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GSE58827: Dynamics of the Mouse Liver

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Results for Onecut1_Cux2

Z-value: 1.04

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Transcription factors associated with Onecut1_Cux2

Gene Symbol Gene ID Gene Info
Onecut1
ENSMUSG00000043013.11 one cut domain, family member 1
Cux2
ENSMUSG00000042589.19 cut-like homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Onecut1mm39_v1_chr9_+_74769166_747692030.554.7e-04Click!
Cux2mm39_v1_chr5_-_122187884_122187947-0.144.2e-01Click!

Activity profile of Onecut1_Cux2 motif

Sorted Z-values of Onecut1_Cux2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_22769822 21.01 ENSMUST00000023590.9
Hrg
histidine-rich glycoprotein
chr16_+_22769844 20.97 ENSMUST00000232422.2
Hrg
histidine-rich glycoprotein
chr4_-_104733580 11.67 ENSMUST00000064873.9
ENSMUST00000106808.10
ENSMUST00000048947.15
C8a
complement component 8, alpha polypeptide
chr6_+_121323577 11.31 ENSMUST00000032200.16
Slc6a12
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr2_-_84605764 7.53 ENSMUST00000111641.2
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84605732 7.53 ENSMUST00000023994.10
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr4_-_63072367 7.44 ENSMUST00000030041.5
Ambp
alpha 1 microglobulin/bikunin precursor
chr15_-_60793115 7.42 ENSMUST00000096418.5
A1bg
alpha-1-B glycoprotein
chr7_+_43856724 6.26 ENSMUST00000077354.5
Klk1b4
kallikrein 1-related pepidase b4
chr11_+_101258368 6.16 ENSMUST00000019469.3
G6pc
glucose-6-phosphatase, catalytic
chr1_+_172525613 5.96 ENSMUST00000038495.5
Crp
C-reactive protein, pentraxin-related
chr3_+_146302832 5.90 ENSMUST00000029837.14
ENSMUST00000147409.2
ENSMUST00000121133.2
Uox
urate oxidase
chr11_+_78389913 5.68 ENSMUST00000017488.5
Vtn
vitronectin
chr3_+_28752050 5.10 ENSMUST00000029240.14
Slc2a2
solute carrier family 2 (facilitated glucose transporter), member 2
chr14_-_30665232 4.74 ENSMUST00000006704.17
ENSMUST00000163118.2
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
chr3_+_94280101 4.38 ENSMUST00000029795.10
Rorc
RAR-related orphan receptor gamma
chr11_-_59927688 4.14 ENSMUST00000102692.10
Pemt
phosphatidylethanolamine N-methyltransferase
chr2_-_147888816 3.92 ENSMUST00000172928.2
ENSMUST00000047315.10
Foxa2
forkhead box A2
chr15_-_78352801 3.43 ENSMUST00000229124.2
ENSMUST00000230226.2
ENSMUST00000017086.5
Tmprss6
transmembrane serine protease 6
chr4_-_46991842 3.42 ENSMUST00000107749.4
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr15_+_54975713 3.31 ENSMUST00000096433.10
Deptor
DEP domain containing MTOR-interacting protein
chr8_+_127790772 3.17 ENSMUST00000079777.12
ENSMUST00000160272.8
ENSMUST00000162907.8
ENSMUST00000162536.8
ENSMUST00000026921.13
ENSMUST00000162665.8
ENSMUST00000162602.8
ENSMUST00000160581.8
ENSMUST00000161355.8
ENSMUST00000162531.8
ENSMUST00000160766.8
ENSMUST00000159537.8
Pard3
par-3 family cell polarity regulator
chr6_-_23132977 3.09 ENSMUST00000031707.14
Aass
aminoadipate-semialdehyde synthase
chr8_+_56747613 2.94 ENSMUST00000034026.10
Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr7_+_67297152 2.64 ENSMUST00000032774.16
ENSMUST00000107471.8
Ttc23
tetratricopeptide repeat domain 23
chr15_-_96929086 2.58 ENSMUST00000230086.2
Slc38a4
solute carrier family 38, member 4
chr7_+_67305162 2.43 ENSMUST00000107470.2
Ttc23
tetratricopeptide repeat domain 23
chr6_-_136899167 2.38 ENSMUST00000032343.7
Erp27
endoplasmic reticulum protein 27
chr5_+_130413532 2.33 ENSMUST00000202728.2
Caln1
calneuron 1
chr3_-_146302343 2.20 ENSMUST00000029836.9
Dnase2b
deoxyribonuclease II beta
chr1_+_191449946 2.20 ENSMUST00000133076.7
ENSMUST00000110855.8
Lpgat1
lysophosphatidylglycerol acyltransferase 1
chrX_+_100420873 2.06 ENSMUST00000052130.14
Gjb1
gap junction protein, beta 1
chr19_-_38113696 2.05 ENSMUST00000025951.14
ENSMUST00000237287.2
Rbp4
retinol binding protein 4, plasma
chr5_+_3646066 1.89 ENSMUST00000006061.13
ENSMUST00000121291.8
ENSMUST00000142516.2
Pex1
peroxisomal biogenesis factor 1
chr15_+_54975814 1.87 ENSMUST00000100660.11
Deptor
DEP domain containing MTOR-interacting protein
chr14_-_55329734 1.65 ENSMUST00000036328.9
Zfhx2
zinc finger homeobox 2
chr19_+_41017714 1.48 ENSMUST00000051806.12
ENSMUST00000112200.3
Dntt
deoxynucleotidyltransferase, terminal
chrM_+_14138 1.46 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr12_+_55646209 1.39 ENSMUST00000051857.5
Insm2
insulinoma-associated 2
chr9_-_114673158 1.39 ENSMUST00000047013.4
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr19_+_56276343 1.38 ENSMUST00000095948.11
Habp2
hyaluronic acid binding protein 2
chr18_+_36098090 1.29 ENSMUST00000176873.8
ENSMUST00000177432.8
ENSMUST00000175734.2
Psd2
pleckstrin and Sec7 domain containing 2
chr19_-_57185988 1.27 ENSMUST00000099294.9
Ablim1
actin-binding LIM protein 1
chr19_-_57185928 1.16 ENSMUST00000111544.8
Ablim1
actin-binding LIM protein 1
chr14_-_4488167 1.11 ENSMUST00000022304.12
Thrb
thyroid hormone receptor beta
chr19_+_31060237 1.11 ENSMUST00000066039.8
Cstf2t
cleavage stimulation factor, 3' pre-RNA subunit 2, tau
chr10_+_29019645 1.11 ENSMUST00000092629.4
Soga3
SOGA family member 3
chr12_-_25146078 1.07 ENSMUST00000222667.2
ENSMUST00000020974.7
Id2
inhibitor of DNA binding 2
chr19_-_57185808 1.06 ENSMUST00000111546.8
Ablim1
actin-binding LIM protein 1
chrM_-_14061 0.98 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr5_+_3646355 0.98 ENSMUST00000195894.2
Pex1
peroxisomal biogenesis factor 1
chr8_-_13250535 0.91 ENSMUST00000165605.4
ENSMUST00000209691.2
ENSMUST00000211128.2
ENSMUST00000210317.2
Grtp1
GH regulated TBC protein 1
chr19_-_37155410 0.71 ENSMUST00000133988.2
Cpeb3
cytoplasmic polyadenylation element binding protein 3
chr1_-_13197387 0.66 ENSMUST00000047577.7
Prdm14
PR domain containing 14
chr5_+_92831150 0.52 ENSMUST00000113055.9
Shroom3
shroom family member 3
chr3_+_5283577 0.51 ENSMUST00000175866.8
Zfhx4
zinc finger homeodomain 4
chr3_-_79749949 0.50 ENSMUST00000029568.7
Tmem144
transmembrane protein 144
chr13_-_54836059 0.47 ENSMUST00000122935.2
ENSMUST00000128257.8
Rnf44
ring finger protein 44
chr3_+_5283606 0.47 ENSMUST00000026284.13
Zfhx4
zinc finger homeodomain 4
chr2_+_163444248 0.45 ENSMUST00000152135.8
Ttpal
tocopherol (alpha) transfer protein-like
chr19_+_26728339 0.42 ENSMUST00000175953.3
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_-_3646071 0.42 ENSMUST00000121877.3
Rbm48
RNA binding motif protein 48
chr9_+_59496571 0.42 ENSMUST00000121266.8
ENSMUST00000118164.3
Celf6
CUGBP, Elav-like family member 6
chr19_-_57185861 0.40 ENSMUST00000111550.8
Ablim1
actin-binding LIM protein 1
chr6_+_140378688 0.38 ENSMUST00000203774.3
Plekha5
pleckstrin homology domain containing, family A member 5
chr10_+_76089674 0.36 ENSMUST00000036387.8
S100b
S100 protein, beta polypeptide, neural
chr16_-_95260104 0.34 ENSMUST00000176345.10
ENSMUST00000121809.11
ENSMUST00000233664.2
ENSMUST00000122199.10
Erg
ETS transcription factor
chr5_+_92831468 0.33 ENSMUST00000168878.8
Shroom3
shroom family member 3
chr15_-_8739893 0.28 ENSMUST00000157065.2
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_-_120515799 0.25 ENSMUST00000106183.3
ENSMUST00000080202.12
Sirt7
sirtuin 7
chr4_-_97472844 0.24 ENSMUST00000107067.8
ENSMUST00000107068.9
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_+_129642371 0.22 ENSMUST00000165413.9
ENSMUST00000166282.3
Stk35
serine/threonine kinase 35
chr8_+_114369838 0.21 ENSMUST00000095173.3
ENSMUST00000034219.12
ENSMUST00000212269.2
Syce1l
synaptonemal complex central element protein 1 like
chr10_-_63926044 0.20 ENSMUST00000105439.2
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr5_+_63806451 0.19 ENSMUST00000159584.3
Nwd2
NACHT and WD repeat domain containing 2
chr15_+_92059224 0.19 ENSMUST00000068378.6
Cntn1
contactin 1
chr19_-_32038838 0.18 ENSMUST00000096119.5
Asah2
N-acylsphingosine amidohydrolase 2
chr1_+_88334678 0.18 ENSMUST00000027518.12
Spp2
secreted phosphoprotein 2
chr15_+_22549108 0.16 ENSMUST00000163361.8
Cdh18
cadherin 18
chr18_-_72484126 0.15 ENSMUST00000114943.11
Dcc
deleted in colorectal carcinoma
chr2_-_60503998 0.15 ENSMUST00000059888.15
ENSMUST00000154764.2
Itgb6
integrin beta 6
chr2_-_7086018 0.15 ENSMUST00000114923.3
ENSMUST00000182706.8
Celf2
CUGBP, Elav-like family member 2
chrX_-_50294867 0.14 ENSMUST00000114876.9
Mbnl3
muscleblind like splicing factor 3
chr15_-_8740218 0.14 ENSMUST00000005493.14
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_-_46865709 0.13 ENSMUST00000021438.8
Nova1
NOVA alternative splicing regulator 1
chr2_+_147206910 0.11 ENSMUST00000109968.3
Pax1
paired box 1
chr8_+_59364789 0.10 ENSMUST00000062978.7
BC030500
cDNA sequence BC030500
chr12_+_72488625 0.10 ENSMUST00000161284.3
ENSMUST00000162159.8
Lrrc9
leucine rich repeat containing 9
chr7_-_105460172 0.09 ENSMUST00000033170.7
ENSMUST00000176498.2
ENSMUST00000176887.2
ENSMUST00000124482.3
Mrpl17
mitochondrial ribosomal protein L17
chr3_+_68479578 0.08 ENSMUST00000170788.9
Schip1
schwannomin interacting protein 1
chr8_-_32408380 0.08 ENSMUST00000208497.3
ENSMUST00000207584.3
Nrg1
neuregulin 1
chr6_+_40468167 0.07 ENSMUST00000064932.6
Tas2r137
taste receptor, type 2, member 137
chr8_+_23114035 0.04 ENSMUST00000033936.8
Dkk4
dickkopf WNT signaling pathway inhibitor 4
chr5_-_3646540 0.03 ENSMUST00000042753.14
Rbm48
RNA binding motif protein 48
chr1_+_59621555 0.03 ENSMUST00000212835.2
Gm973
predicted gene 973
chr9_-_29874401 0.02 ENSMUST00000075069.11
Ntm
neurotrimin
chr3_-_33136153 0.01 ENSMUST00000108225.10
Pex5l
peroxisomal biogenesis factor 5-like

Network of associatons between targets according to the STRING database.

First level regulatory network of Onecut1_Cux2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.0 42.0 GO:0097037 heme export(GO:0097037)
5.0 15.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
2.3 11.3 GO:0009992 cellular water homeostasis(GO:0009992)
1.3 3.9 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
1.0 3.1 GO:0006553 lysine metabolic process(GO:0006553)
1.0 5.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
1.0 2.9 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.7 6.0 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.7 11.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.6 6.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.6 4.1 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.5 7.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.5 3.2 GO:0003383 apical constriction(GO:0003383)
0.4 5.7 GO:0097421 smooth muscle cell-matrix adhesion(GO:0061302) liver regeneration(GO:0097421)
0.4 2.1 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.4 4.4 GO:0072615 interleukin-17 secretion(GO:0072615)
0.4 1.1 GO:0001966 thigmotaxis(GO:0001966)
0.3 5.9 GO:0046415 urate metabolic process(GO:0046415)
0.2 0.7 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.2 1.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.2 5.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.2 2.9 GO:0007567 parturition(GO:0007567)
0.2 1.5 GO:0033762 response to glucagon(GO:0033762)
0.2 2.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.2 3.4 GO:0097264 self proteolysis(GO:0097264)
0.2 6.3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.2 0.7 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.1 1.4 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 4.7 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 1.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 2.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 0.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 3.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.4 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.1 0.3 GO:0045896 regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.1 0.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.1 0.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 2.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.3 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0 1.5 GO:0033198 response to ATP(GO:0033198)
0.0 1.3 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 3.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965) dorsal/ventral axon guidance(GO:0033563)
0.0 0.5 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0061056 sclerotome development(GO:0061056)
0.0 0.2 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324)
0.0 0.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
14.0 42.0 GO:0061474 phagolysosome membrane(GO:0061474)
1.3 11.7 GO:0005579 membrane attack complex(GO:0005579)
0.8 5.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.7 3.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.4 3.2 GO:0033269 internode region of axon(GO:0033269)
0.1 1.5 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 33.5 GO:0072562 blood microparticle(GO:0072562)
0.1 2.1 GO:0005922 connexon complex(GO:0005922)
0.1 0.2 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.1 9.2 GO:0031526 brush border membrane(GO:0031526)
0.1 2.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 6.0 GO:0030175 filopodium(GO:0030175)
0.0 8.8 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 6.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.5 GO:0000791 euchromatin(GO:0000791)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 1.0 GO:0070469 respiratory chain(GO:0070469)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.4 GO:0019862 IgA binding(GO:0019862)
1.6 11.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
1.5 6.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.2 32.7 GO:0001848 complement binding(GO:0001848)
1.0 5.1 GO:0055056 dehydroascorbic acid transporter activity(GO:0033300) D-glucose transmembrane transporter activity(GO:0055056)
0.7 4.4 GO:0008142 oxysterol binding(GO:0008142)
0.7 2.1 GO:0034632 retinol transporter activity(GO:0034632)
0.6 3.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.5 5.9 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.4 2.2 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.4 2.9 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.4 4.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.4 42.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 5.7 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 1.5 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 2.1 GO:0005243 gap junction channel activity(GO:0005243)
0.1 3.1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1 1.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.1 GO:0070324 thyroid hormone receptor activity(GO:0004887) thyroid hormone binding(GO:0070324)
0.1 0.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.3 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 3.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 6.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 2.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 4.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 70.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 5.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 15.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 7.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 6.0 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 3.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 1.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 2.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.0 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.7 15.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.5 11.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.4 11.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 40.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 5.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 3.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 4.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 3.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 6.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 3.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 2.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 5.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 3.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives