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GSE58827: Dynamics of the Mouse Liver

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Results for Prdm14

Z-value: 0.42

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Transcription factors associated with Prdm14

Gene Symbol Gene ID Gene Info
Prdm14
ENSMUSG00000042414.8 PR domain containing 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Prdm14mm39_v1_chr1_-_13197387_13197473-0.372.7e-02Click!

Activity profile of Prdm14 motif

Sorted Z-values of Prdm14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_88062508 2.15 ENSMUST00000113134.8
ENSMUST00000140092.8
Ugt1a6a
UDP glucuronosyltransferase 1 family, polypeptide A6A
chr4_+_133280680 2.13 ENSMUST00000042706.3
Nr0b2
nuclear receptor subfamily 0, group B, member 2
chr1_+_88030951 1.97 ENSMUST00000113135.6
ENSMUST00000113138.8
Ugt1a7c
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A7C
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr6_+_54016543 1.92 ENSMUST00000046856.14
Chn2
chimerin 2
chr6_+_72332449 1.65 ENSMUST00000206064.2
Tmem150a
transmembrane protein 150A
chr17_-_35081129 1.40 ENSMUST00000154526.8
Cfb
complement factor B
chr6_+_72332423 1.33 ENSMUST00000069695.9
ENSMUST00000132243.3
Tmem150a
transmembrane protein 150A
chr17_-_35081456 1.32 ENSMUST00000025229.11
ENSMUST00000176203.9
ENSMUST00000128767.8
Cfb
complement factor B
chr6_+_91661074 1.16 ENSMUST00000205480.2
ENSMUST00000206545.2
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr8_+_46945826 1.12 ENSMUST00000110371.8
Acsl1
acyl-CoA synthetase long-chain family member 1
chr6_+_72333209 0.99 ENSMUST00000206531.2
Tmem150a
transmembrane protein 150A
chr17_+_44445659 0.99 ENSMUST00000239215.2
Clic5
chloride intracellular channel 5
chr13_+_74787952 0.94 ENSMUST00000221822.2
ENSMUST00000221526.2
Erap1
endoplasmic reticulum aminopeptidase 1
chr4_+_155646807 0.93 ENSMUST00000030939.14
Nadk
NAD kinase
chr9_+_94551929 0.90 ENSMUST00000033463.10
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr15_-_76191301 0.85 ENSMUST00000171340.9
ENSMUST00000023222.13
ENSMUST00000164189.2
Oplah
5-oxoprolinase (ATP-hydrolysing)
chr6_+_91661034 0.80 ENSMUST00000032185.9
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr14_-_72947422 0.70 ENSMUST00000089017.12
Fndc3a
fibronectin type III domain containing 3A
chrX_+_67805443 0.68 ENSMUST00000069731.12
ENSMUST00000114647.8
Fmr1nb
Fmr1 neighbor
chr9_+_102595628 0.64 ENSMUST00000156485.2
ENSMUST00000145937.2
ENSMUST00000134483.2
ENSMUST00000190047.7
Amotl2
angiomotin-like 2
chr9_+_65102635 0.52 ENSMUST00000216702.2
Parp16
poly (ADP-ribose) polymerase family, member 16
chr6_-_108162513 0.48 ENSMUST00000167338.8
ENSMUST00000172188.2
ENSMUST00000032191.16
Sumf1
sulfatase modifying factor 1
chr6_+_87405968 0.47 ENSMUST00000032125.7
Bmp10
bone morphogenetic protein 10
chr2_-_143853122 0.47 ENSMUST00000016072.12
ENSMUST00000037875.6
Rrbp1
ribosome binding protein 1
chr7_+_114344920 0.41 ENSMUST00000136645.8
ENSMUST00000169913.8
Insc
INSC spindle orientation adaptor protein
chr9_+_4376556 0.40 ENSMUST00000212075.2
Msantd4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chrX_+_98086187 0.38 ENSMUST00000036606.14
Stard8
START domain containing 8
chr2_+_91560472 0.33 ENSMUST00000099712.10
ENSMUST00000111317.9
ENSMUST00000111316.9
ENSMUST00000045705.14
Ambra1
autophagy/beclin 1 regulator 1
chr11_+_3599183 0.31 ENSMUST00000096441.5
Morc2a
microrchidia 2A
chrM_+_7779 0.31 ENSMUST00000082408.1
mt-Atp6
mitochondrially encoded ATP synthase 6
chrX_+_13147209 0.29 ENSMUST00000000804.7
Ddx3x
DEAD box helicase 3, X-linked
chr1_+_191709329 0.24 ENSMUST00000180463.3
ENSMUST00000181512.8
Rd3
retinal degeneration 3
chrX_+_67805497 0.20 ENSMUST00000071848.7
Fmr1nb
Fmr1 neighbor
chr4_+_152358648 0.19 ENSMUST00000105650.8
ENSMUST00000105651.8
Gpr153
G protein-coupled receptor 153
chr1_-_173703424 0.18 ENSMUST00000186442.7
Mndal
myeloid nuclear differentiation antigen like
chr11_+_43046476 0.16 ENSMUST00000238415.2
Atp10b
ATPase, class V, type 10B
chr2_+_128809268 0.14 ENSMUST00000110320.9
ENSMUST00000110319.3
Zc3h6
zinc finger CCCH type containing 6
chr4_+_116983973 0.14 ENSMUST00000134074.8
Dynlt4
dynein light chain Tctex-type 4
chr7_+_18721325 0.14 ENSMUST00000063563.9
Nanos2
nanos C2HC-type zinc finger 2
chr9_-_14815228 0.08 ENSMUST00000034409.14
ENSMUST00000117620.8
Izumo1r
IZUMO1 receptor, JUNO
chr7_+_27510238 0.07 ENSMUST00000080175.7
Zfp626
zinc finger protein 626
chrX_-_93585668 0.06 ENSMUST00000026142.8
Maged1
MAGE family member D1
chr15_+_99499252 0.06 ENSMUST00000230075.2
ENSMUST00000023754.6
Aqp6
aquaporin 6
chr10_-_128579879 0.05 ENSMUST00000026414.9
Dgka
diacylglycerol kinase, alpha
chr4_+_128777339 0.05 ENSMUST00000035667.9
Trim62
tripartite motif-containing 62
chr4_+_116983995 0.05 ENSMUST00000062206.3
Dynlt4
dynein light chain Tctex-type 4
chr18_-_70663382 0.05 ENSMUST00000043286.15
Poli
polymerase (DNA directed), iota
chr15_-_73114855 0.04 ENSMUST00000227686.2
Ptk2
PTK2 protein tyrosine kinase 2
chr4_-_133399909 0.03 ENSMUST00000062118.11
ENSMUST00000067902.13
Pigv
phosphatidylinositol glycan anchor biosynthesis, class V
chr4_+_119671688 0.03 ENSMUST00000106307.9
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr18_-_70663209 0.03 ENSMUST00000161542.8
ENSMUST00000159389.8
Poli
polymerase (DNA directed), iota
chr5_-_38842084 0.03 ENSMUST00000057258.11
ENSMUST00000178760.2
ENSMUST00000179555.8
ENSMUST00000180214.8
Zfp518b
zinc finger protein 518B
chr8_-_93774820 0.02 ENSMUST00000095211.5
Ces1a
carboxylesterase 1A
chr12_+_69939879 0.02 ENSMUST00000021466.10
Atl1
atlastin GTPase 1
chr17_+_27000034 0.02 ENSMUST00000015725.16
ENSMUST00000135824.8
ENSMUST00000137989.2
Bnip1
BCL2/adenovirus E1B interacting protein 1
chr9_-_14815050 0.01 ENSMUST00000148155.2
ENSMUST00000121116.8
Izumo1r
IZUMO1 receptor, JUNO
chr15_-_73579236 0.01 ENSMUST00000064166.5
Gpr20
G protein-coupled receptor 20
chr9_-_14815163 0.01 ENSMUST00000069408.10
Izumo1r
IZUMO1 receptor, JUNO
chr6_-_42437951 0.00 ENSMUST00000090156.2
Olfr458
olfactory receptor 458

Network of associatons between targets according to the STRING database.

First level regulatory network of Prdm14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0006711 estrogen catabolic process(GO:0006711)
0.7 2.0 GO:0015734 beta-alanine transport(GO:0001762) taurine transport(GO:0015734)
0.2 2.1 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 2.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.9 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 4.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.5 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.1 0.9 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.1 GO:0044539 long-chain fatty acid import(GO:0044539)
0.1 0.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.5 GO:0010612 regulation of cardiac muscle adaptation(GO:0010612) positive regulation of sarcomere organization(GO:0060298) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242)
0.0 1.0 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.3 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.7 GO:0060009 Sertoli cell development(GO:0060009)
0.0 2.1 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.1 GO:0044838 cell quiescence(GO:0044838)
0.0 0.6 GO:0035329 hippo signaling(GO:0035329)
0.0 0.3 GO:0098780 response to mitochondrial depolarisation(GO:0098780)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0005368 beta-alanine transmembrane transporter activity(GO:0001761) taurine transmembrane transporter activity(GO:0005368) taurine:sodium symporter activity(GO:0005369)
0.2 1.1 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 4.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.8 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 0.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 2.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.5 GO:0031433 telethonin binding(GO:0031433)
0.0 0.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 1.0 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.7 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.9 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 2.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.5 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 2.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation