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GSE58827: Dynamics of the Mouse Liver

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Results for Klf3

Z-value: 0.31

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Transcription factors associated with Klf3

Gene Symbol Gene ID Gene Info
Klf3
ENSMUSG00000029178.15 Kruppel-like factor 3 (basic)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf3mm39_v1_chr5_+_64969679_649697270.316.9e-02Click!

Activity profile of Klf3 motif

Sorted Z-values of Klf3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_101295787 2.74 ENSMUST00000050551.10
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chrX_-_101295458 2.48 ENSMUST00000101336.10
ENSMUST00000136277.2
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr7_-_103477126 1.39 ENSMUST00000023934.8
Hbb-bs
hemoglobin, beta adult s chain
chr15_+_78810919 1.39 ENSMUST00000089377.6
Lgals1
lectin, galactose binding, soluble 1
chr19_+_10019023 1.31 ENSMUST00000237672.2
Fads3
fatty acid desaturase 3
chr7_+_24069680 1.26 ENSMUST00000205428.2
ENSMUST00000171904.3
ENSMUST00000205626.2
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_+_10018914 0.85 ENSMUST00000115995.4
Fads3
fatty acid desaturase 3
chr5_+_137628377 0.40 ENSMUST00000175968.8
Lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chrX_-_73290140 0.37 ENSMUST00000101454.9
ENSMUST00000033699.13
Flna
filamin, alpha
chr7_-_140676623 0.34 ENSMUST00000209352.2
Sigirr
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chrX_-_73289970 0.29 ENSMUST00000130007.8
Flna
filamin, alpha
chr7_-_105218472 0.28 ENSMUST00000187683.7
ENSMUST00000210079.2
ENSMUST00000187051.7
ENSMUST00000189265.7
ENSMUST00000190369.7
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr7_-_142628298 0.26 ENSMUST00000148715.8
Trpm5
transient receptor potential cation channel, subfamily M, member 5
chr7_-_105217851 0.25 ENSMUST00000188368.7
ENSMUST00000187057.7
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr13_+_55468313 0.20 ENSMUST00000021942.8
Prelid1
PRELI domain containing 1
chr15_-_102630496 0.19 ENSMUST00000171838.2
Calcoco1
calcium binding and coiled coil domain 1
chr15_-_102630589 0.17 ENSMUST00000023818.11
Calcoco1
calcium binding and coiled coil domain 1
chr12_+_33365371 0.16 ENSMUST00000154742.2
Atxn7l1
ataxin 7-like 1
chrX_-_50031587 0.16 ENSMUST00000060650.7
Frmd7
FERM domain containing 7
chrX_+_7750558 0.15 ENSMUST00000208640.2
ENSMUST00000207114.2
ENSMUST00000208633.2
ENSMUST00000208397.2
ENSMUST00000153620.3
ENSMUST00000123277.8
Slc35a2
solute carrier family 35 (UDP-galactose transporter), member A2
chr19_-_5738177 0.14 ENSMUST00000068169.12
Pcnx3
pecanex homolog 3
chr13_+_89687915 0.13 ENSMUST00000022108.9
Hapln1
hyaluronan and proteoglycan link protein 1
chr19_-_53378990 0.12 ENSMUST00000025997.7
Smndc1
survival motor neuron domain containing 1
chr3_-_108306267 0.12 ENSMUST00000147251.2
Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chr7_-_140676596 0.12 ENSMUST00000209199.2
Sigirr
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr12_+_87073338 0.11 ENSMUST00000110187.8
ENSMUST00000156162.8
Tmem63c
transmembrane protein 63c
chr3_+_89173859 0.10 ENSMUST00000040824.2
Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr7_-_142627774 0.09 ENSMUST00000136602.8
Trpm5
transient receptor potential cation channel, subfamily M, member 5
chr2_+_119863909 0.09 ENSMUST00000126150.2
Pla2g4b
phospholipase A2, group IVB (cytosolic)
chr3_-_88241735 0.08 ENSMUST00000107552.2
Tmem79
transmembrane protein 79
chr14_+_63284438 0.07 ENSMUST00000067990.8
ENSMUST00000111203.2
Defb42
defensin beta 42
chr3_+_89986831 0.06 ENSMUST00000029549.16
Tpm3
tropomyosin 3, gamma
chr1_+_85992341 0.05 ENSMUST00000027432.9
Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr17_-_23941757 0.03 ENSMUST00000178006.8
1520401A03Rik
RIKEN cDNA 1520401A03 gene
chr3_+_89986925 0.02 ENSMUST00000118566.8
ENSMUST00000119158.8
Tpm3
tropomyosin 3, gamma
chr4_-_41774097 0.02 ENSMUST00000108036.8
ENSMUST00000108037.9
ENSMUST00000108032.3
ENSMUST00000173865.9
ENSMUST00000155240.2
Ccl27a
chemokine (C-C motif) ligand 27A
chr14_+_123897383 0.02 ENSMUST00000049681.14
Itgbl1
integrin, beta-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.2 GO:0071104 response to interleukin-9(GO:0071104)
0.5 1.4 GO:0034117 erythrocyte aggregation(GO:0034117) regulation of erythrocyte aggregation(GO:0034118)
0.2 0.7 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 0.5 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.1 0.5 GO:0050757 thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.1 1.3 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 0.4 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.1 GO:0042335 cuticle development(GO:0042335)
0.0 0.2 GO:1901857 negative regulation of mitochondrial membrane potential(GO:0010917) positive regulation of cellular respiration(GO:1901857)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.7 GO:0031523 Myb complex(GO:0031523)
0.0 0.5 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.1 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031720 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.3 1.4 GO:0048030 disaccharide binding(GO:0048030)
0.3 5.2 GO:0050693 LBD domain binding(GO:0050693)
0.2 0.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 1.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.1 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.7 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway