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GSE58827: Dynamics of the Mouse Liver

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Results for Mafa

Z-value: 0.72

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Transcription factors associated with Mafa

Gene Symbol Gene ID Gene Info
Mafa
ENSMUSG00000047591.6 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mafamm39_v1_chr15_-_75620060_756200870.173.1e-01Click!

Activity profile of Mafa motif

Sorted Z-values of Mafa motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_142233270 6.38 ENSMUST00000162317.2
ENSMUST00000125933.2
ENSMUST00000105931.8
ENSMUST00000105930.8
ENSMUST00000105933.8
ENSMUST00000105932.2
ENSMUST00000000220.3
Ins2
insulin II
chr1_-_121255448 5.34 ENSMUST00000186915.2
ENSMUST00000160968.8
ENSMUST00000162582.2
Insig2
insulin induced gene 2
chr1_-_121255753 5.20 ENSMUST00000003818.14
Insig2
insulin induced gene 2
chr10_+_87695352 4.63 ENSMUST00000121952.8
ENSMUST00000126490.8
Igf1
insulin-like growth factor 1
chr1_-_121255400 4.44 ENSMUST00000159085.8
ENSMUST00000159125.2
ENSMUST00000161818.2
Insig2
insulin induced gene 2
chr19_+_52252735 4.39 ENSMUST00000039652.6
Ins1
insulin I
chr1_-_121255503 4.13 ENSMUST00000160688.2
Insig2
insulin induced gene 2
chr9_-_107556823 2.16 ENSMUST00000010205.9
Gnat1
guanine nucleotide binding protein, alpha transducing 1
chr1_+_171041583 1.96 ENSMUST00000111328.8
Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr1_+_171041539 1.93 ENSMUST00000005820.11
ENSMUST00000075469.12
ENSMUST00000155126.8
Nr1i3
nuclear receptor subfamily 1, group I, member 3
chr4_+_102112189 1.80 ENSMUST00000106908.9
Pde4b
phosphodiesterase 4B, cAMP specific
chr1_-_169575203 1.59 ENSMUST00000027991.12
ENSMUST00000111357.2
Rgs4
regulator of G-protein signaling 4
chr5_+_111565129 1.01 ENSMUST00000094463.5
Mn1
meningioma 1
chr14_-_24054352 1.00 ENSMUST00000190339.2
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr9_+_45817795 0.92 ENSMUST00000039059.8
Pcsk7
proprotein convertase subtilisin/kexin type 7
chr3_+_108561223 0.92 ENSMUST00000106609.8
Clcc1
chloride channel CLIC-like 1
chr5_-_24628483 0.90 ENSMUST00000198990.2
Cdk5
cyclin-dependent kinase 5
chr5_-_24628514 0.85 ENSMUST00000030814.11
Cdk5
cyclin-dependent kinase 5
chr4_+_116578117 0.78 ENSMUST00000045542.13
ENSMUST00000106459.8
Tesk2
testis-specific kinase 2
chr6_-_23839419 0.68 ENSMUST00000115358.9
ENSMUST00000163871.9
Cadps2
Ca2+-dependent activator protein for secretion 2
chr3_-_153650068 0.65 ENSMUST00000150070.2
Acadm
acyl-Coenzyme A dehydrogenase, medium chain
chr5_-_46014809 0.64 ENSMUST00000190036.7
ENSMUST00000189859.7
ENSMUST00000186633.3
ENSMUST00000016026.14
ENSMUST00000045586.13
ENSMUST00000238522.2
Lcorl
ligand dependent nuclear receptor corepressor-like
chr3_-_153650269 0.63 ENSMUST00000072697.13
Acadm
acyl-Coenzyme A dehydrogenase, medium chain
chr7_-_65020955 0.63 ENSMUST00000102592.10
Tjp1
tight junction protein 1
chr16_+_17149235 0.62 ENSMUST00000023450.15
ENSMUST00000231884.2
Serpind1
serine (or cysteine) peptidase inhibitor, clade D, member 1
chr11_-_66416790 0.62 ENSMUST00000066679.7
Shisa6
shisa family member 6
chr9_-_105009023 0.61 ENSMUST00000035179.9
Nudt16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr11_+_98818640 0.56 ENSMUST00000107474.8
Rara
retinoic acid receptor, alpha
chr4_+_124696394 0.54 ENSMUST00000175875.2
Mtf1
metal response element binding transcription factor 1
chr9_+_21746785 0.53 ENSMUST00000058777.8
Angptl8
angiopoietin-like 8
chr4_+_155685830 0.49 ENSMUST00000105608.9
Slc35e2
solute carrier family 35, member E2
chr11_-_66416621 0.47 ENSMUST00000123454.8
Shisa6
shisa family member 6
chr6_+_85164420 0.47 ENSMUST00000045942.9
Emx1
empty spiracles homeobox 1
chr1_-_135095344 0.47 ENSMUST00000027682.9
Gpr37l1
G protein-coupled receptor 37-like 1
chr17_-_47321430 0.46 ENSMUST00000113337.10
ENSMUST00000113335.4
Ubr2
ubiquitin protein ligase E3 component n-recognin 2
chr4_+_155686311 0.46 ENSMUST00000118607.2
Slc35e2
solute carrier family 35, member E2
chr19_-_36097233 0.44 ENSMUST00000025718.10
Ankrd1
ankyrin repeat domain 1 (cardiac muscle)
chr9_-_97915036 0.43 ENSMUST00000162295.2
Clstn2
calsyntenin 2
chr5_+_24628802 0.42 ENSMUST00000153274.2
ENSMUST00000141966.8
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr9_-_105008972 0.42 ENSMUST00000186925.2
Nudt16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr11_+_87486472 0.41 ENSMUST00000134216.3
Mtmr4
myotubularin related protein 4
chr5_-_124018055 0.40 ENSMUST00000164267.2
Hcar1
hydrocarboxylic acid receptor 1
chr17_-_28299544 0.37 ENSMUST00000042692.13
ENSMUST00000114836.9
Tcp11
t-complex protein 11
chr17_-_27732364 0.37 ENSMUST00000118161.3
Grm4
glutamate receptor, metabotropic 4
chr2_-_73605684 0.36 ENSMUST00000112024.10
ENSMUST00000180045.8
Chn1
chimerin 1
chr19_+_27194757 0.35 ENSMUST00000047645.13
ENSMUST00000167487.8
Vldlr
very low density lipoprotein receptor
chrX_-_20816841 0.34 ENSMUST00000009550.14
Elk1
ELK1, member of ETS oncogene family
chr13_-_43634695 0.33 ENSMUST00000144326.4
Ranbp9
RAN binding protein 9
chrX_+_150961960 0.32 ENSMUST00000096275.5
Iqsec2
IQ motif and Sec7 domain 2
chr4_+_43406435 0.31 ENSMUST00000098106.9
ENSMUST00000139198.2
Rusc2
RUN and SH3 domain containing 2
chr19_+_34899811 0.31 ENSMUST00000223776.2
Kif20b
kinesin family member 20B
chr12_-_87346479 0.30 ENSMUST00000125733.8
Ism2
isthmin 2
chr16_+_96268806 0.30 ENSMUST00000061739.9
Pcp4
Purkinje cell protein 4
chr14_-_24054273 0.27 ENSMUST00000188285.7
ENSMUST00000190044.7
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr7_+_24335969 0.27 ENSMUST00000080718.6
Lypd3
Ly6/Plaur domain containing 3
chr9_-_44366273 0.27 ENSMUST00000047740.4
Upk2
uroplakin 2
chr2_-_73605387 0.26 ENSMUST00000166199.9
Chn1
chimerin 1
chr2_+_38821987 0.25 ENSMUST00000057279.6
Olfml2a
olfactomedin-like 2A
chr4_-_59138983 0.24 ENSMUST00000107547.2
Shoc1
shortage in chiasmata 1
chr12_-_75224099 0.24 ENSMUST00000042299.4
Kcnh5
potassium voltage-gated channel, subfamily H (eag-related), member 5
chr8_+_106099894 0.24 ENSMUST00000160650.2
Plekhg4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr11_+_105858764 0.24 ENSMUST00000001963.14
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr5_+_124767114 0.24 ENSMUST00000037865.13
Atp6v0a2
ATPase, H+ transporting, lysosomal V0 subunit A2
chr17_-_28299569 0.23 ENSMUST00000129046.9
ENSMUST00000043925.16
Tcp11
t-complex protein 11
chr6_-_35285045 0.23 ENSMUST00000031868.5
Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr9_-_97915227 0.22 ENSMUST00000035027.13
Clstn2
calsyntenin 2
chr11_-_119119287 0.21 ENSMUST00000207655.2
ENSMUST00000036113.4
Tbc1d16
TBC1 domain family, member 16
chr14_-_24054186 0.21 ENSMUST00000188991.7
ENSMUST00000224468.2
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chrX_-_96420756 0.20 ENSMUST00000113832.2
ENSMUST00000037353.10
Eda2r
ectodysplasin A2 receptor
chr2_+_86127161 0.19 ENSMUST00000215090.2
Olfr1052
olfactory receptor 1052
chrX_-_138683102 0.18 ENSMUST00000101217.4
Ripply1
ripply transcriptional repressor 1
chr1_-_58735106 0.18 ENSMUST00000055313.14
ENSMUST00000188772.7
Flacc1
flagellum associated containing coiled-coil domains 1
chr19_+_27194411 0.18 ENSMUST00000164746.8
ENSMUST00000172302.8
Vldlr
very low density lipoprotein receptor
chr7_-_12418918 0.17 ENSMUST00000167771.2
ENSMUST00000172743.9
ENSMUST00000233763.2
ENSMUST00000232880.2
Vmn2r55
vomeronasal 2, receptor 55
chr17_+_31896781 0.16 ENSMUST00000228716.3
ENSMUST00000019192.8
ENSMUST00000228089.3
Cryaa
crystallin, alpha A
chr19_-_59158488 0.14 ENSMUST00000172821.4
Vax1
ventral anterior homeobox 1
chr6_+_119213541 0.14 ENSMUST00000186622.3
Cacna2d4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr7_+_54485336 0.13 ENSMUST00000082373.8
Luzp2
leucine zipper protein 2
chr16_+_64672334 0.12 ENSMUST00000067744.8
Cggbp1
CGG triplet repeat binding protein 1
chr14_+_79825131 0.11 ENSMUST00000054908.10
Sugt1
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chrX_+_103526380 0.11 ENSMUST00000087867.6
Uprt
uracil phosphoribosyltransferase
chr12_+_53294940 0.10 ENSMUST00000223358.3
Npas3
neuronal PAS domain protein 3
chr14_-_24053994 0.10 ENSMUST00000225431.2
ENSMUST00000188210.8
ENSMUST00000224787.2
ENSMUST00000225315.2
ENSMUST00000225556.2
ENSMUST00000223727.2
ENSMUST00000223655.2
ENSMUST00000224077.2
ENSMUST00000224812.2
ENSMUST00000224285.2
ENSMUST00000225471.2
ENSMUST00000224232.2
ENSMUST00000223749.2
ENSMUST00000224025.2
Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr6_+_119213468 0.08 ENSMUST00000238905.2
ENSMUST00000037434.13
Cacna2d4
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr7_-_103814019 0.08 ENSMUST00000154555.2
ENSMUST00000051137.15
Olfm5
olfactomedin 5
chr16_-_17394495 0.08 ENSMUST00000231645.2
ENSMUST00000232226.2
ENSMUST00000232336.2
ENSMUST00000232385.2
ENSMUST00000231615.2
ENSMUST00000231283.2
ENSMUST00000172164.10
Slc7a4
solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
chr6_+_65358089 0.07 ENSMUST00000133352.8
Qrfprl
pyroglutamylated RFamide peptide receptor like
chr17_-_72910822 0.07 ENSMUST00000086639.6
Alk
anaplastic lymphoma kinase
chr11_+_119119925 0.06 ENSMUST00000053440.8
Ccdc40
coiled-coil domain containing 40
chr4_-_141143313 0.04 ENSMUST00000006378.9
ENSMUST00000105788.2
Clcnkb
chloride channel, voltage-sensitive Kb
chr9_-_108888284 0.01 ENSMUST00000112053.2
Trex1
three prime repair exonuclease 1
chr9_-_108888779 0.01 ENSMUST00000061973.5
Trex1
three prime repair exonuclease 1
chr16_+_65612394 0.00 ENSMUST00000227997.2
Vgll3
vestigial like family member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Mafa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.4 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) neuron projection maintenance(GO:1990535)
1.1 19.1 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.7 4.6 GO:1904075 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.4 2.2 GO:0050917 sensory perception of umami taste(GO:0050917) regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342)
0.3 1.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.3 1.6 GO:0034465 response to carbon monoxide(GO:0034465) eye blink reflex(GO:0060082)
0.2 1.0 GO:0046707 IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709)
0.2 0.6 GO:1902490 regulation of sperm capacitation(GO:1902490)
0.2 0.6 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.2 1.7 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.1 1.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.0 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.5 GO:0034436 glycoprotein transport(GO:0034436)
0.1 0.7 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 0.2 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.0 1.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.5 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0 0.1 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.4 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.5 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.1 GO:0046049 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 4.4 GO:0015758 glucose transport(GO:0015758)
0.0 0.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.2 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.3 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 3.9 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 0.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.2 GO:0008272 sulfate transport(GO:0008272)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 19.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.5 4.6 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.4 1.7 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.2 6.4 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.1 1.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 2.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.8 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0005883 neurofilament(GO:0005883)
0.0 0.5 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0035870 dITP diphosphatase activity(GO:0035870)
0.3 1.3 GO:0070991 medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.3 3.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 1.7 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.2 11.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 1.6 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 0.5 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.1 4.4 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 0.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 2.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.4 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.2 GO:0031711 tripeptidyl-peptidase activity(GO:0008240) bradykinin receptor binding(GO:0031711)
0.0 0.6 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 1.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 1.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 19.4 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID IGF1 PATHWAY IGF1 pathway
0.1 2.2 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 2.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 3.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 3.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 4.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.6 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)