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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc6

Z-value: 0.67

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Transcription factors associated with Hoxc6

Gene Symbol Gene ID Gene Info
Hoxc6
ENSMUSG00000001661.6 homeobox C6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc6mm39_v1_chr15_+_102917977_102918011-0.299.1e-02Click!

Activity profile of Hoxc6 motif

Sorted Z-values of Hoxc6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39275518 9.45 ENSMUST00000003137.15
Cyp2c29
cytochrome P450, family 2, subfamily c, polypeptide 29
chr7_+_51537645 2.39 ENSMUST00000208711.2
Gas2
growth arrest specific 2
chr18_-_56705960 2.13 ENSMUST00000174518.8
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr19_+_32597379 2.07 ENSMUST00000236290.2
ENSMUST00000025833.7
Papss2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr1_+_88062508 1.93 ENSMUST00000113134.8
ENSMUST00000140092.8
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr3_+_151143524 1.86 ENSMUST00000046977.12
Adgrl4
adhesion G protein-coupled receptor L4
chr19_+_26725589 1.72 ENSMUST00000207812.2
ENSMUST00000175791.9
ENSMUST00000207118.2
ENSMUST00000209085.2
ENSMUST00000112637.10
ENSMUST00000207054.2
ENSMUST00000208589.2
ENSMUST00000176475.9
ENSMUST00000176698.9
ENSMUST00000207832.2
ENSMUST00000177252.9
ENSMUST00000208712.2
ENSMUST00000208186.2
ENSMUST00000208806.2
ENSMUST00000208027.2
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_+_88030951 1.72 ENSMUST00000113135.6
ENSMUST00000113138.8
Ugt1a7c
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A7C
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr14_-_64654397 1.61 ENSMUST00000210428.2
Msra
methionine sulfoxide reductase A
chrM_-_14061 1.28 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chrM_+_14138 1.26 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr19_+_24853039 1.23 ENSMUST00000073080.7
Gm10053
predicted gene 10053
chr14_-_64654592 1.11 ENSMUST00000210363.2
Msra
methionine sulfoxide reductase A
chr15_+_44482667 1.02 ENSMUST00000228648.2
ENSMUST00000226165.2
Ebag9
estrogen receptor-binding fragment-associated gene 9
chrX_-_93256291 1.01 ENSMUST00000050328.15
Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chrM_+_9459 1.00 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr15_+_44482944 0.94 ENSMUST00000022964.9
Ebag9
estrogen receptor-binding fragment-associated gene 9
chr3_+_151143557 0.84 ENSMUST00000196970.3
Adgrl4
adhesion G protein-coupled receptor L4
chr19_+_39499288 0.82 ENSMUST00000025968.5
Cyp2c39
cytochrome P450, family 2, subfamily c, polypeptide 39
chr7_-_13856967 0.77 ENSMUST00000098809.4
Sult2a3
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
chr14_+_79086492 0.74 ENSMUST00000040990.7
Vwa8
von Willebrand factor A domain containing 8
chr1_+_171052623 0.71 ENSMUST00000111321.8
ENSMUST00000005824.12
ENSMUST00000111320.8
ENSMUST00000111319.2
Apoa2
apolipoprotein A-II
chr3_+_66893031 0.70 ENSMUST00000046542.13
ENSMUST00000162693.8
Rsrc1
arginine/serine-rich coiled-coil 1
chr18_+_56705894 0.60 ENSMUST00000008445.7
Phax
phosphorylated adaptor for RNA export
chr2_-_121211410 0.58 ENSMUST00000038389.15
Strc
stereocilin
chr1_+_46464625 0.56 ENSMUST00000189749.7
Dnah7c
dynein, axonemal, heavy chain 7C
chr8_-_23196523 0.55 ENSMUST00000033939.13
ENSMUST00000063401.10
Ikbkb
inhibitor of kappaB kinase beta
chr11_-_23845207 0.54 ENSMUST00000102863.3
ENSMUST00000020513.10
Papolg
poly(A) polymerase gamma
chr9_+_40092216 0.51 ENSMUST00000218134.2
ENSMUST00000216720.2
ENSMUST00000214763.2
Olfr986
olfactory receptor 986
chr3_+_66892979 0.50 ENSMUST00000162362.8
ENSMUST00000065074.14
ENSMUST00000065047.13
Rsrc1
arginine/serine-rich coiled-coil 1
chr5_+_24618380 0.48 ENSMUST00000049346.10
Asic3
acid-sensing (proton-gated) ion channel 3
chrX_-_93256244 0.46 ENSMUST00000113922.2
Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr14_+_75479727 0.46 ENSMUST00000022576.10
Cpb2
carboxypeptidase B2 (plasma)
chrX_-_104918911 0.41 ENSMUST00000200471.2
Atrx
ATRX, chromatin remodeler
chr13_+_93440572 0.41 ENSMUST00000109493.9
Homer1
homer scaffolding protein 1
chr2_-_51039112 0.40 ENSMUST00000154545.2
ENSMUST00000017288.9
Rnd3
Rho family GTPase 3
chrM_+_8603 0.40 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr11_-_94673526 0.39 ENSMUST00000100554.8
Tmem92
transmembrane protein 92
chr8_+_46111778 0.37 ENSMUST00000143820.8
Sorbs2
sorbin and SH3 domain containing 2
chr10_-_112764879 0.37 ENSMUST00000099276.4
Atxn7l3b
ataxin 7-like 3B
chr15_-_50752437 0.36 ENSMUST00000183997.8
ENSMUST00000183757.8
Trps1
transcriptional repressor GATA binding 1
chrX_-_135642025 0.35 ENSMUST00000155207.8
ENSMUST00000080411.13
ENSMUST00000169418.8
Morf4l2
mortality factor 4 like 2
chr10_+_61010983 0.34 ENSMUST00000143207.8
ENSMUST00000148181.8
ENSMUST00000151886.8
Tbata
thymus, brain and testes associated
chr6_+_11926757 0.33 ENSMUST00000133776.2
Phf14
PHD finger protein 14
chr1_-_85239791 0.31 ENSMUST00000162421.2
C130026I21Rik
RIKEN cDNA C130026I21 gene
chr3_-_144738526 0.31 ENSMUST00000029919.7
Clca1
chloride channel accessory 1
chr17_+_3532455 0.31 ENSMUST00000227604.2
Tiam2
T cell lymphoma invasion and metastasis 2
chr7_+_45204350 0.30 ENSMUST00000210300.2
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr13_+_93441307 0.29 ENSMUST00000080127.12
Homer1
homer scaffolding protein 1
chr5_-_129030367 0.28 ENSMUST00000111346.6
ENSMUST00000200470.5
Rimbp2
RIMS binding protein 2
chr1_-_53745920 0.27 ENSMUST00000094964.7
Dnah7a
dynein, axonemal, heavy chain 7A
chrX_-_142716085 0.26 ENSMUST00000087313.10
Dcx
doublecortin
chr11_-_70560110 0.24 ENSMUST00000129434.2
ENSMUST00000018431.13
Spag7
sperm associated antigen 7
chr1_-_22386016 0.23 ENSMUST00000164877.8
Rims1
regulating synaptic membrane exocytosis 1
chr10_+_23814470 0.22 ENSMUST00000079134.5
Taar2
trace amine-associated receptor 2
chr6_-_30693675 0.22 ENSMUST00000169422.8
ENSMUST00000115131.8
ENSMUST00000115130.3
ENSMUST00000031810.15
Cep41
centrosomal protein 41
chr3_-_129518723 0.22 ENSMUST00000199615.5
ENSMUST00000197079.5
Egf
epidermal growth factor
chr17_-_29162794 0.21 ENSMUST00000232977.2
Pxt1
peroxisomal, testis specific 1
chr6_-_123830422 0.20 ENSMUST00000162046.3
Vmn2r25
vomeronasal 2, receptor 25
chr5_-_129030111 0.20 ENSMUST00000196085.5
Rimbp2
RIMS binding protein 2
chr9_-_19088608 0.20 ENSMUST00000212127.3
Olfr839-ps1
olfactory receptor 839, pseudogene 1
chr11_+_58556387 0.20 ENSMUST00000072030.4
Olfr322
olfactory receptor 322
chrX_-_142716200 0.19 ENSMUST00000112851.8
ENSMUST00000112856.3
ENSMUST00000033642.10
Dcx
doublecortin
chr10_-_100425067 0.18 ENSMUST00000218821.2
ENSMUST00000054471.10
4930430F08Rik
RIKEN cDNA 4930430F08 gene
chr5_-_110194352 0.18 ENSMUST00000167969.2
Gm17655
predicted gene, 17655
chr9_+_65268304 0.18 ENSMUST00000147185.3
Ubap1l
ubiquitin-associated protein 1-like
chr17_+_13094921 0.16 ENSMUST00000075296.4
Mrgprh
MAS-related GPR, member H
chr14_-_52616625 0.15 ENSMUST00000214980.2
Olfr1512
olfactory receptor 1512
chr7_-_85974838 0.15 ENSMUST00000214977.2
Olfr308
olfactory receptor 308
chr14_-_50586329 0.15 ENSMUST00000216634.2
Olfr735
olfactory receptor 735
chrX_-_135641869 0.14 ENSMUST00000166930.8
ENSMUST00000113095.8
Morf4l2
mortality factor 4 like 2
chr10_-_108535970 0.14 ENSMUST00000218023.2
Gm5136
predicted gene 5136
chr8_-_55177510 0.13 ENSMUST00000175915.8
Wdr17
WD repeat domain 17
chr10_-_70491764 0.13 ENSMUST00000162144.2
ENSMUST00000162793.8
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr4_-_84464521 0.12 ENSMUST00000177040.2
Bnc2
basonuclin 2
chr17_+_38082190 0.11 ENSMUST00000217119.2
Olfr122
olfactory receptor 122
chr10_+_19588318 0.11 ENSMUST00000020185.5
Il20ra
interleukin 20 receptor, alpha
chr6_-_53955647 0.11 ENSMUST00000204674.3
ENSMUST00000166545.2
ENSMUST00000203101.3
Cpvl
carboxypeptidase, vitellogenic-like
chr7_-_16019379 0.11 ENSMUST00000174270.8
Ccdc9
coiled-coil domain containing 9
chrX_+_111150171 0.10 ENSMUST00000164272.3
ENSMUST00000132037.2
4933403O08Rik
RIKEN cDNA 4933403O08 gene
chr7_+_108064533 0.09 ENSMUST00000217616.3
Olfr498
olfactory receptor 498
chr3_+_5283606 0.09 ENSMUST00000026284.13
Zfhx4
zinc finger homeodomain 4
chrX_-_104919201 0.05 ENSMUST00000198209.2
Atrx
ATRX, chromatin remodeler
chr5_+_17779273 0.05 ENSMUST00000030568.14
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr4_+_147445744 0.05 ENSMUST00000133078.8
ENSMUST00000154154.2
Zfp978
zinc finger protein 978
chr6_+_36364990 0.05 ENSMUST00000172278.8
Chrm2
cholinergic receptor, muscarinic 2, cardiac
chr9_-_39161290 0.04 ENSMUST00000213472.2
Olfr1537
olfactory receptor 1537
chr19_+_12972378 0.04 ENSMUST00000207997.3
Olfr1451
olfactory receptor 1451
chr8_-_10026292 0.01 ENSMUST00000095476.6
Lig4
ligase IV, DNA, ATP-dependent

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0006711 estrogen catabolic process(GO:0006711)
0.5 2.1 GO:0034036 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.3 10.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.2 1.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 0.6 GO:0051030 snRNA transport(GO:0051030)
0.2 1.9 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 0.7 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901) diacylglycerol catabolic process(GO:0046340)
0.2 1.3 GO:0033762 response to glucagon(GO:0033762)
0.2 0.5 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.6 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 0.5 GO:0050968 sensory perception of sour taste(GO:0050915) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.1 0.5 GO:1901581 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1 0.3 GO:2000583 regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.1 0.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.8 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.2 GO:0007262 STAT protein import into nucleus(GO:0007262) negative regulation of cholesterol efflux(GO:0090370)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 1.2 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.0 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 1.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 0.5 GO:1990707 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 1.7 GO:0071564 npBAF complex(GO:0071564)
0.1 0.8 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.6 GO:0060091 kinocilium(GO:0060091)
0.0 0.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 2.3 GO:0070469 respiratory chain(GO:0070469)
0.0 0.5 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.7 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 10.3 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.7 2.7 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.5 2.1 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.5 2.1 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 0.7 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.2 1.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.8 GO:0050656 alcohol sulfotransferase activity(GO:0004027) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.6 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 3.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.8 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 1.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0001595 angiotensin receptor activity(GO:0001595)
0.0 1.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.0 GO:1990763 arrestin family protein binding(GO:1990763)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.7 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle