00000005452.6
Fgfr4
fibroblast growth factor receptor 4
chr2_+_162829422 4.82 ENSMUST00000117123.2
Sgk2
serum/glucocorticoid regulated kinase 2
chr9_-_70842090 4.71 ENSMUST00000034731.10
Lipc
lipase, hepatic
chr2_+_163348728 4.27 ENSMUST00000143911.8
Hnf4a
hepatic nuclear factor 4, alpha
chr8_-_95869114 4.24 ENSMUST00000212554.2
ENSMUST00000169748.9
ENSMUST00000034240.15
Kifc3
kinesin family member C3
chr10_+_60925130 4.11 ENSMUST00000020298.8
Pcbd1
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr1_-_20688196 4.06 ENSMUST00000088448.12
Pkhd1
polycystic kidney and hepatic disease 1
chrX_+_100419965 4.06 ENSMUST00000119080.8
Gjb1
gap junction protein, beta 1
chr10_+_60925108 3.91 ENSMUST00000218005.2
Pcbd1
pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1
chr9_+_21746785 3.81 ENSMUST00000058777.8
Angptl8
angiopoietin-like 8
chr7_-_44711771 3.70 ENSMUST00000210101.2
ENSMUST00000209219.2
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr12_+_76580386 3.60 ENSMUST00000219063.2
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr17_+_12803019 3.20 ENSMUST00000046959.9
ENSMUST00000233066.2
Slc22a2
solute carrier family 22 (organic cation transporter), member 2
chr9_-_106035308 3.11 ENSMUST00000159809.2
ENSMUST00000162562.2
ENSMUST00000036382.13
Glyctk
glycerate kinase
chr9_-_106035332 3.03 ENSMUST00000112543.9
Glyctk
glycerate kinase
chr3_-_82957104 3.01 ENSMUST00000048246.5
Fgb
fibrinogen beta chain
chr1_+_133237516 2.92 ENSMUST00000094557.7
ENSMUST00000192465.2
ENSMUST00000193888.6
ENSMUST00000194044.6
ENSMUST00000184603.8
Golt1a
Gm28040
Gm28040
golgi transport 1A
predicted gene, 28040
predicted gene, 28040
chr11_+_70410009 2.90 ENSMUST00000057685.3
Gltpd2
glycolipid transfer protein domain containing 2
chr11_+_118319029 2.64 ENSMUST00000124861.2
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr19_-_43879031 2.63 ENSMUST00000212048.2
Dnmbp
dynamin binding protein
chr17_+_14087827 2.52 ENSMUST00000239324.2
Afdn
afadin, adherens junction formation factor
chr5_-_114796425 2.46 ENSMUST00000112225.8
ENSMUST00000071968.9
Trpv4
transient receptor potential cation channel, subfamily V, member 4
chr9_+_108925727 2.37 ENSMUST00000130366.2
Plxnb1
plexin B1
chr12_+_59142439 2.32 ENSMUST00000219140.3
Mia2
MIA SH3 domain ER export factor 2
chr6_-_52160816 2.23 ENSMUST00000134831.2
Hoxa3
homeobox A3
chr3_-_75177378 2.22 ENSMUST00000039047.5
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr12_-_103597663 1.94 ENSMUST00000121625.2
ENSMUST00000044231.12
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_91095597 1.94 ENSMUST00000028691.7
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr4_+_97665992 1.94 ENSMUST00000107062.9
ENSMUST00000052018.12
ENSMUST00000107057.8
Nfia
nuclear factor I/A
chr11_+_83742961 1.84 ENSMUST00000146786.8
Hnf1b
HNF1 homeobox B
chr12_-_103623418 1.80 ENSMUST00000044159.7
Serpina6
serine (or cysteine) peptidase inhibitor, clade A, member 6
chr10_+_34359395 1.68 ENSMUST00000019913.15
Frk
fyn-related kinase
chr4_-_32923505 1.57 ENSMUST00000084749.8
Ankrd6
ankyrin repeat domain 6
chr4_-_32923389 1.49 ENSMUST00000035719.11
Ankrd6
ankyrin repeat domain 6
chr10_+_34359513 1.45 ENSMUST00000170771.3
Frk
fyn-related kinase
chr3_+_94305824 1.44 ENSMUST00000050975.6
Lingo4
leucine rich repeat and Ig domain containing 4
chr17_-_35265702 1.43 ENSMUST00000097338.11
Msh5
mutS homolog 5
chr8_+_65399831 1.42 ENSMUST00000026595.13
ENSMUST00000209852.2
ENSMUST00000079896.9
Tmem192
transmembrane protein 192
chr3_+_82933383 1.37 ENSMUST00000029630.15
ENSMUST00000166581.4
Fga
fibrinogen alpha chain
chr4_-_139695337 1.35 ENSMUST00000105031.4
Klhdc7a
kelch domain containing 7A
chr4_+_97665843 1.30 ENSMUST00000075448.13
ENSMUST00000092532.13
Nfia
nuclear factor I/A
chr5_+_102992873 1.26 ENSMUST00000070000.6
Arhgap24
Rho GTPase activating protein 24
chr5_+_33261563 1.04 ENSMUST00000011178.5
Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr7_+_140796559 0.81 ENSMUST00000148975.3
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr7_+_140795866 0.79 ENSMUST00000210993.2
ENSMUST00000133763.8
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr11_+_115197980 0.78 ENSMUST00000055490.9
Otop2
otopetrin 2
chr2_+_74557418 0.73 ENSMUST00000111980.4
Hoxd4
homeobox D4
chr17_-_35351026 0.68 ENSMUST00000025249.7
Apom
apolipoprotein M
chr3_-_122778052 0.65 ENSMUST00000199401.2
ENSMUST00000197314.5
ENSMUST00000197934.5
ENSMUST00000090379.7
Usp53
ubiquitin specific peptidase 53
chr14_-_36641470 0.59 ENSMUST00000182042.2
Ccser2
coiled-coil serine rich 2
chr18_+_65158873 0.46 ENSMUST00000226058.2
Nedd4l
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr15_+_7840327 0.43 ENSMUST00000022744.5
Gdnf
glial cell line derived neurotrophic factor
chr14_-_36641270 0.32 ENSMUST00000182797.8
Ccser2
coiled-coil serine rich 2
chr7_+_140796096 0.31 ENSMUST00000153081.2
Rassf7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr6_-_52217821 0.27 ENSMUST00000121043.2
Hoxa10
homeobox A10
chr16_+_24266829 0.26 ENSMUST00000078988.10
Lpp
LIM domain containing preferred translocation partner in lipoma
chrX_-_42256694 0.23 ENSMUST00000115058.8
ENSMUST00000115059.8
Tenm1
teneurin transmembrane protein 1
chr15_-_58261093 0.22 ENSMUST00000227274.3
Anxa13
annexin A13
chr19_-_47907628 0.03 ENSMUST00000237029.2
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr11_-_78313043 0.02 ENSMUST00000001122.6
Slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 26.9 GO:0018879 biphenyl metabolic process(GO:0018879)
4.7 14.2 GO:0051659 maintenance of mitochondrion location(GO:0051659)
4.1 16.4 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
4.0 12.0 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
4.0 11.9 GO:0033189 response to vitamin A(GO:0033189)
3.9 27.2 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
3.3 16.4 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
3.1 15.6 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
3.0 12.2 GO:0009436 glyoxylate catabolic process(GO:0009436)
2.6 26.3 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
2.4 11.9 GO:0034371 chylomicron remodeling(GO:0034371)
2.3 11.6 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
2.3 16.0 GO:0009750 response to fructose(GO:0009750)
2.2 13.5 GO:0038161 prolactin signaling pathway(GO:0038161)
2.2 11.0 GO:0009441 glycolate metabolic process(GO:0009441)
2.1 22.6 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
1.9 13.0 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
1.7 5.1 GO:0061144 alveolar secondary septum development(GO:0061144)
1.5 9.1 GO:0010616 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
1.2 24.5 GO:0042359 vitamin D metabolic process(GO:0042359)
1.1 4.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.1 31.2 GO:0017144 drug metabolic process(GO:0017144)
1.1 16.8 GO:0006857 oligopeptide transport(GO:0006857)
0.9 7.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.9 10.2 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.9 6.0 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.8 2.5 GO:0071640 regulation of macrophage inflammatory protein 1 alpha production(GO:0071640)
0.8 8.0 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.6 3.8 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.6 4.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.6 2.4 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.5 1.8 GO:0061206 regulation of pronephros size(GO:0035565) mesonephros morphogenesis(GO:0061206) mesonephric nephron development(GO:0061215) mesonephric nephron morphogenesis(GO:0061228) mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis(GO:0061235) regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061295) negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:0061296) mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis(GO:1901146)
0.4 22.1 GO:0051180 vitamin transport(GO:0051180)
0.4 2.5 GO:0034334 adherens junction maintenance(GO:0034334)
0.4 64.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.4 2.2 GO:0021615 specification of organ position(GO:0010159) glossopharyngeal nerve morphogenesis(GO:0021615)
0.3 16.8 GO:0006953 acute-phase response(GO:0006953)
0.3 5.6 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.3 2.6 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.2 0.7 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.2 0.4 GO:0072107 regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107)
0.2 5.2 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.2 1.0 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.2 8.4 GO:0014823 response to activity(GO:0014823)
0.2 3.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 3.2 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.2 33.4 GO:0009267 cellular response to starvation(GO:0009267)
0.2 3.2 GO:0072189 ureter development(GO:0072189)
0.1 9.6 GO:0006094 gluconeogenesis(GO:0006094)
0.1 61.4 GO:0043434 response to peptide hormone(GO:0043434)
0.1 1.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 1.4 GO:0051026 chiasma assembly(GO:0051026)
0.1 4.1 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.1 2.3 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 10.4 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.1 5.6 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 8.0 GO:0007050 cell cycle arrest(GO:0007050)
0.0 3.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 5.6 GO:0016042 lipid catabolic process(GO:0016042)
0.0 0.7 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.3 GO:0060065 uterus development(GO:0060065)
0.0 3.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 27.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
2.6 15.6 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
1.8 26.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
1.5 11.6 GO:0005579 membrane attack complex(GO:0005579)
0.5 4.4 GO:0005577 fibrinogen complex(GO:0005577)
0.4 10.2 GO:0005922 connexon complex(GO:0005922)
0.4 5.6 GO:0031983 vesicle lumen(GO:0031983)
0.3 82.6 GO:0072562 blood microparticle(GO:0072562)
0.3 12.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.3 58.1 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.3 4.2 GO:0005915 zonula adherens(GO:0005915)
0.2 7.7 GO:0002080 acrosomal membrane(GO:0002080)
0.1 9.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 6.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 2.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 22.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 12.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 7.5 GO:0030175 filopodium(GO:0030175)
0.1 13.0 GO:0008021 synaptic vesicle(GO:0008021)
0.0 11.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 76.8 GO:0005794 Golgi apparatus(GO:0005794)
0.0 4.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 18.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.6 GO:0005581 collagen trimer(GO:0005581)
0.0 12.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.4 GO:0005770 late endosome(GO:0005770)
0.0 1.4 GO:0000795 synaptonemal complex(GO:0000795)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.2 27.5 GO:0008431 vitamin E binding(GO:0008431)
6.6 26.3 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
6.1 24.5 GO:1902271 D3 vitamins binding(GO:1902271)
4.0 12.0 GO:0070540 stearic acid binding(GO:0070540)
3.3 16.4 GO:0005350 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
3.3 19.6 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
3.2 13.0 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
3.0 12.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
2.7 11.0 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
2.7 13.5 GO:0004925 prolactin receptor activity(GO:0004925)
2.7 8.0 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
1.9 16.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
1.6 16.0 GO:0070095 fructose-6-phosphate binding(GO:0070095)
1.5 16.4 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.2 49.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
1.1 3.2 GO:0005333 acetylcholine transmembrane transporter activity(GO:0005277) norepinephrine transmembrane transporter activity(GO:0005333) acetate ester transmembrane transporter activity(GO:1901375)
1.0 15.6 GO:1990405 protein antigen binding(GO:1990405)
0.9 7.5 GO:0001849 complement component C1q binding(GO:0001849)
0.9 32.2 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.9 6.0 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.8 2.5 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.8 8.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.7 14.2 GO:0015643 toxic substance binding(GO:0015643)
0.6 10.2 GO:0005243 gap junction channel activity(GO:0005243)
0.6 27.2 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.5 83.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 9.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.5 5.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.4 10.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.3 5.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 32.5 GO:0004540 ribonuclease activity(GO:0004540)
0.2 11.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 5.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 2.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 2.5 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.4 GO:0030116 glial cell-derived neurotrophic factor receptor binding(GO:0030116)
0.1 4.2 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 23.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 10.7 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 8.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 3.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 9.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.6 GO:0005518 collagen binding(GO:0005518)
0.0 3.0 GO:0051087 chaperone binding(GO:0051087)
0.0 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.2 GO:1901611 phosphatidylglycerol binding(GO:1901611)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 16.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.4 27.2 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.4 20.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 26.3 PID FOXO PATHWAY FoxO family signaling
0.3 16.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 13.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 7.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 28.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 12.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 5.1 PID FGF PATHWAY FGF signaling pathway
0.1 4.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 6.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 3.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 5.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 3.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 6.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 32.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
3.5 38.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
1.3 14.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
1.2 20.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.2 16.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
1.0 13.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.9 7.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.7 42.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.6 13.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.6 24.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.5 15.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.5 10.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.5 13.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.4 11.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 6.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.3 10.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.3 5.1 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 3.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 8.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 4.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 18.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 2.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 5.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides