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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxa3

Z-value: 0.39

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Transcription factors associated with Hoxa3

Gene Symbol Gene ID Gene Info
ENSMUSG00000079560.14 homeobox A3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa3mm39_v1_chr6_-_52160816_521608370.231.8e-01Click!

Activity profile of Hoxa3 motif

Sorted Z-values of Hoxa3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_172994841 3.29 ENSMUST00000029017.6
phosphoenolpyruvate carboxykinase 1, cytosolic
chr19_-_7943365 2.77 ENSMUST00000182102.8
ENSMUST00000075619.5
solute carrier family 22, member 27
chr6_-_136758716 1.20 ENSMUST00000078095.11
ENSMUST00000032338.10
guanylate cyclase 2c
chr9_+_118892497 1.04 ENSMUST00000141185.8
ENSMUST00000126251.8
ENSMUST00000136561.2
villin-like
chr10_-_37014859 0.86 ENSMUST00000092584.6
myristoylated alanine rich protein kinase C substrate
chr5_+_90708962 0.84 ENSMUST00000094615.8
ENSMUST00000200765.2
albumin superfamily member 1
chr2_+_36120438 0.84 ENSMUST00000062069.6
prostaglandin-endoperoxide synthase 1
chr6_-_129449739 0.63 ENSMUST00000112076.9
ENSMUST00000184581.3
C-type lectin domain family 7, member a
chr3_+_159545309 0.61 ENSMUST00000068952.10
ENSMUST00000198878.2
wntless WNT ligand secretion mediator
chr11_-_107228382 0.50 ENSMUST00000040380.13
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_+_125529911 0.46 ENSMUST00000112254.8
ENSMUST00000112253.6
Von Willebrand factor
chr7_-_44753168 0.44 ENSMUST00000211085.2
ENSMUST00000210642.2
ENSMUST00000003512.9
Fc fragment of IgG receptor and transporter
chr2_-_27365633 0.35 ENSMUST00000138693.8
ENSMUST00000113941.9
ENSMUST00000077737.13
bromodomain containing 3
chr14_+_79753055 0.34 ENSMUST00000110835.3
ENSMUST00000227192.2
E74-like factor 1
chr12_+_59060162 0.27 ENSMUST00000021379.8
gem nuclear organelle associated protein 2
chr10_+_40225272 0.26 ENSMUST00000044672.11
ENSMUST00000095743.4
cyclin-dependent kinase 19
chr16_+_35861554 0.16 ENSMUST00000042203.10
WD repeat domain 5B
chr5_+_138185747 0.14 ENSMUST00000110934.9
canopy FGF signaling regulator 4
chr17_-_71160477 0.14 ENSMUST00000118283.8
TGFB-induced factor homeobox 1
chr9_+_40092216 0.10 ENSMUST00000218134.2
ENSMUST00000216720.2
ENSMUST00000214763.2
olfactory receptor 986
chr2_-_69542805 0.10 ENSMUST00000102706.4
ENSMUST00000073152.13
FAST kinase domains 1
chr1_-_171854818 0.09 ENSMUST00000138714.2
ENSMUST00000027837.13
ENSMUST00000111264.8
VANGL planar cell polarity 2
chr15_+_65682066 0.09 ENSMUST00000211878.2
EFR3 homolog A
chr2_-_168609110 0.08 ENSMUST00000029061.12
ENSMUST00000103074.2
spalt like transcription factor 4
chr14_+_65612788 0.08 ENSMUST00000224687.2
zinc finger protein 395
chr2_-_86109346 0.08 ENSMUST00000217294.2
ENSMUST00000217245.2
ENSMUST00000216432.2
olfactory receptor 1051
chr4_-_43710231 0.07 ENSMUST00000217544.2
ENSMUST00000107862.3
olfactory receptor 71
chr16_-_92196954 0.07 ENSMUST00000023672.10
regulator of calcineurin 1
chr3_+_55689921 0.06 ENSMUST00000075422.6
mab-21-like 1
chr2_-_111843053 0.04 ENSMUST00000213559.3
olfactory receptor 1310
chr1_-_173018204 0.02 ENSMUST00000215878.2
ENSMUST00000201132.3
olfactory receptor 1406
chr7_-_115637970 0.02 ENSMUST00000166877.8
SRY (sex determining region Y)-box 6
chr18_-_38336893 0.02 ENSMUST00000194312.2
protocadherin 1
chr14_-_50586329 0.01 ENSMUST00000216634.2
olfactory receptor 735
chr11_-_99265721 0.01 ENSMUST00000006963.3
keratin 28

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0061402 glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
0.2 0.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 2.8 GO:0015747 urate transport(GO:0015747)
0.1 0.8 GO:0019371 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.9 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.2 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 1.0 GO:0051693 actin filament capping(GO:0051693)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0042585 germinal vesicle(GO:0042585)
0.0 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.2 2.8 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 1.2 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.5 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 0.9 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.8 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds