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GSE58827: Dynamics of the Mouse Liver

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Results for Nfe2_Bach1_Mafk

Z-value: 1.24

Motif logo

Transcription factors associated with Nfe2_Bach1_Mafk

Gene Symbol Gene ID Gene Info
ENSMUSG00000058794.13 nuclear factor, erythroid derived 2
ENSMUSG00000025612.6 BTB and CNC homology 1, basic leucine zipper transcription factor 1
ENSMUSG00000018143.11 v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nfe2mm39_v1_chr15_-_103163860_103163879-0.591.5e-04Click!
Mafkmm39_v1_chr5_+_139777263_139777271-0.492.6e-03Click!
Bach1mm39_v1_chr16_+_87495792_874958720.038.6e-01Click!

Activity profile of Nfe2_Bach1_Mafk motif

Sorted Z-values of Nfe2_Bach1_Mafk motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_86577940 23.25 ENSMUST00000034989.15
malic enzyme 1, NADP(+)-dependent, cytosolic
chr1_+_58069090 11.97 ENSMUST00000001027.7
aldehyde oxidase 1
chr19_+_12610870 10.91 ENSMUST00000119960.2
glycine-N-acyltransferase
chr19_-_4087907 8.73 ENSMUST00000237982.2
glutathione S-transferase, pi 1
chr19_-_4087940 8.61 ENSMUST00000237893.2
ENSMUST00000169613.4
glutathione S-transferase, pi 1
chr19_-_4092218 8.27 ENSMUST00000237999.2
ENSMUST00000042700.12
glutathione S-transferase, pi 2
chr19_+_12610668 7.57 ENSMUST00000044976.12
glycine-N-acyltransferase
chr6_+_129510331 6.89 ENSMUST00000204956.2
ENSMUST00000204639.2
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr1_+_165596961 6.06 ENSMUST00000040298.5
cellular repressor of E1A-stimulated genes 1
chr16_+_90017634 5.69 ENSMUST00000023707.11
superoxide dismutase 1, soluble
chr5_-_108823435 5.67 ENSMUST00000051757.14
solute carrier family 26 (sulfate transporter), member 1
chr11_+_80319424 5.58 ENSMUST00000173938.8
ENSMUST00000017572.14
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr18_+_24786748 4.79 ENSMUST00000068006.9
molybdenum cofactor sulfurase
chr8_+_120163857 4.55 ENSMUST00000152420.8
ENSMUST00000212112.2
ENSMUST00000098365.4
oxidative stress induced growth inhibitor 1
chr5_-_24963006 4.51 ENSMUST00000047119.5
crystallin, gamma N
chr11_-_50101592 4.47 ENSMUST00000143379.2
ENSMUST00000015981.12
ENSMUST00000102774.11
sequestosome 1
chr7_-_140856642 4.39 ENSMUST00000080654.7
ENSMUST00000167263.9
cadherin-related family member 5
chr3_+_123061094 4.30 ENSMUST00000047923.12
ENSMUST00000200333.2
Sec24 related gene family, member D (S. cerevisiae)
chr5_-_65585720 4.04 ENSMUST00000131263.3
UDP-glucose dehydrogenase
chr7_+_127399789 3.95 ENSMUST00000125188.8
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr7_+_127399776 3.84 ENSMUST00000046863.12
ENSMUST00000206674.2
ENSMUST00000106272.8
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr6_+_129510117 3.71 ENSMUST00000032264.9
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr15_-_82291372 3.60 ENSMUST00000230198.2
ENSMUST00000230248.2
ENSMUST00000072776.5
ENSMUST00000229911.2
cytochrome P450, family 2, subfamily d, polypeptide 10
chr18_-_3281089 3.22 ENSMUST00000139537.2
ENSMUST00000124747.8
cAMP responsive element modulator
chr11_-_50216426 3.22 ENSMUST00000179865.8
ENSMUST00000020637.9
calnexin
chr2_+_25318642 3.18 ENSMUST00000102919.4
ATP-binding cassette, sub-family A (ABC1), member 2
chr12_-_84447702 3.16 ENSMUST00000122194.8
ectonucleoside triphosphate diphosphohydrolase 5
chr11_-_69696428 2.94 ENSMUST00000051025.5
transmembrane protein 102
chr6_-_72212547 2.91 ENSMUST00000042646.8
atonal bHLH transcription factor 8
chr18_+_12776358 2.91 ENSMUST00000234966.2
ENSMUST00000025294.9
tetratricopeptide repeat domain 39C
chr7_+_127400016 2.90 ENSMUST00000106271.2
ENSMUST00000138432.2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr12_-_84447625 2.85 ENSMUST00000117286.2
ectonucleoside triphosphate diphosphohydrolase 5
chr5_-_147831610 2.70 ENSMUST00000118527.8
ENSMUST00000031655.4
ENSMUST00000138244.2
solute carrier family 46, member 3
chr4_+_116542741 2.67 ENSMUST00000135573.8
ENSMUST00000151129.8
peroxiredoxin 1
chr1_-_180027151 2.42 ENSMUST00000161743.3
coenzyme Q8A
chr11_-_120521382 2.42 ENSMUST00000106181.8
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr8_+_105996469 2.38 ENSMUST00000172525.8
ENSMUST00000174837.8
ENSMUST00000173859.2
heat shock transcription factor 4
chr13_-_12476313 2.38 ENSMUST00000143693.8
ENSMUST00000144283.2
ENSMUST00000099820.10
ENSMUST00000135166.8
lectin, galactose binding, soluble 8
chr14_+_66872699 2.37 ENSMUST00000159365.8
ENSMUST00000054661.8
ENSMUST00000225182.2
ENSMUST00000159068.2
adrenergic receptor, alpha 1a
chr6_+_138118565 2.37 ENSMUST00000118091.8
microsomal glutathione S-transferase 1
chr9_-_106353571 2.34 ENSMUST00000123555.8
ENSMUST00000125850.2
poly (ADP-ribose) polymerase family, member 3
chr4_+_116543045 2.28 ENSMUST00000129315.8
ENSMUST00000106470.8
peroxiredoxin 1
chr7_+_127399848 2.20 ENSMUST00000139068.8
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr13_-_58363431 2.19 ENSMUST00000076454.8
ENSMUST00000058735.12
ubiquilin 1
chrX_+_163052367 2.17 ENSMUST00000145412.8
ENSMUST00000033749.9
pirin
chr8_+_105996419 2.16 ENSMUST00000036127.9
ENSMUST00000163734.9
heat shock transcription factor 4
chr2_+_151947444 2.12 ENSMUST00000041500.8
sulfiredoxin 1 homolog (S. cerevisiae)
chr7_+_143028831 2.11 ENSMUST00000105917.3
solute carrier family 22 (organic cation transporter), member 18
chr1_+_33947250 2.11 ENSMUST00000183034.5
dystonin
chr11_+_120564185 2.10 ENSMUST00000135346.8
ENSMUST00000127269.8
ENSMUST00000131727.9
ENSMUST00000149389.8
ENSMUST00000153346.8
alveolar soft part sarcoma chromosome region, candidate 1 (human)
chr15_-_98575332 2.09 ENSMUST00000120997.2
ENSMUST00000109149.9
ENSMUST00000003451.11
Rho family GTPase 1
chr9_-_106353792 2.06 ENSMUST00000214682.2
ENSMUST00000112479.9
poly (ADP-ribose) polymerase family, member 3
chr4_-_57956411 2.03 ENSMUST00000030051.6
thioredoxin 1
chr10_+_60113449 2.01 ENSMUST00000105465.8
ENSMUST00000179238.8
ENSMUST00000177779.8
ENSMUST00000004316.15
prosaposin
chr10_+_128769642 1.99 ENSMUST00000099112.4
ENSMUST00000218290.2
integrin alpha 7
chr15_+_54434576 1.97 ENSMUST00000025356.4
mal, T cell differentiation protein 2
chr19_+_8816663 1.97 ENSMUST00000160556.8
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr18_-_35087355 1.92 ENSMUST00000025217.11
heat shock protein 9
chr2_-_32271833 1.84 ENSMUST00000146423.2
RIKEN cDNA 1110008P14 gene
chr5_+_30971915 1.83 ENSMUST00000031058.15
microtubule-associated protein, RP/EB family, member 3
chr18_-_3280999 1.83 ENSMUST00000049942.13
cAMP responsive element modulator
chr12_+_71021395 1.79 ENSMUST00000160027.8
ENSMUST00000160864.8
proteasome subunit alpha 3
chr5_+_30972067 1.79 ENSMUST00000200692.4
microtubule-associated protein, RP/EB family, member 3
chr16_+_20367327 1.73 ENSMUST00000003319.6
ENSMUST00000232680.2
ENSMUST00000232490.2
ATP-binding cassette, sub-family F (GCN20), member 3
chr15_+_10224052 1.54 ENSMUST00000128450.8
ENSMUST00000148257.8
ENSMUST00000128921.8
prolactin receptor
chr18_+_12637217 1.53 ENSMUST00000188815.2
laminin, alpha 3
chr9_-_43151179 1.52 ENSMUST00000034512.7
out at first homolog
chr14_+_67953584 1.51 ENSMUST00000145542.8
ENSMUST00000125212.2
potassium channel tetramerisation domain containing 9
chr10_-_34294461 1.48 ENSMUST00000213269.2
ENSMUST00000099973.4
ENSMUST00000105512.8
ENSMUST00000047885.14
5'-nucleotidase domain containing 1
chr15_+_3300249 1.46 ENSMUST00000082424.12
ENSMUST00000159158.9
ENSMUST00000159216.10
ENSMUST00000160311.3
selenoprotein P
chr4_-_42665763 1.45 ENSMUST00000238770.2
interleukin 11 receptor, alpha chain 2
chr4_-_42168603 1.44 ENSMUST00000098121.4
predicted gene 13305
chr2_+_11710633 1.44 ENSMUST00000114832.3
interleukin 15 receptor, alpha chain
chr14_+_67953687 1.42 ENSMUST00000150768.8
potassium channel tetramerisation domain containing 9
chr1_-_173195236 1.41 ENSMUST00000005470.5
ENSMUST00000111220.8
cell adhesion molecule 3
chr6_+_17463925 1.37 ENSMUST00000115442.8
met proto-oncogene
chr7_+_139414057 1.33 ENSMUST00000026548.14
adhesion G protein-coupled receptor A1
chr7_+_101032021 1.31 ENSMUST00000141083.9
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr9_+_7272514 1.31 ENSMUST00000015394.10
matrix metallopeptidase 13
chr15_+_80139371 1.31 ENSMUST00000109605.5
ENSMUST00000229828.2
activating transcription factor 4
chr11_+_120421496 1.29 ENSMUST00000026119.8
glucagon receptor
chr5_-_108022900 1.27 ENSMUST00000138111.8
ENSMUST00000112642.8
ecotropic viral integration site 5
chr15_-_75886166 1.27 ENSMUST00000060807.12
family with sequence similarity 83, member H
chr14_+_28740162 1.23 ENSMUST00000055662.4
leucine-rich repeats and transmembrane domains 1
chr11_-_116080361 1.23 ENSMUST00000148601.2
acyl-Coenzyme A oxidase 1, palmitoyl
chr13_+_41040657 1.22 ENSMUST00000069958.15
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr15_-_76079891 1.21 ENSMUST00000023226.13
plectin
chr6_+_17463748 1.20 ENSMUST00000115443.8
met proto-oncogene
chr7_-_44320244 1.19 ENSMUST00000048102.15
myosin, heavy polypeptide 14
chr14_-_20844074 1.19 ENSMUST00000080440.14
ENSMUST00000100837.11
ENSMUST00000071816.7
calcium/calmodulin-dependent protein kinase II gamma
chr12_+_111504640 1.19 ENSMUST00000222375.2
ENSMUST00000222388.2
eukaryotic translation initiation factor 5
chr17_-_24439712 1.18 ENSMUST00000024930.8
tubulin epsilon and delta complex 2
chr11_+_60619224 1.18 ENSMUST00000018743.5
mitochondrial elongation factor 2
chr10_-_81262948 1.17 ENSMUST00000078185.14
ENSMUST00000020461.15
ENSMUST00000105321.10
nuclear factor I/C
chr14_+_67953547 1.16 ENSMUST00000078053.13
potassium channel tetramerisation domain containing 9
chr15_+_25933632 1.13 ENSMUST00000228327.2
reticulophagy regulator 1
chr11_-_106378622 1.13 ENSMUST00000001059.9
ENSMUST00000106799.2
ENSMUST00000106800.2
endoplasmic reticulum (ER) to nucleus signalling 1
chr11_+_120563844 1.10 ENSMUST00000106158.9
ENSMUST00000103016.8
ENSMUST00000168714.9
alveolar soft part sarcoma chromosome region, candidate 1 (human)
chr5_+_147797425 1.09 ENSMUST00000201376.4
ENSMUST00000201120.2
proteasome maturation protein
chr10_+_127894816 1.08 ENSMUST00000052798.14
prostaglandin E synthase 3
chrX_+_73468140 1.08 ENSMUST00000135165.8
ENSMUST00000114128.8
ENSMUST00000004330.10
ENSMUST00000114133.9
ENSMUST00000114129.9
ENSMUST00000132749.2
inhibitor of kappaB kinase gamma
chr5_+_34683141 1.08 ENSMUST00000125817.8
ENSMUST00000067638.14
SH3-domain binding protein 2
chr9_+_32135540 1.07 ENSMUST00000168954.9
Rho GTPase activating protein 32
chr9_-_121745354 1.07 ENSMUST00000062474.5
cytochrome P450, family 8, subfamily b, polypeptide 1
chr3_+_122039206 1.06 ENSMUST00000029769.14
glutamate-cysteine ligase, modifier subunit
chr1_-_74932266 1.05 ENSMUST00000006721.3
crystallin, beta A2
chr19_+_57599452 1.05 ENSMUST00000077282.7
attractin like 1
chr9_+_108566513 1.04 ENSMUST00000192344.2
protein kinase, cAMP dependent regulatory, type II alpha
chr11_-_120520954 1.03 ENSMUST00000106180.2
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr14_-_21898992 1.03 ENSMUST00000124549.9
catechol-O-methyltransferase domain containing 1
chr1_+_107517726 1.03 ENSMUST00000000514.11
ENSMUST00000112706.4
serine (or cysteine) peptidase inhibitor, clade B, member 8
chr5_+_147797258 1.01 ENSMUST00000031654.10
proteasome maturation protein
chr9_-_25063068 1.00 ENSMUST00000008573.9
HERPUD family member 2
chr8_-_3767547 1.00 ENSMUST00000058040.7
C-type lectin domain family 4, member g
chr13_-_23894828 1.00 ENSMUST00000091706.14
homeostatic iron regulator
chr10_+_127894843 1.00 ENSMUST00000084771.3
prostaglandin E synthase 3
chr19_-_4384029 1.00 ENSMUST00000176653.2
lysine (K)-specific demethylase 2A
chr10_+_43777777 0.98 ENSMUST00000054418.12
reticulon 4 interacting protein 1
chr7_-_119461027 0.97 ENSMUST00000137888.2
ENSMUST00000142120.2
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr13_-_23894697 0.97 ENSMUST00000091707.13
ENSMUST00000006787.8
homeostatic iron regulator
chr3_-_84128160 0.97 ENSMUST00000154152.2
ENSMUST00000107693.9
ENSMUST00000107695.9
tripartite motif-containing 2
chr14_+_4230569 0.95 ENSMUST00000090543.6
nuclear receptor subfamily 1, group D, member 2
chr11_-_30599510 0.95 ENSMUST00000074613.4
acylphosphatase 2, muscle type
chr2_+_160722562 0.94 ENSMUST00000109456.9
lipin 3
chr5_+_43390513 0.94 ENSMUST00000166713.9
ENSMUST00000169035.8
ENSMUST00000114065.9
cytoplasmic polyadenylation element binding protein 2
chr12_+_111504450 0.94 ENSMUST00000166123.9
ENSMUST00000222441.2
eukaryotic translation initiation factor 5
chr3_-_88460166 0.93 ENSMUST00000119002.2
ENSMUST00000029698.15
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr12_+_82303350 0.92 ENSMUST00000222714.2
signal-induced proliferation-associated 1 like 1
chr6_-_83633064 0.91 ENSMUST00000014686.3
C-type lectin domain family 4, member f
chr11_+_87482971 0.90 ENSMUST00000103179.10
ENSMUST00000092802.12
ENSMUST00000146871.8
myotubularin related protein 4
chr2_+_143757193 0.90 ENSMUST00000103172.4
destrin
chr15_-_100497863 0.90 ENSMUST00000073837.13
POU domain, class 6, transcription factor 1
chr8_+_106052970 0.89 ENSMUST00000015000.12
ENSMUST00000098453.9
transmembrane protein 208
chr19_+_5927821 0.89 ENSMUST00000145200.8
ENSMUST00000025732.14
ENSMUST00000125114.8
ENSMUST00000155697.8
solute carrier family 25, member 45
chr8_-_71308040 0.88 ENSMUST00000212509.3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr19_+_5927876 0.87 ENSMUST00000235340.2
solute carrier family 25, member 45
chr17_+_25059079 0.87 ENSMUST00000164251.8
hydroxyacyl glutathione hydrolase
chr11_+_78068931 0.86 ENSMUST00000147819.8
TLC domain containing 1
chr11_+_121036969 0.86 ENSMUST00000039088.9
ENSMUST00000155694.2
testis expressed gene 19.1
chr19_-_41252370 0.86 ENSMUST00000237871.2
ENSMUST00000025989.10
transmembrane 9 superfamily member 3
chr6_-_146403410 0.86 ENSMUST00000053273.15
inositol 1,4,5-triphosphate receptor 2
chr12_+_35097179 0.85 ENSMUST00000163677.3
ENSMUST00000048519.17
sorting nexin 13
chr12_+_111132908 0.85 ENSMUST00000139162.8
ENSMUST00000060274.7
TNF receptor-associated factor 3
chr6_+_17463819 0.84 ENSMUST00000140070.8
met proto-oncogene
chr3_+_81906768 0.84 ENSMUST00000107736.2
acid-sensing (proton-gated) ion channel family member 5
chr1_-_75195127 0.84 ENSMUST00000079464.13
tubulin, alpha 4A
chr9_-_107556823 0.83 ENSMUST00000010205.9
guanine nucleotide binding protein, alpha transducing 1
chr14_-_36857083 0.82 ENSMUST00000042564.17
growth hormone inducible transmembrane protein
chrX_+_5959507 0.81 ENSMUST00000103007.4
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr11_-_98329782 0.81 ENSMUST00000002655.8
migration and invasion enhancer 1
chr11_+_107370375 0.80 ENSMUST00000106750.5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr11_+_107370303 0.80 ENSMUST00000021063.13
ENSMUST00000106752.10
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr17_-_24863956 0.79 ENSMUST00000019684.13
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr1_+_191710209 0.78 ENSMUST00000175680.3
retinal degeneration 3
chr9_-_106353303 0.78 ENSMUST00000156426.8
poly (ADP-ribose) polymerase family, member 3
chr2_+_163389068 0.76 ENSMUST00000109411.8
ENSMUST00000018094.13
hepatic nuclear factor 4, alpha
chr12_+_111505253 0.73 ENSMUST00000220803.2
eukaryotic translation initiation factor 5
chr13_-_65353757 0.73 ENSMUST00000223418.2
ENSMUST00000222559.2
ENSMUST00000221659.2
ENSMUST00000222273.2
NLR family, pyrin domain containing 4F
chr13_-_8921732 0.72 ENSMUST00000054251.13
ENSMUST00000176813.8
ENSMUST00000175958.2
WD repeat domain 37
chr18_-_63825491 0.72 ENSMUST00000237004.2
thioredoxin-like 1
chr9_-_110571645 0.72 ENSMUST00000006005.12
parathyroid hormone 1 receptor
chr19_-_38113056 0.72 ENSMUST00000236283.2
retinol binding protein 4, plasma
chr12_+_111505216 0.71 ENSMUST00000050993.11
eukaryotic translation initiation factor 5
chr17_-_24863907 0.71 ENSMUST00000234505.2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr15_-_76501525 0.71 ENSMUST00000230977.2
solute carrier family 39 (zinc transporter), member 4
chr11_-_121009503 0.70 ENSMUST00000039146.4
testis expressed gene 19.2
chr16_+_58548273 0.70 ENSMUST00000023426.12
ENSMUST00000162057.8
ENSMUST00000162191.2
claudin domain containing 1
chr6_+_30509826 0.69 ENSMUST00000031797.11
serine-rich single-pass membrane protein 1
chr14_-_36857202 0.69 ENSMUST00000165649.4
ENSMUST00000224769.2
growth hormone inducible transmembrane protein
chr7_+_49408847 0.69 ENSMUST00000085272.7
ENSMUST00000207895.2
HIV-1 Tat interactive protein 2
chr9_+_54858066 0.68 ENSMUST00000034848.14
proteasome subunit alpha 4
chr18_-_63825380 0.68 ENSMUST00000025476.4
thioredoxin-like 1
chr12_-_85335193 0.67 ENSMUST00000121930.2
acylphosphatase 1, erythrocyte (common) type
chr3_+_137923521 0.67 ENSMUST00000090171.7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr12_+_86999366 0.67 ENSMUST00000191463.2
CLOCK interacting protein, circadian
chr14_-_34032311 0.67 ENSMUST00000111917.3
ENSMUST00000228704.2
shieldin complex subunit 2
chr7_+_28466160 0.66 ENSMUST00000122915.8
ENSMUST00000072965.5
ENSMUST00000170068.9
sirtuin 2
chr5_-_122640255 0.65 ENSMUST00000031423.10
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr18_-_10030017 0.65 ENSMUST00000116669.2
ENSMUST00000092096.14
ubiquitin specific peptidase 14
chr2_+_91087668 0.65 ENSMUST00000111349.9
ENSMUST00000131711.8
protein kinase C and casein kinase substrate in neurons 3
chr3_+_144283355 0.63 ENSMUST00000151086.3
selenoprotein F
chr7_-_103964662 0.62 ENSMUST00000106837.8
ENSMUST00000106839.9
ENSMUST00000070943.7
tripartite motif-containing 12A
chr2_+_136555364 0.62 ENSMUST00000028727.11
ENSMUST00000110098.4
synaptosomal-associated protein 25
chr6_-_146403638 0.62 ENSMUST00000079573.13
inositol 1,4,5-triphosphate receptor 2
chr2_+_29968225 0.61 ENSMUST00000150770.8
protein kinase N3
chr11_-_106378659 0.61 ENSMUST00000106801.8
endoplasmic reticulum (ER) to nucleus signalling 1
chr7_+_126365506 0.60 ENSMUST00000032944.9
glycerophosphodiester phosphodiesterase domain containing 3
chr5_-_122639840 0.59 ENSMUST00000177974.8
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr11_+_106146966 0.59 ENSMUST00000021049.9
protease (prosome, macropain) 26S subunit, ATPase 5
chr9_-_103243039 0.58 ENSMUST00000035484.11
carnitine deficiency-associated gene expressed in ventricle 3
chr2_+_11710246 0.58 ENSMUST00000148748.8
interleukin 15 receptor, alpha chain
chr3_+_122039274 0.58 ENSMUST00000178826.8
glutamate-cysteine ligase, modifier subunit
chr9_+_54858388 0.58 ENSMUST00000171900.2
proteasome subunit alpha 4
chr12_+_55445560 0.57 ENSMUST00000021412.9
proteasome subunit alpha 6
chr9_+_54858092 0.56 ENSMUST00000172407.8
proteasome subunit alpha 4
chr14_-_20529974 0.56 ENSMUST00000224975.2
annexin A7
chr8_-_71308229 0.56 ENSMUST00000212086.2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr2_-_20948230 0.55 ENSMUST00000140230.2
Rho GTPase activating protein 21
chr12_-_101943134 0.54 ENSMUST00000221227.2
NADH:ubiquinone oxidoreductase subunit B1
chr13_-_64460491 0.54 ENSMUST00000222570.2
ENSMUST00000220895.2
peroxiredoxin like 2C

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfe2_Bach1_Mafk

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.3 GO:2000469 negative regulation of peroxidase activity(GO:2000469)
2.9 23.3 GO:1902031 regulation of NADP metabolic process(GO:1902031)
2.4 12.0 GO:0009115 xanthine catabolic process(GO:0009115)
1.2 12.9 GO:0035754 B cell chemotaxis(GO:0035754)
0.9 3.6 GO:1903033 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.9 4.4 GO:1904970 brush border assembly(GO:1904970)
0.9 5.2 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.8 2.4 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.7 2.2 GO:0035973 aggrephagy(GO:0035973)
0.7 10.6 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.7 2.0 GO:0034758 negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.6 5.7 GO:0019532 oxalate transport(GO:0019532)
0.6 4.8 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.6 2.4 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.5 5.7 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.5 3.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.5 1.9 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.5 7.7 GO:0043248 proteasome assembly(GO:0043248)
0.5 3.2 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.4 1.3 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.4 1.2 GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233)
0.4 4.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.3 2.4 GO:0002317 plasma cell differentiation(GO:0002317)
0.3 1.3 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.3 0.9 GO:1900195 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.3 0.9 GO:0060722 spongiotrophoblast cell proliferation(GO:0060720) cell proliferation involved in embryonic placenta development(GO:0060722)
0.3 1.5 GO:0038161 prolactin signaling pathway(GO:0038161)
0.3 0.8 GO:0042977 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.3 1.8 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.2 0.7 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.2 4.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 0.7 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.2 0.7 GO:0006069 ethanol oxidation(GO:0006069)
0.2 0.9 GO:0006624 vacuolar protein processing(GO:0006624)
0.2 3.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 2.9 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.2 3.6 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.2 0.6 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.2 1.6 GO:0051409 response to nitrosative stress(GO:0051409)
0.2 1.2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2 2.0 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 4.5 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.2 6.0 GO:0045821 positive regulation of glycolytic process(GO:0045821)
0.2 2.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.2 1.5 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 0.5 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.2 0.2 GO:0009609 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
0.2 5.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.2 1.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.2 0.7 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.2 1.3 GO:0033762 response to glucagon(GO:0033762)
0.2 0.2 GO:0090265 immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265)
0.2 0.5 GO:1904117 activation of meiosis involved in egg activation(GO:0060466) response to fluoride(GO:1902617) response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.1 0.9 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 2.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 2.9 GO:0051450 myoblast proliferation(GO:0051450)
0.1 0.7 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.1 0.7 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.1 1.2 GO:0061709 reticulophagy(GO:0061709)
0.1 0.8 GO:0051342 sensory perception of umami taste(GO:0050917) regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342)
0.1 0.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 2.5 GO:0060736 prostate gland growth(GO:0060736)
0.1 0.9 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.1 1.0 GO:0033184 positive regulation of histone ubiquitination(GO:0033184) histone H3-K36 demethylation(GO:0070544)
0.1 0.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.6 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.1 9.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.8 GO:1901906 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.6 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.6 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.4 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.4 GO:0042335 cuticle development(GO:0042335)
0.1 1.5 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 0.2 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.1 2.6 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
0.1 0.5 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.1 2.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 0.3 GO:0015881 creatine transport(GO:0015881)
0.1 0.7 GO:0015862 uridine transport(GO:0015862)
0.1 0.5 GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway(GO:0035660)
0.1 0.4 GO:0009992 cellular water homeostasis(GO:0009992)
0.1 2.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 0.5 GO:1901674 histone H3-K27 acetylation(GO:0043974) spongiotrophoblast differentiation(GO:0060708) regulation of histone H3-K27 acetylation(GO:1901674)
0.1 2.0 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.3 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.1 0.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 2.0 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.2 GO:0045643 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1 0.3 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 0.9 GO:2000580 regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 4.0 GO:0001702 gastrulation with mouth forming second(GO:0001702)
0.1 0.8 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.4 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 5.3 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.1 1.2 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.1 13.0 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.3 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1 0.9 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.3 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 2.2 GO:0030224 monocyte differentiation(GO:0030224)
0.1 1.7 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.1 1.0 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 1.5 GO:0042118 endothelial cell activation(GO:0042118)
0.1 3.8 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 1.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.5 GO:0002551 mast cell chemotaxis(GO:0002551) mast cell migration(GO:0097531)
0.1 0.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 1.2 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 1.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.4 GO:0042148 strand invasion(GO:0042148)
0.0 0.6 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 2.2 GO:0015893 drug transport(GO:0015893)
0.0 0.7 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 1.4 GO:2000505 regulation of energy homeostasis(GO:2000505)
0.0 0.2 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 1.1 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0001712 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.0 1.0 GO:0010225 response to UV-C(GO:0010225)
0.0 0.3 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.0 2.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.4 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.9 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 2.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.2 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.2 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.0 0.1 GO:0035747 negative regulation of glial cell apoptotic process(GO:0034351) natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.0 0.2 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
0.0 0.2 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.0 0.3 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.0 0.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857) embryonic brain development(GO:1990403)
0.0 1.5 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.0 0.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.4 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.6 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.4 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.0 0.9 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.2 GO:0042226 interleukin-6 biosynthetic process(GO:0042226)
0.0 2.2 GO:0046324 regulation of glucose import(GO:0046324)
0.0 2.2 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.3 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.4 GO:2000269 regulation of fibroblast apoptotic process(GO:2000269)
0.0 0.1 GO:0021769 orbitofrontal cortex development(GO:0021769) motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.0 1.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.3 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 1.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.2 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.3 GO:0001553 luteinization(GO:0001553)
0.0 0.3 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0007527 adult somatic muscle development(GO:0007527)
0.0 0.4 GO:0032212 positive regulation of telomere maintenance via telomerase(GO:0032212)
0.0 0.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 25.6 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
1.5 4.5 GO:0044753 amphisome(GO:0044753)
0.7 2.0 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.6 7.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.6 1.7 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
0.5 1.6 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.5 19.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.4 4.4 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.4 1.2 GO:0014801 longitudinal sarcoplasmic reticulum(GO:0014801)
0.4 1.5 GO:0005608 laminin-3 complex(GO:0005608)
0.3 1.3 GO:1990589 Lewy body core(GO:1990037) ATF4-CREB1 transcription factor complex(GO:1990589) ATF1-ATF4 transcription factor complex(GO:1990590)
0.3 0.9 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.3 2.1 GO:0031673 H zone(GO:0031673)
0.2 3.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 4.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 2.0 GO:1990357 terminal web(GO:1990357)
0.2 1.2 GO:0097513 myosin II filament(GO:0097513)
0.2 1.8 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.2 5.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 0.9 GO:0071986 Ragulator complex(GO:0071986)
0.1 5.8 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.9 GO:0033010 paranodal junction(GO:0033010)
0.1 0.7 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.2 GO:0098855 HCN channel complex(GO:0098855)
0.1 1.7 GO:0030056 hemidesmosome(GO:0030056)
0.1 3.6 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.8 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.4 GO:0043293 apoptosome(GO:0043293)
0.1 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 4.0 GO:0000502 proteasome complex(GO:0000502)
0.0 0.6 GO:0008278 cohesin complex(GO:0008278)
0.0 1.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.2 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 3.4 GO:0044439 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 0.3 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.4 GO:0001520 outer dense fiber(GO:0001520)
0.0 2.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0031523 Myb complex(GO:0031523)
0.0 0.3 GO:0044754 autolysosome(GO:0044754)
0.0 0.1 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.6 GO:0032420 stereocilium(GO:0032420)
0.0 0.2 GO:0044299 C-fiber(GO:0044299)
0.0 12.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 3.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.5 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.5 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 1.3 GO:0030315 T-tubule(GO:0030315)
0.0 2.3 GO:0001650 fibrillar center(GO:0001650)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.4 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 25.6 GO:0035731 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
7.8 23.3 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
4.6 18.5 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
3.2 12.9 GO:0047016 cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity(GO:0047016)
2.5 12.6 GO:0016623 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
1.6 4.8 GO:0030151 molybdenum ion binding(GO:0030151)
1.2 6.0 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.9 5.5 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.9 3.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.7 2.2 GO:0008127 quercetin 2,3-dioxygenase activity(GO:0008127)
0.6 2.4 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.5 1.6 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.5 10.6 GO:0030957 Tat protein binding(GO:0030957)
0.5 2.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.5 5.2 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.4 3.6 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.4 1.3 GO:0004967 glucagon receptor activity(GO:0004967)
0.4 1.3 GO:1990254 keratin filament binding(GO:1990254)
0.4 1.6 GO:0003998 acylphosphatase activity(GO:0003998)
0.4 3.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.4 5.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 5.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.3 1.5 GO:0004925 prolactin receptor activity(GO:0004925)
0.3 1.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.3 1.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.3 0.8 GO:0070540 stearic acid binding(GO:0070540)
0.2 0.7 GO:0034632 retinol transporter activity(GO:0034632)
0.2 2.0 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 0.9 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.2 6.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 0.6 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.2 5.1 GO:0097602 cullin family protein binding(GO:0097602)
0.2 1.2 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.2 1.0 GO:0045322 unmethylated CpG binding(GO:0045322)
0.2 1.4 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 2.0 GO:0039706 co-receptor binding(GO:0039706)
0.2 0.6 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.2 0.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 2.2 GO:0019215 intermediate filament binding(GO:0019215)
0.1 1.5 GO:0008430 selenium binding(GO:0008430)
0.1 2.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.5 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 0.4 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.1 3.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.8 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 3.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.9 GO:0005534 galactose binding(GO:0005534)
0.1 0.9 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 1.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 3.6 GO:0070330 aromatase activity(GO:0070330)
0.1 0.7 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 1.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.3 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.1 2.4 GO:0043295 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.3 GO:0001962 alpha-1,3-galactosyltransferase activity(GO:0001962)
0.1 0.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.8 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.1 1.2 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.2 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.1 1.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.3 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 1.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 4.2 GO:0043531 ADP binding(GO:0043531)
0.1 1.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 3.0 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 4.7 GO:0051287 NAD binding(GO:0051287)
0.1 1.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 2.0 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.1 0.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 0.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.2 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 0.4 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.1 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 2.0 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.4 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 2.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.5 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.5 GO:0019841 retinol binding(GO:0019841)
0.0 2.7 GO:0016209 antioxidant activity(GO:0016209)
0.0 1.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.2 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.9 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.1 GO:0046979 TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0 4.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.6 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 3.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.7 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 4.9 GO:0000149 SNARE binding(GO:0000149)
0.0 5.1 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.1 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.1 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 0.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.7 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 6.1 GO:0048037 cofactor binding(GO:0048037)
0.0 1.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 3.1 GO:0005178 integrin binding(GO:0005178)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 5.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.5 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 4.3 GO:0008017 microtubule binding(GO:0008017)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.9 GO:0017022 myosin binding(GO:0017022)
0.0 1.1 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 7.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 5.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.2 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 1.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.0 PID IL1 PATHWAY IL1-mediated signaling events
0.1 1.2 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 2.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 3.4 PID ARF6 PATHWAY Arf6 signaling events
0.1 1.4 PID AP1 PATHWAY AP-1 transcription factor network
0.1 7.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.1 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.9 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.2 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.9 PID P73PATHWAY p73 transcription factor network
0.0 1.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 14.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.5 43.9 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.4 7.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 4.5 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.2 12.3 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.2 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 6.8 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 24.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 3.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 0.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 1.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 4.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 2.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 0.6 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 0.9 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.4 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 2.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 5.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 2.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.6 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus