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GSE58827: Dynamics of the Mouse Liver

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Results for Irf3

Z-value: 1.18

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Transcription factors associated with Irf3

Gene Symbol Gene ID Gene Info
Irf3
ENSMUSG00000003184.16 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irf3mm39_v1_chr7_+_44647072_446471260.241.6e-01Click!

Activity profile of Irf3 motif

Sorted Z-values of Irf3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_48883053 7.01 ENSMUST00000059930.3
ENSMUST00000068063.4
Gm12185
Tgtp1
predicted gene 12185
T cell specific GTPase 1
chr11_-_48955028 6.35 ENSMUST00000046745.7
Tgtp2
T cell specific GTPase 2
chr4_-_156285247 5.48 ENSMUST00000085425.6
Isg15
ISG15 ubiquitin-like modifier
chr19_+_34560922 4.46 ENSMUST00000102825.4
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
chr2_-_173060647 3.82 ENSMUST00000109116.3
ENSMUST00000029018.14
Zbp1
Z-DNA binding protein 1
chr5_+_115034997 3.49 ENSMUST00000031542.13
ENSMUST00000146072.8
ENSMUST00000150361.2
Oasl2
2'-5' oligoadenylate synthetase-like 2
chr7_-_140846328 3.37 ENSMUST00000106023.8
ENSMUST00000097952.9
ENSMUST00000026571.11
Irf7
interferon regulatory factor 7
chr5_-_121045568 3.32 ENSMUST00000080322.8
Oas1a
2'-5' oligoadenylate synthetase 1A
chr11_+_72192455 2.97 ENSMUST00000151440.8
ENSMUST00000146233.8
ENSMUST00000140842.9
Xaf1
XIAP associated factor 1
chr17_+_34406762 2.90 ENSMUST00000041633.15
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34406523 2.88 ENSMUST00000170086.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_+_58090382 2.78 ENSMUST00000035266.11
ENSMUST00000094169.11
ENSMUST00000168280.2
ENSMUST00000058704.9
Igtp
Irgm2
interferon gamma induced GTPase
immunity-related GTPase family M member 2
chr5_-_121025645 2.64 ENSMUST00000086368.12
Oas1g
2'-5' oligoadenylate synthetase 1G
chr11_-_48762170 2.52 ENSMUST00000049519.4
ENSMUST00000097271.4
Irgm1
immunity-related GTPase family M member 1
chr16_+_23428650 2.49 ENSMUST00000038423.6
ENSMUST00000211349.2
Rtp4
receptor transporter protein 4
chr11_-_100595019 2.44 ENSMUST00000017974.13
Dhx58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr15_-_77295234 2.13 ENSMUST00000089452.6
ENSMUST00000081776.11
Apol9a
apolipoprotein L 9a
chr3_+_142236086 2.09 ENSMUST00000171263.8
ENSMUST00000045097.11
Gbp7
guanylate binding protein 7
chr15_+_77613239 1.86 ENSMUST00000230979.2
ENSMUST00000109775.4
Apol9b
apolipoprotein L 9b
chr5_-_120950570 1.76 ENSMUST00000117193.8
Oas1c
2'-5' oligoadenylate synthetase 1C
chr11_-_83421333 1.76 ENSMUST00000035938.3
Ccl5
chemokine (C-C motif) ligand 5
chr5_+_120950690 1.42 ENSMUST00000086377.9
Oas1b
2'-5' oligoadenylate synthetase 1B
chr8_-_71990085 1.36 ENSMUST00000051672.9
Bst2
bone marrow stromal cell antigen 2
chr10_+_128106414 1.35 ENSMUST00000085708.3
ENSMUST00000105238.10
Stat2
signal transducer and activator of transcription 2
chr18_-_32692967 1.32 ENSMUST00000174000.2
ENSMUST00000174459.2
Gypc
glycophorin C
chr17_-_36331416 1.28 ENSMUST00000174063.2
ENSMUST00000113760.10
H2-T24
histocompatibility 2, T region locus 24
chr15_+_77613348 1.24 ENSMUST00000230742.2
Apol9b
apolipoprotein L 9b
chr14_+_55815879 1.22 ENSMUST00000174563.8
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_+_142265787 1.22 ENSMUST00000199325.5
ENSMUST00000106222.9
Gbp3
guanylate binding protein 3
chr14_+_55815817 1.21 ENSMUST00000174259.8
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr14_+_55815580 1.17 ENSMUST00000174484.8
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr17_-_34406193 1.15 ENSMUST00000173831.3
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr14_+_55815999 1.14 ENSMUST00000172738.2
ENSMUST00000089619.13
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr11_+_119283887 1.12 ENSMUST00000093902.12
ENSMUST00000131035.10
Rnf213
ring finger protein 213
chr16_-_35691914 1.11 ENSMUST00000042665.9
Parp14
poly (ADP-ribose) polymerase family, member 14
chr6_-_39095144 1.08 ENSMUST00000038398.7
Parp12
poly (ADP-ribose) polymerase family, member 12
chr7_-_103964662 1.06 ENSMUST00000106837.8
ENSMUST00000106839.9
ENSMUST00000070943.7
Trim12a
tripartite motif-containing 12A
chr8_-_124045292 1.01 ENSMUST00000118395.2
ENSMUST00000035495.15
Fanca
Fanconi anemia, complementation group A
chr1_-_85526517 0.94 ENSMUST00000093508.7
Sp110
Sp110 nuclear body protein
chr2_+_180231038 0.85 ENSMUST00000029087.4
Ogfr
opioid growth factor receptor
chr7_-_102214636 0.83 ENSMUST00000106913.3
ENSMUST00000033264.12
Trim21
tripartite motif-containing 21
chr3_+_142265904 0.79 ENSMUST00000128609.8
ENSMUST00000029935.14
Gbp3
guanylate binding protein 3
chr7_+_78563964 0.73 ENSMUST00000120331.4
Isg20
interferon-stimulated protein
chr1_-_75294234 0.67 ENSMUST00000066668.14
ENSMUST00000185797.7
Dnpep
aspartyl aminopeptidase
chr3_+_142266113 0.66 ENSMUST00000106221.8
Gbp3
guanylate binding protein 3
chr1_+_85528392 0.66 ENSMUST00000080204.11
Sp140
Sp140 nuclear body protein
chr7_+_78563184 0.64 ENSMUST00000121645.8
Isg20
interferon-stimulated protein
chr16_-_10603389 0.59 ENSMUST00000229866.2
ENSMUST00000038099.6
Socs1
suppressor of cytokine signaling 1
chr2_-_166904902 0.57 ENSMUST00000048988.14
Znfx1
zinc finger, NFX1-type containing 1
chr1_-_75293793 0.55 ENSMUST00000187836.7
Dnpep
aspartyl aminopeptidase
chr11_+_109253598 0.55 ENSMUST00000106702.4
ENSMUST00000020930.14
Gna13
guanine nucleotide binding protein, alpha 13
chr2_-_166904625 0.55 ENSMUST00000128676.2
Znfx1
zinc finger, NFX1-type containing 1
chr15_-_82128538 0.54 ENSMUST00000229747.2
ENSMUST00000230408.2
Cenpm
centromere protein M
chr7_+_78564062 0.48 ENSMUST00000205981.2
Isg20
interferon-stimulated protein
chr3_-_151455514 0.48 ENSMUST00000029671.9
Ifi44
interferon-induced protein 44
chr6_-_125208738 0.46 ENSMUST00000043422.8
Tapbpl
TAP binding protein-like
chr7_+_78563513 0.46 ENSMUST00000038142.15
Isg20
interferon-stimulated protein
chr2_-_152174565 0.44 ENSMUST00000028964.14
Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr2_-_155668567 0.43 ENSMUST00000109638.2
ENSMUST00000134278.2
Eif6
eukaryotic translation initiation factor 6
chr6_-_34294377 0.42 ENSMUST00000154655.2
ENSMUST00000102980.11
Akr1b3
aldo-keto reductase family 1, member B3 (aldose reductase)
chr1_-_75293637 0.39 ENSMUST00000185419.7
ENSMUST00000187000.7
Dnpep
aspartyl aminopeptidase
chr7_+_103893658 0.38 ENSMUST00000106849.9
ENSMUST00000060315.12
Trim34a
tripartite motif-containing 34A
chr1_-_75293942 0.36 ENSMUST00000187075.7
Dnpep
aspartyl aminopeptidase
chr2_-_152174273 0.31 ENSMUST00000109847.9
Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_75293589 0.30 ENSMUST00000113605.10
Dnpep
aspartyl aminopeptidase
chr13_+_42205790 0.30 ENSMUST00000220525.2
Hivep1
human immunodeficiency virus type I enhancer binding protein 1
chr1_-_75293447 0.28 ENSMUST00000189551.7
Dnpep
aspartyl aminopeptidase
chr14_-_55828511 0.27 ENSMUST00000161807.8
ENSMUST00000111378.10
ENSMUST00000159687.2
Psme2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr16_+_35759346 0.26 ENSMUST00000023622.13
Parp9
poly (ADP-ribose) polymerase family, member 9
chr10_-_81332163 0.25 ENSMUST00000020463.14
Ncln
nicalin
chr9_+_20779924 0.24 ENSMUST00000043911.8
Shfl
shiftless antiviral inhibitor of ribosomal frameshifting
chr9_-_35087348 0.24 ENSMUST00000119847.2
ENSMUST00000034539.12
Dcps
decapping enzyme, scavenger
chr5_-_120950549 0.24 ENSMUST00000125547.2
Oas1c
2'-5' oligoadenylate synthetase 1C
chr6_-_54949587 0.24 ENSMUST00000060655.15
Nod1
nucleotide-binding oligomerization domain containing 1
chr6_+_34840151 0.22 ENSMUST00000202010.2
Tmem140
transmembrane protein 140
chr7_-_3551003 0.22 ENSMUST00000065703.9
ENSMUST00000203020.3
ENSMUST00000203821.3
Tarm1
T cell-interacting, activating receptor on myeloid cells 1
chr10_-_81332147 0.21 ENSMUST00000118498.8
Ncln
nicalin
chr7_-_104002534 0.21 ENSMUST00000130139.3
ENSMUST00000059037.15
Trim12c
tripartite motif-containing 12C
chr4_-_40239778 0.19 ENSMUST00000037907.13
Ddx58
DEAD/H box helicase 58
chr8_-_106665060 0.18 ENSMUST00000034369.10
Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr6_+_34840057 0.17 ENSMUST00000074949.4
Tmem140
transmembrane protein 140
chr7_+_128125339 0.16 ENSMUST00000033136.9
Bag3
BCL2-associated athanogene 3
chr2_-_62476487 0.15 ENSMUST00000112459.4
ENSMUST00000028259.12
Ifih1
interferon induced with helicase C domain 1
chr1_-_75293997 0.14 ENSMUST00000189282.3
ENSMUST00000191254.7
Dnpep
aspartyl aminopeptidase
chrX_+_100473161 0.14 ENSMUST00000033673.7
Nono
non-POU-domain-containing, octamer binding protein
chr12_-_83643964 0.09 ENSMUST00000048319.6
Zfyve1
zinc finger, FYVE domain containing 1
chr17_+_57665691 0.08 ENSMUST00000086763.13
ENSMUST00000233376.2
ENSMUST00000233840.2
ENSMUST00000232808.2
ENSMUST00000004850.8
Adgre1
adhesion G protein-coupled receptor E1
chr9_+_108385247 0.06 ENSMUST00000207810.2
ENSMUST00000207862.2
ENSMUST00000208581.2
ENSMUST00000134939.9
ENSMUST00000207713.2
Qars
glutaminyl-tRNA synthetase
chr19_+_6096606 0.06 ENSMUST00000138532.8
ENSMUST00000129081.8
ENSMUST00000156550.8
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr1_-_85087567 0.05 ENSMUST00000161675.3
ENSMUST00000160792.8
A530032D15Rik
RIKEN cDNA A530032D15Rik gene
chr7_-_15656285 0.04 ENSMUST00000044355.11
Selenow
selenoprotein W
chr6_-_3399451 0.04 ENSMUST00000120087.6
Samd9l
sterile alpha motif domain containing 9-like
chr7_+_103893672 0.03 ENSMUST00000106848.8
Trim34a
tripartite motif-containing 34A
chr7_-_100164007 0.02 ENSMUST00000207405.2
Dnajb13
DnaJ heat shock protein family (Hsp40) member B13
chr17_+_37148015 0.02 ENSMUST00000179968.8
ENSMUST00000130367.8
ENSMUST00000053434.15
ENSMUST00000130801.8
ENSMUST00000144182.8
ENSMUST00000123715.8
Trim26
tripartite motif-containing 26
chr2_-_173117936 0.01 ENSMUST00000139306.2
Pmepa1
prostate transmembrane protein, androgen induced 1
chr15_-_77417512 0.01 ENSMUST00000062562.7
ENSMUST00000230863.2
Apol7c
apolipoprotein L 7c

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0046967 cytosol to ER transport(GO:0046967)
0.9 2.8 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.7 5.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.6 3.4 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.4 23.0 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.4 1.8 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.4 2.4 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.4 2.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.4 4.3 GO:0035456 response to interferon-beta(GO:0035456)
0.3 3.8 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.3 1.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.4 GO:0018931 hexitol metabolic process(GO:0006059) naphthalene metabolic process(GO:0018931) naphthalene-containing compound metabolic process(GO:0090420)
0.1 2.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 4.3 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.1 0.8 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 1.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.0 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 2.1 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.1 0.6 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.1 1.4 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 0.8 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 0.2 GO:0036245 cellular response to menadione(GO:0036245)
0.1 0.5 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.2 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.1 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.0 0.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.0 1.6 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 4.4 GO:0051607 defense response to virus(GO:0051607)
0.0 2.1 GO:0048525 negative regulation of viral process(GO:0048525)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 1.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.7 GO:0008537 proteasome activator complex(GO:0008537)
0.7 5.8 GO:0042825 TAP complex(GO:0042825)
0.5 7.5 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.2 1.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 2.5 GO:0044754 autolysosome(GO:0044754)
0.2 0.8 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.4 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.4 GO:0005638 lamin filament(GO:0005638)
0.1 1.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 12.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.3 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629) omegasome membrane(GO:1903349)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0046980 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
1.3 3.8 GO:0003692 left-handed Z-DNA binding(GO:0003692)
1.0 11.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.6 1.8 GO:0031726 receptor signaling protein tyrosine kinase activator activity(GO:0030298) CCR1 chemokine receptor binding(GO:0031726)
0.5 2.3 GO:0008859 exoribonuclease II activity(GO:0008859)
0.5 5.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.4 2.5 GO:0031849 olfactory receptor binding(GO:0031849)
0.3 5.5 GO:0031386 protein tag(GO:0031386)
0.3 2.8 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.5 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 1.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.2 GO:0070628 proteasome binding(GO:0070628)
0.0 18.5 GO:0003924 GTPase activity(GO:0003924)
0.0 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 1.3 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.0 2.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 5.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 3.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.1 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 20.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 4.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.8 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 5.4 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 2.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.0 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 2.6 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 1.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.5 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor