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GSE58827: Dynamics of the Mouse Liver

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Results for Pax6

Z-value: 0.48

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Transcription factors associated with Pax6

Gene Symbol Gene ID Gene Info
Pax6
ENSMUSG00000027168.22 paired box 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax6mm39_v1_chr2_+_105499280_1054992970.124.9e-01Click!

Activity profile of Pax6 motif

Sorted Z-values of Pax6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_25760922 3.59 ENSMUST00000005669.9
Cyp2b13
cytochrome P450, family 2, subfamily b, polypeptide 13
chr14_-_44057096 1.85 ENSMUST00000100691.4
Ear1
eosinophil-associated, ribonuclease A family, member 1
chr13_-_24098951 1.70 ENSMUST00000021769.16
Slc17a4
solute carrier family 17 (sodium phosphate), member 4
chr13_-_24098981 1.66 ENSMUST00000110407.4
Slc17a4
solute carrier family 17 (sodium phosphate), member 4
chr13_-_4573312 1.48 ENSMUST00000221564.2
ENSMUST00000078239.5
ENSMUST00000080361.13
Akr1c20
aldo-keto reductase family 1, member C20
chr1_+_131566044 1.07 ENSMUST00000073350.13
Ctse
cathepsin E
chr11_-_95478517 1.02 ENSMUST00000000122.7
Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr3_-_98660781 0.84 ENSMUST00000094050.11
ENSMUST00000090743.13
Hsd3b3
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3
chr7_+_12631727 0.60 ENSMUST00000055528.11
ENSMUST00000117189.2
ENSMUST00000120809.2
ENSMUST00000119989.3
Zscan22
zinc finger and SCAN domain containing 22
chr16_+_34605282 0.59 ENSMUST00000023538.9
Mylk
myosin, light polypeptide kinase
chr5_-_38637624 0.59 ENSMUST00000067886.12
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr17_+_25585255 0.56 ENSMUST00000234477.2
Tpsb2
tryptase beta 2
chr15_+_6329263 0.52 ENSMUST00000078019.13
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr19_+_34268071 0.48 ENSMUST00000112472.4
ENSMUST00000235232.2
Fas
Fas (TNF receptor superfamily member 6)
chr2_-_131987008 0.48 ENSMUST00000028815.15
Slc23a2
solute carrier family 23 (nucleobase transporters), member 2
chr4_-_70328659 0.47 ENSMUST00000144099.8
Cdk5rap2
CDK5 regulatory subunit associated protein 2
chr5_-_38637474 0.45 ENSMUST00000143758.8
ENSMUST00000156272.8
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr15_+_6329278 0.44 ENSMUST00000159046.2
ENSMUST00000161040.8
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr19_+_34268053 0.43 ENSMUST00000025691.13
Fas
Fas (TNF receptor superfamily member 6)
chr11_+_33996920 0.42 ENSMUST00000052413.12
Lcp2
lymphocyte cytosolic protein 2
chr7_-_44198157 0.38 ENSMUST00000145956.2
ENSMUST00000049343.15
Pold1
polymerase (DNA directed), delta 1, catalytic subunit
chr11_-_121410152 0.38 ENSMUST00000092298.6
Zfp750
zinc finger protein 750
chr7_+_5054514 0.36 ENSMUST00000069324.7
Zfp580
zinc finger protein 580
chr13_-_113755082 0.36 ENSMUST00000109241.5
Snx18
sorting nexin 18
chr8_-_81607109 0.35 ENSMUST00000034150.10
Gab1
growth factor receptor bound protein 2-associated protein 1
chr19_-_57107413 0.33 ENSMUST00000111528.8
ENSMUST00000111529.8
ENSMUST00000104902.9
Ablim1
actin-binding LIM protein 1
chr16_-_52272828 0.33 ENSMUST00000170035.8
ENSMUST00000164728.8
ENSMUST00000168071.2
Alcam
activated leukocyte cell adhesion molecule
chr8_-_81607140 0.31 ENSMUST00000210676.2
Gab1
growth factor receptor bound protein 2-associated protein 1
chr2_-_33777874 0.30 ENSMUST00000041555.10
Mvb12b
multivesicular body subunit 12B
chr6_-_122833109 0.28 ENSMUST00000042081.9
C3ar1
complement component 3a receptor 1
chr4_+_148123554 0.26 ENSMUST00000141283.8
Mthfr
methylenetetrahydrofolate reductase
chr11_+_72981377 0.24 ENSMUST00000006101.4
Itgae
integrin alpha E, epithelial-associated
chr5_+_87148697 0.24 ENSMUST00000031186.9
Ugt2b35
UDP glucuronosyltransferase 2 family, polypeptide B35
chr6_+_123206802 0.24 ENSMUST00000112554.9
ENSMUST00000024118.11
ENSMUST00000117130.8
Clec4n
C-type lectin domain family 4, member n
chr13_+_73775001 0.24 ENSMUST00000022104.9
Tert
telomerase reverse transcriptase
chr15_+_95698574 0.22 ENSMUST00000226793.2
Ano6
anoctamin 6
chr2_+_120331784 0.22 ENSMUST00000151342.3
Capn3
calpain 3
chr7_+_140808680 0.22 ENSMUST00000106027.9
Phrf1
PHD and ring finger domains 1
chr19_-_57107330 0.20 ENSMUST00000111526.8
Ablim1
actin-binding LIM protein 1
chr4_+_155575792 0.20 ENSMUST00000165335.8
ENSMUST00000105616.10
ENSMUST00000030940.14
Gnb1
guanine nucleotide binding protein (G protein), beta 1
chr10_-_127025851 0.19 ENSMUST00000222006.2
ENSMUST00000019611.15
ENSMUST00000219245.2
Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr10_-_126866658 0.18 ENSMUST00000120547.2
ENSMUST00000152054.8
Tsfm
Ts translation elongation factor, mitochondrial
chr6_-_125213911 0.18 ENSMUST00000112282.3
ENSMUST00000112281.8
ENSMUST00000032486.13
Cd27
CD27 antigen
chr9_+_21249118 0.18 ENSMUST00000034697.8
Slc44a2
solute carrier family 44, member 2
chr2_-_75812311 0.18 ENSMUST00000099994.5
Ttc30a1
tetratricopeptide repeat domain 30A1
chr9_-_62719208 0.17 ENSMUST00000034775.10
Fem1b
fem 1 homolog b
chr9_+_50686647 0.17 ENSMUST00000159576.2
Alg9
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
chr9_+_105520154 0.17 ENSMUST00000190358.2
ENSMUST00000191268.7
ENSMUST00000065778.13
ENSMUST00000188784.2
Pik3r4
phosphoinositide-3-kinase regulatory subunit 4
chr10_-_126866682 0.16 ENSMUST00000040560.11
Tsfm
Ts translation elongation factor, mitochondrial
chr9_+_64086553 0.16 ENSMUST00000034965.8
Snapc5
small nuclear RNA activating complex, polypeptide 5
chr9_+_15150341 0.15 ENSMUST00000034413.8
Vstm5
V-set and transmembrane domain containing 5
chr2_-_117173190 0.14 ENSMUST00000173541.8
ENSMUST00000172901.8
ENSMUST00000173252.2
Rasgrp1
RAS guanyl releasing protein 1
chr6_+_83119368 0.13 ENSMUST00000130622.8
ENSMUST00000129316.2
Rtkn
rhotekin
chr8_-_73229056 0.12 ENSMUST00000212991.2
Cherp
calcium homeostasis endoplasmic reticulum protein
chr5_+_110248276 0.11 ENSMUST00000141066.8
Plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr2_-_105734829 0.11 ENSMUST00000122965.8
Elp4
elongator acetyltransferase complex subunit 4
chr13_+_63963054 0.10 ENSMUST00000021926.13
ENSMUST00000067821.13
ENSMUST00000144763.2
ENSMUST00000021925.14
ENSMUST00000238465.2
Ercc6l2
excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
chr8_-_73228953 0.09 ENSMUST00000079510.6
Cherp
calcium homeostasis endoplasmic reticulum protein
chr8_+_96551974 0.09 ENSMUST00000074053.6
Sap18b
Sin3-associated polypeptide 18B
chr3_-_79760067 0.09 ENSMUST00000192341.2
ENSMUST00000193410.3
Tmem144
transmembrane protein 144
chr6_-_124718316 0.09 ENSMUST00000004389.6
Grcc10
gene rich cluster, C10 gene
chr2_-_117173312 0.09 ENSMUST00000178884.8
Rasgrp1
RAS guanyl releasing protein 1
chr11_+_67857268 0.08 ENSMUST00000021286.11
ENSMUST00000108675.2
Stx8
syntaxin 8
chr11_+_78219241 0.08 ENSMUST00000048073.9
Pigs
phosphatidylinositol glycan anchor biosynthesis, class S
chr17_-_57366795 0.08 ENSMUST00000040280.14
Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr4_+_138920210 0.07 ENSMUST00000102508.10
ENSMUST00000131912.8
ENSMUST00000102507.10
Capzb
capping protein (actin filament) muscle Z-line, beta
chr11_+_104441489 0.07 ENSMUST00000018800.9
Myl4
myosin, light polypeptide 4
chr7_+_75259778 0.07 ENSMUST00000207923.2
Akap13
A kinase (PRKA) anchor protein 13
chr5_-_134668152 0.07 ENSMUST00000036125.10
ENSMUST00000202622.4
Eif4h
eukaryotic translation initiation factor 4H
chr14_-_103583785 0.07 ENSMUST00000160758.8
Mycbp2
MYC binding protein 2, E3 ubiquitin protein ligase
chr11_-_6150411 0.07 ENSMUST00000066496.10
Nudcd3
NudC domain containing 3
chr10_+_26105605 0.05 ENSMUST00000218301.2
ENSMUST00000164660.8
ENSMUST00000060716.6
Samd3
sterile alpha motif domain containing 3
chr1_+_155916655 0.05 ENSMUST00000065648.15
ENSMUST00000097526.3
Tor1aip2
torsin A interacting protein 2
chr18_+_77877611 0.05 ENSMUST00000238172.2
Pstpip2
proline-serine-threonine phosphatase-interacting protein 2
chr6_-_88021999 0.04 ENSMUST00000113598.8
Rab7
RAB7, member RAS oncogene family
chr8_+_106587212 0.03 ENSMUST00000008594.9
Nutf2
nuclear transport factor 2
chr5_+_124045238 0.03 ENSMUST00000023869.15
Denr
density-regulated protein
chr1_-_192812509 0.03 ENSMUST00000085555.7
Utp25
UTP25 small subunit processome component
chr16_+_3702523 0.02 ENSMUST00000176625.8
ENSMUST00000186375.8
Naa60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr12_+_76593799 0.02 ENSMUST00000218380.2
ENSMUST00000219751.2
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_+_60590584 0.02 ENSMUST00000108719.4
Llgl1
LLGL1 scribble cell polarity complex component
chr8_+_106587268 0.02 ENSMUST00000212610.2
ENSMUST00000212484.2
ENSMUST00000212200.2
Nutf2
nuclear transport factor 2
chr7_+_86645323 0.01 ENSMUST00000233714.2
ENSMUST00000233648.2
ENSMUST00000164462.3
ENSMUST00000233730.2
Vmn2r79
vomeronasal 2, receptor 79
chr5_+_124045552 0.01 ENSMUST00000166233.2
Denr
density-regulated protein
chr16_+_3702604 0.01 ENSMUST00000115860.8
Naa60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr2_-_111104451 0.00 ENSMUST00000214760.2
Olfr1277
olfactory receptor 1277
chr16_+_32698470 0.00 ENSMUST00000232272.2
Fyttd1
forty-two-three domain containing 1
chr11_+_60590498 0.00 ENSMUST00000052346.10
Llgl1
LLGL1 scribble cell polarity complex component

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3 0.9 GO:0031104 dendrite regeneration(GO:0031104)
0.2 1.0 GO:0035026 leading edge cell differentiation(GO:0035026)
0.2 0.5 GO:0070904 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.1 0.4 GO:0045004 DNA replication proofreading(GO:0045004)
0.1 0.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 3.6 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 0.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.2 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 0.2 GO:0002543 activation of blood coagulation via clotting cascade(GO:0002543) phosphatidylserine exposure on blood platelet(GO:0097045)
0.1 0.5 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 0.2 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 1.1 GO:0016540 protein autoprocessing(GO:0016540)
0.1 0.2 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
0.1 0.3 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 1.0 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.4 GO:0036089 cleavage furrow formation(GO:0036089)
0.0 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.3 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) tolerance induction dependent upon immune response(GO:0002461)
0.0 0.7 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.2 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 3.4 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.1 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.1 GO:0036343 psychomotor behavior(GO:0036343)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.0 0.1 GO:1904046 negative regulation of vascular endothelial growth factor production(GO:1904046)
0.0 0.1 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.2 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 0.2 GO:0045078 regulation of interferon-gamma biosynthetic process(GO:0045072) positive regulation of interferon-gamma biosynthetic process(GO:0045078)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.4 GO:0036398 TCR signalosome(GO:0036398)
0.1 0.9 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 1.0 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.0 GO:0070992 translation initiation complex(GO:0070992)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.2 3.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.2 0.5 GO:0008520 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1 0.8 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 3.6 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 0.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 1.0 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 1.0 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.1 0.6 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.5 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 1.0 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 1.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.3 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.2 GO:0031432 titin binding(GO:0031432)
0.0 1.9 GO:0004540 ribonuclease activity(GO:0004540)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.0 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 1.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 0.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.0 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.7 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane