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GSE58827: Dynamics of the Mouse Liver

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Results for Mef2c

Z-value: 1.04

Motif logo

Transcription factors associated with Mef2c

Gene Symbol Gene ID Gene Info
ENSMUSG00000005583.17 myocyte enhancer factor 2C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mef2cmm39_v1_chr13_+_83672389_836724110.464.4e-03Click!

Activity profile of Mef2c motif

Sorted Z-values of Mef2c motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_141995545 9.36 ENSMUST00000105971.8
ENSMUST00000145287.8
troponin I, skeletal, fast 2
chr1_-_66974492 6.25 ENSMUST00000120415.8
ENSMUST00000119429.8
myosin, light polypeptide 1
chr7_+_142052569 6.19 ENSMUST00000078497.15
ENSMUST00000105953.10
ENSMUST00000179658.8
ENSMUST00000105954.10
ENSMUST00000105952.10
ENSMUST00000105955.8
ENSMUST00000074187.13
ENSMUST00000169299.9
ENSMUST00000105957.10
ENSMUST00000180152.8
ENSMUST00000105950.11
ENSMUST00000105958.10
ENSMUST00000105949.8
troponin T3, skeletal, fast
chr7_+_141996067 5.33 ENSMUST00000149529.8
troponin I, skeletal, fast 2
chr1_-_66974694 5.15 ENSMUST00000186202.7
myosin, light polypeptide 1
chr11_+_98274637 5.03 ENSMUST00000008021.3
titin-cap
chr1_-_172047282 4.15 ENSMUST00000170700.2
ENSMUST00000003554.11
calsequestrin 1
chr7_-_127805518 4.05 ENSMUST00000033049.9
cytochrome c oxidase subunit 6A2
chr5_+_122239007 3.98 ENSMUST00000014080.13
ENSMUST00000111750.8
myosin, light polypeptide 2, regulatory, cardiac, slow
chr3_-_122828592 3.95 ENSMUST00000029761.14
myozenin 2
chr11_+_70548022 3.86 ENSMUST00000157027.8
ENSMUST00000072841.12
ENSMUST00000108548.8
ENSMUST00000126241.8
enolase 3, beta muscle
chr5_+_122239030 3.55 ENSMUST00000139213.8
ENSMUST00000111751.8
ENSMUST00000155612.8
myosin, light polypeptide 2, regulatory, cardiac, slow
chr10_-_88440869 3.40 ENSMUST00000119185.8
ENSMUST00000238199.2
myosin binding protein C, slow-type
chr19_+_6434416 3.13 ENSMUST00000035269.15
ENSMUST00000113483.2
muscle glycogen phosphorylase
chr4_+_130202388 2.88 ENSMUST00000070532.8
fatty acid binding protein 3, muscle and heart
chr10_-_88440996 2.78 ENSMUST00000121629.8
myosin binding protein C, slow-type
chr11_+_120839879 2.53 ENSMUST00000154187.8
ENSMUST00000100130.10
ENSMUST00000129473.8
ENSMUST00000168579.8
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr3_+_101993787 2.50 ENSMUST00000165540.9
ENSMUST00000164123.2
calsequestrin 2
chr4_+_46039202 2.32 ENSMUST00000156200.8
tropomodulin 1
chr14_-_34310602 2.31 ENSMUST00000064098.14
ENSMUST00000090040.12
ENSMUST00000022330.9
ENSMUST00000022327.13
LIM domain binding 3
chr1_+_135727140 2.25 ENSMUST00000152208.8
ENSMUST00000152075.8
troponin I, skeletal, slow 1
chr17_+_71326510 2.20 ENSMUST00000073211.13
ENSMUST00000024847.14
myomesin 1
chr11_+_70548513 2.13 ENSMUST00000134087.8
enolase 3, beta muscle
chr3_+_101993731 2.05 ENSMUST00000029454.12
calsequestrin 2
chr9_+_110592709 2.03 ENSMUST00000079784.12
myosin, light polypeptide 3
chr14_-_34310637 1.99 ENSMUST00000227819.2
LIM domain binding 3
chr6_+_112250719 1.98 ENSMUST00000032376.6
LIM and cysteine-rich domains 1
chr15_-_76906832 1.95 ENSMUST00000019037.10
ENSMUST00000169226.9
myoglobin
chr11_+_67689094 1.95 ENSMUST00000168612.8
dehydrogenase/reductase (SDR family) member 7C
chr15_-_89310060 1.80 ENSMUST00000109313.9
carnitine palmitoyltransferase 1b, muscle
chr6_+_30541581 1.70 ENSMUST00000096066.5
carboxypeptidase A2, pancreatic
chr7_+_101750943 1.69 ENSMUST00000033300.4
ADP-ribosyltransferase 1
chr15_-_91075933 1.68 ENSMUST00000069511.8
ATP-binding cassette, sub-family D (ALD), member 2
chr16_-_18440388 1.66 ENSMUST00000167388.3
glycoprotein Ib, beta polypeptide
chr1_+_135727228 1.64 ENSMUST00000154463.8
ENSMUST00000139986.8
troponin I, skeletal, slow 1
chr5_-_18093739 1.62 ENSMUST00000169095.6
ENSMUST00000197574.2
CD36 molecule
chr5_+_135916764 1.57 ENSMUST00000005077.7
heat shock protein 1
chr8_+_15107646 1.57 ENSMUST00000033842.4
myomesin 2
chr11_-_107607343 1.55 ENSMUST00000021065.6
calcium channel, voltage-dependent, gamma subunit 1
chr17_+_71326542 1.54 ENSMUST00000179759.3
myomesin 1
chrX_+_55825033 1.49 ENSMUST00000114772.9
ENSMUST00000114768.10
ENSMUST00000155882.8
four and a half LIM domains 1
chr5_+_135916847 1.47 ENSMUST00000111155.2
heat shock protein 1
chr2_+_69500444 1.42 ENSMUST00000100050.4
kelch-like 41
chr1_+_40844739 1.38 ENSMUST00000114765.4
transmembrane protein 182
chr1_+_135727571 1.38 ENSMUST00000148201.8
troponin I, skeletal, slow 1
chr7_+_127603083 1.38 ENSMUST00000106248.8
tripartite motif-containing 72
chr11_-_69838971 1.34 ENSMUST00000179298.3
ENSMUST00000018710.13
ENSMUST00000135437.3
ENSMUST00000141837.9
ENSMUST00000142500.8
solute carrier family 2 (facilitated glucose transporter), member 4
chr15_-_78090591 1.33 ENSMUST00000120592.2
parvalbumin
chr5_-_113044216 1.33 ENSMUST00000086617.11
myosin XVIIIb
chr15_+_73620213 1.31 ENSMUST00000053232.8
protein tyrosine phosphatase 4a3
chr11_-_94867153 1.28 ENSMUST00000103162.8
ENSMUST00000166320.8
sarcoglycan, alpha (dystrophin-associated glycoprotein)
chrX_+_55824797 1.27 ENSMUST00000114773.10
four and a half LIM domains 1
chr7_-_4517367 1.26 ENSMUST00000166161.8
troponin T1, skeletal, slow
chrX_-_92875712 1.26 ENSMUST00000045748.7
pyruvate dehydrogenase kinase, isoenzyme 3
chr3_-_142101339 1.26 ENSMUST00000198381.5
ENSMUST00000090134.12
ENSMUST00000196908.5
PDZ and LIM domain 5
chr15_+_25940931 1.20 ENSMUST00000110438.3
reticulophagy regulator 1
chr4_+_49059255 1.20 ENSMUST00000076670.3
phospholipid phosphatase related 1
chr5_+_149202157 1.13 ENSMUST00000200806.4
arachidonate 5-lipoxygenase activating protein
chr7_-_126399208 1.11 ENSMUST00000133514.8
ENSMUST00000151137.8
aldolase A, fructose-bisphosphate
chr9_+_121606750 1.10 ENSMUST00000098272.4
kelch-like 40
chr17_-_14914484 1.06 ENSMUST00000170872.3
thrombospondin 2
chr3_+_102981326 1.05 ENSMUST00000090715.13
ENSMUST00000155034.6
adenosine monophosphate deaminase 1
chr9_-_119852624 1.05 ENSMUST00000111635.4
xin actin-binding repeat containing 1
chr7_-_4517559 1.03 ENSMUST00000163538.8
troponin T1, skeletal, slow
chr7_+_130467564 1.02 ENSMUST00000075181.11
ENSMUST00000151119.9
ENSMUST00000048180.12
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr3_-_65865656 1.02 ENSMUST00000029416.14
cyclin L1
chr7_-_126399778 1.00 ENSMUST00000141355.4
aldolase A, fructose-bisphosphate
chr7_-_4517608 0.98 ENSMUST00000166959.8
troponin T1, skeletal, slow
chr15_+_25940781 0.97 ENSMUST00000227275.2
reticulophagy regulator 1
chr1_+_135764092 0.92 ENSMUST00000188028.7
ENSMUST00000178204.8
ENSMUST00000190451.7
ENSMUST00000189732.7
ENSMUST00000189355.7
troponin T2, cardiac
chr15_+_25940859 0.90 ENSMUST00000226750.2
reticulophagy regulator 1
chr6_-_142647985 0.88 ENSMUST00000205202.3
ENSMUST00000073173.12
ENSMUST00000111771.8
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr14_-_20718337 0.87 ENSMUST00000057090.12
ENSMUST00000117386.2
synaptopodin 2-like
chr5_+_105667254 0.87 ENSMUST00000067924.13
ENSMUST00000150981.2
leucine rich repeat containing 8 family, member C
chr7_-_126399574 0.87 ENSMUST00000106348.8
aldolase A, fructose-bisphosphate
chr15_+_25940912 0.86 ENSMUST00000226438.2
reticulophagy regulator 1
chr14_-_34310438 0.85 ENSMUST00000228044.2
ENSMUST00000022328.14
LIM domain binding 3
chr14_+_47886748 0.85 ENSMUST00000190252.7
ENSMUST00000186466.3
kinectin 1
chr11_+_3280401 0.84 ENSMUST00000045153.11
phosphoinositide-3-kinase interacting protein 1
chr7_+_130467486 0.83 ENSMUST00000120441.8
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr14_-_55019387 0.82 ENSMUST00000022787.8
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
chr15_+_102391614 0.81 ENSMUST00000229432.2
poly(rC) binding protein 2
chrX_+_72818003 0.81 ENSMUST00000002081.6
serine/arginine-rich protein specific kinase 3
chrX_+_9138995 0.79 ENSMUST00000015486.7
X-linked Kx blood group
chr2_+_90927053 0.77 ENSMUST00000132741.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr7_-_67022520 0.77 ENSMUST00000156690.8
ENSMUST00000107476.8
ENSMUST00000076325.12
ENSMUST00000032776.15
ENSMUST00000133074.2
myocyte enhancer factor 2A
chr4_+_156300325 0.76 ENSMUST00000105572.3
PPARGC1 and ESRR induced regulator, muscle 1
chr8_+_23548541 0.73 ENSMUST00000173248.8
ankyrin 1, erythroid
chr7_+_46495521 0.68 ENSMUST00000133062.2
lactate dehydrogenase A
chr6_-_142647944 0.65 ENSMUST00000100827.5
ENSMUST00000087527.11
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr4_-_9643636 0.64 ENSMUST00000108333.8
ENSMUST00000108334.8
ENSMUST00000108335.8
ENSMUST00000152526.8
ENSMUST00000103004.10
aspartate-beta-hydroxylase
chr10_+_94386714 0.61 ENSMUST00000148910.3
ENSMUST00000117460.8
transmembrane and coiled coil domains 3
chr11_+_31822211 0.60 ENSMUST00000020543.13
ENSMUST00000109412.9
cytoplasmic polyadenylation element binding protein 4
chr16_+_44913974 0.59 ENSMUST00000099498.10
coiled-coil domain containing 80
chr5_+_65505657 0.59 ENSMUST00000031096.11
klotho beta
chr6_-_70051586 0.59 ENSMUST00000103377.3
immunoglobulin kappa variable 6-32
chr17_-_66079681 0.59 ENSMUST00000070673.9
RAB31, member RAS oncogene family
chr7_-_81216687 0.57 ENSMUST00000042318.6
fibronectin type III and SPRY domain containing 2
chr5_+_75312939 0.56 ENSMUST00000202681.4
ENSMUST00000000476.15
platelet derived growth factor receptor, alpha polypeptide
chr2_+_120294046 0.55 ENSMUST00000028749.15
ENSMUST00000110721.9
ENSMUST00000239364.2
calpain 3
chr6_-_71239216 0.55 ENSMUST00000129630.3
ENSMUST00000114186.9
ENSMUST00000074301.10
SET and MYND domain containing 1
chr5_+_146769700 0.54 ENSMUST00000035983.12
ribosomal protein L21
chr2_-_92222979 0.53 ENSMUST00000111279.9
mitogen-activated protein kinase 8 interacting protein 1
chrX_+_163156359 0.52 ENSMUST00000033751.8
vascular endothelial growth factor D
chr4_-_141391406 0.49 ENSMUST00000084203.11
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr3_-_20209260 0.48 ENSMUST00000178328.8
glycogenin
chr7_-_115630282 0.47 ENSMUST00000206034.2
ENSMUST00000106612.8
SRY (sex determining region Y)-box 6
chr14_-_20714634 0.47 ENSMUST00000119483.2
synaptopodin 2-like
chr3_-_20209220 0.47 ENSMUST00000184552.2
glycogenin
chr17_-_71305003 0.47 ENSMUST00000024846.13
ENSMUST00000232766.2
myosin, light chain 12A, regulatory, non-sarcomeric
chr8_-_41469786 0.46 ENSMUST00000117735.8
mitochondrial tumor suppressor 1
chr13_+_38010879 0.46 ENSMUST00000149745.8
ras responsive element binding protein 1
chr11_+_20597149 0.45 ENSMUST00000109585.2
SERTA domain containing 2
chr1_-_134162231 0.44 ENSMUST00000169927.2
adenosine A1 receptor
chr7_-_115445315 0.43 ENSMUST00000166207.3
SRY (sex determining region Y)-box 6
chr8_+_55024446 0.43 ENSMUST00000239166.2
ENSMUST00000239106.2
ENSMUST00000239152.2
ankyrin repeat and SOCs box-containing 5
chr14_-_21764638 0.42 ENSMUST00000073870.7
dual specificity phosphatase and pro isomerase domain containing 1
chr2_-_51039112 0.41 ENSMUST00000154545.2
ENSMUST00000017288.9
Rho family GTPase 3
chr16_+_13176238 0.40 ENSMUST00000149359.2
myocardin related transcription factor B
chr2_+_71884943 0.40 ENSMUST00000028525.6
Rap guanine nucleotide exchange factor (GEF) 4
chr6_+_55313409 0.40 ENSMUST00000004774.4
aquaporin 1
chr9_-_7873171 0.39 ENSMUST00000159323.2
ENSMUST00000115673.3
baculoviral IAP repeat-containing 3
chr13_+_5911481 0.39 ENSMUST00000000080.8
Kruppel-like factor 6
chr11_+_82802079 0.38 ENSMUST00000018989.14
ENSMUST00000164945.3
unc-45 myosin chaperone B
chr10_-_61814852 0.38 ENSMUST00000105453.8
ENSMUST00000105452.9
ENSMUST00000105454.3
collagen, type XIII, alpha 1
chr4_+_137589581 0.37 ENSMUST00000130407.3
endothelin converting enzyme 1
chr4_-_73869071 0.37 ENSMUST00000095023.2
ENSMUST00000030101.4
RIKEN cDNA 2310002L09 gene
chr19_-_40365318 0.37 ENSMUST00000239304.2
sorbin and SH3 domain containing 1
chr13_+_38388904 0.37 ENSMUST00000091641.13
ENSMUST00000178564.2
small nuclear ribonucleoprotein 48 (U11/U12)
chr6_-_128503666 0.36 ENSMUST00000143664.2
ENSMUST00000112132.8
PZP, alpha-2-macroglobulin like
chr2_-_76812799 0.36 ENSMUST00000011934.13
ENSMUST00000099981.10
ENSMUST00000099980.10
ENSMUST00000111882.9
ENSMUST00000140091.8
titin
chr10_-_8638215 0.36 ENSMUST00000212553.2
SAM and SH3 domain containing 1
chr17_+_57556449 0.36 ENSMUST00000224947.2
ENSMUST00000019631.11
ENSMUST00000224885.2
ENSMUST00000224152.2
thyroid hormone receptor interactor 10
chr12_+_117621644 0.36 ENSMUST00000222105.2
Rap guanine nucleotide exchange factor (GEF) 5
chr13_+_30529498 0.35 ENSMUST00000221743.2
angiotensin II receptor, type 1a
chr15_+_102379503 0.35 ENSMUST00000229222.2
poly(rC) binding protein 2
chr11_+_23234644 0.35 ENSMUST00000150750.3
exportin 1
chr14_-_32407203 0.34 ENSMUST00000096038.4
RIKEN cDNA 3425401B19 gene
chr11_-_59029996 0.34 ENSMUST00000219084.3
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr16_-_56533179 0.33 ENSMUST00000136394.8
Trk-fused gene
chr11_+_67128843 0.32 ENSMUST00000018632.11
myosin, heavy polypeptide 4, skeletal muscle
chr12_+_59177780 0.32 ENSMUST00000177460.8
MIA SH3 domain ER export factor 2
chr12_-_103304573 0.32 ENSMUST00000149431.2
ankyrin repeat and SOCS box-containing 2
chr3_-_142101418 0.31 ENSMUST00000029941.16
ENSMUST00000058626.9
PDZ and LIM domain 5
chr15_+_80507671 0.30 ENSMUST00000043149.9
GRB2-related adaptor protein 2
chr13_+_38010203 0.29 ENSMUST00000128570.9
ras responsive element binding protein 1
chrX_-_94521712 0.29 ENSMUST00000033549.3
ankyrin repeat and SOCS box-containing 12
chr9_-_7873017 0.29 ENSMUST00000013949.15
baculoviral IAP repeat-containing 3
chr6_+_108190050 0.29 ENSMUST00000032192.9
inositol 1,4,5-trisphosphate receptor 1
chr13_+_102830029 0.29 ENSMUST00000022124.10
ENSMUST00000171267.2
ENSMUST00000167144.2
ENSMUST00000170878.2
CD180 antigen
chr5_-_51711237 0.28 ENSMUST00000132734.8
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr1_+_171265103 0.27 ENSMUST00000043839.5
F11 receptor
chr10_-_79744726 0.26 ENSMUST00000165684.8
ENSMUST00000164705.8
ENSMUST00000105378.9
ENSMUST00000170409.2
mediator complex subunit 16
chr11_-_120538928 0.26 ENSMUST00000239158.2
ENSMUST00000026134.3
myeloid-associated differentiation marker-like 2
chr3_-_51248032 0.26 ENSMUST00000062009.14
ENSMUST00000194641.6
E74-like factor 2
chr1_+_179936757 0.25 ENSMUST00000143176.8
ENSMUST00000135056.8
CDC42 binding protein kinase alpha
chr8_-_62355690 0.25 ENSMUST00000121785.9
ENSMUST00000034057.14
palladin, cytoskeletal associated protein
chr2_+_112097087 0.25 ENSMUST00000110987.9
ENSMUST00000028549.14
solute carrier family 12, member 6
chr17_+_73433422 0.25 ENSMUST00000232703.2
lysocardiolipin acyltransferase 1
chr3_+_102981352 0.25 ENSMUST00000176440.2
adenosine monophosphate deaminase 1
chr3_+_116356592 0.24 ENSMUST00000029573.8
leucine rich repeat containing 39
chr11_+_75546989 0.24 ENSMUST00000136935.2
myosin IC
chr8_-_24928953 0.24 ENSMUST00000052622.6
transcriptional and immune response regulator
chr11_-_78950641 0.24 ENSMUST00000226282.2
kinase suppressor of ras 1
chr1_+_63485002 0.24 ENSMUST00000087374.10
a disintegrin and metallopeptidase domain 23
chr2_+_27566452 0.23 ENSMUST00000129514.8
retinoid X receptor alpha
chr5_-_88675700 0.23 ENSMUST00000087033.6
immunoglobulin joining chain
chr10_+_69048506 0.23 ENSMUST00000167384.8
Rho-related BTB domain containing 1
chr7_-_100164007 0.22 ENSMUST00000207405.2
DnaJ heat shock protein family (Hsp40) member B13
chr11_-_69289052 0.22 ENSMUST00000050140.6
transmembrane protein 88
chr2_-_77000936 0.22 ENSMUST00000164114.9
ENSMUST00000049544.14
coiled-coil domain containing 141
chr7_-_128020397 0.22 ENSMUST00000147840.2
regulator of G-protein signalling 10
chrX_+_158086253 0.21 ENSMUST00000112491.2
ribosomal protein S6 kinase polypeptide 3
chr5_-_122140403 0.21 ENSMUST00000134326.2
cut-like homeobox 2
chr12_+_111387978 0.20 ENSMUST00000222897.2
exocyst complex component 3-like 4
chr18_+_4994600 0.20 ENSMUST00000140448.8
supervillin
chr10_+_69048914 0.19 ENSMUST00000163497.8
ENSMUST00000164212.8
ENSMUST00000067908.14
Rho-related BTB domain containing 1
chr19_-_6065872 0.19 ENSMUST00000164843.10
calpain 1
chr4_+_11485945 0.19 ENSMUST00000055372.14
ENSMUST00000059914.13
vir like m6A methyltransferase associated
chr5_-_51711204 0.18 ENSMUST00000196968.5
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr15_+_102379621 0.18 ENSMUST00000229918.2
poly(rC) binding protein 2
chr3_-_123029782 0.18 ENSMUST00000106427.8
ENSMUST00000198584.2
synaptopodin 2
chr1_+_131755715 0.18 ENSMUST00000086559.7
solute carrier family 41, member 1
chr11_+_75546671 0.18 ENSMUST00000108431.3
myosin IC
chr5_+_64316771 0.17 ENSMUST00000043893.13
TBC1 domain family, member 1
chr6_+_5390386 0.17 ENSMUST00000183358.2
ankyrin repeat and SOCS box-containing 4
chr11_+_120123727 0.16 ENSMUST00000122148.8
ENSMUST00000044985.14
BAH domain and coiled-coil containing 1
chr6_+_108190163 0.15 ENSMUST00000203615.3
inositol 1,4,5-trisphosphate receptor 1
chr5_-_122752508 0.15 ENSMUST00000127220.8
ENSMUST00000031426.14
intraflagellar transport 81
chr13_+_44994167 0.14 ENSMUST00000173906.3
jumonji, AT rich interactive domain 2
chr19_-_24839219 0.14 ENSMUST00000047666.5
phosphoglucomutase 5
chr1_-_88629843 0.13 ENSMUST00000159814.2
ADP-ribosylation factor-like 4C
chr14_+_102078038 0.13 ENSMUST00000159314.8
LIM domain only 7
chr6_+_116627635 0.13 ENSMUST00000204555.2
DEPP1 autophagy regulator
chr9_-_66421868 0.12 ENSMUST00000056890.10
F-box and leucine-rich repeat protein 22
chr15_+_101152078 0.12 ENSMUST00000228985.2
nuclear receptor subfamily 4, group A, member 1
chr16_+_29884153 0.11 ENSMUST00000023171.8
hes family bHLH transcription factor 1
chr18_+_89195089 0.11 ENSMUST00000236644.2
ENSMUST00000236828.2
CD226 antigen
chr4_+_135487016 0.11 ENSMUST00000105854.2
myomesin family, member 3
chr9_-_79884920 0.11 ENSMUST00000239133.2
filamin A interacting protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Mef2c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.5 GO:0042694 muscle cell fate specification(GO:0042694)
1.3 7.7 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
1.1 10.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
1.0 4.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.7 2.9 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.6 29.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.5 4.5 GO:0071313 cellular response to caffeine(GO:0071313)
0.4 3.9 GO:0061709 reticulophagy(GO:0061709)
0.3 3.0 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.3 1.6 GO:0070543 response to linoleic acid(GO:0070543)
0.3 1.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.3 0.9 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.2 0.6 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 2.5 GO:0035879 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 1.8 GO:0015671 oxygen transport(GO:0015671)
0.2 3.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 1.1 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.2 0.6 GO:0038091 VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.2 1.7 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.2 3.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 0.5 GO:1904633 glomerular visceral epithelial cell apoptotic process(GO:1903210) regulation of glomerular visceral epithelial cell apoptotic process(GO:1904633) positive regulation of glomerular visceral epithelial cell apoptotic process(GO:1904635) positive regulation of progesterone biosynthetic process(GO:2000184)
0.2 0.8 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.2 0.8 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.1 0.4 GO:0032242 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.1 0.5 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
0.1 3.1 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 1.3 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.4 GO:0071288 cellular response to mercury ion(GO:0071288)
0.1 0.8 GO:0031133 regulation of axon diameter(GO:0031133)
0.1 1.3 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.1 1.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.1 0.4 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 0.8 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 9.4 GO:0030239 myofibril assembly(GO:0030239)
0.1 1.0 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.5 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 3.3 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.1 0.7 GO:0019659 glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 0.4 GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway(GO:0038089)
0.1 0.2 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.4 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.1 1.5 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 1.3 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.1 0.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.6 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1 0.4 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.5 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.1 2.0 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 1.5 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 1.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.4 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.1 2.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 0.4 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.1 7.6 GO:0060048 cardiac muscle contraction(GO:0060048)
0.0 0.8 GO:0060546 negative regulation of necroptotic process(GO:0060546)
0.0 0.2 GO:0045994 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.0 1.3 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.6 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:0045168 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) cell-cell signaling involved in cell fate commitment(GO:0045168) negative regulation of forebrain neuron differentiation(GO:2000978)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 3.0 GO:0006096 glycolytic process(GO:0006096)
0.0 0.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 1.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.3 GO:0014823 response to activity(GO:0014823)
0.0 1.8 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.1 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.8 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.7 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.5 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.5 GO:0090382 phagosome maturation(GO:0090382)
0.0 0.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.2 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.4 GO:0070875 positive regulation of glycogen biosynthetic process(GO:0045725) positive regulation of glycogen metabolic process(GO:0070875)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.2 GO:0080009 mRNA methylation(GO:0080009)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.6 30.3 GO:0005861 troponin complex(GO:0005861)
0.7 9.7 GO:0097512 cardiac myofibril(GO:0097512)
0.6 1.9 GO:0014801 longitudinal sarcoplasmic reticulum(GO:0014801)
0.5 11.5 GO:0005859 muscle myosin complex(GO:0005859)
0.4 6.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 0.5 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.2 15.2 GO:0016459 myosin complex(GO:0016459)
0.2 3.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.5 GO:0031430 M band(GO:0031430)
0.2 0.5 GO:1990844 subsarcolemmal mitochondrion(GO:1990843) interfibrillar mitochondrion(GO:1990844)
0.1 3.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 0.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 1.1 GO:0031672 A band(GO:0031672)
0.1 0.4 GO:0032127 dense core granule membrane(GO:0032127)
0.1 1.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 16.7 GO:0030018 Z disc(GO:0030018)
0.1 2.3 GO:0036379 myofilament(GO:0036379)
0.1 0.4 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 0.4 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.6 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 3.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 3.7 GO:0016528 sarcoplasm(GO:0016528)
0.0 0.5 GO:0005916 fascia adherens(GO:0005916)
0.0 1.1 GO:0031091 platelet alpha granule(GO:0031091)
0.0 1.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0036396 MIS complex(GO:0036396)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.7 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 18.0 GO:0031014 troponin T binding(GO:0031014)
1.8 9.0 GO:0051373 FATZ binding(GO:0051373)
1.8 7.1 GO:0030172 troponin C binding(GO:0030172)
0.8 3.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.6 16.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.5 4.5 GO:0070538 oleic acid binding(GO:0070538)
0.4 6.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 1.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.3 1.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.3 3.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 2.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 0.8 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.3 1.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 1.1 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
0.2 0.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 1.3 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.2 1.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 9.6 GO:0003785 actin monomer binding(GO:0003785)
0.2 0.6 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.2 2.3 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.3 GO:0032036 AMP deaminase activity(GO:0003876) myosin heavy chain binding(GO:0032036) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.4 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 3.3 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.1 1.3 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 0.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.9 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.2 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 3.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.9 GO:0031432 titin binding(GO:0031432)
0.1 0.9 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.2 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.1 0.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.4 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 0.2 GO:0019862 IgA binding(GO:0019862)
0.1 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.5 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1 0.8 GO:0051525 NFAT protein binding(GO:0051525)
0.0 1.0 GO:0031005 filamin binding(GO:0031005)
0.0 0.4 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 4.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 1.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0071820 N-box binding(GO:0071820)
0.0 0.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.4 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 1.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.9 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 16.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.3 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.7 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 3.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.5 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.4 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.4 ST GAQ PATHWAY G alpha q Pathway
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 57.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 9.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 4.5 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.2 3.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.7 REACTOME DEFENSINS Genes involved in Defensins
0.1 1.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.6 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 1.3 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 3.0 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.6 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 0.4 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling