ISMARA results: Irf2_Irf1_Irf8_Irf9

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GSE58827: Dynamics of the Mouse Liver

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 2.92

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol	Gene ID	Gene Info
Irf2 Ensembl NCBI MGI UniProt	ENSMUSG00000031627.10	interferon regulatory factor 2
Irf1 Ensembl NCBI MGI UniProt	ENSMUSG00000018899.18	interferon regulatory factor 1
Irf8 Ensembl NCBI MGI UniProt	ENSMUSG00000041515.11	interferon regulatory factor 8
Irf9 Ensembl NCBI MGI UniProt	ENSMUSG00000002325.16	interferon regulatory factor 9
Irf7 Ensembl NCBI MGI UniProt	ENSMUSG00000025498.16	interferon regulatory factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Irf1	mm39_v1_chr11_+_53661251_53661346	0.65	2.0e-05	Click!
Irf7	mm39_v1_chr7_-_140846328_140846394	0.55	5.1e-04	Click!
Irf2	mm39_v1_chr8_+_47192767_47192829	0.36	3.1e-02	Click!
Irf9	mm39_v1_chr14_+_55842002_55842036	0.29	8.1e-02	Click!
Irf8	mm39_v1_chr8_+_121463090_121463124	-0.19	2.7e-01	Click!

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_77613239 Show fit	39.03	ENSMUST00000230979.2 ENSMUST00000109775.4	Apol9b Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 9b
chr15_+_77613348 Show fit	27.22	ENSMUST00000230742.2	Apol9b Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 9b
chr2_-_173060647 Show fit	24.42	ENSMUST00000109116.3 ENSMUST00000029018.14	Zbp1 Ensembl NCBI MGI UniProt Show fit	Z-DNA binding protein 1
chr1_+_130754413 Show fit	21.08	ENSMUST00000027675.14 ENSMUST00000133792.8	Pigr Ensembl NCBI MGI UniProt Show fit	polymeric immunoglobulin receptor
chr8_-_45786226 Show fit	19.82	ENSMUST00000095328.6	Cyp4v3 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 4, subfamily v, polypeptide 3
chr18_+_60515755 Show fit	19.79	ENSMUST00000237185.2	Iigp1 Ensembl NCBI MGI UniProt Show fit	interferon inducible GTPase 1
chr15_-_77295234 Show fit	18.81	ENSMUST00000089452.6 ENSMUST00000081776.11	Apol9a Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 9a
chr8_-_71990085 Show fit	18.56	ENSMUST00000051672.9	Bst2 Ensembl NCBI MGI UniProt Show fit	bone marrow stromal cell antigen 2
chr2_+_121978156 Show fit	16.63	ENSMUST00000102476.5	B2m Ensembl NCBI MGI UniProt Show fit	beta-2 microglobulin
chr11_+_48977852 Show fit	15.38	ENSMUST00000046704.7 ENSMUST00000203810.3 ENSMUST00000203149.3	Ifi47 Ensembl NCBI MGI UniProt Show fit Olfr56 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47 olfactory receptor 56
chr19_+_34560922 Show fit	13.95	ENSMUST00000102825.4	Ifit3 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr16_+_23428650 Show fit	13.94	ENSMUST00000038423.6 ENSMUST00000211349.2	Rtp4 Ensembl NCBI MGI UniProt Show fit	receptor transporter protein 4
chr7_-_140590605 Show fit	13.38	ENSMUST00000026565.7	Ifitm3 Ensembl NCBI MGI UniProt Show fit	interferon induced transmembrane protein 3
chr11_+_48977888 Show fit	13.14	ENSMUST00000214804.2	Ifi47 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47
chr11_-_48883053 Show fit	13.14	ENSMUST00000059930.3 ENSMUST00000068063.4	Gm12185 Ensembl NCBI MGI UniProt Show fit Tgtp1 Ensembl NCBI MGI UniProt Show fit	predicted gene 12185 T cell specific GTPase 1
chr18_+_60345152 Show fit	12.92	ENSMUST00000031549.6	Gm4951 Ensembl NCBI MGI UniProt Show fit	predicted gene 4951
chr3_+_142326363 Show fit	12.88	ENSMUST00000165774.8	Gbp2 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 2
chr7_-_140846328 Show fit	11.35	ENSMUST00000106023.8 ENSMUST00000097952.9 ENSMUST00000026571.11	Irf7 Ensembl NCBI MGI UniProt Show fit	interferon regulatory factor 7
chr11_-_48955028 Show fit	11.16	ENSMUST00000046745.7	Tgtp2 Ensembl NCBI MGI UniProt Show fit	T cell specific GTPase 2
chr1_-_162812087 Show fit	11.08	ENSMUST00000028010.9	Fmo3 Ensembl NCBI MGI UniProt Show fit	flavin containing monooxygenase 3
chr11_+_119283887 Show fit	10.68	ENSMUST00000093902.12 ENSMUST00000131035.10	Rnf213 Ensembl NCBI MGI UniProt Show fit	ring finger protein 213
chr19_+_34585322 Show fit	10.61	ENSMUST00000076249.6	Ifit3b Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3B
chr17_-_35081129 Show fit	10.01	ENSMUST00000154526.8	Cfb Ensembl NCBI MGI UniProt Show fit	complement factor B
chr17_-_34406193 Show fit	9.89	ENSMUST00000173831.3	Psmb9 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr9_-_106353792 Show fit	9.82	ENSMUST00000214682.2 ENSMUST00000112479.9	Parp3 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 3
chr11_-_48762170 Show fit	9.57	ENSMUST00000049519.4 ENSMUST00000097271.4	Irgm1 Ensembl NCBI MGI UniProt Show fit	immunity-related GTPase family M member 1
chr17_-_35081456 Show fit	9.52	ENSMUST00000025229.11 ENSMUST00000176203.9 ENSMUST00000128767.8	Cfb Ensembl NCBI MGI UniProt Show fit	complement factor B
chr17_-_36353582 Show fit	9.45	ENSMUST00000058801.15 ENSMUST00000080015.12 ENSMUST00000077960.7	H2-T22 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, T region locus 22
chr18_+_60509101 Show fit	9.13	ENSMUST00000032473.7 ENSMUST00000066912.13	Iigp1 Ensembl NCBI MGI UniProt Show fit	interferon inducible GTPase 1
chr6_+_121222865 Show fit	9.01	ENSMUST00000032198.11	Usp18 Ensembl NCBI MGI UniProt Show fit	ubiquitin specific peptidase 18
chr6_-_39095144 Show fit	8.98	ENSMUST00000038398.7	Parp12 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 12
chr9_-_106353571 Show fit	8.70	ENSMUST00000123555.8 ENSMUST00000125850.2	Parp3 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 3
chr9_+_77829191 Show fit	8.47	ENSMUST00000133757.8	Elovl5 Ensembl NCBI MGI UniProt Show fit	ELOVL family member 5, elongation of long chain fatty acids (yeast)
chr1_+_52158693 Show fit	8.46	ENSMUST00000189347.7	Stat1 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 1
chr1_+_52158599 Show fit	8.39	ENSMUST00000186574.7 ENSMUST00000070968.14 ENSMUST00000191435.7 ENSMUST00000186857.7 ENSMUST00000188681.7	Stat1 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 1
chr11_-_70350783 Show fit	8.32	ENSMUST00000019064.9	Cxcl16 Ensembl NCBI MGI UniProt Show fit	chemokine (C-X-C motif) ligand 16
chr7_-_14180496 Show fit	8.27	ENSMUST00000063509.11	Sult2a8 Ensembl NCBI MGI UniProt Show fit	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
chr3_-_113368407 Show fit	8.22	ENSMUST00000106540.8	Amy1 Ensembl NCBI MGI UniProt Show fit	amylase 1, salivary
chr3_-_113367891 Show fit	8.06	ENSMUST00000142505.9	Amy1 Ensembl NCBI MGI UniProt Show fit	amylase 1, salivary
chr17_+_34406523 Show fit	7.99	ENSMUST00000170086.8	Tap1 Ensembl NCBI MGI UniProt Show fit	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34406762 Show fit	7.86	ENSMUST00000041633.15	Tap1 Ensembl NCBI MGI UniProt Show fit	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_+_72192455 Show fit	7.86	ENSMUST00000151440.8 ENSMUST00000146233.8 ENSMUST00000140842.9	Xaf1 Ensembl NCBI MGI UniProt Show fit	XIAP associated factor 1
chrX_+_59044796 Show fit	7.82	ENSMUST00000033477.5	F9 Ensembl NCBI MGI UniProt Show fit	coagulation factor IX
chr1_+_175459559 Show fit	7.79	ENSMUST00000040250.15	Kmo Ensembl NCBI MGI UniProt Show fit	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr2_+_102536701 Show fit	7.78	ENSMUST00000123759.8 ENSMUST00000005220.11 ENSMUST00000111212.8	Slc1a2 Ensembl NCBI MGI UniProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_+_175459735 Show fit	7.67	ENSMUST00000097458.4	Kmo Ensembl NCBI MGI UniProt Show fit	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr12_+_103400470 Show fit	7.61	ENSMUST00000079294.12 ENSMUST00000076788.12 ENSMUST00000076702.12 ENSMUST00000066701.13 ENSMUST00000085065.12 ENSMUST00000140838.2	Ifi27 Ensembl NCBI MGI UniProt Show fit	interferon, alpha-inducible protein 27
chr5_-_92496730 Show fit	7.60	ENSMUST00000038816.13 ENSMUST00000118006.3	Cxcl10 Ensembl NCBI MGI UniProt Show fit	chemokine (C-X-C motif) ligand 10
chr15_+_33083358 Show fit	7.58	ENSMUST00000228916.2 ENSMUST00000226483.2 ENSMUST00000228737.2	Cpq Ensembl NCBI MGI UniProt Show fit	carboxypeptidase Q
chr7_+_119125426 Show fit	7.53	ENSMUST00000066465.3	Acsm5 Ensembl NCBI MGI UniProt Show fit	acyl-CoA synthetase medium-chain family member 5
chr1_+_52158721 Show fit	7.53	ENSMUST00000186057.7	Stat1 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 1
chr5_-_105441554 Show fit	7.32	ENSMUST00000050011.10 ENSMUST00000196520.2	Gm43302 Ensembl NCBI MGI UniProt Show fit Gbp6 Ensembl NCBI MGI UniProt Show fit	predicted gene 43302 guanylate binding protein 6
chr7_-_30623592 Show fit	7.21	ENSMUST00000217812.2 ENSMUST00000074671.9	Hamp2 Ensembl NCBI MGI UniProt Show fit	hepcidin antimicrobial peptide 2
chr16_+_35758836 Show fit	7.12	ENSMUST00000114878.8	Parp9 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr5_-_105387395 Show fit	7.11	ENSMUST00000065588.7	Gbp10 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 10
chr7_-_14180576 Show fit	7.10	ENSMUST00000125941.3	Sult2a8 Ensembl NCBI MGI UniProt Show fit	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
chr16_+_35759346 Show fit	6.85	ENSMUST00000023622.13	Parp9 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr9_+_20779924 Show fit	6.77	ENSMUST00000043911.8	Shfl Ensembl NCBI MGI UniProt Show fit	shiftless antiviral inhibitor of ribosomal frameshifting
chr6_-_23839136 Show fit	6.73	ENSMUST00000166458.9 ENSMUST00000142913.9 ENSMUST00000069074.14 ENSMUST00000115361.9 ENSMUST00000018122.14 ENSMUST00000115356.3	Cadps2 Ensembl NCBI MGI UniProt Show fit	Ca2+-dependent activator protein for secretion 2
chr11_-_78875657 Show fit	6.68	ENSMUST00000073001.5	Lgals9 Ensembl NCBI MGI UniProt Show fit	lectin, galactose binding, soluble 9
chr10_+_40505985 Show fit	6.62	ENSMUST00000019977.8 ENSMUST00000214102.2 ENSMUST00000213503.2 ENSMUST00000213442.2 ENSMUST00000216830.2	Ddo Ensembl NCBI MGI UniProt Show fit	D-aspartate oxidase
chr8_-_106665060 Show fit	6.58	ENSMUST00000034369.10	Psmb10 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 10
chr15_+_99290763 Show fit	6.48	ENSMUST00000023749.15	Tmbim6 Ensembl NCBI MGI UniProt Show fit	transmembrane BAX inhibitor motif containing 6
chr17_+_34138611 Show fit	6.39	ENSMUST00000234247.2	Tapbp Ensembl NCBI MGI UniProt Show fit	TAP binding protein
chr14_+_14475188 Show fit	6.35	ENSMUST00000026315.8	Dnase1l3 Ensembl NCBI MGI UniProt Show fit	deoxyribonuclease 1-like 3
chr5_+_115061293 Show fit	6.14	ENSMUST00000031540.11 ENSMUST00000112143.4	Oasl1 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase-like 1
chr4_-_40239778 Show fit	6.13	ENSMUST00000037907.13	Ddx58 Ensembl NCBI MGI UniProt Show fit	DEAD/H box helicase 58
chr3_-_81883509 Show fit	6.09	ENSMUST00000029645.14 ENSMUST00000193879.2	Tdo2 Ensembl NCBI MGI UniProt Show fit	tryptophan 2,3-dioxygenase
chr19_+_34618271 Show fit	6.06	ENSMUST00000102824.4	Ifit1 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 1
chr6_-_85846110 Show fit	6.03	ENSMUST00000045008.8	Nat8f2 Ensembl NCBI MGI UniProt Show fit	N-acetyltransferase 8 (GCN5-related) family member 2
chr13_-_23894697 Show fit	5.99	ENSMUST00000091707.13 ENSMUST00000006787.8	Hfe Ensembl NCBI MGI UniProt Show fit	homeostatic iron regulator
chr7_+_119125443 Show fit	5.99	ENSMUST00000207440.2	Acsm5 Ensembl NCBI MGI UniProt Show fit	acyl-CoA synthetase medium-chain family member 5
chr8_-_94006345 Show fit	5.98	ENSMUST00000034178.9	Ces1f Ensembl NCBI MGI UniProt Show fit	carboxylesterase 1F
chr11_+_58090382 Show fit	5.94	ENSMUST00000035266.11 ENSMUST00000094169.11 ENSMUST00000168280.2 ENSMUST00000058704.9	Igtp Ensembl NCBI MGI UniProt Show fit Irgm2 Ensembl NCBI MGI UniProt Show fit	interferon gamma induced GTPase immunity-related GTPase family M member 2
chr11_-_78875689 Show fit	5.90	ENSMUST00000108269.10 ENSMUST00000108268.10	Lgals9 Ensembl NCBI MGI UniProt Show fit	lectin, galactose binding, soluble 9
chr1_-_150341911 Show fit	5.83	ENSMUST00000162367.8 ENSMUST00000161611.8 ENSMUST00000161320.8 ENSMUST00000159035.2	Prg4 Ensembl NCBI MGI UniProt Show fit	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr4_-_46536088 Show fit	5.82	ENSMUST00000102924.3 ENSMUST00000046897.13	Trim14 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 14
chr7_+_107166653 Show fit	5.74	ENSMUST00000120990.2	Olfml1 Ensembl NCBI MGI UniProt Show fit	olfactomedin-like 1
chr17_+_34138699 Show fit	5.66	ENSMUST00000234320.2	Tapbp Ensembl NCBI MGI UniProt Show fit	TAP binding protein
chr2_-_126775136 Show fit	5.62	ENSMUST00000028844.11	Sppl2a Ensembl NCBI MGI UniProt Show fit	signal peptide peptidase like 2A
chr3_+_142265787 Show fit	5.42	ENSMUST00000199325.5 ENSMUST00000106222.9	Gbp3 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 3
chr2_+_58645189 Show fit	5.42	ENSMUST00000102755.4 ENSMUST00000230627.2 ENSMUST00000229923.2	Upp2 Ensembl NCBI MGI UniProt Show fit	uridine phosphorylase 2
chr11_-_100595019 Show fit	5.39	ENSMUST00000017974.13	Dhx58 Ensembl NCBI MGI UniProt Show fit	DEXH (Asp-Glu-X-His) box polypeptide 58
chr8_-_85500010 Show fit	5.35	ENSMUST00000109764.8	Nfix Ensembl NCBI MGI UniProt Show fit	nuclear factor I/X
chr2_-_51863203 Show fit	5.25	ENSMUST00000028314.9	Nmi Ensembl NCBI MGI UniProt Show fit	N-myc (and STAT) interactor
chr19_+_56385531 Show fit	5.14	ENSMUST00000026062.10	Casp7 Ensembl NCBI MGI UniProt Show fit	caspase 7
chr16_-_35759461 Show fit	5.10	ENSMUST00000081933.14 ENSMUST00000114885.3	Dtx3l Ensembl NCBI MGI UniProt Show fit	deltex 3-like, E3 ubiquitin ligase
chr14_-_78970160 Show fit	5.08	ENSMUST00000226342.3	Dgkh Ensembl NCBI MGI UniProt Show fit	diacylglycerol kinase, eta
chr17_-_34218301 Show fit	5.05	ENSMUST00000235463.2	H2-K1 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, K1, K region
chr7_+_51528715 Show fit	5.01	ENSMUST00000051912.13	Gas2 Ensembl NCBI MGI UniProt Show fit	growth arrest specific 2
chr17_-_34219225 Show fit	4.95	ENSMUST00000238098.2 ENSMUST00000087189.7 ENSMUST00000173075.3 ENSMUST00000172912.8 ENSMUST00000236740.2 ENSMUST00000025181.18	H2-K1 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, K1, K region
chr8_+_127790772 Show fit	4.91	ENSMUST00000079777.12 ENSMUST00000160272.8 ENSMUST00000162907.8 ENSMUST00000162536.8 ENSMUST00000026921.13 ENSMUST00000162665.8 ENSMUST00000162602.8 ENSMUST00000160581.8 ENSMUST00000161355.8 ENSMUST00000162531.8 ENSMUST00000160766.8 ENSMUST00000159537.8	Pard3 Ensembl NCBI MGI UniProt Show fit	par-3 family cell polarity regulator
chr19_+_29344846 Show fit	4.83	ENSMUST00000016640.8	Cd274 Ensembl NCBI MGI UniProt Show fit	CD274 antigen
chr6_+_128639342 Show fit	4.81	ENSMUST00000032518.7 ENSMUST00000204416.2	Clec2h Ensembl NCBI MGI UniProt Show fit	C-type lectin domain family 2, member h
chr12_+_37292029 Show fit	4.74	ENSMUST00000160390.2	Agmo Ensembl NCBI MGI UniProt Show fit	alkylglycerol monooxygenase
chr2_-_51862941 Show fit	4.73	ENSMUST00000145481.8 ENSMUST00000112705.9	Nmi Ensembl NCBI MGI UniProt Show fit	N-myc (and STAT) interactor
chr1_+_155911518 Show fit	4.62	ENSMUST00000133152.2	Tor1aip2 Ensembl NCBI MGI UniProt Show fit	torsin A interacting protein 2
chr15_-_76127600 Show fit	4.59	ENSMUST00000165738.8 ENSMUST00000075689.7	Parp10 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 10
chr7_+_51528788 Show fit	4.59	ENSMUST00000107591.9	Gas2 Ensembl NCBI MGI UniProt Show fit	growth arrest specific 2
chr17_+_35481702 Show fit	4.51	ENSMUST00000172785.8	H2-D1 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, D region locus 1
chr4_-_42773987 Show fit	4.50	ENSMUST00000095114.5	Ccl21a Ensembl NCBI MGI UniProt Show fit	chemokine (C-C motif) ligand 21A (serine)
chr1_+_155911451 Show fit	4.45	ENSMUST00000111754.9	Tor1aip2 Ensembl NCBI MGI UniProt Show fit	torsin A interacting protein 2
chr3_+_81839908 Show fit	4.44	ENSMUST00000029649.3	Ctso Ensembl NCBI MGI UniProt Show fit	cathepsin O
chr2_+_58644922 Show fit	4.43	ENSMUST00000059102.13	Upp2 Ensembl NCBI MGI UniProt Show fit	uridine phosphorylase 2
chr7_+_25872836 Show fit	4.41	ENSMUST00000082214.5	Cyp2b9 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily b, polypeptide 9
chr16_+_26400454 Show fit	4.36	ENSMUST00000096129.9 ENSMUST00000166294.9 ENSMUST00000174202.8 ENSMUST00000023156.13	Il1rap Ensembl NCBI MGI UniProt Show fit	interleukin 1 receptor accessory protein
chr5_+_9163244 Show fit	4.32	ENSMUST00000198935.2	Tmem243 Ensembl NCBI MGI UniProt Show fit	transmembrane protein 243, mitochondrial
chr3_+_142300601 Show fit	4.26	ENSMUST00000029936.5	Gbp2b Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 2b
chr7_+_119125546 Show fit	4.24	ENSMUST00000207387.2 ENSMUST00000207813.2	Acsm5 Ensembl NCBI MGI UniProt Show fit	acyl-CoA synthetase medium-chain family member 5
chr2_-_166904625 Show fit	4.23	ENSMUST00000128676.2	Znfx1 Ensembl NCBI MGI UniProt Show fit	zinc finger, NFX1-type containing 1
chr6_+_124489364 Show fit	4.21	ENSMUST00000068593.9	C1ra Ensembl NCBI MGI UniProt Show fit	complement component 1, r subcomponent A
chr3_-_98537568 Show fit	4.19	ENSMUST00000044094.6	Hsd3b5 Ensembl NCBI MGI UniProt Show fit	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
chr6_-_125208738 Show fit	4.18	ENSMUST00000043422.8	Tapbpl Ensembl NCBI MGI UniProt Show fit	TAP binding protein-like
chr10_+_116111441 Show fit	4.11	ENSMUST00000218553.2	Ptprb Ensembl NCBI MGI UniProt Show fit	protein tyrosine phosphatase, receptor type, B
chr4_-_42756489 Show fit	4.02	ENSMUST00000140546.3 ENSMUST00000102957.6	Ccl19 Ensembl NCBI MGI UniProt Show fit	chemokine (C-C motif) ligand 19
chr13_+_74787952 Show fit	3.95	ENSMUST00000221822.2 ENSMUST00000221526.2	Erap1 Ensembl NCBI MGI UniProt Show fit	endoplasmic reticulum aminopeptidase 1
chr12_+_37291728 Show fit	3.90	ENSMUST00000160768.8	Agmo Ensembl NCBI MGI UniProt Show fit	alkylglycerol monooxygenase
chr14_+_40827317 Show fit	3.90	ENSMUST00000047286.7	Mat1a Ensembl NCBI MGI UniProt Show fit	methionine adenosyltransferase I, alpha
chr14_+_40827108 Show fit	3.87	ENSMUST00000224514.2	Mat1a Ensembl NCBI MGI UniProt Show fit	methionine adenosyltransferase I, alpha
chr17_+_35658131 Show fit	3.87	ENSMUST00000071951.14 ENSMUST00000116598.10 ENSMUST00000078205.14 ENSMUST00000076256.8	H2-Q7 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, Q region locus 7
chr15_+_31268450 Show fit	3.83	ENSMUST00000185618.2	Dap Ensembl NCBI MGI UniProt Show fit	death-associated protein
chr3_+_142265904 Show fit	3.81	ENSMUST00000128609.8 ENSMUST00000029935.14	Gbp3 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 3
chr18_-_60406338 Show fit	3.81	ENSMUST00000090260.6	Gm4841 Ensembl NCBI MGI UniProt Show fit	predicted gene 4841
chr17_+_35780977 Show fit	3.80	ENSMUST00000174525.8 ENSMUST00000068291.7	H2-Q10 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, Q region locus 10
chr3_-_86906591 Show fit	3.74	ENSMUST00000063869.11 ENSMUST00000029717.4	Cd1d1 Ensembl NCBI MGI UniProt Show fit	CD1d1 antigen
chr11_+_48977495 Show fit	3.72	ENSMUST00000152914.2	Ifi47 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47
chr11_+_114741948 Show fit	3.70	ENSMUST00000133245.2 ENSMUST00000122967.3	Gprc5c Ensembl NCBI MGI UniProt Show fit	G protein-coupled receptor, family C, group 5, member C
chr19_-_7943365 Show fit	3.69	ENSMUST00000182102.8 ENSMUST00000075619.5	Slc22a27 Ensembl NCBI MGI UniProt Show fit	solute carrier family 22, member 27
chr6_+_40619913 Show fit	3.65	ENSMUST00000238599.2	Mgam Ensembl NCBI MGI UniProt Show fit	maltase-glucoamylase
chr1_+_167445815 Show fit	3.65	ENSMUST00000111380.2	Rxrg Ensembl NCBI MGI UniProt Show fit	retinoid X receptor gamma
chr14_+_40826970 Show fit	3.64	ENSMUST00000225720.2	Mat1a Ensembl NCBI MGI UniProt Show fit	methionine adenosyltransferase I, alpha
chr4_-_40239700 Show fit	3.64	ENSMUST00000142055.2	Ddx58 Ensembl NCBI MGI UniProt Show fit	DEAD/H box helicase 58
chr15_+_75734159 Show fit	3.60	ENSMUST00000023238.6 ENSMUST00000230514.2 ENSMUST00000229331.2	Gsdmd Ensembl NCBI MGI UniProt Show fit	gasdermin D
chr1_+_9618173 Show fit	3.58	ENSMUST00000144177.8	Adhfe1 Ensembl NCBI MGI UniProt Show fit	alcohol dehydrogenase, iron containing, 1
chr16_-_35691914 Show fit	3.57	ENSMUST00000042665.9	Parp14 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 14
chr10_-_34003933 Show fit	3.56	ENSMUST00000062784.8	Calhm6 Ensembl NCBI MGI UniProt Show fit	calcium homeostasis modulator family member 6
chr2_+_43445333 Show fit	3.53	ENSMUST00000028223.9 ENSMUST00000112826.8	Kynu Ensembl NCBI MGI UniProt Show fit	kynureninase
chr9_-_43151179 Show fit	3.52	ENSMUST00000034512.7	Oaf Ensembl NCBI MGI UniProt Show fit	out at first homolog
chr11_-_53750016 Show fit	3.49	ENSMUST00000117316.8 ENSMUST00000120776.8 ENSMUST00000121435.2	Gm12216 Ensembl NCBI MGI UniProt Show fit	predicted gene 12216
chr13_+_52000704 Show fit	3.49	ENSMUST00000021903.3	Gadd45g Ensembl NCBI MGI UniProt Show fit	growth arrest and DNA-damage-inducible 45 gamma
chr16_-_38253507 Show fit	3.45	ENSMUST00000002926.8	Pla1a Ensembl NCBI MGI UniProt Show fit	phospholipase A1 member A
chr5_+_67418137 Show fit	3.44	ENSMUST00000161369.3	Tmem33 Ensembl NCBI MGI UniProt Show fit	transmembrane protein 33
chr3_+_59989282 Show fit	3.44	ENSMUST00000029326.6	Sucnr1 Ensembl NCBI MGI UniProt Show fit	succinate receptor 1
chr2_+_27566452 Show fit	3.37	ENSMUST00000129514.8	Rxra Ensembl NCBI MGI UniProt Show fit	retinoid X receptor alpha
chr13_-_23894828 Show fit	3.36	ENSMUST00000091706.14	Hfe Ensembl NCBI MGI UniProt Show fit	homeostatic iron regulator
chr10_+_128106414 Show fit	3.34	ENSMUST00000085708.3 ENSMUST00000105238.10	Stat2 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 2
chr12_+_37291632 Show fit	3.33	ENSMUST00000049874.14	Agmo Ensembl NCBI MGI UniProt Show fit	alkylglycerol monooxygenase
chr8_-_85526653 Show fit	3.31	ENSMUST00000126806.2 ENSMUST00000076715.13	Nfix Ensembl NCBI MGI UniProt Show fit	nuclear factor I/X
chr1_+_173501215 Show fit	3.30	ENSMUST00000085876.12	Ifi208 Ensembl NCBI MGI UniProt Show fit	interferon activated gene 208
chr3_+_142266113 Show fit	3.28	ENSMUST00000106221.8	Gbp3 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 3
chr8_-_112064783 Show fit	3.23	ENSMUST00000056157.14 ENSMUST00000120432.3	Mlkl Ensembl NCBI MGI UniProt Show fit	mixed lineage kinase domain-like
chr11_+_70350436 Show fit	3.23	ENSMUST00000039093.10	Zmynd15 Ensembl NCBI MGI UniProt Show fit	zinc finger, MYND-type containing 15
chr5_-_105287405 Show fit	3.22	ENSMUST00000100961.5 ENSMUST00000031235.13 ENSMUST00000197799.2 ENSMUST00000199629.2 ENSMUST00000196677.5 ENSMUST00000100962.8	Gbp9 Ensembl NCBI MGI UniProt Show fit Gbp8 Ensembl NCBI MGI UniProt Show fit Gbp4 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 9 guanylate-binding protein 8 guanylate binding protein 4
chr2_+_11710101 Show fit	3.14	ENSMUST00000138349.8 ENSMUST00000135341.8 ENSMUST00000128156.9	Il15ra Ensembl NCBI MGI UniProt Show fit	interleukin 15 receptor, alpha chain
chr2_-_166904902 Show fit	3.14	ENSMUST00000048988.14	Znfx1 Ensembl NCBI MGI UniProt Show fit	zinc finger, NFX1-type containing 1
chr13_+_4109566 Show fit	3.10	ENSMUST00000041768.7	Akr1c14 Ensembl NCBI MGI UniProt Show fit	aldo-keto reductase family 1, member C14
chr15_-_75886166 Show fit	3.09	ENSMUST00000060807.12	Fam83h Ensembl NCBI MGI UniProt Show fit	family with sequence similarity 83, member H
chr15_+_99290832 Show fit	3.07	ENSMUST00000160635.8 ENSMUST00000161250.8 ENSMUST00000229392.2 ENSMUST00000161778.8	Tmbim6 Ensembl NCBI MGI UniProt Show fit	transmembrane BAX inhibitor motif containing 6
chr13_-_63036096 Show fit	3.06	ENSMUST00000092888.11	Fbp1 Ensembl NCBI MGI UniProt Show fit	fructose bisphosphatase 1
chr16_-_56984137 Show fit	3.05	ENSMUST00000231733.2	Nit2 Ensembl NCBI MGI UniProt Show fit	nitrilase family, member 2
chr1_+_155911136 Show fit	3.05	ENSMUST00000111757.10	Tor1aip2 Ensembl NCBI MGI UniProt Show fit	torsin A interacting protein 2
chr4_+_135455427 Show fit	3.04	ENSMUST00000102546.4	Il22ra1 Ensembl NCBI MGI UniProt Show fit	interleukin 22 receptor, alpha 1
chr16_+_97337275 Show fit	3.03	ENSMUST00000024112.8	Mx2 Ensembl NCBI MGI UniProt Show fit	MX dynamin-like GTPase 2
chr14_-_64654397 Show fit	2.99	ENSMUST00000210428.2	Msra Ensembl NCBI MGI UniProt Show fit	methionine sulfoxide reductase A
chr2_+_71884943 Show fit	2.96	ENSMUST00000028525.6	Rapgef4 Ensembl NCBI MGI UniProt Show fit	Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_172418058 Show fit	2.92	ENSMUST00000065679.8	Slamf8 Ensembl NCBI MGI UniProt Show fit	SLAM family member 8
chr7_+_103893658 Show fit	2.89	ENSMUST00000106849.9 ENSMUST00000060315.12	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr2_+_43445359 Show fit	2.89	ENSMUST00000050511.7	Kynu Ensembl NCBI MGI UniProt Show fit	kynureninase
chr12_-_84497718 Show fit	2.88	ENSMUST00000085192.7 ENSMUST00000220491.2	Aldh6a1 Ensembl NCBI MGI UniProt Show fit	aldehyde dehydrogenase family 6, subfamily A1
chr19_+_8875459 Show fit	2.85	ENSMUST00000096246.5 ENSMUST00000235274.2	Ganab Ensembl NCBI MGI UniProt Show fit	alpha glucosidase 2 alpha neutral subunit
chr3_+_142236086 Show fit	2.83	ENSMUST00000171263.8 ENSMUST00000045097.11	Gbp7 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 7
chr19_+_3372296 Show fit	2.83	ENSMUST00000237938.2	Cpt1a Ensembl NCBI MGI UniProt Show fit	carnitine palmitoyltransferase 1a, liver
chr15_+_100202642 Show fit	2.79	ENSMUST00000067752.5 ENSMUST00000229588.2	Mettl7a1 Ensembl NCBI MGI UniProt Show fit	methyltransferase like 7A1
chrX_-_37545311 Show fit	2.79	ENSMUST00000074913.12 ENSMUST00000016678.14 ENSMUST00000061755.9	Lamp2 Ensembl NCBI MGI UniProt Show fit	lysosomal-associated membrane protein 2
chr7_-_141015240 Show fit	2.78	ENSMUST00000138865.8	Slc25a22 Ensembl NCBI MGI UniProt Show fit	solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr2_+_91033230 Show fit	2.77	ENSMUST00000150403.8 ENSMUST00000002172.14 ENSMUST00000238832.2 ENSMUST00000239169.2 ENSMUST00000155418.2	Acp2 Ensembl NCBI MGI UniProt Show fit	acid phosphatase 2, lysosomal
chr14_+_64890008 Show fit	2.77	ENSMUST00000224503.2	Kif13b Ensembl NCBI MGI UniProt Show fit	kinesin family member 13B
chr18_-_61669641 Show fit	2.76	ENSMUST00000237557.2 ENSMUST00000171629.3	Arhgef37 Ensembl NCBI MGI UniProt Show fit	Rho guanine nucleotide exchange factor (GEF) 37
chr4_-_96441854 Show fit	2.75	ENSMUST00000030303.6	Cyp2j6 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily j, polypeptide 6
chrX_-_8059597 Show fit	2.73	ENSMUST00000143223.2 ENSMUST00000033509.15	Ebp Ensembl NCBI MGI UniProt Show fit	phenylalkylamine Ca2+ antagonist (emopamil) binding protein
chr14_+_64889973 Show fit	2.72	ENSMUST00000100473.5	Kif13b Ensembl NCBI MGI UniProt Show fit	kinesin family member 13B
chr4_+_155666933 Show fit	2.70	ENSMUST00000105612.2	Nadk Ensembl NCBI MGI UniProt Show fit	NAD kinase
chr6_+_34722887 Show fit	2.68	ENSMUST00000123823.8 ENSMUST00000136907.8	Cald1 Ensembl NCBI MGI UniProt Show fit	caldesmon 1
chr1_+_16758629 Show fit	2.66	ENSMUST00000026881.11	Ly96 Ensembl NCBI MGI UniProt Show fit	lymphocyte antigen 96
chr14_+_122771734 Show fit	2.63	ENSMUST00000154206.8 ENSMUST00000038374.13 ENSMUST00000135578.8	Pcca Ensembl NCBI MGI UniProt Show fit	propionyl-Coenzyme A carboxylase, alpha polypeptide
chr1_+_88015524 Show fit	2.63	ENSMUST00000113139.2	Ugt1a8 Ensembl NCBI MGI UniProt Show fit	UDP glucuronosyltransferase 1 family, polypeptide A8
chr15_-_76191301 Show fit	2.61	ENSMUST00000171340.9 ENSMUST00000023222.13 ENSMUST00000164189.2	Oplah Ensembl NCBI MGI UniProt Show fit	5-oxoprolinase (ATP-hydrolysing)
chr13_+_33188511 Show fit	2.60	ENSMUST00000006391.5	Serpinb9 Ensembl NCBI MGI UniProt Show fit	serine (or cysteine) peptidase inhibitor, clade B, member 9
chr1_-_155912159 Show fit	2.59	ENSMUST00000097527.10	Tor1aip1 Ensembl NCBI MGI UniProt Show fit	torsin A interacting protein 1
chr8_-_93956143 Show fit	2.57	ENSMUST00000176282.2 ENSMUST00000034173.14	Ces1e Ensembl NCBI MGI UniProt Show fit	carboxylesterase 1E
chr2_-_34990689 Show fit	2.57	ENSMUST00000226631.2 ENSMUST00000045776.5 ENSMUST00000226972.2	AI182371 Ensembl NCBI MGI UniProt Show fit	expressed sequence AI182371
chr18_+_60936910 Show fit	2.56	ENSMUST00000097563.9 ENSMUST00000050487.16 ENSMUST00000167610.2	Cd74 Ensembl NCBI MGI UniProt Show fit	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
chr7_+_107166925 Show fit	2.56	ENSMUST00000239087.2	Olfml1 Ensembl NCBI MGI UniProt Show fit	olfactomedin-like 1
chr15_+_99291100 Show fit	2.56	ENSMUST00000159209.8	Tmbim6 Ensembl NCBI MGI UniProt Show fit	transmembrane BAX inhibitor motif containing 6
chr4_+_138700195 Show fit	2.55	ENSMUST00000123636.8 ENSMUST00000043042.10 ENSMUST00000050949.9	Tmco4 Ensembl NCBI MGI UniProt Show fit	transmembrane and coiled-coil domains 4
chr8_-_3517617 Show fit	2.55	ENSMUST00000111081.10 ENSMUST00000004686.13	Pex11g Ensembl NCBI MGI UniProt Show fit	peroxisomal biogenesis factor 11 gamma
chr9_-_106353303 Show fit	2.52	ENSMUST00000156426.8	Parp3 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 3
chr8_-_85526972 Show fit	2.52	ENSMUST00000099070.10	Nfix Ensembl NCBI MGI UniProt Show fit	nuclear factor I/X
chr6_+_138117295 Show fit	2.51	ENSMUST00000008684.11	Mgst1 Ensembl NCBI MGI UniProt Show fit	microsomal glutathione S-transferase 1
chr11_-_48884999 Show fit	2.47	ENSMUST00000146439.8	Tgtp1 Ensembl NCBI MGI UniProt Show fit	T cell specific GTPase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
8.7	26.0	GO:1904440	positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
8.1	24.4	GO:0034240	negative regulation of macrophage fusion(GO:0034240)
7.0	21.1	GO:0002414	immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells(GO:0002414)
5.6	16.9	GO:0046967	cytosol to ER transport(GO:0046967)
4.2	4.2	GO:0002589	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
4.2	12.5	GO:0019442	tryptophan catabolic process to acetyl-CoA(GO:0019442)
4.0	19.9	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
3.8	11.4	GO:0009087	methionine catabolic process(GO:0009087)
3.8	15.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
3.6	14.5	GO:0002484	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
3.5	183.6	GO:0035458	cellular response to interferon-beta(GO:0035458)
3.5	21.0	GO:1990166	protein localization to site of double-strand break(GO:1990166)
3.4	16.8	GO:1904721	regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
3.3	10.0	GO:1902524	positive regulation of protein K48-linked ubiquitination(GO:1902524)
3.2	16.0	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
2.9	38.3	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
2.8	8.5	GO:2000547	regulation of dendritic cell dendrite assembly(GO:2000547)
2.5	12.6	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
2.2	6.6	GO:0006533	aspartate catabolic process(GO:0006533)
2.2	10.8	GO:0035546	interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
2.1	8.6	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
2.0	8.2	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
2.0	6.0	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
2.0	21.6	GO:0035456	response to interferon-beta(GO:0035456)
1.8	7.2	GO:0034757	negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
1.6	4.9	GO:1903896	positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
1.5	6.0	GO:0019883	antigen processing and presentation of endogenous antigen(GO:0019883)
1.3	5.0	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
1.3	21.3	GO:0006957	complement activation, alternative pathway(GO:0006957)
1.2	12.9	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.1	7.8	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.0	5.1	GO:0072733	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
1.0	3.0	GO:0042450	arginine biosynthetic process via ornithine(GO:0042450)
1.0	8.0	GO:1990504	dense core granule exocytosis(GO:1990504)
1.0	5.0	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
1.0	2.9	GO:1902623	negative regulation of neutrophil migration(GO:1902623)
0.9	13.0	GO:0060330	regulation of response to interferon-gamma(GO:0060330)
0.9	2.8	GO:0071211	protein targeting to vacuole involved in autophagy(GO:0071211)
0.9	11.8	GO:0046485	ether lipid metabolic process(GO:0046485)
0.9	3.6	GO:0051673	membrane disruption in other organism(GO:0051673)
0.8	14.4	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.8	3.1	GO:0046351	disaccharide biosynthetic process(GO:0046351)
0.8	14.5	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.8	4.5	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.7	5.1	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.7	2.9	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.7	2.1	GO:0002014	vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.7	8.5	GO:0034626	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.7	3.5	GO:0044565	dendritic cell proliferation(GO:0044565)
0.7	4.9	GO:0003383	apical constriction(GO:0003383)
0.7	4.8	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
0.7	0.7	GO:1904933	regulation of cell proliferation in midbrain(GO:1904933)
0.7	3.4	GO:0006447	regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.6	5.8	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.6	1.9	GO:1903538	meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.6	2.5	GO:0071449	cellular response to lipid hydroperoxide(GO:0071449)
0.6	3.0	GO:1904457	positive regulation of neuronal action potential(GO:1904457)
0.6	1.7	GO:0031104	dendrite regeneration(GO:0031104)
0.6	5.6	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.6	0.6	GO:0038018	Wnt receptor catabolic process(GO:0038018)
0.5	2.7	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.5	1.6	GO:0072695	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.5	11.3	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5	1.6	GO:0018900	dichloromethane metabolic process(GO:0018900)
0.5	1.6	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931) cellular response to mercury ion(GO:0071288)
0.5	2.5	GO:0044375	regulation of peroxisome size(GO:0044375)
0.5	8.0	GO:0006590	thyroid hormone generation(GO:0006590)
0.5	7.9	GO:0044406	adhesion of symbiont to host(GO:0044406)
0.5	3.0	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.5	2.0	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.5	1.4	GO:0006601	creatine biosynthetic process(GO:0006601)
0.5	1.9	GO:0032379	positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
0.5	14.4	GO:0035634	response to stilbenoid(GO:0035634)
0.4	1.8	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.4	1.3	GO:0019255	UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.4	9.6	GO:0010818	T cell chemotaxis(GO:0010818)
0.4	4.7	GO:0071763	nuclear membrane organization(GO:0071763)
0.4	0.8	GO:0010899	regulation of phosphatidylcholine catabolic process(GO:0010899)
0.4	1.7	GO:0046098	guanine metabolic process(GO:0046098)
0.4	2.0	GO:0097527	regulation of dendritic cell cytokine production(GO:0002730) necroptotic signaling pathway(GO:0097527)
0.4	2.4	GO:0018992	germ-line sex determination(GO:0018992)
0.4	1.2	GO:0072488	ammonium transmembrane transport(GO:0072488)
0.4	3.9	GO:0072602	interleukin-4 secretion(GO:0072602)
0.4	2.3	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.4	1.9	GO:0071649	regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.4	2.2	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.4	2.2	GO:0060751	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.4	11.1	GO:0017144	drug metabolic process(GO:0017144)
0.4	4.8	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.4	1.4	GO:0030091	protein repair(GO:0030091)
0.4	0.4	GO:0044830	modulation by host of viral RNA genome replication(GO:0044830)
0.4	1.1	GO:1903976	negative regulation of glial cell migration(GO:1903976)
0.3	1.4	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.3	3.0	GO:0006528	asparagine metabolic process(GO:0006528)
0.3	10.8	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.3	0.3	GO:1990009	retinal cell apoptotic process(GO:1990009)
0.3	2.2	GO:1900170	negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3	0.9	GO:1903487	regulation of lactation(GO:1903487)
0.3	6.8	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
0.3	1.2	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.3	0.9	GO:0061763	multivesicular body-lysosome fusion(GO:0061763)
0.3	2.7	GO:0006741	NADP biosynthetic process(GO:0006741)
0.3	1.2	GO:0010609	mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609)
0.3	0.8	GO:0006553	lysine metabolic process(GO:0006553)
0.3	1.7	GO:0051490	negative regulation of filopodium assembly(GO:0051490)
0.3	0.8	GO:0045013	carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.3	1.3	GO:0006041	glucosamine metabolic process(GO:0006041) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.3	3.5	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.3	0.5	GO:0002661	B cell tolerance induction(GO:0002514) regulation of tolerance induction to self antigen(GO:0002649) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.3	1.6	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.3	1.0	GO:0003134	BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134)
0.3	0.8	GO:0042231	interleukin-13 biosynthetic process(GO:0042231)
0.2	1.7	GO:0019348	dolichol metabolic process(GO:0019348)
0.2	4.0	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.2	2.2	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.2	0.7	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
0.2	0.5	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.2	1.2	GO:0070495	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2	1.9	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.2	5.1	GO:0046473	phosphatidic acid metabolic process(GO:0046473)
0.2	6.2	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.2	0.7	GO:0021627	olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
0.2	0.9	GO:1905053	regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.2	0.7	GO:0030887	positive regulation of myeloid dendritic cell activation(GO:0030887)
0.2	1.1	GO:0060355	regulation of cell adhesion molecule production(GO:0060353) positive regulation of cell adhesion molecule production(GO:0060355)
0.2	1.8	GO:0006105	succinate metabolic process(GO:0006105)
0.2	2.4	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.2	2.6	GO:0052697	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2	3.9	GO:0033601	positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.2	2.8	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2	2.3	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.2	1.5	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.2	4.9	GO:0032825	positive regulation of natural killer cell differentiation(GO:0032825)
0.2	1.7	GO:0032494	response to peptidoglycan(GO:0032494)
0.2	1.4	GO:0052805	imidazole-containing compound catabolic process(GO:0052805)
0.2	22.9	GO:0019395	fatty acid oxidation(GO:0019395)
0.2	0.8	GO:1904569	regulation of selenocysteine incorporation(GO:1904569)
0.2	1.8	GO:0035902	response to immobilization stress(GO:0035902)
0.2	1.4	GO:0051204	protein insertion into mitochondrial membrane(GO:0051204)
0.2	2.6	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2	0.8	GO:0072086	specification of loop of Henle identity(GO:0072086)
0.2	0.4	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of pro-B cell differentiation(GO:2000974)
0.2	3.2	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.2	1.5	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.2	17.7	GO:0035383	acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.2	1.7	GO:0015961	diadenosine polyphosphate catabolic process(GO:0015961)
0.2	4.0	GO:0046069	cGMP catabolic process(GO:0046069)
0.2	0.5	GO:0006203	dGTP catabolic process(GO:0006203) DNA protection(GO:0042262)
0.2	0.7	GO:0070317	negative regulation of G0 to G1 transition(GO:0070317)
0.2	8.0	GO:0071346	cellular response to interferon-gamma(GO:0071346)
0.2	1.2	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.2	1.9	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.2	0.7	GO:0036367	adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.2	0.8	GO:0051138	positive regulation of NK T cell differentiation(GO:0051138)
0.2	1.0	GO:0010990	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.2	1.5	GO:0061709	reticulophagy(GO:0061709)
0.2	0.8	GO:0035063	nuclear speck organization(GO:0035063)
0.2	0.6	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.2	1.3	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.2	0.3	GO:1905161	protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.2	1.4	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2	3.3	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.1	0.9	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.1	3.9	GO:0061462	protein localization to lysosome(GO:0061462)
0.1	1.5	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1	2.6	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.1	4.4	GO:0070266	necroptotic process(GO:0070266)
0.1	1.6	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.1	1.7	GO:0006623	protein targeting to vacuole(GO:0006623)
0.1	1.7	GO:0032815	negative regulation of natural killer cell activation(GO:0032815)
0.1	7.9	GO:0019882	antigen processing and presentation(GO:0019882)
0.1	1.8	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.1	2.9	GO:0006491	N-glycan processing(GO:0006491)
0.1	1.2	GO:0006682	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1	3.6	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1	2.0	GO:0015747	urate transport(GO:0015747)
0.1	0.4	GO:0048698	negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1	0.3	GO:0035927	RNA import into mitochondrion(GO:0035927) rRNA import into mitochondrion(GO:0035928)
0.1	1.7	GO:0060337	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1	0.5	GO:0006669	sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.1	0.5	GO:1903999	regulation of eating behavior(GO:1903998) negative regulation of eating behavior(GO:1903999) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.1	6.0	GO:0001702	gastrulation with mouth forming second(GO:0001702)
0.1	3.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.1	0.4	GO:0006404	RNA import into nucleus(GO:0006404) snRNA transport(GO:0051030)
0.1	2.0	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.1	0.8	GO:0036438	maintenance of lens transparency(GO:0036438)
0.1	0.6	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1	0.2	GO:0035935	androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.1	1.4	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.1	6.4	GO:0006687	glycosphingolipid metabolic process(GO:0006687)
0.1	0.3	GO:0021852	pyramidal neuron migration(GO:0021852)
0.1	0.9	GO:0033184	positive regulation of histone ubiquitination(GO:0033184)
0.1	0.5	GO:0006063	uronic acid metabolic process(GO:0006063) glucuronate metabolic process(GO:0019585)
0.1	1.3	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1	0.3	GO:0018146	keratan sulfate biosynthetic process(GO:0018146)
0.1	0.4	GO:1901026	ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.1	0.9	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.3	GO:2000851	positive regulation of glucocorticoid secretion(GO:2000851)
0.1	0.4	GO:0002143	tRNA wobble position uridine thiolation(GO:0002143)
0.1	7.0	GO:0006695	cholesterol biosynthetic process(GO:0006695)
0.1	1.3	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.1	1.7	GO:0046415	urate metabolic process(GO:0046415)
0.1	3.2	GO:0008053	mitochondrial fusion(GO:0008053)
0.1	2.1	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1	0.3	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.1	1.4	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1	5.5	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1	1.4	GO:0035988	chondrocyte proliferation(GO:0035988)
0.1	0.7	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1	0.8	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1	1.5	GO:0045723	positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1	0.7	GO:0019532	oxalate transport(GO:0019532)
0.1	1.6	GO:0060628	regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1	1.6	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.1	0.6	GO:0034334	adherens junction maintenance(GO:0034334)
0.1	2.4	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.1	0.2	GO:1900135	positive regulation of renin secretion into blood stream(GO:1900135)
0.1	0.4	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of serotonin uptake(GO:0051612)
0.1	4.1	GO:0046825	regulation of protein export from nucleus(GO:0046825)
0.1	1.0	GO:0060613	fat pad development(GO:0060613)
0.1	0.5	GO:0003373	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1	1.5	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.1	3.4	GO:0010390	histone monoubiquitination(GO:0010390)
0.1	1.1	GO:0007028	cytoplasm organization(GO:0007028)
0.1	0.4	GO:0098957	anterograde axonal transport of mitochondrion(GO:0098957)
0.1	0.3	GO:0009305	protein biotinylation(GO:0009305) response to biotin(GO:0070781) histone biotinylation(GO:0071110)
0.1	0.5	GO:0097475	motor neuron migration(GO:0097475)
0.1	0.4	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.1	0.4	GO:0021853	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1	0.6	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.1	1.8	GO:0009214	cyclic nucleotide catabolic process(GO:0009214)
0.1	0.5	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.1	1.0	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1	1.1	GO:2000778	positive regulation of interleukin-6 secretion(GO:2000778)
0.1	0.2	GO:0061090	positive regulation of sequestering of zinc ion(GO:0061090)
0.1	0.2	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.1	0.5	GO:0090234	regulation of kinetochore assembly(GO:0090234)
0.1	0.4	GO:0018343	protein farnesylation(GO:0018343)
0.1	0.3	GO:0033566	gamma-tubulin complex localization(GO:0033566)
0.1	9.3	GO:0016052	carbohydrate catabolic process(GO:0016052)
0.1	0.7	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1	0.2	GO:1900248	cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) positive regulation of mRNA polyadenylation(GO:1900365)
0.1	1.1	GO:0033750	ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.1	0.7	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.1	0.6	GO:0061727	methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1	0.3	GO:0080163	regulation of protein serine/threonine phosphatase activity(GO:0080163)
0.1	0.4	GO:0033227	dsRNA transport(GO:0033227)
0.1	0.1	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.1	0.3	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.1	0.5	GO:0006983	ER overload response(GO:0006983)
0.1	0.2	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1	0.2	GO:1903121	regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1	0.2	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.1	0.5	GO:0048245	eosinophil chemotaxis(GO:0048245)
0.1	2.8	GO:0006376	mRNA splice site selection(GO:0006376)
0.1	2.9	GO:0044380	protein localization to cytoskeleton(GO:0044380)
0.1	0.6	GO:0031953	negative regulation of protein autophosphorylation(GO:0031953)
0.1	0.2	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1	0.4	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.1	0.2	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
0.1	2.6	GO:0035019	somatic stem cell population maintenance(GO:0035019)
0.1	0.5	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1	2.0	GO:0006767	water-soluble vitamin metabolic process(GO:0006767)
0.1	2.2	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.1	0.8	GO:0032836	glomerular basement membrane development(GO:0032836)
0.1	3.8	GO:0032088	negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.1	0.4	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.4	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.0	2.2	GO:0032755	positive regulation of interleukin-6 production(GO:0032755)
0.0	0.8	GO:0019363	pyridine nucleotide biosynthetic process(GO:0019363)
0.0	1.2	GO:1903441	protein localization to ciliary membrane(GO:1903441)
0.0	0.1	GO:0022601	menstrual cycle phase(GO:0022601)
0.0	0.2	GO:2000312	regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0	0.4	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.7	GO:0036295	cellular response to increased oxygen levels(GO:0036295)
0.0	0.9	GO:0015813	L-glutamate transport(GO:0015813)
0.0	0.6	GO:0072189	ureter development(GO:0072189)
0.0	0.7	GO:0019433	triglyceride catabolic process(GO:0019433)
0.0	2.4	GO:0007040	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0	1.0	GO:0032094	response to food(GO:0032094)
0.0	0.3	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.1	GO:1903093	regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.0	0.7	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
0.0	0.2	GO:0035726	common myeloid progenitor cell proliferation(GO:0035726)
0.0	0.2	GO:0060988	lipid tube assembly(GO:0060988)
0.0	0.4	GO:0070072	proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.4	GO:0009188	ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.5	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.5	GO:0022904	respiratory electron transport chain(GO:0022904)
0.0	0.7	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.2	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.3	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0	0.2	GO:0098886	modification of dendritic spine(GO:0098886)
0.0	0.7	GO:0061512	protein localization to cilium(GO:0061512)
0.0	0.3	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.5	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.9	GO:0048011	neurotrophin TRK receptor signaling pathway(GO:0048011)
0.0	1.2	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.3	GO:0010838	positive regulation of keratinocyte proliferation(GO:0010838)
0.0	0.3	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.2	GO:0080154	regulation of fertilization(GO:0080154)
0.0	0.1	GO:0060220	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.0	0.6	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.5	GO:0051923	sulfation(GO:0051923)
0.0	1.2	GO:0050919	negative chemotaxis(GO:0050919)
0.0	1.8	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.2	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.7	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.3	GO:0045974	miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0	0.9	GO:0007143	female meiotic division(GO:0007143)
0.0	0.2	GO:0006450	regulation of translational fidelity(GO:0006450)
0.0	0.3	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.6	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.2	GO:0070445	oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0	0.1	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.0	0.1	GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0	7.4	GO:0009116	nucleoside metabolic process(GO:0009116)
0.0	0.3	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	1.2	GO:0045840	positive regulation of mitotic nuclear division(GO:0045840)
0.0	0.5	GO:0019674	NAD metabolic process(GO:0019674)
0.0	0.1	GO:0046880	regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) positive regulation of ovulation(GO:0060279)
0.0	0.1	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.5	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.2	GO:1901162	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0	0.3	GO:0090129	positive regulation of synapse maturation(GO:0090129)
0.0	0.2	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0	1.3	GO:0006749	glutathione metabolic process(GO:0006749)
0.0	0.2	GO:0051096	regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0	0.1	GO:1902896	terminal web assembly(GO:1902896)
0.0	1.2	GO:0006289	nucleotide-excision repair(GO:0006289)
0.0	0.8	GO:0071385	cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0	1.7	GO:0051781	positive regulation of cell division(GO:0051781)
0.0	0.5	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.2	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	3.4	GO:0030705	cytoskeleton-dependent intracellular transport(GO:0030705)
0.0	0.1	GO:0090032	negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.0	0.2	GO:0002566	somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0	0.3	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	3.5	GO:0007286	spermatid development(GO:0007286)
0.0	0.9	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.5	GO:0050901	leukocyte tethering or rolling(GO:0050901)
0.0	0.0	GO:0090158	endoplasmic reticulum membrane organization(GO:0090158)
0.0	2.6	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	1.1	GO:0021766	hippocampus development(GO:0021766)
0.0	0.4	GO:0050434	positive regulation of viral transcription(GO:0050434)
0.0	0.8	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.6	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0035610	protein side chain deglutamylation(GO:0035610)
0.0	0.4	GO:0046852	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	1.8	GO:0006006	glucose metabolic process(GO:0006006)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.5	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.3	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	1.5	GO:0007281	germ cell development(GO:0007281)
0.0	0.2	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.3	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.3	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0	0.1	GO:0072092	renal vesicle formation(GO:0072033) ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093)
0.0	0.3	GO:1902600	hydrogen ion transmembrane transport(GO:1902600)
0.0	0.2	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.0	GO:0060005	vestibular reflex(GO:0060005)
0.0	2.3	GO:0016042	lipid catabolic process(GO:0016042)
0.0	1.8	GO:0007601	visual perception(GO:0007601)
0.0	0.2	GO:0036159	inner dynein arm assembly(GO:0036159)
0.0	0.3	GO:1901984	negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.1	GO:0036337	Fas signaling pathway(GO:0036337)
0.0	0.2	GO:0007220	Notch receptor processing(GO:0007220)
0.0	0.2	GO:0031643	positive regulation of myelination(GO:0031643)
0.0	0.6	GO:0051453	regulation of intracellular pH(GO:0051453)
0.0	0.1	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.2	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.5	GO:1900047	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0	0.1	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.4	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0	0.1	GO:0060467	negative regulation of fertilization(GO:0060467)
0.0	0.2	GO:2000381	negative regulation of mesoderm development(GO:2000381)
0.0	0.3	GO:0046329	negative regulation of JNK cascade(GO:0046329)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.3	73.8	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
3.6	28.9	GO:0042825	TAP complex(GO:0042825)
3.5	7.1	GO:0020003	symbiont-containing vacuole(GO:0020003)
3.3	46.2	GO:0042612	MHC class I protein complex(GO:0042612)
2.7	16.5	GO:1990111	spermatoproteasome complex(GO:1990111)
2.1	8.5	GO:0097447	dendritic tree(GO:0097447)
1.0	9.4	GO:1990357	terminal web(GO:1990357)
1.0	4.9	GO:0043202	lysosomal lumen(GO:0043202)
1.0	10.6	GO:0045098	type III intermediate filament(GO:0045098)
0.9	5.6	GO:0071556	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.8	8.0	GO:0030478	actin cap(GO:0030478)
0.7	2.9	GO:0031084	BLOC-2 complex(GO:0031084)
0.6	5.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.6	9.4	GO:0044754	autolysosome(GO:0044754)
0.6	4.9	GO:0033269	internode region of axon(GO:0033269)
0.6	3.0	GO:0044316	cone cell pedicle(GO:0044316)
0.6	2.9	GO:0017177	glucosidase II complex(GO:0017177)
0.5	1.6	GO:0030870	Mre11 complex(GO:0030870)
0.5	23.0	GO:0055038	recycling endosome membrane(GO:0055038)
0.5	2.4	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.5	0.5	GO:0042788	polysomal ribosome(GO:0042788)
0.4	1.8	GO:0045257	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.4	1.7	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.4	3.8	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.3	1.4	GO:0019034	viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.3	16.7	GO:0035861	site of double-strand break(GO:0035861)
0.3	3.1	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.3	1.3	GO:0005914	spot adherens junction(GO:0005914)
0.3	0.8	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.3	1.5	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.2	3.1	GO:0042611	MHC protein complex(GO:0042611)
0.2	1.8	GO:0071986	Ragulator complex(GO:0071986)
0.2	1.5	GO:0097550	transcriptional preinitiation complex(GO:0097550)
0.2	2.6	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.2	5.5	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.2	1.7	GO:0005579	membrane attack complex(GO:0005579)
0.2	1.1	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.2	1.5	GO:0045293	mRNA editing complex(GO:0045293)
0.2	1.6	GO:0005577	fibrinogen complex(GO:0005577)
0.2	0.5	GO:0000814	ESCRT II complex(GO:0000814)
0.2	0.8	GO:0005956	protein kinase CK2 complex(GO:0005956)
0.2	1.4	GO:0042587	glycogen granule(GO:0042587)
0.2	1.2	GO:0000439	core TFIIH complex(GO:0000439)
0.2	90.2	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.2	5.3	GO:0033270	paranode region of axon(GO:0033270)
0.1	1.0	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.1	3.5	GO:0002080	acrosomal membrane(GO:0002080)
0.1	7.6	GO:0030673	axolemma(GO:0030673)
0.1	0.4	GO:0043291	RAVE complex(GO:0043291)
0.1	1.5	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1	1.8	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.1	2.1	GO:0016235	aggresome(GO:0016235)
0.1	0.4	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	1.0	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.1	1.3	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.1	2.3	GO:0060293	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1	1.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	1.4	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1	0.8	GO:0098651	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1	9.2	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1	3.5	GO:0045095	keratin filament(GO:0045095)
0.1	5.2	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	0.9	GO:0031931	TORC1 complex(GO:0031931)
0.1	0.5	GO:0043293	apoptosome(GO:0043293)
0.1	1.0	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750)
0.1	9.0	GO:0042734	presynaptic membrane(GO:0042734)
0.1	0.5	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.1	14.3	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.1	6.5	GO:0005811	lipid particle(GO:0005811)
0.1	1.2	GO:1990635	proximal dendrite(GO:1990635)
0.1	10.1	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	1.2	GO:0017119	Golgi transport complex(GO:0017119)
0.1	0.5	GO:0070695	FHF complex(GO:0070695)
0.1	16.9	GO:0031225	anchored component of membrane(GO:0031225)
0.1	0.7	GO:0005839	proteasome core complex(GO:0005839)
0.1	1.5	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1	2.3	GO:0031301	integral component of organelle membrane(GO:0031301)
0.1	1.5	GO:0070069	cytochrome complex(GO:0070069)
0.1	1.3	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1	1.9	GO:0030660	Golgi-associated vesicle membrane(GO:0030660)
0.1	16.1	GO:0072562	blood microparticle(GO:0072562)
0.1	0.2	GO:1990622	CHOP-ATF3 complex(GO:1990622)
0.1	0.7	GO:0071203	WASH complex(GO:0071203)
0.1	0.2	GO:0072534	perineuronal net(GO:0072534)
0.1	2.4	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) respiratory chain complex(GO:0098803)
0.1	74.5	GO:0005783	endoplasmic reticulum(GO:0005783)
0.0	0.2	GO:0097444	spine apparatus(GO:0097444)
0.0	0.9	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	1.1	GO:0030175	filopodium(GO:0030175)
0.0	7.7	GO:0005923	bicellular tight junction(GO:0005923)
0.0	1.4	GO:0005581	collagen trimer(GO:0005581)
0.0	1.4	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.1	GO:0043512	inhibin A complex(GO:0043512)
0.0	0.5	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	1.8	GO:0031901	early endosome membrane(GO:0031901)
0.0	1.5	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.3	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	9.0	GO:0005759	mitochondrial matrix(GO:0005759)
0.0	1.8	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.2	GO:0030897	HOPS complex(GO:0030897)
0.0	0.4	GO:0097542	ciliary tip(GO:0097542)
0.0	47.5	GO:0005615	extracellular space(GO:0005615)
0.0	12.8	GO:0043235	receptor complex(GO:0043235)
0.0	0.3	GO:0000813	ESCRT I complex(GO:0000813)
0.0	0.4	GO:0097440	apical dendrite(GO:0097440)
0.0	0.5	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.1	GO:0098636	protein complex involved in cell adhesion(GO:0098636)
0.0	0.7	GO:0031527	filopodium membrane(GO:0031527)
0.0	4.4	GO:0031965	nuclear membrane(GO:0031965)
0.0	0.3	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	0.6	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	1.2	GO:0045171	intercellular bridge(GO:0045171)
0.0	0.3	GO:0043196	varicosity(GO:0043196)
0.0	3.6	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	0.2	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0	0.4	GO:1904115	axon cytoplasm(GO:1904115)
0.0	2.7	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	3.4	GO:0005770	late endosome(GO:0005770)
0.0	83.3	GO:0005829	cytosol(GO:0005829)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.9	GO:0055037	recycling endosome(GO:0055037)
0.0	0.2	GO:0002177	manchette(GO:0002177)
0.0	0.1	GO:0005746	mitochondrial respiratory chain(GO:0005746)
0.0	0.3	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.8	GO:0005902	microvillus(GO:0005902)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.3	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.4	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.3	GO:0034707	chloride channel complex(GO:0034707)
0.0	0.5	GO:0005882	intermediate filament(GO:0005882)
0.0	3.5	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.0	1.5	GO:0000139	Golgi membrane(GO:0000139)
0.0	1.6	GO:0045177	apical part of cell(GO:0045177)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.8	23.4	GO:0003692	left-handed Z-DNA binding(GO:0003692)
5.6	16.9	GO:0015433	peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
4.0	12.0	GO:0050479	glyceryl-ether monooxygenase activity(GO:0050479)
3.0	12.1	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
2.9	11.4	GO:0004478	methionine adenosyltransferase activity(GO:0004478)
2.8	16.8	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
2.4	40.9	GO:0030881	beta-2-microglobulin binding(GO:0030881)
2.3	16.3	GO:0004556	alpha-amylase activity(GO:0004556)
2.2	17.8	GO:0003996	acyl-CoA ligase activity(GO:0003996)
2.1	21.4	GO:0019763	immunoglobulin receptor activity(GO:0019763)
2.1	25.6	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
2.1	21.0	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
2.0	14.2	GO:0031849	olfactory receptor binding(GO:0031849)
1.8	3.7	GO:0016160	amylase activity(GO:0016160)
1.7	6.6	GO:0003884	D-amino-acid oxidase activity(GO:0003884)
1.6	9.8	GO:0004850	uridine phosphorylase activity(GO:0004850)
1.6	6.4	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
1.4	5.7	GO:0003844	1,4-alpha-glucan branching enzyme activity(GO:0003844)
1.4	4.3	GO:0019002	GMP binding(GO:0019002)
1.4	15.4	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
1.4	12.6	GO:0016936	galactoside binding(GO:0016936)
1.3	4.0	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
1.3	5.2	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
1.3	7.8	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
1.3	7.6	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
1.2	4.7	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
1.1	27.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
1.1	4.4	GO:0002114	interleukin-33 receptor activity(GO:0002114)
1.1	7.6	GO:0070573	metallodipeptidase activity(GO:0070573)
1.0	3.0	GO:0042015	interleukin-20 binding(GO:0042015)
1.0	11.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.9	2.8	GO:1990698	palmitoleoyltransferase activity(GO:1990698)
0.9	3.7	GO:0005118	sevenless binding(GO:0005118)
0.9	3.6	GO:1904408	dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408)
0.9	2.6	GO:0004658	propionyl-CoA carboxylase activity(GO:0004658)
0.9	5.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.8	18.6	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.7	3.0	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.7	2.2	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.7	18.4	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.7	8.5	GO:0102336	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.7	2.7	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.7	6.8	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.6	3.6	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.6	1.8	GO:0008177	succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.6	5.9	GO:0051434	BH3 domain binding(GO:0051434)
0.6	3.5	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.6	5.6	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.5	1.6	GO:0008119	thiopurine S-methyltransferase activity(GO:0008119)
0.5	1.6	GO:0019120	hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
0.5	3.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.5	3.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.5	1.5	GO:0038052	type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.5	7.2	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.5	3.1	GO:1990254	keratin filament binding(GO:1990254)
0.5	15.8	GO:0008009	chemokine activity(GO:0008009)
0.5	1.5	GO:0003863	alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.5	5.8	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.5	1.9	GO:0050632	propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.5	1.9	GO:0047275	glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.5	3.6	GO:1901612	cardiolipin binding(GO:1901612)
0.4	1.8	GO:0008506	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.4	1.7	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.4	1.7	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.4	1.7	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.4	1.7	GO:0047710	bis(5'-adenosyl)-triphosphatase activity(GO:0047710)
0.4	1.2	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.4	30.4	GO:0019003	GDP binding(GO:0019003)
0.4	7.6	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.4	17.5	GO:0001671	ATPase activator activity(GO:0001671)
0.4	2.7	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.4	2.6	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.4	114.2	GO:0003924	GTPase activity(GO:0003924)
0.4	2.2	GO:0004883	glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.4	3.6	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.4	1.4	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.4	3.5	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.3	3.8	GO:0070513	death domain binding(GO:0070513)
0.3	3.1	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.3	7.3	GO:0042605	peptide antigen binding(GO:0042605)
0.3	1.6	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.3	0.9	GO:0008775	acetate CoA-transferase activity(GO:0008775)
0.3	5.1	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.3	1.2	GO:0005008	hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3	2.8	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3	0.8	GO:0050262	ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.3	2.6	GO:0015288	porin activity(GO:0015288)
0.3	1.6	GO:0045340	mercury ion binding(GO:0045340)
0.3	4.6	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3	1.5	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.2	5.8	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2	3.8	GO:0019203	carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.2	5.8	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2	0.7	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.2	0.7	GO:0032394	MHC class Ib receptor activity(GO:0032394)
0.2	1.1	GO:0070287	ferritin receptor activity(GO:0070287)
0.2	3.0	GO:0051400	BH domain binding(GO:0051400)
0.2	1.5	GO:0015315	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.2	3.5	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.2	6.8	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.2	1.2	GO:0045322	unmethylated CpG binding(GO:0045322)
0.2	0.8	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2	1.4	GO:0042328	heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.2	4.6	GO:0005521	lamin binding(GO:0005521)
0.2	3.2	GO:0003951	NAD+ kinase activity(GO:0003951)
0.2	1.3	GO:0070569	uridylyltransferase activity(GO:0070569)
0.2	19.5	GO:0004497	monooxygenase activity(GO:0004497)
0.2	0.5	GO:0005026	transforming growth factor beta receptor activity, type II(GO:0005026)
0.2	2.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.2	2.2	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2	16.2	GO:0003725	double-stranded RNA binding(GO:0003725)
0.1	1.5	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.1	0.6	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.1	1.0	GO:0070699	type II activin receptor binding(GO:0070699)
0.1	0.7	GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761)
0.1	0.8	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1	0.7	GO:0043758	acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1	0.8	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	0.7	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	0.3	GO:0005110	frizzled-2 binding(GO:0005110)
0.1	2.4	GO:0003993	acid phosphatase activity(GO:0003993)
0.1	0.5	GO:0045131	pre-mRNA branch point binding(GO:0045131)
0.1	1.2	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.1	1.4	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1	0.4	GO:0071820	N-box binding(GO:0071820)
0.1	3.6	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1	2.1	GO:0070628	proteasome binding(GO:0070628)
0.1	2.4	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.1	0.4	GO:0033149	FFAT motif binding(GO:0033149)
0.1	7.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1	1.6	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.1	2.4	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.1	24.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	3.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.1	0.5	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.1	0.4	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702) uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1	2.2	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1	0.8	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.1	1.0	GO:0039706	co-receptor binding(GO:0039706)
0.1	2.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.1	2.5	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	0.7	GO:0005042	netrin receptor activity(GO:0005042)
0.1	0.4	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	3.6	GO:0030552	cAMP binding(GO:0030552)
0.1	2.9	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1	5.4	GO:0004520	endodeoxyribonuclease activity(GO:0004520)
0.1	0.4	GO:0050145	nucleoside phosphate kinase activity(GO:0050145)
0.1	0.7	GO:0017040	ceramidase activity(GO:0017040)
0.1	2.5	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1	0.5	GO:0033142	progesterone receptor binding(GO:0033142)
0.1	1.2	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.1	0.3	GO:0004078	biotin-[acetyl-CoA-carboxylase] ligase activity(GO:0004077) biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity(GO:0004078) biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity(GO:0004079) biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity(GO:0004080) biotin-protein ligase activity(GO:0018271)
0.1	1.1	GO:0019869	chloride channel inhibitor activity(GO:0019869)
0.1	2.8	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.1	3.7	GO:0071889	14-3-3 protein binding(GO:0071889)
0.1	0.4	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1	2.2	GO:0005044	scavenger receptor activity(GO:0005044)
0.1	9.3	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1	0.8	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.1	2.1	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1	0.4	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.1	0.8	GO:0016505	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) peptidase activator activity involved in apoptotic process(GO:0016505)
0.1	2.9	GO:0016790	thiolester hydrolase activity(GO:0016790)
0.1	0.2	GO:0033038	bitter taste receptor activity(GO:0033038)
0.1	2.6	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.1	21.1	GO:0001047	core promoter binding(GO:0001047)
0.1	0.5	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1	0.2	GO:0070698	type I activin receptor binding(GO:0070698)
0.1	1.1	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.1	0.5	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1	0.7	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.1	3.5	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	0.8	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1	0.7	GO:0019215	intermediate filament binding(GO:0019215)
0.1	0.5	GO:0005000	vasopressin receptor activity(GO:0005000)
0.1	1.1	GO:0004112	cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1	1.8	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.1	2.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	0.2	GO:0008147	structural constituent of bone(GO:0008147)
0.0	6.7	GO:0005179	hormone activity(GO:0005179)
0.0	0.5	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.5	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.4	GO:0032407	MutSalpha complex binding(GO:0032407)
0.0	0.3	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.6	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.4	GO:0032795	heterotrimeric G-protein binding(GO:0032795)
0.0	2.9	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	1.3	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0	0.1	GO:0071796	K6-linked polyubiquitin binding(GO:0071796)
0.0	3.3	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0	1.2	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.2	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.2	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.0	0.9	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	5.3	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	1.0	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	1.2	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.0	1.1	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.7	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.7	GO:0008276	protein methyltransferase activity(GO:0008276)
0.0	0.5	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.3	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
0.0	1.0	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.3	GO:0008494	translation activator activity(GO:0008494)
0.0	0.7	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.7	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	1.0	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	2.8	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	0.2	GO:0016679	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.2	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0004980	melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0	0.6	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.3	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.0	2.9	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.0	0.3	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.7	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.2	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.9	GO:0005109	frizzled binding(GO:0005109)
0.0	0.4	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.5	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.8	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.3	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	1.1	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.9	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974) histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.6	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.9	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.3	GO:0005537	mannose binding(GO:0005537)
0.0	0.1	GO:0015111	iodide transmembrane transporter activity(GO:0015111)
0.0	0.9	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.4	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.4	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	1.3	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	1.3	GO:0008013	beta-catenin binding(GO:0008013)
0.0	0.1	GO:0008176	tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.0	1.1	GO:0008170	N-methyltransferase activity(GO:0008170)
0.0	0.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	4.1	GO:0008017	microtubule binding(GO:0008017)
0.0	1.4	GO:0005525	GTP binding(GO:0005525)
0.0	1.9	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
0.0	1.6	GO:0005178	integrin binding(GO:0005178)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.5	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.7	GO:0015485	cholesterol binding(GO:0015485)
0.0	0.4	GO:0042974	retinoic acid receptor binding(GO:0042974)
0.0	0.2	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.5	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0046527	glucosyltransferase activity(GO:0046527)
0.0	1.4	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	29.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.7	21.8	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	8.4	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2	13.6	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.2	23.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	18.6	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	6.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	7.6	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.2	6.9	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.2	7.3	PID ARF6 PATHWAY	Arf6 signaling events
0.1	1.6	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	1.6	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.1	1.3	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	11.5	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.1	22.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.8	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.1	12.2	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	1.7	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	0.8	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	2.1	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	3.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	2.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	3.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	1.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	2.7	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	1.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	0.8	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.6	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	1.2	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	12.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.3	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	1.1	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	2.0	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.9	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	1.0	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	2.3	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.8	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	1.2	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	0.4	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	0.6	PID P73PATHWAY	p73 transcription factor network
0.0	1.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.8	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	0.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	1.3	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.9	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	2.0	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	0.6	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.3	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.7	PID ENDOTHELIN PATHWAY	Endothelins
0.0	0.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.6	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.0	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	1.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.2	15.7	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
1.9	26.6	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
1.4	24.4	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
1.4	19.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
1.1	20.9	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.1	11.6	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
1.0	5.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
1.0	25.7	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.9	3.7	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.9	11.4	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.9	10.4	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.6	7.8	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.5	13.3	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.5	9.8	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.5	29.9	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.5	14.7	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4	23.3	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.4	3.9	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.3	11.4	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.3	2.7	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.3	16.6	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.3	3.8	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.3	7.2	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3	6.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	1.6	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.2	2.9	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.2	2.4	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.2	4.4	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.2	11.1	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.2	4.0	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2	6.5	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.2	2.7	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2	3.1	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2	4.8	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.1	5.1	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	1.3	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	2.2	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1	1.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.1	6.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	0.9	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	5.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	4.5	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
0.1	1.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	3.7	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	1.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.1	10.2	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.1	5.3	REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.1	1.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	3.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	0.9	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	1.5	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.1	1.5	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.1	2.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	1.8	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	1.3	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.1	4.7	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.1	3.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	6.9	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	0.7	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.1	1.6	REACTOME BIOLOGICAL OXIDATIONS	Genes involved in Biological oxidations
0.1	1.9	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	1.0	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.1	2.7	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	1.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	0.3	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.1	2.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	4.5	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	0.8	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.7	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.8	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	2.1	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.6	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.9	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.5	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.0	3.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.7	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.8	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.4	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	1.1	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.6	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	1.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	1.0	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	3.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.0	0.7	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.6	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	0.3	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.7	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0	1.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.3	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	2.0	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.0	0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.7	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.0	0.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.4	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.2	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4

Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 2.92

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: