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GSE58827: Dynamics of the Mouse Liver

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Results for Nkx2-3

Z-value: 1.26

Motif logo

Transcription factors associated with Nkx2-3

Gene Symbol Gene ID Gene Info
ENSMUSG00000044220.14 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-3mm39_v1_chr19_+_43600738_43600764-0.711.4e-06Click!

Activity profile of Nkx2-3 motif

Sorted Z-values of Nkx2-3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_40078132 16.08 ENSMUST00000068094.13
ENSMUST00000080171.3
cytochrome P450, family 2, subfamily c, polypeptide 50
chr19_-_8382424 10.94 ENSMUST00000064507.12
ENSMUST00000120540.2
ENSMUST00000096269.11
solute carrier family 22, member 30
chr7_-_19432933 8.81 ENSMUST00000174355.8
ENSMUST00000172983.8
ENSMUST00000174710.2
ENSMUST00000003066.16
ENSMUST00000174064.9
apolipoprotein E
chr5_-_87572060 8.80 ENSMUST00000072818.6
UDP glucuronosyltransferase 2 family, polypeptide B38
chr10_+_87697155 7.85 ENSMUST00000122100.3
insulin-like growth factor 1
chr2_+_70305267 7.46 ENSMUST00000100043.3
trans-acting transcription factor 5
chr19_+_37686240 7.05 ENSMUST00000025946.7
cytochrome P450, family 26, subfamily a, polypeptide 1
chr7_-_48497771 6.72 ENSMUST00000032658.14
cysteine and glycine-rich protein 3
chr3_-_137945419 6.69 ENSMUST00000199804.3
ENSMUST00000185122.8
ENSMUST00000183783.8
RIKEN cDNA 4930579F01 gene
RIKEN cDNA 0610031O16 gene
chr19_-_39637489 5.43 ENSMUST00000067328.7
cytochrome P450, family 2, subfamily c, polypeptide 67
chr14_-_118289557 4.88 ENSMUST00000022725.4
dopachrome tautomerase
chr19_-_4092218 4.75 ENSMUST00000237999.2
ENSMUST00000042700.12
glutathione S-transferase, pi 2
chr5_+_146016064 4.66 ENSMUST00000035571.10
cytochrome P450, family 3, subfamily a, polypeptide 59
chr6_+_125298372 4.62 ENSMUST00000176442.8
ENSMUST00000177329.2
sodium channel, nonvoltage-gated 1 alpha
chr5_+_42225303 4.12 ENSMUST00000087332.5
predicted gene 16223
chr17_+_37253802 4.08 ENSMUST00000040498.12
ring finger protein 39
chr6_+_125298296 3.87 ENSMUST00000081440.14
sodium channel, nonvoltage-gated 1 alpha
chr12_+_112073261 3.81 ENSMUST00000223412.2
asparaginase
chr15_-_96929086 3.61 ENSMUST00000230086.2
solute carrier family 38, member 4
chr4_+_135870808 3.58 ENSMUST00000008016.3
inhibitor of DNA binding 3
chr19_+_39980868 3.31 ENSMUST00000049178.3
cytochrome P450, family 2. subfamily c, polypeptide 37
chr7_+_119217004 3.17 ENSMUST00000047929.13
ENSMUST00000135683.3
acyl-CoA synthetase medium-chain family member 1
chr7_-_12731594 3.10 ENSMUST00000133977.3
solute carrier family 27 (fatty acid transporter), member 5
chr15_+_92495007 2.83 ENSMUST00000035399.10
PDZ domain containing RING finger 4
chr2_-_23939401 2.81 ENSMUST00000051416.12
histamine N-methyltransferase
chr11_-_116080361 2.77 ENSMUST00000148601.2
acyl-Coenzyme A oxidase 1, palmitoyl
chr2_+_22959452 2.64 ENSMUST00000155602.4
acyl-Coenzyme A binding domain containing 5
chr1_-_72323464 2.47 ENSMUST00000027381.13
peroxisomal trans-2-enoyl-CoA reductase
chrM_+_5319 2.45 ENSMUST00000082402.1
mitochondrially encoded cytochrome c oxidase I
chr1_-_72323407 2.34 ENSMUST00000097698.5
peroxisomal trans-2-enoyl-CoA reductase
chr1_+_88034556 2.33 ENSMUST00000113137.2
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr15_+_31224460 2.29 ENSMUST00000044524.16
death-associated protein
chr15_-_50753792 2.20 ENSMUST00000185183.2
transcriptional repressor GATA binding 1
chr1_+_13738967 2.15 ENSMUST00000088542.4
X-linked Kx blood group related 9
chr6_+_54016543 2.09 ENSMUST00000046856.14
chimerin 2
chr6_+_141575226 2.08 ENSMUST00000042812.9
solute carrier organic anion transporter family, member 1b2
chr9_-_50657800 2.07 ENSMUST00000239417.2
ENSMUST00000034564.4
RIKEN cDNA 2310030G06 gene
chr13_-_42001102 2.06 ENSMUST00000121404.8
androgen dependent TFPI regulating protein
chr15_+_100768776 2.03 ENSMUST00000108909.9
sodium channel, voltage-gated, type VIII, alpha
chr8_+_46080840 2.02 ENSMUST00000135336.9
sorbin and SH3 domain containing 2
chr18_+_20380397 2.00 ENSMUST00000054128.7
desmoglein 1 gamma
chr16_-_23339548 1.97 ENSMUST00000089883.7
mannan-binding lectin serine peptidase 1
chr10_-_12689345 1.91 ENSMUST00000217899.2
utrophin
chr15_-_77813123 1.90 ENSMUST00000109748.9
ENSMUST00000109747.9
ENSMUST00000100486.6
ENSMUST00000005487.12
thioredoxin 2
chr4_-_41640321 1.88 ENSMUST00000127306.2
energy homeostasis associated
chr17_+_56312672 1.84 ENSMUST00000133998.8
MPN domain containing
chrX_+_138464065 1.79 ENSMUST00000113027.8
ring finger protein 128
chr17_+_3447465 1.75 ENSMUST00000072156.7
T cell lymphoma invasion and metastasis 2
chr15_+_31224616 1.71 ENSMUST00000186547.7
death-associated protein
chr12_-_25147139 1.68 ENSMUST00000221761.2
inhibitor of DNA binding 2
chr4_-_129155185 1.67 ENSMUST00000145261.8
expressed sequence C77080
chr15_+_31225302 1.67 ENSMUST00000186425.7
death-associated protein
chr19_+_24853039 1.65 ENSMUST00000073080.7
predicted gene 10053
chr1_-_140111018 1.64 ENSMUST00000192880.6
ENSMUST00000111977.8
complement component factor h
chr1_-_14374794 1.60 ENSMUST00000190337.7
EYA transcriptional coactivator and phosphatase 1
chr1_-_140111138 1.59 ENSMUST00000111976.9
ENSMUST00000066859.13
complement component factor h
chr5_-_25305621 1.59 ENSMUST00000030784.14
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr2_+_22959223 1.58 ENSMUST00000114523.10
acyl-Coenzyme A binding domain containing 5
chr2_-_63014622 1.58 ENSMUST00000075052.10
ENSMUST00000112454.8
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr10_+_29019645 1.55 ENSMUST00000092629.4
SOGA family member 3
chr8_-_5155347 1.55 ENSMUST00000023835.3
solute carrier family 10, member 2
chr14_+_67470735 1.55 ENSMUST00000022637.14
early B cell factor 2
chr6_-_83098255 1.55 ENSMUST00000205023.2
ENSMUST00000146328.4
ENSMUST00000151393.7
ENSMUST00000032111.11
ENSMUST00000113936.10
WW domain binding protein 1
chr1_-_14374842 1.53 ENSMUST00000188857.7
ENSMUST00000185453.7
EYA transcriptional coactivator and phosphatase 1
chr16_-_35589726 1.53 ENSMUST00000023554.9
solute carrier family 49 member 4
chr3_-_85648696 1.51 ENSMUST00000094148.6
family with sequence similarity 160, member A1
chr6_+_125298168 1.50 ENSMUST00000176365.2
sodium channel, nonvoltage-gated 1 alpha
chr6_-_84565613 1.49 ENSMUST00000204146.3
cytochrome P450, family 26, subfamily b, polypeptide 1
chr11_+_99764215 1.49 ENSMUST00000093936.5
keratin associated protein 9-1
chr15_-_5093222 1.48 ENSMUST00000110689.5
complement component 7
chr13_-_64277115 1.48 ENSMUST00000220792.2
ENSMUST00000222866.2
ENSMUST00000099441.6
ENSMUST00000222168.2
solute carrier family 35, member D2
chr3_+_55369149 1.48 ENSMUST00000199585.5
ENSMUST00000070418.9
doublecortin-like kinase 1
chr2_+_125876883 1.45 ENSMUST00000110442.2
fibroblast growth factor 7
chr2_-_32976378 1.44 ENSMUST00000049618.9
GTPase activating RANGAP domain-like 3
chrM_+_10167 1.44 ENSMUST00000082414.1
mitochondrially encoded NADH dehydrogenase 4
chr2_+_69727563 1.43 ENSMUST00000055758.16
ENSMUST00000112251.9
ubiquitin protein ligase E3 component n-recognin 3
chr15_+_31224555 1.42 ENSMUST00000186109.2
death-associated protein
chr10_-_85847697 1.41 ENSMUST00000105304.2
ENSMUST00000061699.12
BPI fold containing family C
chr13_+_23991010 1.40 ENSMUST00000006786.11
ENSMUST00000099697.3
solute carrier family 17 (sodium phosphate), member 2
chr11_+_94219046 1.38 ENSMUST00000021227.6
ankyrin repeat domain 40
chr5_-_28415020 1.37 ENSMUST00000118882.2
canopy FGF signaling regulator 1
chr1_-_14380418 1.36 ENSMUST00000027066.13
ENSMUST00000168081.9
EYA transcriptional coactivator and phosphatase 1
chr1_-_14380327 1.35 ENSMUST00000080664.14
EYA transcriptional coactivator and phosphatase 1
chr5_-_28415166 1.32 ENSMUST00000117098.2
canopy FGF signaling regulator 1
chr19_+_31846154 1.31 ENSMUST00000224564.2
ENSMUST00000224304.2
ENSMUST00000075838.8
ENSMUST00000224400.2
APOBEC1 complementation factor
chr19_-_10655391 1.31 ENSMUST00000025647.7
pepsinogen 5, group I
chr8_-_64659004 1.27 ENSMUST00000066166.6
tolloid-like
chr11_+_94218810 1.26 ENSMUST00000107818.9
ENSMUST00000051221.13
ankyrin repeat domain 40
chr12_-_101942463 1.25 ENSMUST00000221422.2
NADH:ubiquinone oxidoreductase subunit B1
chr3_+_62327089 1.23 ENSMUST00000161057.2
Rho guanine nucleotide exchange factor (GEF) 26
chr15_-_81244940 1.22 ENSMUST00000023040.9
solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
chr15_+_58004831 1.22 ENSMUST00000226889.2
WDYHV motif containing 1
chr2_-_63014514 1.22 ENSMUST00000112452.2
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr7_+_140181182 1.22 ENSMUST00000214180.2
ENSMUST00000211771.2
olfactory receptor 46
chr19_+_44980565 1.22 ENSMUST00000179305.2
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr2_+_80447389 1.22 ENSMUST00000028384.5
dual specificity phosphatase 19
chr15_+_100768806 1.21 ENSMUST00000201549.4
ENSMUST00000108908.6
sodium channel, voltage-gated, type VIII, alpha
chr13_-_43634695 1.20 ENSMUST00000144326.4
RAN binding protein 9
chr2_-_147028309 1.20 ENSMUST00000067075.7
NK2 homeobox 2
chr3_+_60380243 1.19 ENSMUST00000195724.6
muscleblind like splicing factor 1
chr7_-_35236962 1.17 ENSMUST00000193633.6
ENSMUST00000187190.7
ENSMUST00000205407.2
ENSMUST00000127472.3
tudor domain containing 12
chrX_+_141010919 1.14 ENSMUST00000042329.12
nuclear transport factor 2-like export factor 2
chr2_-_113844100 1.14 ENSMUST00000090275.5
gap junction protein, delta 2
chr6_-_148847633 1.13 ENSMUST00000132696.8
SIN3-HDAC complex associated factor
chr9_+_119231140 1.12 ENSMUST00000165044.3
activin receptor IIB
chr1_+_66739990 1.11 ENSMUST00000027157.10
ENSMUST00000113995.2
ribulose-5-phosphate-3-epimerase
chr17_-_78725510 1.11 ENSMUST00000234029.2
ENSMUST00000234530.2
ENSMUST00000234052.2
ENSMUST00000070039.14
ENSMUST00000112487.3
fasciculation and elongation protein zeta 2 (zygin II)
chr2_+_152873772 1.08 ENSMUST00000037235.7
X-linked Kx blood group related 7
chr8_+_120955195 1.07 ENSMUST00000180448.3
genetic suppressor element 1, coiled-coil protein
chr13_-_36918424 1.07 ENSMUST00000037623.15
neuritin 1
chr19_+_60800012 1.06 ENSMUST00000128357.8
ENSMUST00000119633.8
ENSMUST00000025957.9
DENN domain containing 10
chr9_-_44714263 1.06 ENSMUST00000044694.8
tetratricopeptide repeat domain 36
chr15_+_102885467 1.06 ENSMUST00000001706.7
homeobox C9
chr18_-_39000056 1.05 ENSMUST00000236630.2
ENSMUST00000237356.2
fibroblast growth factor 1
chr11_-_59466995 1.05 ENSMUST00000215339.2
ENSMUST00000214351.2
olfactory receptor 222
chr5_+_117919082 1.05 ENSMUST00000138579.3
nitric oxide synthase 1, neuronal
chr18_+_37433852 1.04 ENSMUST00000051754.2
protocadherin beta 3
chr1_+_66361252 1.04 ENSMUST00000123647.8
microtubule-associated protein 2
chr1_-_63215952 1.04 ENSMUST00000185412.7
ENSMUST00000027111.15
ENSMUST00000189664.2
NADH:ubiquinone oxidoreductase core subunit S1
chr4_+_135648041 1.03 ENSMUST00000030434.5
fucosidase, alpha-L- 1, tissue
chr6_-_115569504 1.02 ENSMUST00000112957.2
makorin, ring finger protein 2, opposite strand
chr6_-_136148820 1.00 ENSMUST00000188999.3
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr1_-_167294349 0.99 ENSMUST00000036643.6
leucine rich repeat containing 52
chr9_+_46151994 0.99 ENSMUST00000034585.7
apolipoprotein A-IV
chr15_+_100768551 0.97 ENSMUST00000082209.13
sodium channel, voltage-gated, type VIII, alpha
chr8_+_45960931 0.97 ENSMUST00000171337.10
ENSMUST00000067107.15
sorbin and SH3 domain containing 2
chr14_-_68771138 0.97 ENSMUST00000022640.8
a disintegrin and metallopeptidase domain 7
chr15_-_13173736 0.95 ENSMUST00000036439.6
cadherin 6
chr2_+_125876566 0.95 ENSMUST00000064794.14
fibroblast growth factor 7
chr3_-_141687987 0.95 ENSMUST00000029948.15
bone morphogenetic protein receptor, type 1B
chr3_-_154036180 0.94 ENSMUST00000177846.8
LIM homeobox protein 8
chr3_+_122213420 0.94 ENSMUST00000029766.9
breast cancer anti-estrogen resistance 3
chr2_+_57887896 0.94 ENSMUST00000112616.8
ENSMUST00000166729.2
polypeptide N-acetylgalactosaminyltransferase 5
chr6_-_41752111 0.93 ENSMUST00000214976.3
olfactory receptor 459
chr7_-_12829100 0.92 ENSMUST00000209822.3
ENSMUST00000235753.2
vomeronasal 1 receptor 85
chr5_+_81169049 0.92 ENSMUST00000117253.8
ENSMUST00000120128.8
adhesion G protein-coupled receptor L3
chr3_+_85946145 0.91 ENSMUST00000238331.2
SH3 domain protein D19
chr13_-_53627110 0.91 ENSMUST00000021922.10
msh homeobox 2
chr15_+_58004753 0.91 ENSMUST00000067563.9
WDYHV motif containing 1
chr2_-_18053595 0.86 ENSMUST00000142856.2
SKI/DACH domain containing 1
chr18_-_57108405 0.85 ENSMUST00000139243.9
ENSMUST00000025488.15
RIKEN cDNA C330018D20 gene
chr4_-_91264670 0.85 ENSMUST00000107109.9
ENSMUST00000107111.9
ENSMUST00000107120.8
ELAV like RNA binding protein 1
chr15_+_58004793 0.84 ENSMUST00000227142.2
ENSMUST00000226955.2
WDYHV motif containing 1
chrX_-_142716085 0.83 ENSMUST00000087313.10
doublecortin
chr1_-_162687254 0.82 ENSMUST00000131058.8
flavin containing monooxygenase 1
chr2_+_69727599 0.82 ENSMUST00000131553.2
ubiquitin protein ligase E3 component n-recognin 3
chr16_+_23338960 0.81 ENSMUST00000211460.2
ENSMUST00000210658.2
ENSMUST00000209198.2
ENSMUST00000210371.2
ENSMUST00000211499.2
ENSMUST00000210795.2
ENSMUST00000209422.2
predicted gene 45338
receptor transporter protein 4
chr13_+_41013230 0.81 ENSMUST00000110191.10
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr15_-_36165017 0.81 ENSMUST00000058643.4
F-box protein 43
chr16_+_8288627 0.80 ENSMUST00000046470.16
ENSMUST00000150790.2
ENSMUST00000142899.2
methyltransferase like 22
chr15_-_36164963 0.80 ENSMUST00000227793.2
F-box protein 43
chr4_-_91264727 0.80 ENSMUST00000107124.10
ELAV like RNA binding protein 1
chr1_-_162687369 0.79 ENSMUST00000193078.6
flavin containing monooxygenase 1
chr2_+_83554770 0.78 ENSMUST00000141725.3
integrin alpha V
chr14_+_75693396 0.78 ENSMUST00000164848.3
siah E3 ubiquitin protein ligase family member 3
chr8_+_24159669 0.77 ENSMUST00000042352.11
ENSMUST00000207301.2
zinc finger, matrin type 4
chr11_-_12362136 0.76 ENSMUST00000174874.8
cordon-bleu WH2 repeat
chr19_+_38253077 0.76 ENSMUST00000198045.5
leucine-rich repeat LGI family, member 1
chr19_+_38253105 0.76 ENSMUST00000196090.2
leucine-rich repeat LGI family, member 1
chr15_-_43733389 0.75 ENSMUST00000067469.6
transmembrane protein 74
chr8_+_46081213 0.75 ENSMUST00000130850.8
sorbin and SH3 domain containing 2
chrX_-_99638466 0.75 ENSMUST00000053373.2
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr9_+_32027335 0.74 ENSMUST00000174641.8
Rho GTPase activating protein 32
chr5_-_25200745 0.74 ENSMUST00000076306.12
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr19_-_44541270 0.72 ENSMUST00000166808.2
predicted gene 20538
chr6_-_138398376 0.72 ENSMUST00000163065.8
LIM domain only 3
chr11_+_59197746 0.72 ENSMUST00000000128.10
ENSMUST00000108783.4
wingless-type MMTV integration site family, member 9A
chr10_-_8632519 0.72 ENSMUST00000212869.2
SAM and SH3 domain containing 1
chr3_-_75177378 0.72 ENSMUST00000039047.5
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr12_-_11486544 0.71 ENSMUST00000072299.7
visinin-like 1
chr3_+_55369384 0.71 ENSMUST00000200352.2
doublecortin-like kinase 1
chr9_-_14411690 0.71 ENSMUST00000115647.3
lysine (K)-specific demethylase 4D
chr2_+_67578556 0.70 ENSMUST00000180887.2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr7_+_144391786 0.70 ENSMUST00000155320.8
fibroblast growth factor 3
chr11_-_99907030 0.70 ENSMUST00000018399.3
keratin 33A
chr1_-_119576347 0.69 ENSMUST00000027632.14
ENSMUST00000187194.2
erythrocyte membrane protein band 4.1 like 5
chr1_+_19282278 0.69 ENSMUST00000064976.6
transcription factor AP-2 beta
chr2_-_64806106 0.69 ENSMUST00000156765.2
growth factor receptor bound protein 14
chr18_-_84104507 0.69 ENSMUST00000060303.10
teashirt zinc finger family member 1
chr1_+_183170293 0.69 ENSMUST00000192076.3
TATA-box binding protein associated factor, RNA polymerase I, A
chr2_+_22512195 0.68 ENSMUST00000028123.4
glutamic acid decarboxylase 2
chr12_+_116239006 0.68 ENSMUST00000090195.5
predicted gene 11027
chr2_-_164013033 0.68 ENSMUST00000045196.4
K+ voltage-gated channel, subfamily S, 1
chrX_+_106193060 0.68 ENSMUST00000125676.8
ENSMUST00000180182.2
purinergic receptor P2Y, G-protein coupled 10B
chr6_+_15185202 0.68 ENSMUST00000154448.2
forkhead box P2
chr3_+_135053762 0.67 ENSMUST00000159658.8
ENSMUST00000078568.12
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr2_-_103114105 0.67 ENSMUST00000111174.8
ets homologous factor
chrM_+_7006 0.67 ENSMUST00000082405.1
mitochondrially encoded cytochrome c oxidase II
chr6_+_30512285 0.66 ENSMUST00000031798.14
serine-rich single-pass membrane protein 1
chr5_+_8472831 0.66 ENSMUST00000066921.10
ENSMUST00000170496.6
solute carrier family 25, member 40
chr9_-_48747474 0.66 ENSMUST00000216150.2
zinc finger and BTB domain containing 16
chr15_-_50753437 0.66 ENSMUST00000077935.6
transcriptional repressor GATA binding 1
chr13_-_104056803 0.66 ENSMUST00000091269.11
ENSMUST00000188997.7
ENSMUST00000169083.8
ENSMUST00000191275.7
Erbb2 interacting protein
chr1_-_63215812 0.65 ENSMUST00000185847.2
ENSMUST00000185732.7
ENSMUST00000188370.7
ENSMUST00000168099.9
NADH:ubiquinone oxidoreductase core subunit S1
chr12_+_101370932 0.65 ENSMUST00000055156.5
cation channel sperm associated auxiliary subunit beta
chr2_-_86857424 0.65 ENSMUST00000214857.2
ENSMUST00000215972.2
olfactory receptor 1104
chr6_+_15184630 0.65 ENSMUST00000115470.3
forkhead box P2
chr19_+_43770619 0.65 ENSMUST00000026208.6
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr9_-_14411778 0.65 ENSMUST00000058796.7
lysine (K)-specific demethylase 4D
chr5_+_73164226 0.64 ENSMUST00000031127.11
ENSMUST00000201304.2
solute carrier family 10 (sodium/bile acid cotransporter family), member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.8 GO:1903000 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
2.2 6.7 GO:1903920 positive regulation of actin filament severing(GO:1903920)
1.6 4.8 GO:1903173 phytol metabolic process(GO:0033306) fatty alcohol metabolic process(GO:1903173)
1.5 4.5 GO:0006583 melanin biosynthetic process from tyrosine(GO:0006583)
1.3 16.1 GO:0043651 linoleic acid metabolic process(GO:0043651)
1.3 3.8 GO:0006530 asparagine catabolic process(GO:0006530)
1.2 8.5 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
1.1 7.9 GO:1904073 regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.8 2.5 GO:0061033 secretion by lung epithelial cell involved in lung growth(GO:0061033)
0.8 3.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.7 10.9 GO:0015747 urate transport(GO:0015747)
0.6 6.4 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.6 2.8 GO:0001692 histamine metabolic process(GO:0001692)
0.6 2.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.6 1.7 GO:0001966 thigmotaxis(GO:0001966)
0.5 1.6 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
0.5 2.8 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.5 1.4 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.4 1.3 GO:2000536 negative regulation of entry of bacterium into host cell(GO:2000536)
0.4 1.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.4 4.2 GO:0030242 pexophagy(GO:0030242)
0.4 3.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.3 1.0 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443) multicellular organism lipid catabolic process(GO:0044240)
0.3 1.3 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609)
0.3 8.0 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.3 0.9 GO:2001055 positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.3 8.7 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.3 1.1 GO:0019323 pentose catabolic process(GO:0019323)
0.3 1.9 GO:0007527 adult somatic muscle development(GO:0007527)
0.3 1.3 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
0.3 1.3 GO:0060023 soft palate development(GO:0060023)
0.2 0.5 GO:0060166 olfactory pit development(GO:0060166)
0.2 0.7 GO:0097275 creatinine homeostasis(GO:0097273) cellular ammonia homeostasis(GO:0097275) cellular creatinine homeostasis(GO:0097276) cellular urea homeostasis(GO:0097277)
0.2 0.7 GO:1903537 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.2 1.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 10.3 GO:0050891 multicellular organismal water homeostasis(GO:0050891)
0.2 0.6 GO:0060300 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) regulation of cytokine activity(GO:0060300)
0.2 1.2 GO:0015867 ATP transport(GO:0015867)
0.2 1.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 2.3 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 0.6 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.2 0.7 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 0.3 GO:0021762 substantia nigra development(GO:0021762)
0.2 0.6 GO:0016999 antibiotic metabolic process(GO:0016999)
0.2 0.8 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.2 2.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 0.5 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.2 1.1 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.6 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.1 4.3 GO:0030903 notochord development(GO:0030903)
0.1 4.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.7 GO:0048319 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) axial mesoderm morphogenesis(GO:0048319)
0.1 0.5 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.1 0.7 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.3 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
0.1 1.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.7 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.5 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.5 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.8 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 6.8 GO:0034198 cellular response to amino acid starvation(GO:0034198)
0.1 0.7 GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433)
0.1 0.3 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.5 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 0.2 GO:0060220 camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.1 1.9 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.5 GO:0060591 chondroblast differentiation(GO:0060591)
0.1 0.5 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 1.0 GO:0033227 dsRNA transport(GO:0033227)
0.1 0.5 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 0.5 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.4 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.1 0.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 1.0 GO:0016139 glycoside catabolic process(GO:0016139)
0.1 0.4 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 1.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.6 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.1 1.1 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.1 1.1 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.7 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 1.9 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 0.2 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.2 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 1.4 GO:0070995 NADPH oxidation(GO:0070995)
0.1 4.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 1.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.4 GO:0035865 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1 0.8 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.1 0.1 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416)
0.1 1.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 2.8 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 1.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 0.6 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 1.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 0.7 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.1 1.2 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 0.4 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 4.7 GO:0007628 adult walking behavior(GO:0007628)
0.1 1.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.4 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.1 1.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.2 GO:2000863 positive regulation of estrogen secretion(GO:2000863)
0.1 0.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.5 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 4.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.5 GO:0014029 neural crest formation(GO:0014029)
0.1 0.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.5 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.2 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.4 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.0 0.2 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.0 1.9 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 1.8 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.0 0.2 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.9 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.3 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0 2.4 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.5 GO:1900004 regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.3 GO:0061370 testosterone biosynthetic process(GO:0061370)
0.0 1.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.7 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.2 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.3 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 1.1 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 1.1 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.4 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.0 0.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.2 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.3 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 1.2 GO:0050919 negative chemotaxis(GO:0050919)
0.0 1.7 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.5 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.8 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.1 GO:0006393 termination of mitochondrial transcription(GO:0006393)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 1.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.0 GO:0015881 creatine transport(GO:0015881)
0.0 0.6 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 2.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.7 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.3 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0098885 modification of postsynaptic actin cytoskeleton(GO:0098885)
0.0 0.2 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.9 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.7 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0010225 response to UV-C(GO:0010225)
0.0 0.2 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.2 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 2.8 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.6 GO:0032094 response to food(GO:0032094)
0.0 0.0 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.3 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.4 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:1902966 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0 0.4 GO:0031424 keratinization(GO:0031424)
0.0 1.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.0 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.6 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.0 2.0 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.3 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 2.1 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.5 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.1 GO:0019236 response to pheromone(GO:0019236)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 8.8 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
1.0 4.8 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.8 7.9 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.5 14.7 GO:0034706 sodium channel complex(GO:0034706)
0.3 1.3 GO:0034683 integrin alphav-beta3 complex(GO:0034683) integrin alphav-beta8 complex(GO:0034686)
0.2 0.6 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.2 1.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 0.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.2 1.2 GO:1990923 PET complex(GO:1990923)
0.2 1.5 GO:0005579 membrane attack complex(GO:0005579)
0.2 3.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.3 GO:0045293 mRNA editing complex(GO:0045293)
0.1 0.7 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 4.5 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 8.8 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.8 GO:1990357 terminal web(GO:1990357)
0.1 2.5 GO:0030057 desmosome(GO:0030057)
0.1 1.1 GO:0005883 neurofilament(GO:0005883)
0.1 2.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.9 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.9 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 1.0 GO:0042627 chylomicron(GO:0042627)
0.1 0.7 GO:0036128 CatSper complex(GO:0036128)
0.0 1.1 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0070992 translation initiation complex(GO:0070992)
0.0 3.4 GO:0070469 respiratory chain(GO:0070469)
0.0 0.2 GO:0002079 inner acrosomal membrane(GO:0002079)
0.0 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 3.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 1.2 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 3.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0036156 inner dynein arm(GO:0036156)
0.0 6.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.5 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.7 GO:0001533 cornified envelope(GO:0001533)
0.0 1.4 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.1 GO:0005858 axonemal dynein complex(GO:0005858) outer dynein arm(GO:0036157)
0.0 1.6 GO:0000502 proteasome complex(GO:0000502)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.1 GO:0051286 cell tip(GO:0051286)
0.0 0.2 GO:0035631 IkappaB kinase complex(GO:0008385) CD40 receptor complex(GO:0035631)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.5 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 16.1 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
2.9 8.8 GO:0046911 metal chelating activity(GO:0046911)
1.6 4.8 GO:0035730 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
1.4 8.5 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
1.3 3.8 GO:0004067 asparaginase activity(GO:0004067)
1.2 4.8 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
1.0 3.0 GO:0070773 protein-N-terminal glutamine amidohydrolase activity(GO:0070773)
1.0 6.7 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.9 4.7 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.8 10.0 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.6 10.9 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.5 1.9 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.5 3.2 GO:0001851 complement component C3b binding(GO:0001851)
0.4 1.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.4 3.2 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.4 2.8 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.4 2.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.4 2.5 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.3 1.0 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.3 7.1 GO:0070513 death domain binding(GO:0070513)
0.3 8.7 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.3 2.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 11.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 0.7 GO:0045030 UTP-activated nucleotide receptor activity(GO:0045030)
0.2 1.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.2 1.2 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 4.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 2.1 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.2 1.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 3.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 0.8 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 1.0 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 0.8 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.2 1.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 7.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 4.9 GO:0031402 sodium ion binding(GO:0031402)
0.2 0.7 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 0.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 1.0 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 1.5 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 1.3 GO:0019960 C-X3-C chemokine binding(GO:0019960) extracellular matrix protein binding(GO:1990430)
0.1 1.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 4.2 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 1.0 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 1.1 GO:0034711 inhibin binding(GO:0034711)
0.1 0.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.5 GO:0019809 spermidine binding(GO:0019809)
0.1 3.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 1.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.5 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.1 1.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.5 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 0.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.6 GO:0043426 MRF binding(GO:0043426)
0.1 2.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.5 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 1.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 0.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 1.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 0.4 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.8 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 2.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.2 GO:0031699 beta-3 adrenergic receptor binding(GO:0031699)
0.1 0.5 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 1.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.5 GO:0036122 BMP binding(GO:0036122)
0.0 0.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.7 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.0 0.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0034046 poly(G) binding(GO:0034046)
0.0 1.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.2 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.0 0.3 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.5 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.5 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 3.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.3 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 1.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.0 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.0 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 1.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.3 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.5 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 3.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.0 GO:0032947 protein complex scaffold(GO:0032947)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.9 PID IGF1 PATHWAY IGF1 pathway
0.1 1.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 7.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 3.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 PID BMP PATHWAY BMP receptor signaling
0.0 1.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 PID INSULIN PATHWAY Insulin Pathway
0.0 1.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 3.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 4.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.2 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.4 8.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 1.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 2.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 1.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.2 5.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.2 4.6 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.1 2.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 4.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 0.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 3.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 1.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 1.4 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME OPSINS Genes involved in Opsins
0.0 0.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 3.2 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 1.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 3.1 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 1.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME BOTULINUM NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.0 0.7 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.7 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.2 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events