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GSE58827: Dynamics of the Mouse Liver

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Results for Irx5

Z-value: 1.31

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Transcription factors associated with Irx5

Gene Symbol Gene ID Gene Info
Irx5
ENSMUSG00000031737.12 Iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx5mm39_v1_chr8_+_93084253_93084379-0.241.6e-01Click!

Activity profile of Irx5 motif

Sorted Z-values of Irx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_87074380 19.29 ENSMUST00000031183.3
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
chr5_-_87485023 19.00 ENSMUST00000031195.3
Ugt2a3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr15_+_82336535 13.00 ENSMUST00000089129.7
ENSMUST00000229313.2
ENSMUST00000231136.2
Cyp2d9
cytochrome P450, family 2, subfamily d, polypeptide 9
chr7_-_14172434 12.44 ENSMUST00000210396.2
ENSMUST00000168252.9
Sult2a8
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
chr15_-_82648376 12.39 ENSMUST00000055721.6
Cyp2d40
cytochrome P450, family 2, subfamily d, polypeptide 40
chr2_+_172994841 11.78 ENSMUST00000029017.6
Pck1
phosphoenolpyruvate carboxykinase 1, cytosolic
chr5_-_87402659 10.45 ENSMUST00000075858.4
Ugt2b37
UDP glucuronosyltransferase 2 family, polypeptide B37
chr19_-_7779943 7.91 ENSMUST00000120522.8
Slc22a26
solute carrier family 22 (organic cation transporter), member 26
chr6_+_71470987 6.68 ENSMUST00000114179.3
Rnf103
ring finger protein 103
chr3_+_20011201 6.66 ENSMUST00000091309.12
ENSMUST00000108329.8
ENSMUST00000003714.13
Cp
ceruloplasmin
chrX_+_20416019 6.24 ENSMUST00000023832.7
Rgn
regucalcin
chr3_+_20011251 5.20 ENSMUST00000108328.8
Cp
ceruloplasmin
chr3_+_20011405 4.59 ENSMUST00000108325.9
Cp
ceruloplasmin
chr15_-_82278223 4.33 ENSMUST00000170255.2
Cyp2d11
cytochrome P450, family 2, subfamily d, polypeptide 11
chr4_+_104623505 4.21 ENSMUST00000031663.10
ENSMUST00000065072.7
C8b
complement component 8, beta polypeptide
chr18_+_56533389 3.72 ENSMUST00000237355.2
ENSMUST00000237422.2
Gramd3
GRAM domain containing 3
chr3_+_63203235 3.10 ENSMUST00000194134.6
Mme
membrane metallo endopeptidase
chr13_+_25127127 3.07 ENSMUST00000021773.13
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr2_+_103858066 2.78 ENSMUST00000028603.10
Fbxo3
F-box protein 3
chr7_-_133384449 2.63 ENSMUST00000063669.8
Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr4_+_141473983 2.58 ENSMUST00000038161.5
Agmat
agmatine ureohydrolase (agmatinase)
chr10_+_86614864 2.40 ENSMUST00000099396.3
Nt5dc3
5'-nucleotidase domain containing 3
chr8_-_73188887 2.36 ENSMUST00000109974.2
Calr3
calreticulin 3
chr19_+_39499288 2.29 ENSMUST00000025968.5
Cyp2c39
cytochrome P450, family 2, subfamily c, polypeptide 39
chr11_-_110142565 2.25 ENSMUST00000044003.14
Abca6
ATP-binding cassette, sub-family A (ABC1), member 6
chr14_+_48358267 2.19 ENSMUST00000073150.6
Peli2
pellino 2
chr4_+_8535604 2.16 ENSMUST00000060232.8
Rab2a
RAB2A, member RAS oncogene family
chr4_-_131871797 2.05 ENSMUST00000056336.2
Oprd1
opioid receptor, delta 1
chr2_-_155661324 2.01 ENSMUST00000124586.2
BC029722
cDNA sequence BC029722
chr2_+_103858168 2.01 ENSMUST00000111135.8
ENSMUST00000111136.8
ENSMUST00000102565.4
Fbxo3
F-box protein 3
chr7_+_102289455 1.92 ENSMUST00000098221.2
Olfr554
olfactory receptor 554
chr2_-_101451383 1.87 ENSMUST00000090513.11
Iftap
intraflagellar transport associated protein
chr11_-_69286159 1.83 ENSMUST00000108660.8
ENSMUST00000051620.5
Cyb5d1
cytochrome b5 domain containing 1
chr12_+_85335365 1.81 ENSMUST00000059341.5
Zc2hc1c
zinc finger, C2HC-type containing 1C
chr6_+_50087826 1.54 ENSMUST00000167628.2
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr5_+_107655487 1.52 ENSMUST00000143074.2
Gm42669
predicted gene 42669
chr11_-_46280298 1.41 ENSMUST00000109237.9
Itk
IL2 inducible T cell kinase
chrX_+_37861548 1.36 ENSMUST00000050744.6
6030498E09Rik
RIKEN cDNA 6030498E09 gene
chr11_-_46280281 1.30 ENSMUST00000101306.4
Itk
IL2 inducible T cell kinase
chr1_-_169796709 1.27 ENSMUST00000027989.13
ENSMUST00000111353.4
Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
chr11_+_69286473 1.23 ENSMUST00000144531.2
Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr16_-_30152708 1.17 ENSMUST00000229503.2
Atp13a3
ATPase type 13A3
chr3_+_138911648 1.08 ENSMUST00000062306.7
Stpg2
sperm tail PG rich repeat containing 2
chr4_-_114991174 1.03 ENSMUST00000051400.8
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr11_+_78067537 1.03 ENSMUST00000098545.12
Tlcd1
TLC domain containing 1
chr11_-_121410152 1.02 ENSMUST00000092298.6
Zfp750
zinc finger protein 750
chr12_-_113223839 0.98 ENSMUST00000194738.6
ENSMUST00000178282.3
Igha
immunoglobulin heavy constant alpha
chr18_-_35348049 0.90 ENSMUST00000091636.5
ENSMUST00000236680.2
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr14_+_48683797 0.89 ENSMUST00000111735.10
Tmem260
transmembrane protein 260
chr1_+_86354045 0.87 ENSMUST00000046004.6
Tex44
testis expressed 44
chr9_+_32305259 0.83 ENSMUST00000172015.3
Kcnj1
potassium inwardly-rectifying channel, subfamily J, member 1
chr14_-_4506874 0.80 ENSMUST00000224934.2
Thrb
thyroid hormone receptor beta
chr8_-_58249608 0.80 ENSMUST00000204067.3
Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr12_-_85335193 0.71 ENSMUST00000121930.2
Acyp1
acylphosphatase 1, erythrocyte (common) type
chr3_-_88669551 0.70 ENSMUST00000183267.2
Syt11
synaptotagmin XI
chr19_-_28945194 0.67 ENSMUST00000162110.8
Spata6l
spermatogenesis associated 6 like
chr4_+_111830119 0.65 ENSMUST00000106568.8
ENSMUST00000055014.11
ENSMUST00000163281.2
Skint7
selection and upkeep of intraepithelial T cells 7
chr17_+_72076728 0.59 ENSMUST00000230305.2
Clip4
CAP-GLY domain containing linker protein family, member 4
chr11_+_42312150 0.58 ENSMUST00000192403.2
Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr6_+_56974228 0.57 ENSMUST00000228285.2
ENSMUST00000227847.2
ENSMUST00000226689.2
ENSMUST00000227131.2
ENSMUST00000227631.2
ENSMUST00000227188.2
Vmn1r6
vomeronasal 1 receptor 6
chr16_+_3408906 0.53 ENSMUST00000216259.2
Olfr161
olfactory receptor 161
chr9_+_110948492 0.53 ENSMUST00000217341.3
Lrrfip2
leucine rich repeat (in FLII) interacting protein 2
chr19_+_26600820 0.52 ENSMUST00000176584.2
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr17_-_35954573 0.49 ENSMUST00000095467.4
Mucl3
mucin like 3
chr7_+_55889488 0.43 ENSMUST00000032633.12
ENSMUST00000155533.2
ENSMUST00000156886.8
Oca2
oculocutaneous albinism II
chr17_+_72076678 0.43 ENSMUST00000230427.2
ENSMUST00000229952.2
ENSMUST00000230333.2
Clip4
CAP-GLY domain containing linker protein family, member 4
chr18_-_64794338 0.41 ENSMUST00000025482.10
Atp8b1
ATPase, class I, type 8B, member 1
chr11_+_73244561 0.40 ENSMUST00000108465.4
Olfr20
olfactory receptor 20
chr5_-_46013838 0.36 ENSMUST00000087164.10
ENSMUST00000121573.8
Lcorl
ligand dependent nuclear receptor corepressor-like
chr3_-_32419609 0.36 ENSMUST00000139660.2
ENSMUST00000168566.3
ENSMUST00000029199.11
Zmat3
zinc finger matrin type 3
chr15_-_81742686 0.35 ENSMUST00000050467.9
ENSMUST00000231000.2
Tob2
transducer of ERBB2, 2
chr14_+_54380308 0.34 ENSMUST00000196323.2
Trdc
T cell receptor delta, constant region
chr4_-_89229256 0.34 ENSMUST00000097981.6
Cdkn2b
cyclin dependent kinase inhibitor 2B
chr2_-_136229849 0.27 ENSMUST00000035264.9
ENSMUST00000077200.4
Pak5
p21 (RAC1) activated kinase 5
chr17_+_87332978 0.27 ENSMUST00000024959.10
Cript
cysteine-rich PDZ-binding protein
chr13_+_27496593 0.26 ENSMUST00000091680.9
Prl6a1
prolactin family 6, subfamily a, member 1
chr6_-_113694633 0.22 ENSMUST00000204533.3
Ghrl
ghrelin
chr4_-_43700807 0.19 ENSMUST00000055545.5
Olfr70
olfactory receptor 70
chr11_-_99176086 0.19 ENSMUST00000017255.4
Krt24
keratin 24
chr6_-_129303659 0.17 ENSMUST00000203159.2
Clec2m
C-type lectin domain family 2, member m
chr6_-_57938488 0.16 ENSMUST00000228097.2
Vmn1r24
vomeronasal 1 receptor 24
chr6_+_56926317 0.11 ENSMUST00000227073.2
Vmn1r4
vomeronasal 1 receptor 4
chr2_+_152269532 0.09 ENSMUST00000128737.2
6820408C15Rik
RIKEN cDNA 6820408C15 gene
chr1_-_132635078 0.06 ENSMUST00000187861.7
Nfasc
neurofascin
chr18_+_35347983 0.06 ENSMUST00000235449.2
ENSMUST00000235269.2
Ctnna1
catenin (cadherin associated protein), alpha 1
chr16_-_22630327 0.06 ENSMUST00000040592.6
Crygs
crystallin, gamma S
chr7_-_86016045 0.06 ENSMUST00000213255.2
ENSMUST00000216700.2
ENSMUST00000213869.2
Olfr305
olfactory receptor 305
chr10_-_43934774 0.04 ENSMUST00000239010.2
Crybg1
crystallin beta-gamma domain containing 1
chr4_+_112089442 0.03 ENSMUST00000038455.12
ENSMUST00000170945.2
Skint3
selection and upkeep of intraepithelial T cells 3
chr4_+_112470794 0.03 ENSMUST00000058791.14
ENSMUST00000186969.2
Skint2
selection and upkeep of intraepithelial T cells 2
chr6_-_57306479 0.02 ENSMUST00000227283.2
ENSMUST00000228356.2
Vmn1r16
vomeronasal 1 receptor 16
chr14_+_8348779 0.00 ENSMUST00000022256.5
Psmd6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 19.3 GO:0018879 biphenyl metabolic process(GO:0018879)
2.9 11.8 GO:0006114 glycerol biosynthetic process(GO:0006114) positive regulation of transcription from RNA polymerase II promoter in response to acidic pH(GO:0061402)
1.6 6.2 GO:1903630 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
1.4 19.0 GO:0052695 cellular glucuronidation(GO:0052695)
0.8 3.1 GO:0010982 GPI anchor release(GO:0006507) regulation of high-density lipoprotein particle clearance(GO:0010982)
0.5 7.9 GO:0015747 urate transport(GO:0015747)
0.4 16.5 GO:0046688 copper ion transport(GO:0006825) response to copper ion(GO:0046688)
0.4 3.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.4 2.6 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.4 30.7 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.3 2.0 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.2 4.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 2.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 0.7 GO:1990927 negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.2 0.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 2.7 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 0.5 GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway(GO:0035660)
0.1 0.8 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.2 GO:0032097 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.1 0.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 6.7 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.1 0.4 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.3 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 1.0 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.6 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.3 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.0 1.3 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 2.2 GO:0007030 Golgi organization(GO:0007030)
0.0 0.4 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 2.4 GO:0006457 protein folding(GO:0006457)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.2 GO:0005579 membrane attack complex(GO:0005579)
0.3 1.2 GO:0031417 NatC complex(GO:0031417)
0.2 16.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 3.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.4 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.7 GO:0032009 early phagosome(GO:0032009)
0.0 3.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.0 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 9.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.5 GO:0005903 brush border(GO:0005903)
0.0 2.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.8 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
1.5 16.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
1.2 48.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.6 20.7 GO:0070330 aromatase activity(GO:0070330)
0.5 7.9 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 3.1 GO:0004630 phospholipase D activity(GO:0004630)
0.3 2.0 GO:0004985 opioid receptor activity(GO:0004985)
0.2 11.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 2.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 1.3 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.2 0.7 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 2.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.2 GO:0031768 ghrelin receptor binding(GO:0031768)
0.1 0.6 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 1.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.8 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 2.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:1901612 cardiolipin binding(GO:1901612)
0.0 2.6 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 2.2 GO:0019003 GDP binding(GO:0019003)
0.0 2.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 2.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.7 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 1.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 16.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 11.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.1 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 2.7 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.4 16.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.2 2.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 2.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 4.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 2.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.8 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels