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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxb4

Z-value: 0.63

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Transcription factors associated with Hoxb4

Gene Symbol Gene ID Gene Info
Hoxb4
ENSMUSG00000038692.9 homeobox B4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb4mm39_v1_chr11_+_96209093_96209093-0.325.9e-02Click!

Activity profile of Hoxb4 motif

Sorted Z-values of Hoxb4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_20329823 10.94 ENSMUST00000011607.6
Cpb1
carboxypeptidase B1 (tissue)
chr7_+_130633776 9.19 ENSMUST00000084509.7
ENSMUST00000213064.3
ENSMUST00000208311.4
Dmbt1
deleted in malignant brain tumors 1
chr2_-_84605732 2.10 ENSMUST00000023994.10
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84605764 2.10 ENSMUST00000111641.2
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr6_+_116627567 1.77 ENSMUST00000067354.10
ENSMUST00000178241.4
Depp1
DEPP1 autophagy regulator
chr2_+_102488985 1.62 ENSMUST00000080210.10
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_+_116627635 1.62 ENSMUST00000204555.2
Depp1
DEPP1 autophagy regulator
chr4_+_43493344 1.60 ENSMUST00000030181.12
ENSMUST00000107922.3
Ccdc107
coiled-coil domain containing 107
chrX_-_8059597 1.20 ENSMUST00000143223.2
ENSMUST00000033509.15
Ebp
phenylalkylamine Ca2+ antagonist (emopamil) binding protein
chr18_-_56695288 1.16 ENSMUST00000170309.8
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr18_-_56695333 1.14 ENSMUST00000066208.13
ENSMUST00000172734.8
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr18_-_56695259 1.10 ENSMUST00000171844.3
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr10_-_59452489 0.91 ENSMUST00000020312.13
Mcu
mitochondrial calcium uniporter
chr10_-_41585293 0.67 ENSMUST00000019955.16
ENSMUST00000099932.10
Ccdc162
coiled-coil domain containing 162
chr7_+_29931309 0.60 ENSMUST00000019882.16
ENSMUST00000149654.8
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr8_+_120955195 0.55 ENSMUST00000180448.3
Gse1
genetic suppressor element 1, coiled-coil protein
chr7_+_29931735 0.55 ENSMUST00000108193.2
ENSMUST00000108192.2
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr10_-_89457115 0.49 ENSMUST00000020102.14
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr1_-_171050077 0.48 ENSMUST00000005817.9
Tomm40l
translocase of outer mitochondrial membrane 40-like
chr17_+_44263890 0.46 ENSMUST00000177857.9
ENSMUST00000044792.6
Rcan2
regulator of calcineurin 2
chr1_-_171050004 0.35 ENSMUST00000147246.2
ENSMUST00000111326.8
ENSMUST00000138184.8
Tomm40l
translocase of outer mitochondrial membrane 40-like
chrX_-_142716085 0.32 ENSMUST00000087313.10
Dcx
doublecortin
chr11_+_85243970 0.30 ENSMUST00000108056.8
ENSMUST00000108061.8
ENSMUST00000108062.8
ENSMUST00000138423.8
ENSMUST00000092821.10
ENSMUST00000074875.11
Bcas3
breast carcinoma amplified sequence 3
chr16_-_19226828 0.27 ENSMUST00000052516.5
ENSMUST00000206410.3
Olfr165
olfactory receptor 165
chr16_-_94171340 0.24 ENSMUST00000138514.2
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr7_+_144391786 0.23 ENSMUST00000155320.8
Fgf3
fibroblast growth factor 3
chr14_+_58308004 0.23 ENSMUST00000165526.9
Fgf9
fibroblast growth factor 9
chr2_-_38604503 0.23 ENSMUST00000028084.5
Nr5a1
nuclear receptor subfamily 5, group A, member 1
chr7_-_29931612 0.19 ENSMUST00000006254.6
Tbcb
tubulin folding cofactor B
chr8_-_23295603 0.18 ENSMUST00000163739.3
ENSMUST00000210656.2
Ap3m2
adaptor-related protein complex 3, mu 2 subunit
chr18_+_61820982 0.14 ENSMUST00000025471.4
Il17b
interleukin 17B
chr3_-_51184730 0.13 ENSMUST00000195432.2
ENSMUST00000091144.11
ENSMUST00000156983.3
Elf2
E74-like factor 2
chrX_+_165127688 0.13 ENSMUST00000112223.8
ENSMUST00000112224.8
ENSMUST00000112229.9
ENSMUST00000112228.8
ENSMUST00000112227.9
ENSMUST00000112226.3
Gpm6b
glycoprotein m6b
chr3_-_144804784 0.11 ENSMUST00000040465.11
ENSMUST00000198993.2
Clca2
chloride channel accessory 2
chr8_-_106198112 0.11 ENSMUST00000014990.13
Tppp3
tubulin polymerization-promoting protein family member 3
chr4_+_58285957 0.10 ENSMUST00000081919.12
ENSMUST00000177951.8
ENSMUST00000098059.10
ENSMUST00000179951.2
ENSMUST00000102893.10
ENSMUST00000084578.12
ENSMUST00000098057.10
Musk
muscle, skeletal, receptor tyrosine kinase
chr1_+_11063678 0.09 ENSMUST00000027056.12
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chrX_-_142716200 0.09 ENSMUST00000112851.8
ENSMUST00000112856.3
ENSMUST00000033642.10
Dcx
doublecortin
chr9_+_40092216 0.08 ENSMUST00000218134.2
ENSMUST00000216720.2
ENSMUST00000214763.2
Olfr986
olfactory receptor 986
chr2_-_118987305 0.08 ENSMUST00000135419.8
ENSMUST00000129351.2
ENSMUST00000139519.2
ENSMUST00000094695.12
Rmdn3
regulator of microtubule dynamics 3
chr3_-_54621774 0.07 ENSMUST00000178832.2
Gm21958
predicted gene, 21958
chr1_+_146373352 0.05 ENSMUST00000132847.8
ENSMUST00000166814.8
Brinp3
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr16_-_37205302 0.04 ENSMUST00000114781.8
ENSMUST00000114780.8
Stxbp5l
syntaxin binding protein 5-like
chr14_+_32972324 0.03 ENSMUST00000131086.3
Arhgap22
Rho GTPase activating protein 22
chr15_+_101013704 0.01 ENSMUST00000229954.2
Ankrd33
ankyrin repeat domain 33

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.4 9.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 1.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 1.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 0.8 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.5 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.5 GO:0007614 short-term memory(GO:0007614)
0.0 0.1 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.0 1.2 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 0.2 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.2 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.8 GO:1990246 uniplex complex(GO:1990246)
0.1 0.5 GO:0097441 basilar dendrite(GO:0097441)
0.1 0.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 1.6 GO:0030673 axolemma(GO:0030673)
0.0 4.2 GO:0072562 blood microparticle(GO:0072562)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.4 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.4 10.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 0.9 GO:0015292 uniporter activity(GO:0015292)
0.3 1.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 4.2 GO:0001848 complement binding(GO:0001848)
0.2 9.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.8 GO:0015288 porin activity(GO:0015288)
0.1 0.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 9.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.1 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.1 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.5 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 3.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives