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GSE58827: Dynamics of the Mouse Liver

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Results for Irx4

Z-value: 0.54

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Transcription factors associated with Irx4

Gene Symbol Gene ID Gene Info
Irx4
ENSMUSG00000021604.16 Iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx4mm39_v1_chr13_+_73408591_734086160.316.4e-02Click!

Activity profile of Irx4 motif

Sorted Z-values of Irx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_11920540 7.92 ENSMUST00000109653.8
Grb10
growth factor receptor bound protein 10
chr6_-_83294526 4.51 ENSMUST00000005810.9
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr16_+_16964801 3.26 ENSMUST00000232479.2
ENSMUST00000232344.2
ENSMUST00000069064.7
Ydjc
YdjC homolog (bacterial)
chr2_+_24235300 2.75 ENSMUST00000114485.9
ENSMUST00000114482.3
Il1rn
interleukin 1 receptor antagonist
chr8_+_85598734 2.46 ENSMUST00000170296.2
ENSMUST00000136026.8
Syce2
synaptonemal complex central element protein 2
chr19_-_32443978 2.28 ENSMUST00000078034.5
Rpl9-ps6
ribosomal protein L9, pseudogene 6
chr16_+_49620883 1.65 ENSMUST00000229640.2
Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr12_-_114252202 1.31 ENSMUST00000195124.6
ENSMUST00000103481.3
Ighv3-6
immunoglobulin heavy variable 3-6
chr9_+_19716202 0.68 ENSMUST00000212540.3
ENSMUST00000217280.2
Olfr859
olfactory receptor 859
chr1_+_45350698 0.67 ENSMUST00000087883.13
Col3a1
collagen, type III, alpha 1
chr6_-_130208601 0.57 ENSMUST00000088011.11
ENSMUST00000112013.8
ENSMUST00000049304.14
Klra7
killer cell lectin-like receptor, subfamily A, member 7
chr6_-_69584812 0.46 ENSMUST00000103359.3
Igkv4-55
immunoglobulin kappa variable 4-55
chr2_-_111253457 0.43 ENSMUST00000213210.2
ENSMUST00000184954.4
Olfr1286
olfactory receptor 1286
chr7_+_106413336 0.30 ENSMUST00000166880.3
ENSMUST00000075414.8
Olfr701
olfactory receptor 701
chr3_+_59832635 0.29 ENSMUST00000049476.3
Aadacl2fm1
AADACL2 family member 1
chr18_+_44467133 0.23 ENSMUST00000025349.12
ENSMUST00000115498.2
Myot
myotilin
chr4_+_48663504 0.19 ENSMUST00000030033.5
Cavin4
caveolae associated 4
chr6_-_3494587 0.18 ENSMUST00000049985.15
Hepacam2
HEPACAM family member 2
chr9_+_35819708 0.15 ENSMUST00000176049.2
ENSMUST00000176153.2
Pate13
prostate and testis expressed 13
chr3_+_84832783 0.14 ENSMUST00000107675.8
Fbxw7
F-box and WD-40 domain protein 7
chr12_-_115825934 0.04 ENSMUST00000198777.2
Ighv1-77
immunoglobulin heavy variable 1-77

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.6 2.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 4.5 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.1 1.6 GO:0008228 opsonization(GO:0008228)
0.1 0.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 2.5 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 GO:0000801 central element(GO:0000801)
0.1 0.7 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 1.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.8 4.5 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 1.6 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 7.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.9 PID IGF1 PATHWAY IGF1 pathway
0.1 2.8 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.6 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.9 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 1.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 2.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions