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GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc9

Z-value: 0.53

Motif logo

Transcription factors associated with Hoxc9

Gene Symbol Gene ID Gene Info
ENSMUSG00000036139.7 homeobox C9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc9mm39_v1_chr15_+_102884874_102884874-0.029.0e-01Click!

Activity profile of Hoxc9 motif

Sorted Z-values of Hoxc9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_102488985 2.83 ENSMUST00000080210.10
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_+_51537645 2.10 ENSMUST00000208711.2
growth arrest specific 2
chr4_-_109059414 1.83 ENSMUST00000160774.8
ENSMUST00000194478.6
ENSMUST00000030288.14
ENSMUST00000162787.9
oxysterol binding protein-like 9
chr2_+_70305267 1.73 ENSMUST00000100043.3
trans-acting transcription factor 5
chr7_+_130633776 1.33 ENSMUST00000084509.7
ENSMUST00000213064.3
ENSMUST00000208311.4
deleted in malignant brain tumors 1
chr4_+_135870808 1.14 ENSMUST00000008016.3
inhibitor of DNA binding 3
chr6_-_119365632 1.07 ENSMUST00000169744.8
adiponectin receptor 2
chr19_+_24853039 0.96 ENSMUST00000073080.7
predicted gene 10053
chr17_-_29768531 0.85 ENSMUST00000168339.3
ENSMUST00000114683.10
ENSMUST00000234620.2
transmembrane protein 217
chr2_+_3514071 0.84 ENSMUST00000036350.3
cerebral dopamine neurotrophic factor
chr10_-_125225298 0.82 ENSMUST00000210780.2
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr1_+_11484313 0.80 ENSMUST00000171690.9
ENSMUST00000048613.14
RIKEN cDNA A830018L16 gene
chr8_+_120955195 0.76 ENSMUST00000180448.3
genetic suppressor element 1, coiled-coil protein
chr15_-_89263790 0.76 ENSMUST00000238996.2
outer dense fiber of sperm tails 3B
chr4_-_91264670 0.73 ENSMUST00000107109.9
ENSMUST00000107111.9
ENSMUST00000107120.8
ELAV like RNA binding protein 1
chrX_-_104972150 0.71 ENSMUST00000101305.9
ATRX, chromatin remodeler
chr1_+_11484489 0.69 ENSMUST00000135014.8
RIKEN cDNA A830018L16 gene
chr6_+_54246120 0.68 ENSMUST00000114401.8
chimerin 2
chr4_-_91264727 0.67 ENSMUST00000107124.10
ELAV like RNA binding protein 1
chr5_-_132570710 0.67 ENSMUST00000182974.9
autism susceptibility candidate 2
chr10_-_67748461 0.62 ENSMUST00000064656.8
zinc finger protein 365
chr7_-_139162706 0.61 ENSMUST00000106095.3
NK6 homeobox 2
chr5_+_67417908 0.58 ENSMUST00000037918.12
ENSMUST00000162543.8
ENSMUST00000161233.8
ENSMUST00000160352.8
transmembrane protein 33
chr5_+_100054110 0.58 ENSMUST00000198837.3
vesicle-associated membrane protein 9
chrX_-_18327610 0.56 ENSMUST00000044188.5
divergent protein kinase domain 2B
chr2_-_34261121 0.52 ENSMUST00000127353.3
ENSMUST00000141653.3
pre B cell leukemia homeobox 3
chr4_+_118217179 0.52 ENSMUST00000006562.6
hydroxypyruvate isomerase (putative)
chr13_-_40891849 0.48 ENSMUST00000223869.2
transcription factor AP-2, alpha
chr2_-_38604503 0.47 ENSMUST00000028084.5
nuclear receptor subfamily 5, group A, member 1
chr1_+_60948149 0.45 ENSMUST00000027164.9
cytotoxic T-lymphocyte-associated protein 4
chr11_+_98555167 0.43 ENSMUST00000017348.3
gasdermin A
chr12_-_99529767 0.42 ENSMUST00000176928.3
ENSMUST00000223484.2
forkhead box N3
chr6_-_52190299 0.42 ENSMUST00000128102.4
predicted gene 28308
chr3_-_51184730 0.41 ENSMUST00000195432.2
ENSMUST00000091144.11
ENSMUST00000156983.3
E74-like factor 2
chr15_+_37425798 0.40 ENSMUST00000022897.2
RIKEN cDNA 4930447A16 gene
chr8_+_119010458 0.39 ENSMUST00000117160.2
cadherin 13
chr2_+_125876883 0.39 ENSMUST00000110442.2
fibroblast growth factor 7
chr16_+_27126239 0.38 ENSMUST00000066852.9
osteocrin
chr18_+_61820982 0.38 ENSMUST00000025471.4
interleukin 17B
chr1_-_43235914 0.36 ENSMUST00000187357.2
four and a half LIM domains 2
chr19_+_22425565 0.34 ENSMUST00000037901.14
transient receptor potential cation channel, subfamily M, member 3
chr13_-_25454058 0.33 ENSMUST00000057866.13
neurensin 1
chr3_+_128993609 0.32 ENSMUST00000173645.4
paired-like homeodomain transcription factor 2
chr3_-_110050312 0.32 ENSMUST00000156177.9
netrin G1
chr3_-_33898405 0.32 ENSMUST00000029222.8
coiled-coil domain containing 39
chr3_+_128993527 0.32 ENSMUST00000174661.9
paired-like homeodomain transcription factor 2
chr8_+_15107646 0.32 ENSMUST00000033842.4
myomesin 2
chr19_+_22425534 0.32 ENSMUST00000235522.2
ENSMUST00000236372.2
ENSMUST00000238066.2
ENSMUST00000235780.2
ENSMUST00000236804.2
transient receptor potential cation channel, subfamily M, member 3
chr19_-_10857734 0.31 ENSMUST00000133303.8
transmembrane protein 109
chr17_+_24645615 0.29 ENSMUST00000234304.2
ENSMUST00000024946.7
ENSMUST00000234150.2
enoyl-Coenzyme A delta isomerase 1
chr10_+_4660119 0.28 ENSMUST00000105588.8
ENSMUST00000105589.2
estrogen receptor 1 (alpha)
chr13_-_64237011 0.28 ENSMUST00000166224.8
ENSMUST00000222810.2
hydroxysteroid (17-beta) dehydrogenase 3
chr7_+_99384352 0.27 ENSMUST00000098264.2
olfactory receptor 520
chr10_+_43400074 0.27 ENSMUST00000057649.8
ENSMUST00000216543.2
predicted gene 9803
chr15_+_8997480 0.26 ENSMUST00000227191.3
RAN binding protein 3-like
chr13_-_64236994 0.26 ENSMUST00000039832.7
hydroxysteroid (17-beta) dehydrogenase 3
chr15_+_82230155 0.26 ENSMUST00000023086.15
single-pass membrane protein with aspartate rich tail 1
chrX_-_142716085 0.25 ENSMUST00000087313.10
doublecortin
chr14_+_53315909 0.25 ENSMUST00000103608.4
T cell receptor alpha variable 14D-3-DV8
chr11_-_97913420 0.25 ENSMUST00000103144.10
ENSMUST00000017552.13
ENSMUST00000092736.11
ENSMUST00000107562.2
calcium channel, voltage-dependent, beta 1 subunit
chr13_-_78345932 0.24 ENSMUST00000127137.3
nuclear receptor subfamily 2, group F, member 1
chr18_+_65715351 0.24 ENSMUST00000235669.2
ENSMUST00000183319.8
ENSMUST00000236523.2
ENSMUST00000237886.2
zinc finger protein 532
chr11_+_96162283 0.23 ENSMUST00000000010.9
ENSMUST00000174042.3
homeobox B9
chr10_+_52267702 0.22 ENSMUST00000067085.7
nephrocan
chr16_-_37205302 0.22 ENSMUST00000114781.8
ENSMUST00000114780.8
syntaxin binding protein 5-like
chr9_+_121539395 0.22 ENSMUST00000035113.11
ENSMUST00000215966.2
ENSMUST00000215833.2
ENSMUST00000215104.2
SS18, nBAF chromatin remodeling complex subunit like 2
chr2_+_125876566 0.22 ENSMUST00000064794.14
fibroblast growth factor 7
chrX_-_140257030 0.21 ENSMUST00000101205.3
collagen, type IV, alpha 6
chr13_-_64237036 0.21 ENSMUST00000222783.2
hydroxysteroid (17-beta) dehydrogenase 3
chr6_+_116627567 0.21 ENSMUST00000067354.10
ENSMUST00000178241.4
DEPP1 autophagy regulator
chr2_-_177269992 0.21 ENSMUST00000108945.8
ENSMUST00000108943.2
predicted gene 14406
chr1_+_66360865 0.21 ENSMUST00000114013.8
microtubule-associated protein 2
chr11_+_85243970 0.20 ENSMUST00000108056.8
ENSMUST00000108061.8
ENSMUST00000108062.8
ENSMUST00000138423.8
ENSMUST00000092821.10
ENSMUST00000074875.11
breast carcinoma amplified sequence 3
chr2_+_174852034 0.20 ENSMUST00000109069.8
ENSMUST00000109070.3
predicted gene 14444
chr4_+_33924632 0.20 ENSMUST00000057188.7
cannabinoid receptor 1 (brain)
chr14_+_54000594 0.20 ENSMUST00000103589.6
T cell receptor alpha variable 14-3
chr1_+_60948307 0.20 ENSMUST00000097720.4
cytotoxic T-lymphocyte-associated protein 4
chr3_+_92864693 0.18 ENSMUST00000059053.11
late cornified envelope 3D
chr13_+_113346193 0.18 ENSMUST00000038144.9
endothelial cell-specific molecule 1
chr3_+_128993568 0.18 ENSMUST00000029657.16
ENSMUST00000106382.11
paired-like homeodomain transcription factor 2
chr19_+_45139098 0.18 ENSMUST00000026236.11
T cell leukemia, homeobox 1
chr11_+_67586140 0.17 ENSMUST00000021290.2
recoverin
chrX_+_21350783 0.17 ENSMUST00000089188.9
angiotensin II receptor, type 2
chr17_-_41225241 0.17 ENSMUST00000166343.3
glycine-N-acyltransferase-like 3
chr16_-_37205277 0.16 ENSMUST00000114787.8
ENSMUST00000114782.8
ENSMUST00000114775.8
syntaxin binding protein 5-like
chr6_+_116627635 0.16 ENSMUST00000204555.2
DEPP1 autophagy regulator
chr18_+_37822865 0.16 ENSMUST00000195112.2
protocadherin gamma subfamily B, 2
chr9_+_110782861 0.16 ENSMUST00000196834.2
leucine rich repeat containing 2
chr2_+_74552322 0.15 ENSMUST00000047904.4
homeobox D4
chrX_+_55655111 0.15 ENSMUST00000144068.8
ENSMUST00000077741.12
ENSMUST00000114784.4
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr6_-_55109960 0.14 ENSMUST00000003568.15
corticotropin releasing hormone receptor 2
chr2_-_26406631 0.12 ENSMUST00000132820.2
notch 1
chr17_-_57307018 0.11 ENSMUST00000002740.3
persephin
chrX_-_142716200 0.10 ENSMUST00000112851.8
ENSMUST00000112856.3
ENSMUST00000033642.10
doublecortin
chr11_+_73051228 0.10 ENSMUST00000006104.10
ENSMUST00000135202.8
ENSMUST00000136894.3
purinergic receptor P2X, ligand-gated ion channel, 5
chr11_-_101785181 0.09 ENSMUST00000057054.8
mesenchyme homeobox 1
chr13_-_96607619 0.08 ENSMUST00000239026.2
ENSMUST00000181613.3
ankyrin repeat and death domain containing 1B
chr1_+_187730018 0.07 ENSMUST00000027906.13
estrogen-related receptor gamma
chr15_-_48655329 0.07 ENSMUST00000160658.8
ENSMUST00000100670.10
ENSMUST00000162830.8
CUB and Sushi multiple domains 3
chr10_+_69761784 0.06 ENSMUST00000181974.8
ENSMUST00000182795.8
ENSMUST00000182437.8
ankyrin 3, epithelial
chr4_-_150087587 0.06 ENSMUST00000084117.13
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr5_+_102916637 0.06 ENSMUST00000112852.8
Rho GTPase activating protein 24
chr12_-_46767619 0.05 ENSMUST00000219886.2
NOVA alternative splicing regulator 1
chr1_-_63808426 0.05 ENSMUST00000027102.2
RIKEN cDNA 4933402D24 gene
chr6_+_134373275 0.04 ENSMUST00000032321.11
BCL2-like 14 (apoptosis facilitator)
chr1_+_58249556 0.04 ENSMUST00000040442.6
aldehyde oxidase 4
chr13_-_96607722 0.04 ENSMUST00000055607.13
ankyrin repeat and death domain containing 1B
chr1_+_187730032 0.02 ENSMUST00000110938.2
estrogen-related receptor gamma
chr11_+_69016722 0.02 ENSMUST00000021268.9
arachidonate lipoxygenase 3
chr3_-_51184895 0.01 ENSMUST00000108051.8
ENSMUST00000108053.9
E74-like factor 2
chrX_-_102230225 0.01 ENSMUST00000121720.2
nucleosome assembly protein 1-like 2
chr4_+_151081538 0.00 ENSMUST00000030803.2
urotensin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 0.6 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.2 0.6 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.2 0.7 GO:0098582 innate vocalization behavior(GO:0098582)
0.2 0.8 GO:0021763 subthalamic nucleus development(GO:0021763) superior vena cava morphogenesis(GO:0060578)
0.2 0.6 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.7 GO:0035128 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1 0.8 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.1 0.6 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.6 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 1.1 GO:0061042 vascular wound healing(GO:0061042)
0.1 0.5 GO:0003409 optic cup structural organization(GO:0003409)
0.1 0.4 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.1 0.7 GO:0061370 testosterone biosynthetic process(GO:0061370)
0.1 0.5 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.1 1.7 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 0.2 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.1 0.3 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.4 GO:1903860 negative regulation of dendrite extension(GO:1903860)
0.1 0.1 GO:0003213 cardiac right atrium morphogenesis(GO:0003213)
0.1 0.4 GO:0055096 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.1 1.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.3 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.2 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.2 GO:0035566 regulation of metanephros size(GO:0035566)
0.0 1.1 GO:0030903 notochord development(GO:0030903)
0.0 0.1 GO:2000292 regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.5 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.4 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.8 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.2 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 1.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 2.8 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.3 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0098651 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.6 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.6 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 1.5 GO:0055100 adiponectin binding(GO:0055100)
0.1 0.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.7 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 0.7 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.2 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 0.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.2 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.1 GO:0047936 glucose 1-dehydrogenase [NAD(P)] activity(GO:0047936)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 1.1 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.8 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.6 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.6 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway