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GSE58827: Dynamics of the Mouse Liver

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Results for Nkx2-6

Z-value: 0.72

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Transcription factors associated with Nkx2-6

Gene Symbol Gene ID Gene Info
Nkx2-6
ENSMUSG00000044186.11 NK2 homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-6mm39_v1_chr14_+_69409251_69409414-0.791.1e-08Click!

Activity profile of Nkx2-6 motif

Sorted Z-values of Nkx2-6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_41681273 18.30 ENSMUST00000031899.14
Kel
Kell blood group
chr4_+_46039202 9.15 ENSMUST00000156200.8
Tmod1
tropomodulin 1
chr15_+_73594965 8.54 ENSMUST00000165541.8
ENSMUST00000167582.8
Ptp4a3
protein tyrosine phosphatase 4a3
chr15_+_73595012 8.43 ENSMUST00000230044.2
Ptp4a3
protein tyrosine phosphatase 4a3
chr7_-_115630282 3.74 ENSMUST00000206034.2
ENSMUST00000106612.8
Sox6
SRY (sex determining region Y)-box 6
chr5_+_110478558 2.18 ENSMUST00000112481.2
Pole
polymerase (DNA directed), epsilon
chr4_-_109522502 1.68 ENSMUST00000063531.5
Cdkn2c
cyclin dependent kinase inhibitor 2C
chr15_-_78657640 1.65 ENSMUST00000018313.6
Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr5_+_145063568 1.34 ENSMUST00000138922.2
Arpc1b
actin related protein 2/3 complex, subunit 1B
chr10_+_4297762 1.20 ENSMUST00000215696.2
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr2_+_3115250 1.06 ENSMUST00000072955.12
Fam171a1
family with sequence similarity 171, member A1
chr19_+_8779903 0.97 ENSMUST00000172175.3
Zbtb3
zinc finger and BTB domain containing 3
chr2_+_85715984 0.60 ENSMUST00000213441.3
Olfr1023
olfactory receptor 1023
chr1_+_179788675 0.38 ENSMUST00000076687.12
ENSMUST00000097450.10
ENSMUST00000212756.2
Cdc42bpa
CDC42 binding protein kinase alpha
chr1_+_179788037 0.31 ENSMUST00000097453.9
ENSMUST00000111117.8
Cdc42bpa
CDC42 binding protein kinase alpha
chr12_-_114263874 0.15 ENSMUST00000103482.2
ENSMUST00000194159.2
Ighv9-4
immunoglobulin heavy variable 9-4
chr4_+_62537750 0.15 ENSMUST00000084521.11
ENSMUST00000107424.2
Rgs3
regulator of G-protein signaling 3
chr12_-_11485639 0.11 ENSMUST00000220506.2
Vsnl1
visinin-like 1
chr11_+_103664976 0.09 ENSMUST00000000127.6
Wnt3
wingless-type MMTV integration site family, member 3
chr7_-_115837034 0.08 ENSMUST00000182834.8
Plekha7
pleckstrin homology domain containing, family A member 7
chr12_-_114073050 0.06 ENSMUST00000103472.4
Ighv9-2
immunoglobulin heavy variable V9-2

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 18.3 GO:0031133 regulation of axon diameter(GO:0031133)
1.5 9.2 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.9 17.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.7 2.2 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 3.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 1.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 1.7 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.0 1.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.7 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 1.3 GO:0036284 tubulobulbar complex(GO:0036284)
0.2 9.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 17.0 GO:0005768 endosome(GO:0005768)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 9.2 GO:0005523 tropomyosin binding(GO:0005523)
0.2 2.2 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 17.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 17.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 3.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 17.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.7 PID E2F PATHWAY E2F transcription factor network
0.0 2.0 PID CDC42 PATHWAY CDC42 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 1.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.7 REACTOME G1 PHASE Genes involved in G1 Phase