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GSE58827: Dynamics of the Mouse Liver

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Results for Nkx6-2

Z-value: 1.25

Motif logo

Transcription factors associated with Nkx6-2

Gene Symbol Gene ID Gene Info
ENSMUSG00000041309.18 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx6-2mm39_v1_chr7_-_139162706_139162724-0.261.2e-01Click!

Activity profile of Nkx6-2 motif

Sorted Z-values of Nkx6-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_142215027 16.17 ENSMUST00000105936.8
insulin-like growth factor 2
chr7_-_142215595 12.39 ENSMUST00000145896.3
insulin-like growth factor 2
chr14_+_80237691 9.81 ENSMUST00000228749.2
ENSMUST00000088735.4
olfactomedin 4
chr19_+_58717319 9.00 ENSMUST00000048644.6
ENSMUST00000236445.2
pancreatic lipase related protein 1
chr3_-_10273628 8.92 ENSMUST00000029041.6
fatty acid binding protein 4, adipocyte
chr10_+_115653152 7.93 ENSMUST00000080630.11
ENSMUST00000179196.3
ENSMUST00000035563.15
tetraspanin 8
chr5_-_110987604 7.20 ENSMUST00000056937.12
HscB iron-sulfur cluster co-chaperone
chr5_+_110987839 7.17 ENSMUST00000200172.2
ENSMUST00000066160.3
checkpoint kinase 2
chr9_+_96141317 6.84 ENSMUST00000165768.4
transcription factor Dp 2
chr9_+_96141299 6.78 ENSMUST00000179065.8
transcription factor Dp 2
chr9_+_96140781 6.54 ENSMUST00000190104.7
ENSMUST00000179416.8
ENSMUST00000189606.7
transcription factor Dp 2
chr18_-_74340885 6.28 ENSMUST00000177604.2
spindle and kinetochore associated complex subunit 1
chr4_-_117039809 6.09 ENSMUST00000065896.9
kinesin family member 2C
chr4_+_140428777 5.97 ENSMUST00000138808.8
ENSMUST00000038893.6
regulator of chromosome condensation 2
chr18_+_34973605 5.83 ENSMUST00000043484.8
receptor accessory protein 2
chr7_+_89814713 5.73 ENSMUST00000207084.2
phosphatidylinositol binding clathrin assembly protein
chr5_+_66833434 5.69 ENSMUST00000031131.11
ubiquitin carboxy-terminal hydrolase L1
chr16_-_21980200 5.41 ENSMUST00000115379.2
insulin-like growth factor 2 mRNA binding protein 2
chr12_+_117807607 5.17 ENSMUST00000176735.8
ENSMUST00000177339.2
cell division cycle associated 7 like
chr10_-_37014859 5.13 ENSMUST00000092584.6
myristoylated alanine rich protein kinase C substrate
chr18_-_74340842 5.12 ENSMUST00000040188.16
spindle and kinetochore associated complex subunit 1
chr5_-_122959321 4.95 ENSMUST00000197074.5
ENSMUST00000199406.5
ENSMUST00000196640.5
ENSMUST00000197719.5
ENSMUST00000200645.5
anaphase-promoting complex subunit 5
chr5_-_110987441 4.85 ENSMUST00000145318.2
HscB iron-sulfur cluster co-chaperone
chr17_+_36172210 4.46 ENSMUST00000074259.15
ENSMUST00000174873.2
nurim (nuclear envelope membrane protein)
chrX_+_74425990 4.40 ENSMUST00000033541.5
FUN14 domain containing 2
chr1_+_63216281 3.64 ENSMUST00000188524.2
eukaryotic translation elongation factor 1 beta 2
chr9_+_96140750 3.64 ENSMUST00000186609.7
transcription factor Dp 2
chr18_-_43610829 3.36 ENSMUST00000057110.11
eukaryotic translation initiation factor 3, subunit J2
chr1_+_63215976 3.24 ENSMUST00000129339.8
eukaryotic translation elongation factor 1 beta 2
chr7_+_28488380 3.21 ENSMUST00000209035.2
ENSMUST00000059857.8
Ras and Rab interactor-like
chr14_-_67246282 3.15 ENSMUST00000111115.8
ENSMUST00000022634.9
BCL2/adenovirus E1B interacting protein 3-like
chr7_-_4400704 3.08 ENSMUST00000108590.4
ENSMUST00000206928.2
glycoprotein 6 (platelet)
chr17_+_36172235 3.07 ENSMUST00000172931.2
nurim (nuclear envelope membrane protein)
chr3_+_5815863 2.95 ENSMUST00000192045.2
predicted pseudogene 8797
chr14_+_26722319 2.93 ENSMUST00000035433.10
homeobox gene expressed in ES cells
chr19_-_17350200 2.88 ENSMUST00000236139.2
glucosaminyl (N-acetyl) transferase 1, core 2
chr8_-_65146079 2.80 ENSMUST00000048967.9
carboxypeptidase E
chr2_-_174188505 2.80 ENSMUST00000168292.2
predicted gene, 20721
chr11_+_20493306 2.67 ENSMUST00000093292.11
SERTA domain containing 2
chr15_-_79718423 2.61 ENSMUST00000109623.8
ENSMUST00000109625.8
ENSMUST00000023060.13
ENSMUST00000089299.6
chromobox 6
neuronal pentraxin chromo domain
chr18_-_32044877 2.49 ENSMUST00000054984.8
SFT2 domain containing 3
chr4_+_109200225 2.49 ENSMUST00000030281.12
epidermal growth factor receptor pathway substrate 15
chr9_-_56151334 2.28 ENSMUST00000188142.7
pseudopodium-enriched atypical kinase 1
chr2_+_163535925 2.28 ENSMUST00000109400.3
protein kinase inhibitor, gamma
chr7_+_89780785 2.27 ENSMUST00000208684.2
phosphatidylinositol binding clathrin assembly protein
chr11_+_23206001 2.25 ENSMUST00000020538.13
ENSMUST00000109551.8
ENSMUST00000102870.8
ENSMUST00000102869.8
exportin 1
chr19_+_13208692 2.21 ENSMUST00000207246.4
olfactory receptor 1463
chr2_+_69691906 2.17 ENSMUST00000090852.11
ENSMUST00000166411.8
Sjogren syndrome antigen B
chr14_+_51366512 2.00 ENSMUST00000095923.4
ribonuclease, RNase A family, 6
chr9_-_123507847 1.96 ENSMUST00000170591.2
ENSMUST00000171647.9
solute carrier family 6 (neurotransmitter transporter), member 20A
chr1_-_126758369 1.90 ENSMUST00000112583.8
ENSMUST00000094609.10
NCK-associated protein 5
chr17_-_78991691 1.89 ENSMUST00000145480.2
striatin, calmodulin binding protein
chr15_-_80989200 1.86 ENSMUST00000109579.9
myocardin related transcription factor A
chr5_+_75312939 1.78 ENSMUST00000202681.4
ENSMUST00000000476.15
platelet derived growth factor receptor, alpha polypeptide
chr9_-_22028370 1.75 ENSMUST00000213233.2
ELF1 homolog, elongation factor 1
chr8_-_62576140 1.71 ENSMUST00000034052.14
ENSMUST00000034054.9
annexin A10
chr7_-_15781838 1.67 ENSMUST00000210781.2
BRD4 interacting chromatin remodeling complex associated protein
chr4_+_3940747 1.65 ENSMUST00000119403.2
coiled-coil-helix-coiled-coil-helix domain containing 7
chr2_+_3115250 1.65 ENSMUST00000072955.12
family with sequence similarity 171, member A1
chr17_-_30107544 1.54 ENSMUST00000171691.9
MAM domain containing glycosylphosphatidylinositol anchor 1
chr3_+_82962823 1.52 ENSMUST00000150268.8
ENSMUST00000122128.2
pleiotropic regulator 1
chr5_-_21156766 1.48 ENSMUST00000036489.10
round spermatid basic protein 1-like
chr1_+_43484895 1.46 ENSMUST00000086421.9
non-catalytic region of tyrosine kinase adaptor protein 2
chr9_-_22028419 1.45 ENSMUST00000214394.2
ENSMUST00000013966.8
ELF1 homolog, elongation factor 1
chr1_-_149836974 1.44 ENSMUST00000190507.2
ENSMUST00000070200.15
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr10_+_79746690 1.41 ENSMUST00000181321.2
predicted gene, 26602
chr6_-_87510200 1.39 ENSMUST00000113637.9
ENSMUST00000071024.7
Rho GTPase activating protein 25
chr11_-_73382303 1.38 ENSMUST00000119863.2
ENSMUST00000215358.2
ENSMUST00000214623.2
olfactory receptor 381
chr19_-_14575395 1.35 ENSMUST00000052011.15
ENSMUST00000167776.3
transducin-like enhancer of split 4
chr2_+_170353338 1.34 ENSMUST00000136839.2
ENSMUST00000109148.8
ENSMUST00000170167.8
prefoldin 4
chr19_+_8779903 1.32 ENSMUST00000172175.3
zinc finger and BTB domain containing 3
chr8_+_21515561 1.31 ENSMUST00000076754.3
defensin, alpha, 21
chr6_-_102441628 1.28 ENSMUST00000032159.7
contactin 3
chr11_+_100750316 1.14 ENSMUST00000107356.8
signal transducer and activator of transcription 5A
chr3_+_96128427 1.14 ENSMUST00000090781.8
H2B clustered histone 21
chr11_+_115824108 1.12 ENSMUST00000140991.2
SAP30 binding protein
chr2_+_157209506 1.09 ENSMUST00000081202.6
mannosidase, beta A, lysosomal-like
chrX_+_110801086 1.08 ENSMUST00000207962.2
predicted gene 45194
chr2_+_85838122 1.06 ENSMUST00000062166.2
olfactory receptor 1032
chr19_-_33764859 1.05 ENSMUST00000148137.9
lipase, member O1
chr2_+_69050315 1.05 ENSMUST00000005364.12
ENSMUST00000112317.3
glucose-6-phosphatase, catalytic, 2
chr4_-_147726953 1.04 ENSMUST00000133006.2
ENSMUST00000037565.14
ENSMUST00000105720.8
zinc finger protein 979
chr3_+_96508400 1.02 ENSMUST00000062058.5
Lix1-like
chr2_+_87609827 1.02 ENSMUST00000105210.3
olfactory receptor 152
chr2_+_109522781 1.02 ENSMUST00000111050.10
brain derived neurotrophic factor
chr8_+_94537910 1.01 ENSMUST00000138659.9
guanine nucleotide binding protein, alpha O
chr7_+_44711853 0.97 ENSMUST00000107829.9
ENSMUST00000003513.11
ENSMUST00000211465.2
ENSMUST00000210088.2
ENSMUST00000210520.2
nitric oxide synthase interacting protein
chr5_+_123280250 0.97 ENSMUST00000174836.8
ENSMUST00000163030.9
SET domain containing 1B
chr17_-_48739874 0.96 ENSMUST00000046549.5
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr14_+_27598021 0.94 ENSMUST00000211684.2
ENSMUST00000210924.2
ELKS/RAB6-interacting/CAST family member 2
chr11_-_109886601 0.92 ENSMUST00000020948.15
ATP-binding cassette, sub-family A (ABC1), member 8b
chr11_+_100750177 0.91 ENSMUST00000004145.14
ENSMUST00000133036.8
signal transducer and activator of transcription 5A
chr11_-_109886569 0.88 ENSMUST00000106669.3
ATP-binding cassette, sub-family A (ABC1), member 8b
chr11_+_99748741 0.88 ENSMUST00000107434.2
predicted gene 11568
chr2_-_125466985 0.88 ENSMUST00000089776.3
centrosomal protein 152
chr3_-_135373560 0.86 ENSMUST00000164430.7
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr8_+_21652293 0.85 ENSMUST00000098897.2
defensin, alpha, 22
chr13_+_83723743 0.84 ENSMUST00000198217.5
ENSMUST00000199210.5
myocyte enhancer factor 2C
chr2_+_85715984 0.83 ENSMUST00000213441.3
olfactory receptor 1023
chr15_+_34453432 0.76 ENSMUST00000060894.9
glutamate rich 5
chr11_-_107238956 0.74 ENSMUST00000134763.2
phosphatidylinositol transfer protein, cytoplasmic 1
chr10_+_26698556 0.69 ENSMUST00000135866.2
Rho GTPase activating protein 18
chr5_+_140404997 0.68 ENSMUST00000100507.8
eukaryotic translation initiation factor 3, subunit B
chr4_-_133484080 0.65 ENSMUST00000008024.7
AT rich interactive domain 1A (SWI-like)
chr1_-_185061525 0.65 ENSMUST00000027921.11
ENSMUST00000110975.8
ENSMUST00000110974.4
isoleucine-tRNA synthetase 2, mitochondrial
chr19_-_12742811 0.64 ENSMUST00000112933.2
ciliary neurotrophic factor
chr7_+_107679062 0.63 ENSMUST00000213601.2
olfactory receptor 481
chr9_-_113537277 0.61 ENSMUST00000111861.4
ENSMUST00000035086.13
programmed cell death 6 interacting protein
chrX_-_42363663 0.61 ENSMUST00000016294.8
teneurin transmembrane protein 1
chr1_-_64160557 0.60 ENSMUST00000055001.10
ENSMUST00000114086.8
Kruppel-like factor 7 (ubiquitous)
chr8_-_49008305 0.59 ENSMUST00000110346.9
ENSMUST00000211976.2
teneurin transmembrane protein 3
chr4_+_146586445 0.59 ENSMUST00000105735.9
zinc finger protein 981
chr13_+_110063364 0.57 ENSMUST00000117420.8
phosphodiesterase 4D, cAMP specific
chr3_+_106020545 0.57 ENSMUST00000079132.12
ENSMUST00000139086.2
chitinase, acidic 1
chr5_+_25451771 0.56 ENSMUST00000144971.2
polypeptide N-acetylgalactosaminyltransferase 11
chr18_+_57275854 0.54 ENSMUST00000139892.2
multiple EGF-like-domains 10
chr2_-_37537224 0.54 ENSMUST00000028279.10
spermatid perinuclear RNA binding protein
chr7_-_84328553 0.54 ENSMUST00000069537.3
ENSMUST00000207865.2
ENSMUST00000178385.9
ENSMUST00000208782.2
zinc finger, AN1-type domain 6
chr4_-_154721288 0.53 ENSMUST00000030902.13
ENSMUST00000105637.8
ENSMUST00000070313.14
ENSMUST00000105636.8
ENSMUST00000105638.9
ENSMUST00000097759.9
ENSMUST00000124771.2
PR domain containing 16
chr11_-_17903861 0.50 ENSMUST00000076661.7
Ewing tumor-associated antigen 1
chr18_+_4993795 0.49 ENSMUST00000153016.8
supervillin
chr4_+_147390131 0.49 ENSMUST00000148762.4
zinc finger protein 988
chr2_-_87467879 0.48 ENSMUST00000216082.2
olfactory receptor 1132
chr5_+_43672856 0.48 ENSMUST00000076939.10
C1q and tumor necrosis factor related protein 7
chr1_-_126758520 0.48 ENSMUST00000162646.8
NCK-associated protein 5
chr7_-_19449319 0.45 ENSMUST00000032555.10
ENSMUST00000093552.12
translocase of outer mitochondrial membrane 40
chr2_-_88581690 0.44 ENSMUST00000215179.3
ENSMUST00000215529.3
olfactory receptor 1198
chr4_-_52859227 0.42 ENSMUST00000107670.3
olfactory receptor 273
chr4_+_147637714 0.42 ENSMUST00000139784.8
ENSMUST00000143885.8
ENSMUST00000081742.7
zinc finger protein 985
chr11_+_100902572 0.39 ENSMUST00000092663.4
ATPase, H+ transporting, lysosomal V0 subunit A1
chr9_-_21223631 0.39 ENSMUST00000115433.11
adaptor protein complex AP-1, mu 2 subunit
chr19_-_13828056 0.39 ENSMUST00000208493.3
olfactory receptor 1501
chr8_+_22055402 0.39 ENSMUST00000084040.3
defensin, alpha, 37
chr11_-_115824290 0.36 ENSMUST00000021097.10
RecQ protein-like 5
chr3_+_69129745 0.35 ENSMUST00000183126.2
ADP-ribosylation factor-like 14
chr7_+_4925781 0.34 ENSMUST00000207527.2
ENSMUST00000207687.2
ENSMUST00000208754.2
N-acetyltransferase 14
chr9_+_51958453 0.34 ENSMUST00000163153.9
radixin
chr13_+_83723255 0.33 ENSMUST00000199167.5
ENSMUST00000195904.5
myocyte enhancer factor 2C
chr8_+_21917427 0.33 ENSMUST00000095424.6
defensin, alpha, 36
chr1_-_171854818 0.30 ENSMUST00000138714.2
ENSMUST00000027837.13
ENSMUST00000111264.8
VANGL planar cell polarity 2
chr2_-_88768449 0.29 ENSMUST00000215205.2
ENSMUST00000213412.2
olfactory receptor 1211
chr16_+_44215136 0.27 ENSMUST00000099742.9
cilia and flagella associated protein 44
chr8_+_22155813 0.24 ENSMUST00000075268.5
defensin, alpha, 34
chr4_+_43851565 0.24 ENSMUST00000107860.3
olfactory receptor 155
chr1_-_135513083 0.23 ENSMUST00000040599.15
neuron navigator 1
chr15_+_39255185 0.22 ENSMUST00000228839.2
regulating synaptic membrane exocytosis 2
chr16_-_16647139 0.22 ENSMUST00000023468.6
sperm associated antigen 6-like
chr2_-_131021905 0.22 ENSMUST00000089510.5
centromere protein B
chr19_-_13827773 0.21 ENSMUST00000215350.2
olfactory receptor 1501
chr5_-_131336914 0.19 ENSMUST00000160609.2
polypeptide N-acetylgalactosaminyltransferase 17
chr2_-_84480804 0.19 ENSMUST00000066177.10
catenin (cadherin associated protein), delta 1
chr4_-_147787010 0.19 ENSMUST00000117638.2
zinc finger protein 534
chrX_+_132960055 0.19 ENSMUST00000144483.2
cleavage stimulation factor, 3' pre-RNA subunit 2
chr5_+_20112704 0.18 ENSMUST00000115267.7
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_+_129610507 0.17 ENSMUST00000203598.3
olfactory receptor 809
chr4_+_148642879 0.16 ENSMUST00000017408.14
ENSMUST00000076022.7
exosome component 10
chr14_-_31503869 0.16 ENSMUST00000227089.2
ankyrin repeat domain 28
chr4_+_147056433 0.14 ENSMUST00000146688.3
zinc finger protein 989
chr2_+_24043159 0.13 ENSMUST00000028363.2
interleukin 1 family, member 8
chr15_-_84804239 0.13 ENSMUST00000189185.2
predicted gene 29666
chr6_-_81942906 0.13 ENSMUST00000032124.9
mitochondrial ribosomal protein L19
chr5_+_20112500 0.12 ENSMUST00000101558.10
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr9_-_39188114 0.12 ENSMUST00000216698.2
olfactory receptor 945
chr19_-_12313274 0.12 ENSMUST00000208398.3
olfactory receptor 1438, pseudogene 1
chr4_+_145397238 0.12 ENSMUST00000105738.9
zinc finger protein 980
chr7_-_102998876 0.10 ENSMUST00000215042.2
olfactory receptor 600
chr4_+_147445744 0.09 ENSMUST00000133078.8
ENSMUST00000154154.2
zinc finger protein 978
chr13_-_27697185 0.09 ENSMUST00000018389.5
ENSMUST00000110350.9
prolactin family 8, subfamily a, member 81
chr3_-_96359622 0.08 ENSMUST00000093126.11
ENSMUST00000098841.4
cDNA sequence BC107364
chrX_+_151922936 0.08 ENSMUST00000039720.11
ENSMUST00000144175.3
Ras-related GTP binding B
chrX_+_99019176 0.05 ENSMUST00000113781.8
ENSMUST00000113783.8
ENSMUST00000113779.8
ENSMUST00000113776.8
ENSMUST00000113775.8
ENSMUST00000113780.8
ENSMUST00000113778.8
ENSMUST00000113777.8
ENSMUST00000071453.3
ectodysplasin-A
chr12_-_80807454 0.05 ENSMUST00000073251.8
coiled-coil domain containing 177
chr8_+_21787455 0.03 ENSMUST00000098892.5
defensin, alpha, 5
chr3_+_68479578 0.02 ENSMUST00000170788.9
schwannomin interacting protein 1
chr2_-_89491811 0.02 ENSMUST00000215730.3
olfactory receptor 1250
chr4_+_151012375 0.01 ENSMUST00000139826.8
ENSMUST00000116257.8
tumor necrosis factor receptor superfamily, member 9
chr11_+_98754434 0.01 ENSMUST00000142414.8
ENSMUST00000037480.9
WAS/WASL interacting protein family, member 2
chr2_+_85835884 0.01 ENSMUST00000111589.3
olfactory receptor 1032
chr14_+_51366306 0.00 ENSMUST00000226210.2
ribonuclease, RNase A family, 6
chr15_+_65682066 0.00 ENSMUST00000211878.2
EFR3 homolog A

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx6-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 28.6 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
2.2 6.7 GO:0051325 interphase(GO:0051325) mitotic interphase(GO:0051329)
2.0 6.0 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
1.5 12.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
1.3 8.0 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
1.1 6.7 GO:0007412 axon target recognition(GO:0007412)
1.0 6.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.0 5.8 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.9 2.8 GO:0030070 insulin processing(GO:0030070)
0.5 2.2 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.5 3.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.5 2.1 GO:0060376 positive regulation of mast cell differentiation(GO:0060376)
0.5 2.0 GO:0035524 proline transmembrane transport(GO:0035524)
0.5 8.9 GO:0071285 cellular response to lithium ion(GO:0071285)
0.4 1.8 GO:0072276 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.3 1.5 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.3 0.9 GO:1904632 negative regulation of interleukin-12 biosynthetic process(GO:0045083) response to diterpene(GO:1904629) cellular response to diterpene(GO:1904630) response to glucoside(GO:1904631) cellular response to glucoside(GO:1904632)
0.3 2.9 GO:0030916 otic vesicle formation(GO:0030916)
0.2 1.4 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.2 2.5 GO:0075509 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.2 2.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 0.6 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.2 5.1 GO:0051764 actin crosslink formation(GO:0051764)
0.2 0.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.2 0.6 GO:0048691 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.2 0.6 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 1.5 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.2 0.3 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 9.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 3.1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 3.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 7.9 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 5.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 2.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 6.9 GO:0006414 translational elongation(GO:0006414)
0.1 0.9 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 1.2 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.7 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 1.0 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 0.6 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.1 2.9 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.6 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 0.5 GO:0043654 engulfment of apoptotic cell(GO:0043652) recognition of apoptotic cell(GO:0043654)
0.1 9.1 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 0.6 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 2.0 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.3 GO:1902966 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0 0.2 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.5 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 4.4 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 1.0 GO:0080111 DNA demethylation(GO:0080111)
0.0 1.5 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.6 GO:0097264 self proteolysis(GO:0097264)
0.0 1.0 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.4 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 2.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 23.2 GO:0000278 mitotic cell cycle(GO:0000278)
0.0 0.5 GO:0006625 protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.2 GO:0097151 spontaneous neurotransmitter secretion(GO:0061669) positive regulation of inhibitory postsynaptic potential(GO:0097151) spontaneous synaptic transmission(GO:0098814) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 1.0 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.0 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.0 GO:0006094 gluconeogenesis(GO:0006094)
0.0 2.7 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 4.5 GO:0006417 regulation of translation(GO:0006417)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 8.0 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
1.0 6.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.9 5.1 GO:0042585 germinal vesicle(GO:0042585)
0.8 11.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.4 9.8 GO:0042581 specific granule(GO:0042581)
0.3 7.5 GO:0005652 nuclear lamina(GO:0005652)
0.3 5.9 GO:1990023 mitotic spindle midzone(GO:1990023)
0.3 3.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 4.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 2.3 GO:0005642 annulate lamellae(GO:0005642)
0.2 2.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.2 5.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.8 GO:0031045 dense core granule(GO:0031045)
0.1 4.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 6.1 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.6 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 0.9 GO:0098536 deuterosome(GO:0098536)
0.1 1.3 GO:0016272 prefoldin complex(GO:0016272)
0.1 23.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.1 1.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 5.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.2 GO:1990716 axonemal central apparatus(GO:1990716)
0.1 1.0 GO:0030061 mitochondrial crista(GO:0030061)
0.1 6.7 GO:0016605 PML body(GO:0016605)
0.1 3.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.6 GO:0090543 Flemming body(GO:0090543)
0.0 0.2 GO:0071920 cleavage body(GO:0071920)
0.0 1.4 GO:0042588 zymogen granule(GO:0042588)
0.0 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.6 GO:0031519 PcG protein complex(GO:0031519)
0.0 2.9 GO:0031985 Golgi cisterna(GO:0031985)
0.0 5.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 1.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 6.6 GO:0044306 neuron projection terminus(GO:0044306)
0.0 2.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.5 GO:0043596 nuclear replication fork(GO:0043596)
0.0 3.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.3 GO:0051286 cell tip(GO:0051286)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.5 GO:0016235 aggresome(GO:0016235)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.7 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.6 29.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.6 1.8 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.6 2.9 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.5 8.0 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.5 9.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 1.0 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.3 6.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 1.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.3 12.1 GO:0001671 ATPase activator activity(GO:0001671)
0.3 6.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 2.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 3.1 GO:0038064 collagen receptor activity(GO:0038064)
0.2 0.6 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.2 0.6 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.2 2.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 5.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 2.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 2.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 1.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 3.1 GO:0005521 lamin binding(GO:0005521)
0.1 1.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 3.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 2.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 6.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.6 GO:0004568 chitinase activity(GO:0004568)
0.1 0.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 4.0 GO:0005504 fatty acid binding(GO:0005504)
0.1 4.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.2 GO:0003696 satellite DNA binding(GO:0003696)
0.1 5.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.2 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.4 GO:0015288 porin activity(GO:0015288)
0.0 3.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 26.8 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 3.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 4.2 GO:0005178 integrin binding(GO:0005178)
0.0 2.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 8.7 GO:0008017 microtubule binding(GO:0008017)
0.0 10.8 GO:0045296 cadherin binding(GO:0045296)
0.0 5.0 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 1.0 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 2.9 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 2.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 5.7 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 2.2 GO:0004540 ribonuclease activity(GO:0004540)
0.0 6.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 5.2 GO:0005549 odorant binding(GO:0005549)
0.0 1.3 GO:0051087 chaperone binding(GO:0051087)
0.0 2.2 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 3.7 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 25.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 6.7 PID ATM PATHWAY ATM pathway
0.2 23.8 PID E2F PATHWAY E2F transcription factor network
0.1 2.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 6.1 PID AURORA B PATHWAY Aurora B signaling
0.1 5.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 8.9 PID AP1 PATHWAY AP-1 transcription factor network
0.1 1.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 2.1 PID IL5 PATHWAY IL5-mediated signaling events
0.1 1.8 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 1.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 2.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.9 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.9 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 2.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 2.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.3 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 28.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 6.7 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 5.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 8.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 5.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.2 12.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 25.7 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.8 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 2.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 7.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 2.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 2.5 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 3.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 5.4 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 7.6 REACTOME TRANSLATION Genes involved in Translation
0.0 1.3 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 1.0 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.0 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions