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GSE58827: Dynamics of the Mouse Liver

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Results for Pou3f3

Z-value: 0.49

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Transcription factors associated with Pou3f3

Gene Symbol Gene ID Gene Info
Pou3f3
ENSMUSG00000045515.5 POU domain, class 3, transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou3f3mm39_v1_chr1_+_42734051_427341050.105.5e-01Click!

Activity profile of Pou3f3 motif

Sorted Z-values of Pou3f3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_134238310 4.31 ENSMUST00000105866.3
Aunip
aurora kinase A and ninein interacting protein
chr4_-_149221998 2.95 ENSMUST00000176124.8
ENSMUST00000177408.2
ENSMUST00000105695.2
Cenps
centromere protein S
chr5_+_66833434 2.88 ENSMUST00000031131.11
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr4_-_149222057 2.50 ENSMUST00000030813.10
Cenps
centromere protein S
chr6_+_129326927 2.12 ENSMUST00000065289.6
Clec12a
C-type lectin domain family 12, member a
chr14_+_26722319 2.02 ENSMUST00000035433.10
Hesx1
homeobox gene expressed in ES cells
chr5_-_74226394 1.76 ENSMUST00000145016.3
Usp46
ubiquitin specific peptidase 46
chr7_-_126391657 1.32 ENSMUST00000032936.8
Ppp4c
protein phosphatase 4, catalytic subunit
chr7_-_126391388 1.31 ENSMUST00000206570.2
Ppp4c
protein phosphatase 4, catalytic subunit
chr13_+_21906214 1.12 ENSMUST00000224651.2
H2bc14
H2B clustered histone 14
chr8_-_106022676 0.81 ENSMUST00000057855.4
Exoc3l
exocyst complex component 3-like
chr11_-_99134885 0.76 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr15_-_42540363 0.68 ENSMUST00000022921.7
Angpt1
angiopoietin 1
chr3_+_83673606 0.68 ENSMUST00000029625.8
Sfrp2
secreted frizzled-related protein 2
chr1_+_43571536 0.55 ENSMUST00000202540.2
Nck2
non-catalytic region of tyrosine kinase adaptor protein 2
chr3_-_122828592 0.50 ENSMUST00000029761.14
Myoz2
myozenin 2
chr12_-_113912416 0.34 ENSMUST00000103464.3
Ighv4-1
immunoglobulin heavy variable 4-1
chr3_-_144555062 0.28 ENSMUST00000159989.2
Clca3b
chloride channel accessory 3B
chr2_-_154214622 0.24 ENSMUST00000028990.10
ENSMUST00000109730.3
Cdk5rap1
CDK5 regulatory subunit associated protein 1
chr2_+_164664920 0.13 ENSMUST00000132282.2
Zswim1
zinc finger SWIM-type containing 1
chr2_+_67004178 0.11 ENSMUST00000239009.2
ENSMUST00000238912.2
Xirp2
xin actin-binding repeat containing 2
chr6_+_96092230 0.07 ENSMUST00000075080.6
Tafa1
TAFA chemokine like family member 1
chr10_+_26105605 0.05 ENSMUST00000218301.2
ENSMUST00000164660.8
ENSMUST00000060716.6
Samd3
sterile alpha motif domain containing 3
chr3_+_92223927 0.04 ENSMUST00000061038.4
Sprr2b
small proline-rich protein 2B
chr3_-_133250889 0.03 ENSMUST00000197118.5
Tet2
tet methylcytosine dioxygenase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou3f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:0007412 axon target recognition(GO:0007412)
0.3 5.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.2 0.7 GO:2000041 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.2 2.0 GO:0030916 otic vesicle formation(GO:0030916)
0.2 0.7 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 1.8 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.5 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.1 2.6 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1 0.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.8 GO:0051601 exocyst localization(GO:0051601)
0.0 4.3 GO:0007051 spindle organization(GO:0007051)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.5 GO:0071821 FANCM-MHF complex(GO:0071821)
0.4 2.6 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.8 GO:0000145 exocyst(GO:0000145)
0.0 4.3 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.4 2.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.5 GO:0051373 FATZ binding(GO:0051373)
0.1 0.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling