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GSE58827: Dynamics of the Mouse Liver

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Results for Nr2e3

Z-value: 1.07

Motif logo

Transcription factors associated with Nr2e3

Gene Symbol Gene ID Gene Info
ENSMUSG00000032292.9 nuclear receptor subfamily 2, group E, member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr2e3mm39_v1_chr9_-_59857355_598574070.307.1e-02Click!

Activity profile of Nr2e3 motif

Sorted Z-values of Nr2e3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_90603013 21.51 ENSMUST00000069960.12
ENSMUST00000117167.2
S100 calcium binding protein A9 (calgranulin B)
chr7_+_100143250 9.03 ENSMUST00000153287.8
uncoupling protein 2 (mitochondrial, proton carrier)
chr7_-_110462446 6.46 ENSMUST00000033050.5
lymphatic vessel endothelial hyaluronan receptor 1
chr19_+_38121248 6.38 ENSMUST00000025956.13
phosphodiesterase 6C, cGMP specific, cone, alpha prime
chr19_+_38121214 6.22 ENSMUST00000112329.3
phosphodiesterase 6C, cGMP specific, cone, alpha prime
chr11_-_55075855 6.19 ENSMUST00000039305.6
solute carrier family 36 (proton/amino acid symporter), member 2
chr4_+_123176570 5.85 ENSMUST00000106243.8
ENSMUST00000106241.8
ENSMUST00000080178.13
poly(A) binding protein, cytoplasmic 4
chr7_-_103492361 5.64 ENSMUST00000063957.6
hemoglobin Z, beta-like embryonic chain
chr6_+_142244145 4.72 ENSMUST00000041993.3
islet amyloid polypeptide
chr2_-_164198427 4.49 ENSMUST00000109367.10
secretory leukocyte peptidase inhibitor
chr2_-_164197987 4.37 ENSMUST00000165980.2
secretory leukocyte peptidase inhibitor
chr3_-_10273628 4.28 ENSMUST00000029041.6
fatty acid binding protein 4, adipocyte
chr3_-_137687284 4.20 ENSMUST00000136613.4
ENSMUST00000029806.13
dual adaptor for phosphotyrosine and 3-phosphoinositides 1
chr8_+_84335176 3.91 ENSMUST00000212300.2
DnaJ heat shock protein family (Hsp40) member B1
chr3_-_88410495 3.79 ENSMUST00000120377.8
ENSMUST00000029699.13
lamin A
chr7_-_19005721 3.36 ENSMUST00000032561.9
vasodilator-stimulated phosphoprotein
chr9_+_106080307 3.05 ENSMUST00000024047.12
ENSMUST00000216348.2
twinfilin actin binding protein 2
chr13_-_29137673 3.02 ENSMUST00000067230.6
SRY (sex determining region Y)-box 4
chr9_+_65494469 2.85 ENSMUST00000239405.2
ENSMUST00000047099.13
ENSMUST00000131483.3
ENSMUST00000141046.3
PIF1 5'-to-3' DNA helicase
chr16_+_17051423 2.79 ENSMUST00000090190.14
ENSMUST00000232082.2
ENSMUST00000232426.2
hypermethylated in cancer 2
predicted gene, 49573
chr8_+_89015705 2.65 ENSMUST00000171456.9
adenylate cyclase 7
chr11_+_69804714 2.63 ENSMUST00000072581.9
ENSMUST00000116358.8
G protein pathway suppressor 2
chr4_+_119052476 2.59 ENSMUST00000030395.9
small vasohibin binding protein
chr14_+_76741918 2.46 ENSMUST00000022587.10
ENSMUST00000134109.2
TSC22 domain family, member 1
chr10_-_45346297 2.40 ENSMUST00000079390.7
lin-28 homolog B (C. elegans)
chr11_+_67167950 2.39 ENSMUST00000019625.12
myosin, heavy polypeptide 8, skeletal muscle, perinatal
chr9_+_113641615 2.39 ENSMUST00000111838.10
ENSMUST00000166734.10
ENSMUST00000214522.2
ENSMUST00000163895.3
CLIP associating protein 2
chr5_-_22755274 2.32 ENSMUST00000030872.12
origin recognition complex, subunit 5
chr14_+_76741625 2.30 ENSMUST00000177207.2
TSC22 domain family, member 1
chr4_+_119052693 2.25 ENSMUST00000097908.4
small vasohibin binding protein
chrX_+_20483742 2.20 ENSMUST00000115375.8
ENSMUST00000115374.8
ENSMUST00000084383.10
RNA binding motif protein 10
chrX_-_93585668 2.17 ENSMUST00000026142.8
MAGE family member D1
chr6_-_36787096 2.13 ENSMUST00000201321.2
ENSMUST00000101534.5
pleiotrophin
chr11_-_100986192 2.10 ENSMUST00000019447.15
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
chr10_-_119948890 2.07 ENSMUST00000020449.12
helicase (DNA) B
chr17_+_35460722 2.03 ENSMUST00000068056.12
ENSMUST00000174757.8
ENSMUST00000173731.8
DEAD box helicase 39b
chr13_+_112425322 2.00 ENSMUST00000022275.14
ankyrin repeat domain 55
chr7_+_30450896 1.99 ENSMUST00000182229.8
ENSMUST00000080518.14
ENSMUST00000182227.8
ENSMUST00000182721.8
suprabasin
chr7_+_4918199 1.93 ENSMUST00000116354.4
zinc finger protein 628
chr8_+_79755194 1.91 ENSMUST00000119254.8
ENSMUST00000238669.2
zinc finger protein 827
chr7_+_101714943 1.91 ENSMUST00000094130.4
ENSMUST00000084843.10
Xrcc1 N-terminal domain containing 1
Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough
chr7_-_110673269 1.90 ENSMUST00000163014.2
eukaryotic translation initiation factor 4, gamma 2
chr5_+_76331727 1.87 ENSMUST00000031144.14
transmembrane protein 165
chr19_-_7318798 1.87 ENSMUST00000165965.8
ENSMUST00000051711.16
ENSMUST00000169541.8
ENSMUST00000165989.2
MAP/microtubule affinity regulating kinase 2
chr4_+_119052548 1.86 ENSMUST00000106345.3
small vasohibin binding protein
chrX_+_168662592 1.85 ENSMUST00000112105.8
ENSMUST00000078947.12
midline 1
chr6_+_136509922 1.81 ENSMUST00000187429.4
activating transcription factor 7 interacting protein
chr5_-_65117375 1.79 ENSMUST00000062315.7
ENSMUST00000239485.2
ENSMUST00000201307.3
toll-like receptor 6
chr2_+_124452194 1.79 ENSMUST00000051419.15
ENSMUST00000076335.12
ENSMUST00000078621.12
ENSMUST00000077847.12
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr12_-_54842488 1.78 ENSMUST00000005798.9
sorting nexin 6
chr15_+_6329263 1.76 ENSMUST00000078019.13
disabled 2, mitogen-responsive phosphoprotein
chr1_+_90131702 1.74 ENSMUST00000065587.5
ENSMUST00000159654.2
atypical chemokine receptor 3
chr2_-_45002902 1.74 ENSMUST00000076836.13
ENSMUST00000176732.8
ENSMUST00000200844.4
zinc finger E-box binding homeobox 2
chr19_-_40365318 1.64 ENSMUST00000239304.2
sorbin and SH3 domain containing 1
chr16_-_25924527 1.58 ENSMUST00000039990.6
prolyl 3-hydroxylase 2
chr12_-_110669076 1.58 ENSMUST00000155242.8
heat shock protein 90, alpha (cytosolic), class A member 1
chr13_+_35925296 1.56 ENSMUST00000163595.3
chromodomain protein, Y chromosome-like
chr17_+_75485791 1.54 ENSMUST00000135447.8
ENSMUST00000112516.8
latent transforming growth factor beta binding protein 1
chr15_+_6329278 1.47 ENSMUST00000159046.2
ENSMUST00000161040.8
disabled 2, mitogen-responsive phosphoprotein
chr8_+_105267431 1.47 ENSMUST00000056051.11
carbonic anhydrase 7
chr2_+_24839758 1.45 ENSMUST00000028350.9
zinc finger, MYND domain containing 19
chr8_+_79754980 1.42 ENSMUST00000087927.11
ENSMUST00000098614.9
zinc finger protein 827
chr7_-_118091135 1.41 ENSMUST00000178344.3
inositol 1,4,5-triphosphate receptor interacting protein-like 2
chr5_-_65492940 1.39 ENSMUST00000203471.3
ENSMUST00000172732.8
ENSMUST00000204965.3
replication factor C (activator 1) 1
chr3_-_79053182 1.37 ENSMUST00000118340.7
Rap guanine nucleotide exchange factor (GEF) 2
chrX_-_7054952 1.34 ENSMUST00000004428.14
chloride channel, voltage-sensitive 5
chr7_+_92426772 1.32 ENSMUST00000208945.2
RAB30, member RAS oncogene family
chr7_+_101714692 1.32 ENSMUST00000106950.8
ENSMUST00000146450.8
Xrcc1 N-terminal domain containing 1
chrX_+_41238193 1.29 ENSMUST00000115073.9
ENSMUST00000115072.8
stromal antigen 2
chr8_+_84334805 1.29 ENSMUST00000005620.10
DnaJ heat shock protein family (Hsp40) member B1
chr13_-_74882374 1.29 ENSMUST00000220738.2
calpastatin
chr5_+_65505657 1.26 ENSMUST00000031096.11
klotho beta
chr2_+_124452493 1.26 ENSMUST00000103239.10
ENSMUST00000103240.9
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr2_-_126517458 1.25 ENSMUST00000103227.8
ENSMUST00000110425.9
ENSMUST00000089745.11
GA repeat binding protein, beta 1
chr5_+_35156454 1.25 ENSMUST00000114283.8
regulator of G-protein signaling 12
chr6_-_129599645 1.23 ENSMUST00000032252.8
killer cell lectin-like receptor subfamily K, member 1
chr4_-_129534403 1.23 ENSMUST00000084264.12
taxilin alpha
chr19_+_39102342 1.23 ENSMUST00000087234.3
cytochrome P450, family 2, subfamily c, polypeptide 66
chr2_-_126517383 1.20 ENSMUST00000103226.10
ENSMUST00000110424.9
GA repeat binding protein, beta 1
chr4_-_109522502 1.18 ENSMUST00000063531.5
cyclin dependent kinase inhibitor 2C
chr16_+_31241085 1.17 ENSMUST00000089759.9
3-hydroxybutyrate dehydrogenase, type 1
chr2_+_18059982 1.16 ENSMUST00000028076.15
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
chr18_+_35347983 1.12 ENSMUST00000235449.2
ENSMUST00000235269.2
catenin (cadherin associated protein), alpha 1
chr13_-_74882328 1.07 ENSMUST00000223309.2
calpastatin
chr6_-_122317484 1.07 ENSMUST00000112600.9
polyhomeotic 1
chr8_+_107237483 1.05 ENSMUST00000080797.8
cadherin 3
chrX_+_7656225 1.04 ENSMUST00000136930.8
ENSMUST00000115675.9
ENSMUST00000101694.10
GRIP1 associated protein 1
chr10_+_119655294 1.03 ENSMUST00000105262.9
ENSMUST00000147454.8
ENSMUST00000138410.8
ENSMUST00000144825.8
ENSMUST00000148954.8
ENSMUST00000144959.8
glutamate receptor interacting protein 1
chr8_-_58106057 1.01 ENSMUST00000034021.12
polypeptide N-acetylgalactosaminyltransferase 7
chr8_-_61407760 1.00 ENSMUST00000110302.8
chloride channel, voltage-sensitive 3
chr2_+_127750978 0.99 ENSMUST00000110344.2
acyl-Coenzyme A oxidase-like
chr11_+_100210705 0.98 ENSMUST00000049385.14
eukaryotic translation initiation factor 1
chr11_+_67090878 0.98 ENSMUST00000124516.8
ENSMUST00000018637.15
ENSMUST00000129018.8
myosin, heavy polypeptide 1, skeletal muscle, adult
chr17_+_75485906 0.97 ENSMUST00000112514.2
latent transforming growth factor beta binding protein 1
chr15_-_80989200 0.97 ENSMUST00000109579.9
myocardin related transcription factor A
chr9_+_65494429 0.96 ENSMUST00000134538.9
PIF1 5'-to-3' DNA helicase
chr13_-_92931317 0.88 ENSMUST00000022213.8
thrombospondin 4
chr8_-_58106027 0.87 ENSMUST00000110316.3
polypeptide N-acetylgalactosaminyltransferase 7
chr5_-_69699965 0.85 ENSMUST00000031045.10
Yip1 domain family, member 7
chr4_-_49521036 0.82 ENSMUST00000057829.4
mitochondrial ribosomal protein L50
chr15_-_76906832 0.82 ENSMUST00000019037.10
ENSMUST00000169226.9
myoglobin
chr1_-_97904958 0.82 ENSMUST00000161567.8
peptidylglycine alpha-amidating monooxygenase
chr14_+_20724366 0.81 ENSMUST00000048657.10
Sec24 related gene family, member C (S. cerevisiae)
chr11_-_65053710 0.76 ENSMUST00000093002.12
ENSMUST00000047463.15
Rho GTPase activating protein 44
chr5_-_69699932 0.76 ENSMUST00000202423.2
Yip1 domain family, member 7
chrX_-_58211440 0.73 ENSMUST00000119306.2
fibroblast growth factor 13
chr9_-_111086528 0.71 ENSMUST00000199404.2
mutL homolog 1
chr3_-_110158280 0.69 ENSMUST00000190378.2
ENSMUST00000106567.2
protein arginine N-methyltransferase 6
chr6_-_68887957 0.69 ENSMUST00000200454.2
immunoglobulin kappa variable 4-86
chrX_+_41241049 0.68 ENSMUST00000128799.3
stromal antigen 2
chr17_+_87270504 0.66 ENSMUST00000024956.15
ras homolog family member Q
chrX_+_7656251 0.65 ENSMUST00000140540.2
GRIP1 associated protein 1
chr14_+_20724378 0.63 ENSMUST00000224492.2
ENSMUST00000223751.2
ENSMUST00000225108.2
ENSMUST00000224754.2
Sec24 related gene family, member C (S. cerevisiae)
chr2_+_65451100 0.62 ENSMUST00000144254.6
ENSMUST00000028377.14
sodium channel, voltage-gated, type II, alpha
chr19_-_45619559 0.61 ENSMUST00000160718.9
F-box and WD-40 domain protein 4
chr1_-_37575313 0.58 ENSMUST00000042161.15
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr9_-_77255069 0.58 ENSMUST00000184848.8
ENSMUST00000184415.8
muscular LMNA-interacting protein
chr5_-_65492907 0.57 ENSMUST00000203581.3
replication factor C (activator 1) 1
chr7_-_105218472 0.57 ENSMUST00000187683.7
ENSMUST00000210079.2
ENSMUST00000187051.7
ENSMUST00000189265.7
ENSMUST00000190369.7
amyloid beta (A4) precursor protein-binding, family B, member 1
chr18_+_35695485 0.56 ENSMUST00000235199.2
ENSMUST00000237744.2
ENSMUST00000236276.2
matrin 3
chr1_-_179572765 0.55 ENSMUST00000211943.3
ENSMUST00000131716.4
ENSMUST00000221136.2
kinesin family member 28
chr15_-_81756076 0.55 ENSMUST00000023117.10
PHD finger protein 5A
chr9_-_20085353 0.53 ENSMUST00000215984.3
olfactory receptor 870
chr3_-_143908111 0.52 ENSMUST00000121796.8
LIM domain only 4
chr2_+_104961228 0.51 ENSMUST00000111098.8
ENSMUST00000111099.2
Wilms tumor 1 homolog
chr8_-_24928953 0.49 ENSMUST00000052622.6
transcriptional and immune response regulator
chr5_-_5315968 0.48 ENSMUST00000115451.8
ENSMUST00000115452.8
ENSMUST00000131392.8
cyclin-dependent kinase 14
chr4_-_136776006 0.44 ENSMUST00000049583.8
zinc finger and BTB domain containing 40
chr1_-_160040286 0.44 ENSMUST00000195654.2
ENSMUST00000014370.11
calcyclin binding protein
chr9_-_77255099 0.43 ENSMUST00000184138.8
ENSMUST00000184006.8
ENSMUST00000185144.8
ENSMUST00000034910.16
muscular LMNA-interacting protein
chr3_-_143908060 0.41 ENSMUST00000121112.6
LIM domain only 4
chr13_+_49697919 0.39 ENSMUST00000177948.2
ENSMUST00000021820.14
asporin
chr8_-_55171699 0.37 ENSMUST00000144711.9
WD repeat domain 17
chr1_-_58463200 0.35 ENSMUST00000034868.14
CDC-like kinase 1
chr7_+_120634834 0.33 ENSMUST00000207351.2
methyltransferase like 9
chr3_+_103739877 0.32 ENSMUST00000062945.12
BCLl2-like 15
chr10_-_129524028 0.31 ENSMUST00000203785.3
ENSMUST00000217576.2
olfactory receptor 802
chr8_+_22717338 0.31 ENSMUST00000160585.2
ENSMUST00000162447.2
thrombospondin, type I, domain 1
chr16_-_16377982 0.30 ENSMUST00000161861.8
FYVE, RhoGEF and PH domain containing 4
chr4_-_154721288 0.30 ENSMUST00000030902.13
ENSMUST00000105637.8
ENSMUST00000070313.14
ENSMUST00000105636.8
ENSMUST00000105638.9
ENSMUST00000097759.9
ENSMUST00000124771.2
PR domain containing 16
chr2_-_25471703 0.29 ENSMUST00000114217.3
ENSMUST00000191602.2
apical junction component 1
chr16_-_22258469 0.28 ENSMUST00000079601.13
ets variant 5
chr7_-_105217851 0.28 ENSMUST00000188368.7
ENSMUST00000187057.7
amyloid beta (A4) precursor protein-binding, family B, member 1
chr18_+_61688378 0.27 ENSMUST00000165721.8
ENSMUST00000115246.9
ENSMUST00000166990.8
ENSMUST00000163205.8
ENSMUST00000170862.8
casein kinase 1, alpha 1
chrX_-_133012600 0.27 ENSMUST00000033610.13
NADPH oxidase 1
chr1_+_177273226 0.26 ENSMUST00000077225.8
zinc finger and BTB domain containing 18
chr16_-_63684477 0.26 ENSMUST00000232654.2
ENSMUST00000064405.8
Eph receptor A3
chr6_+_34840057 0.25 ENSMUST00000074949.4
transmembrane protein 140
chr1_+_97697881 0.25 ENSMUST00000112844.10
ENSMUST00000112842.8
ENSMUST00000027571.13
gypsy retrotransposon integrase 1
chr19_+_4264470 0.23 ENSMUST00000237171.2
predicted gene, 45928
chr11_+_19874354 0.23 ENSMUST00000093299.13
sprouty-related EVH1 domain containing 2
chr11_+_93934940 0.21 ENSMUST00000132079.8
sperm associated antigen 9
chr14_-_78866714 0.20 ENSMUST00000228362.2
ENSMUST00000227767.2
diacylglycerol kinase, eta
chr1_+_151631088 0.19 ENSMUST00000188145.7
ENSMUST00000059498.12
ER degradation enhancer, mannosidase alpha-like 3
chr12_-_115884332 0.18 ENSMUST00000103548.3
immunoglobulin heavy variable 1-81
chr2_-_140513382 0.17 ENSMUST00000110057.3
fibronectin leucine rich transmembrane protein 3
chr19_+_4264292 0.17 ENSMUST00000046506.7
cardiotrophin-like cytokine factor 1
chr17_+_87270707 0.15 ENSMUST00000139344.2
ras homolog family member Q
chr1_+_178015287 0.15 ENSMUST00000159284.2
desumoylating isopeptidase 2
chr2_-_140513320 0.13 ENSMUST00000056760.4
fibronectin leucine rich transmembrane protein 3
chrX_-_133012457 0.13 ENSMUST00000159259.3
ENSMUST00000113275.10
NADPH oxidase 1
chr6_-_122317457 0.12 ENSMUST00000160843.8
polyhomeotic 1
chr11_+_34264757 0.10 ENSMUST00000165963.9
ENSMUST00000093192.4
inhibitory synaptic factor family member 2B
chr11_+_96173355 0.08 ENSMUST00000125410.2
homeobox B8
chr8_+_22717308 0.08 ENSMUST00000069828.10
thrombospondin, type I, domain 1
chr1_-_75293447 0.08 ENSMUST00000189551.7
aspartyl aminopeptidase
chr12_+_95662124 0.07 ENSMUST00000110117.2
fibronectin leucine rich transmembrane protein 2
chr14_-_62998561 0.07 ENSMUST00000053959.7
ENSMUST00000223585.2
integrator complex subunit 6
chr6_+_122530758 0.06 ENSMUST00000043301.14
activation-induced cytidine deaminase
chr4_-_120808820 0.05 ENSMUST00000106280.8
zinc finger protein 69
chr14_-_9015639 0.05 ENSMUST00000112656.4
synaptoporin
chr3_+_68375495 0.05 ENSMUST00000182532.8
schwannomin interacting protein 1
chr5_+_20112704 0.05 ENSMUST00000115267.7
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr18_+_65054188 0.05 ENSMUST00000236898.2
ENSMUST00000237410.2
neural precursor cell expressed, developmentally down-regulated gene 4-like
chr11_+_19874403 0.04 ENSMUST00000093298.12
sprouty-related EVH1 domain containing 2
chr14_+_102077937 0.03 ENSMUST00000159026.8
LIM domain only 7
chr2_+_67004178 0.03 ENSMUST00000239009.2
ENSMUST00000238912.2
xin actin-binding repeat containing 2
chr3_+_69129745 0.02 ENSMUST00000183126.2
ADP-ribosylation factor-like 14
chr11_+_96173475 0.02 ENSMUST00000168043.2
homeobox B8
chr14_+_102078038 0.01 ENSMUST00000159314.8
LIM domain only 7
chr9_-_77255171 0.01 ENSMUST00000185039.8
muscular LMNA-interacting protein
chr2_+_83554741 0.00 ENSMUST00000028499.11
integrin alpha V
chr16_-_63684425 0.00 ENSMUST00000232049.2
Eph receptor A3

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2e3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.2 21.5 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.5 6.2 GO:0035524 proline transmembrane transport(GO:0035524) glycine import(GO:0036233)
0.8 12.6 GO:0046549 retinal cone cell development(GO:0046549)
0.7 6.5 GO:0015671 oxygen transport(GO:0015671)
0.6 3.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.6 3.0 GO:0035910 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.6 1.8 GO:0034136 negative regulation of toll-like receptor 2 signaling pathway(GO:0034136)
0.6 4.7 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.5 3.2 GO:0035026 leading edge cell differentiation(GO:0035026)
0.5 2.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.5 2.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.5 1.4 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.5 9.0 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.4 1.2 GO:0030887 positive regulation of myeloid dendritic cell activation(GO:0030887)
0.4 2.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 3.8 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.4 1.9 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.4 5.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.4 1.5 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.4 1.1 GO:0051794 regulation of catagen(GO:0051794)
0.3 1.0 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.3 6.5 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.3 3.1 GO:0032532 regulation of microvillus length(GO:0032532)
0.3 0.9 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.3 2.0 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 8.9 GO:0019731 antibacterial humoral response(GO:0019731)
0.2 1.2 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 2.5 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.2 2.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 0.7 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.2 1.6 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.2 1.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 3.7 GO:0071285 cellular response to lithium ion(GO:0071285)
0.2 1.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 0.7 GO:0043060 meiotic metaphase I plate congression(GO:0043060) meiotic metaphase plate congression(GO:0051311)
0.2 0.5 GO:2001076 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076)
0.2 2.2 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.2 1.3 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1 0.8 GO:0050757 thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.1 0.4 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.1 1.9 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 1.6 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 2.4 GO:0007343 egg activation(GO:0007343)
0.1 1.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 2.4 GO:0030049 muscle filament sliding(GO:0030049)
0.1 2.6 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 6.7 GO:0010596 negative regulation of endothelial cell migration(GO:0010596)
0.1 0.7 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.8 GO:0031179 peptide modification(GO:0031179)
0.1 1.0 GO:0009048 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.1 0.3 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.1 1.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 2.2 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1 2.5 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 2.9 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 1.8 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.6 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.9 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 2.3 GO:0006270 DNA replication initiation(GO:0006270)
0.0 5.9 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 1.7 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 1.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 1.0 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 2.1 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 1.6 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 0.3 GO:0030035 microspike assembly(GO:0030035)
0.0 0.3 GO:0003344 pericardium morphogenesis(GO:0003344)
0.0 2.0 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 1.8 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.8 GO:1904376 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 1.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.2 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 3.4 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 1.0 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 1.8 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.9 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 1.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.4 GO:0060416 response to growth hormone(GO:0060416)
0.0 0.1 GO:0021516 dorsal spinal cord development(GO:0021516)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.2 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.8 2.5 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.8 2.4 GO:1904511 cortical microtubule plus-end(GO:1903754) cytoplasmic microtubule plus-end(GO:1904511)
0.7 5.6 GO:0005833 hemoglobin complex(GO:0005833)
0.6 3.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.5 3.8 GO:0005638 lamin filament(GO:0005638)
0.3 2.0 GO:0005663 DNA replication factor C complex(GO:0005663)
0.3 2.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 1.6 GO:0005899 insulin receptor complex(GO:0005899)
0.3 1.6 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.2 0.7 GO:0005712 chiasma(GO:0005712) late recombination nodule(GO:0005715)
0.2 1.8 GO:0097422 tubular endosome(GO:0097422)
0.2 1.7 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.2 2.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 2.0 GO:0005687 U4 snRNP(GO:0005687)
0.1 1.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.9 GO:0097427 microtubule bundle(GO:0097427)
0.1 3.4 GO:0032982 myosin filament(GO:0032982)
0.1 2.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.2 GO:0001739 sex chromatin(GO:0001739)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.8 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.1 1.1 GO:0005915 zonula adherens(GO:0005915)
0.1 5.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 3.8 GO:0005657 replication fork(GO:0005657)
0.1 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.0 34.4 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 6.0 GO:0030175 filopodium(GO:0030175)
0.0 1.0 GO:0042581 specific granule(GO:0042581)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.3 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 6.9 GO:0005774 vacuolar membrane(GO:0005774)
0.0 6.9 GO:0045177 apical part of cell(GO:0045177)
0.0 0.8 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.1 GO:0005913 cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 21.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
2.1 6.2 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
1.5 9.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.4 5.6 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.3 3.8 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680)
0.7 2.1 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.6 2.5 GO:0050436 microfibril binding(GO:0050436)
0.6 1.8 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.5 2.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.5 1.6 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.5 12.6 GO:0030553 cGMP binding(GO:0030553)
0.4 1.2 GO:0032394 MHC class Ib receptor activity(GO:0032394)
0.4 2.0 GO:0030621 U4 snRNA binding(GO:0030621)
0.4 1.2 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.3 2.4 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.3 1.0 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 1.7 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.2 4.2 GO:0005522 profilin binding(GO:0005522)
0.2 1.2 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.2 6.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 1.6 GO:0002135 CTP binding(GO:0002135)
0.2 0.8 GO:0016842 amidine-lyase activity(GO:0016842)
0.2 5.9 GO:0008143 poly(A) binding(GO:0008143)
0.2 2.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.2 2.0 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 0.7 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.2 3.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 1.2 GO:0034452 dynactin binding(GO:0034452)
0.2 3.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 2.1 GO:0050692 DBD domain binding(GO:0050692)
0.1 2.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.7 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 5.2 GO:0001671 ATPase activator activity(GO:0001671)
0.1 2.4 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 4.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 1.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.0 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.1 1.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 2.4 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.5 GO:0010385 double-stranded methylated DNA binding(GO:0010385) hemi-methylated DNA-binding(GO:0044729)
0.1 3.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.1 4.3 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 3.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.6 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 8.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 3.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.1 GO:0017166 vinculin binding(GO:0017166)
0.0 1.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.8 GO:0048156 tau protein binding(GO:0048156)
0.0 4.7 GO:0005179 hormone activity(GO:0005179)
0.0 1.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 1.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.2 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 4.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 23.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 12.6 PID CONE PATHWAY Visual signal transduction: Cones
0.1 10.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 2.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 4.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 4.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 1.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 4.3 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 2.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.6 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 4.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 3.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.0 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 9.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 2.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 2.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.2 2.3 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2 3.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 4.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 2.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 4.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 3.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 6.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 5.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.6 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 7.1 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 0.9 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 2.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 4.0 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 1.3 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 1.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.8 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis