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GSE58827: Dynamics of the Mouse Liver

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Results for Prox1

Z-value: 1.07

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Transcription factors associated with Prox1

Gene Symbol Gene ID Gene Info
Prox1
ENSMUSG00000010175.14 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Prox1mm39_v1_chr1_-_189901596_1899017230.048.0e-01Click!

Activity profile of Prox1 motif

Sorted Z-values of Prox1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_137157824 18.08 ENSMUST00000102522.5
Cela3b
chymotrypsin-like elastase family, member 3B
chr14_-_51384236 17.26 ENSMUST00000080126.4
Rnase1
ribonuclease, RNase A family, 1 (pancreatic)
chr19_-_15901919 9.31 ENSMUST00000162053.8
Psat1
phosphoserine aminotransferase 1
chr7_+_141995545 4.71 ENSMUST00000105971.8
ENSMUST00000145287.8
Tnni2
troponin I, skeletal, fast 2
chr4_+_130640611 4.56 ENSMUST00000156225.8
ENSMUST00000156742.8
Laptm5
lysosomal-associated protein transmembrane 5
chr6_-_131365380 4.09 ENSMUST00000032309.13
ENSMUST00000087865.4
Ybx3
Y box protein 3
chr4_-_133694607 4.03 ENSMUST00000105893.8
Hmgn2
high mobility group nucleosomal binding domain 2
chr4_-_137137088 3.66 ENSMUST00000024200.7
Cela3a
chymotrypsin-like elastase family, member 3A
chr4_-_133694543 3.58 ENSMUST00000123234.8
Hmgn2
high mobility group nucleosomal binding domain 2
chr4_+_130640436 3.54 ENSMUST00000151698.8
Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_140428777 3.07 ENSMUST00000138808.8
ENSMUST00000038893.6
Rcc2
regulator of chromosome condensation 2
chr17_-_35827676 3.05 ENSMUST00000160885.2
ENSMUST00000159009.2
ENSMUST00000161012.8
Tcf19
transcription factor 19
chr11_+_4936824 2.93 ENSMUST00000109897.8
ENSMUST00000009234.16
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr19_+_46044972 2.90 ENSMUST00000111899.8
ENSMUST00000099392.10
ENSMUST00000062322.11
Pprc1
peroxisome proliferative activated receptor, gamma, coactivator-related 1
chr2_+_36120438 2.90 ENSMUST00000062069.6
Ptgs1
prostaglandin-endoperoxide synthase 1
chr15_-_86070338 2.84 ENSMUST00000044332.16
Cerk
ceramide kinase
chr17_+_29538157 2.61 ENSMUST00000114699.9
ENSMUST00000155348.3
ENSMUST00000234618.2
Pi16
peptidase inhibitor 16
chr12_+_111409087 2.33 ENSMUST00000109792.8
Tnfaip2
tumor necrosis factor, alpha-induced protein 2
chr5_+_139238089 2.13 ENSMUST00000130326.8
Get4
golgi to ER traffic protein 4
chr2_-_26800581 1.99 ENSMUST00000015920.12
ENSMUST00000139815.2
ENSMUST00000102899.10
Med22
mediator complex subunit 22
chr3_+_153549846 1.75 ENSMUST00000044089.4
Asb17
ankyrin repeat and SOCS box-containing 17
chr14_-_56181993 1.74 ENSMUST00000022834.7
ENSMUST00000226280.2
Cma1
chymase 1, mast cell
chr5_+_139238069 1.74 ENSMUST00000026976.12
Get4
golgi to ER traffic protein 4
chr4_+_132903646 1.72 ENSMUST00000105912.2
Wasf2
WASP family, member 2
chrX_-_73009933 1.70 ENSMUST00000114372.3
ENSMUST00000033761.13
Hcfc1
host cell factor C1
chr17_+_28059129 1.69 ENSMUST00000233657.2
Snrpc
U1 small nuclear ribonucleoprotein C
chr12_-_83534482 1.67 ENSMUST00000177959.8
ENSMUST00000178756.8
Dpf3
D4, zinc and double PHD fingers, family 3
chr19_-_8691797 1.62 ENSMUST00000206797.2
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr7_-_126460820 1.58 ENSMUST00000129812.2
ENSMUST00000106342.8
Ino80e
INO80 complex subunit E
chr8_+_89015705 1.54 ENSMUST00000171456.9
Adcy7
adenylate cyclase 7
chr12_-_40273173 1.44 ENSMUST00000001672.12
Ifrd1
interferon-related developmental regulator 1
chr17_+_28059099 1.42 ENSMUST00000233752.2
Snrpc
U1 small nuclear ribonucleoprotein C
chr8_-_70929555 1.38 ENSMUST00000066597.13
ENSMUST00000210250.2
ENSMUST00000209415.2
ENSMUST00000166976.3
Klhl26
kelch-like 26
chr17_+_28059036 1.30 ENSMUST00000071006.9
Snrpc
U1 small nuclear ribonucleoprotein C
chr19_-_8691220 1.27 ENSMUST00000010239.6
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr18_+_10617773 1.24 ENSMUST00000002551.5
ENSMUST00000234207.2
Snrpd1
small nuclear ribonucleoprotein D1
chr18_-_68562385 1.15 ENSMUST00000052347.8
Mc2r
melanocortin 2 receptor
chr4_+_117692583 1.15 ENSMUST00000169885.8
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr5_-_124492734 1.15 ENSMUST00000031341.11
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr6_+_58617521 1.04 ENSMUST00000145161.8
ENSMUST00000203146.3
ENSMUST00000114294.8
ENSMUST00000204948.2
Abcg2
ATP binding cassette subfamily G member 2 (Junior blood group)
chr8_+_31601837 1.01 ENSMUST00000046941.8
ENSMUST00000217278.2
Rnf122
ring finger protein 122
chr5_+_139197689 0.94 ENSMUST00000148772.8
ENSMUST00000110882.8
Sun1
Sad1 and UNC84 domain containing 1
chr2_+_26800757 0.91 ENSMUST00000102898.5
Rpl7a
ribosomal protein L7A
chr11_-_8614497 0.90 ENSMUST00000020695.13
Tns3
tensin 3
chr3_+_89738654 0.89 ENSMUST00000050401.6
She
src homology 2 domain-containing transforming protein E
chr10_-_80649315 0.89 ENSMUST00000181039.8
ENSMUST00000180438.2
Jsrp1
junctional sarcoplasmic reticulum protein 1
chr5_+_24305577 0.87 ENSMUST00000030841.10
ENSMUST00000163409.5
Klhl7
kelch-like 7
chr6_+_29361408 0.77 ENSMUST00000156163.2
Calu
calumenin
chr7_+_127376267 0.76 ENSMUST00000144406.8
Setd1a
SET domain containing 1A
chr6_+_60921456 0.75 ENSMUST00000129603.4
ENSMUST00000204333.2
Mmrn1
multimerin 1
chr6_-_42350188 0.71 ENSMUST00000073387.5
ENSMUST00000204357.2
Epha1
Eph receptor A1
chr18_-_67378886 0.66 ENSMUST00000073054.5
Mppe1
metallophosphoesterase 1
chr11_-_115824290 0.54 ENSMUST00000021097.10
Recql5
RecQ protein-like 5
chr2_+_109848224 0.49 ENSMUST00000150183.9
Ccdc34
coiled-coil domain containing 34
chr18_+_37864045 0.44 ENSMUST00000192535.2
Pcdhgb5
protocadherin gamma subfamily B, 5
chrX_-_42363663 0.41 ENSMUST00000016294.8
Tenm1
teneurin transmembrane protein 1
chr17_-_83821716 0.36 ENSMUST00000025095.9
ENSMUST00000167741.9
Cox7a2l
cytochrome c oxidase subunit 7A2 like
chr2_-_92290128 0.30 ENSMUST00000067631.7
Slc35c1
solute carrier family 35, member C1
chr2_-_92290054 0.29 ENSMUST00000136718.2
Slc35c1
solute carrier family 35, member C1
chr2_+_26899935 0.27 ENSMUST00000114005.9
ENSMUST00000114004.8
ENSMUST00000114006.8
ENSMUST00000114007.8
ENSMUST00000133807.2
Cacfd1
calcium channel flower domain containing 1
chr9_-_64633865 0.23 ENSMUST00000168366.2
Rab11a
RAB11A, member RAS oncogene family
chr7_+_28416270 0.22 ENSMUST00000108279.9
Fbxo17
F-box protein 17
chr2_+_86128161 0.20 ENSMUST00000054746.5
Olfr1052
olfactory receptor 1052
chr5_+_62968993 0.18 ENSMUST00000238474.2
Dthd1
death domain containing 1
chr7_+_23781311 0.17 ENSMUST00000207002.2
ENSMUST00000068975.6
ENSMUST00000203854.3
Zfp180
zinc finger protein 180
chr1_+_78794475 0.13 ENSMUST00000057262.8
ENSMUST00000187432.2
Kcne4
potassium voltage-gated channel, Isk-related subfamily, gene 4
chr9_+_109760931 0.10 ENSMUST00000165876.8
Map4
microtubule-associated protein 4
chr11_+_115671523 0.03 ENSMUST00000239299.2
Tmem94
transmembrane protein 94

Network of associatons between targets according to the STRING database.

First level regulatory network of Prox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 9.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.0 4.1 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
1.0 3.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.6 2.9 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.6 2.9 GO:0060356 leucine import(GO:0060356)
0.5 4.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.5 3.9 GO:1904378 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.4 1.7 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.4 1.7 GO:0019046 release from viral latency(GO:0019046)
0.4 1.2 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.0 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.2 7.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.2 17.3 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.1 2.6 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.1 2.3 GO:0051601 exocyst localization(GO:0051601)
0.1 0.9 GO:0090292 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.5 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 21.6 GO:0008203 cholesterol metabolic process(GO:0008203)
0.1 1.5 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 5.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 3.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 2.9 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.8 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 1.4 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 1.7 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.0 0.6 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.2 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.0 7.7 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.9 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 2.8 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 1.1 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.0 1.2 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.9 GO:0048286 lung alveolus development(GO:0048286)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.9 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.3 4.5 GO:0000243 commitment complex(GO:0000243)
0.2 4.7 GO:0005861 troponin complex(GO:0005861)
0.1 3.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 2.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 1.7 GO:0031209 SCAR complex(GO:0031209)
0.1 4.1 GO:0005921 gap junction(GO:0005921)
0.1 2.3 GO:0000145 exocyst(GO:0000145)
0.1 0.9 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.6 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.9 GO:0042788 polysomal ribosome(GO:0042788)
0.1 2.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 1.7 GO:0071565 nBAF complex(GO:0071565)
0.0 2.0 GO:0016592 mediator complex(GO:0016592)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 8.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 17.3 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
1.1 4.4 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.9 2.8 GO:0001729 ceramide kinase activity(GO:0001729)
0.5 4.7 GO:0031014 troponin T binding(GO:0031014)
0.2 1.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 1.2 GO:0004977 melanocortin receptor activity(GO:0004977)
0.2 0.8 GO:1990188 euchromatin binding(GO:1990188)
0.1 5.6 GO:0008483 transaminase activity(GO:0008483)
0.1 1.7 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 1.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 1.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 23.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.5 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 2.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 0.9 GO:0043495 protein anchor(GO:0043495)
0.0 1.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 2.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 4.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 3.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 3.4 GO:0051087 chaperone binding(GO:0051087)
0.0 2.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.3 GO:0000149 SNARE binding(GO:0000149)
0.0 0.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 20.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 2.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 5.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 4.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 2.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 2.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 3.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules