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GSE58827: Dynamics of the Mouse Liver

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Results for Pax7

Z-value: 0.27

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Transcription factors associated with Pax7

Gene Symbol Gene ID Gene Info
Pax7
ENSMUSG00000028736.14 paired box 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax7mm39_v1_chr4_-_139560831_139560846-0.271.2e-01Click!

Activity profile of Pax7 motif

Sorted Z-values of Pax7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_138169253 0.92 ENSMUST00000139983.8
Mcm7
minichromosome maintenance complex component 7
chr12_+_117807224 0.75 ENSMUST00000021592.16
Cdca7l
cell division cycle associated 7 like
chr19_-_15902292 0.65 ENSMUST00000025542.10
Psat1
phosphoserine aminotransferase 1
chr19_-_15901919 0.64 ENSMUST00000162053.8
Psat1
phosphoserine aminotransferase 1
chr9_-_20871081 0.60 ENSMUST00000177754.9
Dnmt1
DNA methyltransferase (cytosine-5) 1
chr17_-_35827676 0.54 ENSMUST00000160885.2
ENSMUST00000159009.2
ENSMUST00000161012.8
Tcf19
transcription factor 19
chr10_-_62215631 0.46 ENSMUST00000143236.8
ENSMUST00000133429.8
ENSMUST00000132926.8
ENSMUST00000116238.9
Hk1
hexokinase 1
chr8_-_49008305 0.43 ENSMUST00000110346.9
ENSMUST00000211976.2
Tenm3
teneurin transmembrane protein 3
chr15_+_9436114 0.42 ENSMUST00000042360.5
ENSMUST00000226688.2
Capsl
calcyphosine-like
chr4_+_102446883 0.31 ENSMUST00000097949.11
ENSMUST00000106901.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr19_-_24178000 0.31 ENSMUST00000233658.3
Tjp2
tight junction protein 2
chr9_-_71070506 0.28 ENSMUST00000074465.9
Aqp9
aquaporin 9
chr11_+_99748741 0.27 ENSMUST00000107434.2
Gm11568
predicted gene 11568
chr6_-_129449739 0.26 ENSMUST00000112076.9
ENSMUST00000184581.3
Clec7a
C-type lectin domain family 7, member a
chr5_-_92496730 0.26 ENSMUST00000038816.13
ENSMUST00000118006.3
Cxcl10
chemokine (C-X-C motif) ligand 10
chr13_+_75855695 0.25 ENSMUST00000222194.2
ENSMUST00000223535.2
ENSMUST00000222853.2
Ell2
elongation factor for RNA polymerase II 2
chr11_-_99134885 0.24 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr14_+_32507920 0.23 ENSMUST00000039191.8
ENSMUST00000227060.2
ENSMUST00000228481.2
Tmem273
transmembrane protein 273
chr15_-_66985760 0.23 ENSMUST00000092640.6
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr6_+_37847721 0.22 ENSMUST00000031859.14
ENSMUST00000120428.8
Trim24
tripartite motif-containing 24
chr14_+_65612788 0.22 ENSMUST00000224687.2
Zfp395
zinc finger protein 395
chr3_+_62327089 0.22 ENSMUST00000161057.2
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr11_-_107228382 0.22 ENSMUST00000040380.13
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr14_-_69945022 0.22 ENSMUST00000118374.8
R3hcc1
R3H domain and coiled-coil containing 1
chr14_-_69944942 0.21 ENSMUST00000121142.4
R3hcc1
R3H domain and coiled-coil containing 1
chr11_+_43572825 0.21 ENSMUST00000061070.6
ENSMUST00000094294.5
Pwwp2a
PWWP domain containing 2A
chr8_+_84728123 0.17 ENSMUST00000060357.15
ENSMUST00000239176.2
1700067K01Rik
RIKEN cDNA 1700067K01 gene
chr19_-_46033353 0.17 ENSMUST00000026252.14
ENSMUST00000156585.9
ENSMUST00000185355.7
ENSMUST00000152946.8
Ldb1
LIM domain binding 1
chr9_+_50686647 0.16 ENSMUST00000159576.2
Alg9
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
chr3_-_106697459 0.16 ENSMUST00000038845.10
Cd53
CD53 antigen
chr8_-_62355690 0.14 ENSMUST00000121785.9
ENSMUST00000034057.14
Palld
palladin, cytoskeletal associated protein
chr3_-_87081939 0.14 ENSMUST00000159976.8
ENSMUST00000107618.9
Kirrel
kirre like nephrin family adhesion molecule 1
chr14_+_55797468 0.14 ENSMUST00000147981.2
ENSMUST00000133256.8
Dcaf11
DDB1 and CUL4 associated factor 11
chr3_-_75177378 0.14 ENSMUST00000039047.5
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr1_-_55265925 0.14 ENSMUST00000027121.15
ENSMUST00000114428.3
Rftn2
raftlin family member 2
chr1_-_131441962 0.13 ENSMUST00000185445.3
Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr9_-_96601574 0.12 ENSMUST00000128269.8
Zbtb38
zinc finger and BTB domain containing 38
chr14_-_26184767 0.10 ENSMUST00000146438.2
Slmap
sarcolemma associated protein
chr6_-_87510200 0.10 ENSMUST00000113637.9
ENSMUST00000071024.7
Arhgap25
Rho GTPase activating protein 25
chr6_-_57512355 0.10 ENSMUST00000042766.6
Ppm1k
protein phosphatase 1K (PP2C domain containing)
chr10_-_53252210 0.09 ENSMUST00000095691.7
Cep85l
centrosomal protein 85-like
chr4_+_136013372 0.09 ENSMUST00000069195.5
ENSMUST00000130658.2
Zfp46
zinc finger protein 46
chrX_+_9751861 0.09 ENSMUST00000067529.9
ENSMUST00000086165.4
Sytl5
synaptotagmin-like 5
chr9_+_21634779 0.08 ENSMUST00000034713.9
Ldlr
low density lipoprotein receptor
chr13_-_78344492 0.07 ENSMUST00000125176.3
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr9_+_21867043 0.07 ENSMUST00000053583.7
Swsap1
SWIM type zinc finger 7 associated protein 1
chr2_-_144112700 0.07 ENSMUST00000110030.10
Snx5
sorting nexin 5
chr4_-_43710231 0.07 ENSMUST00000217544.2
ENSMUST00000107862.3
Olfr71
olfactory receptor 71
chr16_-_59092995 0.07 ENSMUST00000216834.2
Olfr201
olfactory receptor 201
chr17_+_79919267 0.06 ENSMUST00000223924.2
Rmdn2
regulator of microtubule dynamics 2
chr10_+_127226180 0.06 ENSMUST00000077046.12
ENSMUST00000105250.9
R3hdm2
R3H domain containing 2
chr12_-_113649535 0.06 ENSMUST00000103449.4
ENSMUST00000195707.3
Ighv2-5
immunoglobulin heavy variable 2-5
chr6_-_69584812 0.06 ENSMUST00000103359.3
Igkv4-55
immunoglobulin kappa variable 4-55
chr2_+_124910037 0.06 ENSMUST00000070353.4
Slc24a5
solute carrier family 24, member 5
chr19_+_8779903 0.06 ENSMUST00000172175.3
Zbtb3
zinc finger and BTB domain containing 3
chr9_+_102597486 0.06 ENSMUST00000130602.2
Amotl2
angiomotin-like 2
chr8_-_35432783 0.05 ENSMUST00000033929.6
Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr9_+_108183996 0.05 ENSMUST00000194701.6
ENSMUST00000193490.2
Rhoa
ras homolog family member A
chr2_-_37249247 0.05 ENSMUST00000112940.8
ENSMUST00000009174.15
Pdcl
phosducin-like
chr5_+_124679359 0.05 ENSMUST00000124529.8
Tmed2
transmembrane p24 trafficking protein 2
chr2_-_111843053 0.04 ENSMUST00000213559.3
Olfr1310
olfactory receptor 1310
chr15_-_79658608 0.04 ENSMUST00000229644.2
ENSMUST00000023055.8
Dnal4
dynein, axonemal, light chain 4
chr10_+_23952398 0.04 ENSMUST00000051133.6
Taar8a
trace amine-associated receptor 8A
chr7_+_45271229 0.04 ENSMUST00000033100.5
Izumo1
izumo sperm-egg fusion 1
chrX_-_156381652 0.04 ENSMUST00000149249.2
ENSMUST00000058098.15
Mbtps2
membrane-bound transcription factor peptidase, site 2
chr10_+_85222677 0.03 ENSMUST00000105307.8
ENSMUST00000020231.10
Btbd11
BTB (POZ) domain containing 11
chr2_+_85838122 0.03 ENSMUST00000062166.2
Olfr1032
olfactory receptor 1032
chr2_-_86109346 0.03 ENSMUST00000217294.2
ENSMUST00000217245.2
ENSMUST00000216432.2
Olfr1051
olfactory receptor 1051
chr18_+_31742565 0.03 ENSMUST00000164667.2
B930094E09Rik
RIKEN cDNA B930094E09 gene
chr3_+_32490525 0.02 ENSMUST00000108242.2
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
chr17_+_35827997 0.02 ENSMUST00000164242.9
ENSMUST00000045956.14
Cchcr1
coiled-coil alpha-helical rod protein 1
chr19_-_11261177 0.02 ENSMUST00000186937.7
ENSMUST00000067673.13
Ms4a5
membrane-spanning 4-domains, subfamily A, member 5
chr7_+_18962252 0.02 ENSMUST00000063976.9
Opa3
optic atrophy 3
chr13_+_76727787 0.02 ENSMUST00000126960.8
ENSMUST00000109583.9
Mctp1
multiple C2 domains, transmembrane 1
chr18_-_77134980 0.02 ENSMUST00000154665.2
ENSMUST00000026486.13
ENSMUST00000123650.2
ENSMUST00000126153.8
Katnal2
katanin p60 subunit A-like 2
chr13_+_23718038 0.02 ENSMUST00000073261.3
H2ac10
H2A clustered histone 10
chr3_+_32490300 0.02 ENSMUST00000029201.14
Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
chr8_+_107757847 0.01 ENSMUST00000034388.10
Vps4a
vacuolar protein sorting 4A
chr4_+_108576846 0.01 ENSMUST00000178992.2
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr13_-_23302396 0.01 ENSMUST00000227110.2
Vmn1r217
vomeronasal 1 receptor 217
chr11_-_29197222 0.01 ENSMUST00000020754.10
Cfap36
cilia and flagella associated protein 36
chr3_-_72875187 0.00 ENSMUST00000167334.8
Sis
sucrase isomaltase (alpha-glucosidase)
chr18_-_77134939 0.00 ENSMUST00000137354.8
ENSMUST00000137498.8
Katnal2
katanin p60 subunit A-like 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.6 GO:0090116 C-5 methylation of cytosine(GO:0090116) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.3 GO:0015855 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.1 0.3 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.1 0.2 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 0.5 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.3 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.0 0.2 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.2 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.4 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0010899 regulation of phosphatidylcholine catabolic process(GO:0010899) receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 0.1 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.0 0.1 GO:0032596 protein transport into membrane raft(GO:0032596)
0.0 0.1 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.0 0.1 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0 0.5 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.0 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:0001998 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998)
0.0 0.0 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.3 GO:0015205 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205) glycerol channel activity(GO:0015254)
0.0 0.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 1.3 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis