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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxb6

Z-value: 0.32

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Transcription factors associated with Hoxb6

Gene Symbol Gene ID Gene Info
Hoxb6
ENSMUSG00000000690.6 homeobox B6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb6mm39_v1_chr11_+_96183294_961833340.251.5e-01Click!

Activity profile of Hoxb6 motif

Sorted Z-values of Hoxb6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_164611812 3.97 ENSMUST00000088248.13
ENSMUST00000001439.7
Ube2c
ubiquitin-conjugating enzyme E2C
chr15_+_34306812 1.40 ENSMUST00000226766.2
ENSMUST00000163455.9
ENSMUST00000022947.7
ENSMUST00000228570.2
ENSMUST00000227759.2
Matn2
matrilin 2
chr6_+_86348286 1.28 ENSMUST00000089558.7
Snrpg
small nuclear ribonucleoprotein polypeptide G
chr10_-_117628565 1.23 ENSMUST00000167943.8
ENSMUST00000064848.7
Nup107
nucleoporin 107
chr13_-_22017677 1.09 ENSMUST00000081342.7
H2ac24
H2A clustered histone 24
chr3_-_100876960 0.88 ENSMUST00000076941.12
Ttf2
transcription termination factor, RNA polymerase II
chr6_+_142244145 0.79 ENSMUST00000041993.3
Iapp
islet amyloid polypeptide
chr11_-_96868483 0.79 ENSMUST00000107624.8
Sp2
Sp2 transcription factor
chr2_+_85809620 0.77 ENSMUST00000056849.3
Olfr1030
olfactory receptor 1030
chr16_-_19079594 0.71 ENSMUST00000103752.3
ENSMUST00000197518.2
Iglv2
immunoglobulin lambda variable 2
chr7_-_115459082 0.68 ENSMUST00000206123.2
Sox6
SRY (sex determining region Y)-box 6
chr11_-_99134885 0.64 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr16_-_18904240 0.63 ENSMUST00000103746.3
Iglv1
immunoglobulin lambda variable 1
chr2_+_29236815 0.54 ENSMUST00000028139.11
ENSMUST00000113830.11
Med27
mediator complex subunit 27
chrX_-_100266032 0.50 ENSMUST00000120389.8
ENSMUST00000156473.8
ENSMUST00000077876.4
Snx12
sorting nexin 12
chr9_-_56151334 0.47 ENSMUST00000188142.7
Peak1
pseudopodium-enriched atypical kinase 1
chr3_+_94320548 0.47 ENSMUST00000166032.8
ENSMUST00000200486.5
ENSMUST00000196386.5
ENSMUST00000045245.10
ENSMUST00000197901.5
ENSMUST00000198041.2
Tdrkh
Gm42463
tudor and KH domain containing protein
predicted gene 42463
chrX_-_8118541 0.46 ENSMUST00000115594.8
ENSMUST00000115595.8
ENSMUST00000033513.10
Ftsj1
FtsJ RNA methyltransferase homolog 1 (E. coli)
chr16_+_44167484 0.45 ENSMUST00000050897.7
Spice1
spindle and centriole associated protein 1
chr8_-_106198112 0.43 ENSMUST00000014990.13
Tppp3
tubulin polymerization-promoting protein family member 3
chr1_-_138103021 0.42 ENSMUST00000182755.8
ENSMUST00000193650.2
ENSMUST00000182283.8
Ptprc
protein tyrosine phosphatase, receptor type, C
chr11_-_74615496 0.40 ENSMUST00000021091.15
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr13_+_65298054 0.40 ENSMUST00000214214.2
Olfr466
olfactory receptor 466
chr14_-_57353340 0.38 ENSMUST00000159455.2
Gm4491
predicted gene 4491
chr1_-_36312482 0.37 ENSMUST00000056946.8
Neurl3
neuralized E3 ubiquitin protein ligase 3
chr9_-_35481689 0.31 ENSMUST00000115110.5
Hyls1
HYLS1, centriolar and ciliogenesis associated
chr7_-_28661648 0.25 ENSMUST00000127210.8
Actn4
actinin alpha 4
chr3_+_138058139 0.25 ENSMUST00000090166.5
Adh6b
alcohol dehydrogenase 6B (class V)
chr8_+_31601837 0.25 ENSMUST00000046941.8
ENSMUST00000217278.2
Rnf122
ring finger protein 122
chr1_-_138102972 0.24 ENSMUST00000195533.6
ENSMUST00000183301.8
Ptprc
protein tyrosine phosphatase, receptor type, C
chr1_-_179572765 0.24 ENSMUST00000211943.3
ENSMUST00000131716.4
ENSMUST00000221136.2
Kif28
kinesin family member 28
chr5_-_123804745 0.24 ENSMUST00000149410.2
Clip1
CAP-GLY domain containing linker protein 1
chr1_+_106866678 0.23 ENSMUST00000112724.3
Serpinb12
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12
chr3_+_64884839 0.21 ENSMUST00000239069.2
Kcnab1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr9_+_74959259 0.21 ENSMUST00000170310.2
ENSMUST00000166549.2
Arpp19
cAMP-regulated phosphoprotein 19
chr11_+_49410475 0.20 ENSMUST00000204706.3
Olfr1383
olfactory receptor 1383
chr2_-_88157559 0.19 ENSMUST00000214207.2
Olfr1175
olfactory receptor 1175
chr3_-_79053182 0.16 ENSMUST00000118340.7
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr11_-_72106418 0.15 ENSMUST00000021157.9
Med31
mediator complex subunit 31
chr2_-_125701059 0.14 ENSMUST00000110463.8
ENSMUST00000028635.6
Cops2
COP9 signalosome subunit 2
chrX_+_162945162 0.14 ENSMUST00000131543.2
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr4_-_52919172 0.14 ENSMUST00000107667.3
ENSMUST00000213989.2
Olfr272
olfactory receptor 272
chrX_+_106132055 0.14 ENSMUST00000150494.2
P2ry10
purinergic receptor P2Y, G-protein coupled 10
chr18_+_37864045 0.12 ENSMUST00000192535.2
Pcdhgb5
protocadherin gamma subfamily B, 5
chr17_+_18518361 0.11 ENSMUST00000231938.2
ENSMUST00000079206.8
ENSMUST00000231879.3
Vmn2r93
vomeronasal 2, receptor 93
chr3_+_66892979 0.10 ENSMUST00000162362.8
ENSMUST00000065074.14
ENSMUST00000065047.13
Rsrc1
arginine/serine-rich coiled-coil 1
chr4_+_151081538 0.10 ENSMUST00000030803.2
Uts2
urotensin 2
chrX_+_56257374 0.08 ENSMUST00000033466.2
Cd40lg
CD40 ligand
chr7_-_28661751 0.07 ENSMUST00000068045.14
ENSMUST00000217157.2
Actn4
actinin alpha 4
chr16_+_58967409 0.07 ENSMUST00000216957.3
Olfr195
olfactory receptor 195
chr2_-_86589298 0.07 ENSMUST00000215991.2
ENSMUST00000217043.3
Olfr1090
olfactory receptor 1090
chr11_-_65636651 0.07 ENSMUST00000138093.2
Map2k4
mitogen-activated protein kinase kinase 4
chr6_-_69245427 0.06 ENSMUST00000103348.3
Igkv4-70
immunoglobulin kappa chain variable 4-70
chr6_-_3494587 0.06 ENSMUST00000049985.15
Hepacam2
HEPACAM family member 2
chr5_-_31684036 0.05 ENSMUST00000202421.2
ENSMUST00000201769.4
ENSMUST00000065388.11
Supt7l
SPT7-like, STAGA complex gamma subunit
chr10_+_78816884 0.05 ENSMUST00000058991.5
ENSMUST00000203973.2
Olfr1352
olfactory receptor 1352
chr1_+_161222980 0.05 ENSMUST00000028024.5
Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
chr7_-_38227617 0.04 ENSMUST00000079759.6
Gm5591
predicted gene 5591
chr4_+_15881256 0.04 ENSMUST00000029876.2
Calb1
calbindin 1
chr5_-_52723607 0.03 ENSMUST00000199942.5
Lgi2
leucine-rich repeat LGI family, member 2
chr6_+_142359099 0.03 ENSMUST00000126521.9
ENSMUST00000211094.2
Spx
spexin hormone
chr7_+_108019628 0.02 ENSMUST00000213521.3
Olfr497
olfactory receptor 497
chr19_+_4189786 0.02 ENSMUST00000096338.5
Gpr152
G protein-coupled receptor 152
chr10_-_38998272 0.01 ENSMUST00000136546.8
Fam229b
family with sequence similarity 229, member B
chr4_+_33062999 0.01 ENSMUST00000108162.8
ENSMUST00000024035.9
Gabrr2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr19_+_46385448 0.00 ENSMUST00000118440.3
Sufu
SUFU negative regulator of hedgehog signaling

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.5 1.4 GO:0031104 dendrite regeneration(GO:0031104)
0.2 1.2 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.2 0.5 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 0.7 GO:2000473 regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.1 0.8 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.3 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.2 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.9 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.1 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.0 0.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0 0.1 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.0 0.5 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.5 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 0.0 GO:0043382 defense response to nematode(GO:0002215) positive regulation of memory T cell differentiation(GO:0043382) negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.3 GO:0005687 U4 snRNP(GO:0005687)
0.1 1.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.5 GO:0071547 piP-body(GO:0071547)
0.0 0.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.4 GO:0000235 astral microtubule(GO:0000235)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 4.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.5 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 1.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.4 GO:0070840 dynein complex binding(GO:0070840)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 1.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.7 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 1.2 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.8 REACTOME AMYLOIDS Genes involved in Amyloids