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GSE58827: Dynamics of the Mouse Liver

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Results for Relb

Z-value: 0.41

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Transcription factors associated with Relb

Gene Symbol Gene ID Gene Info
Relb
ENSMUSG00000002983.18 avian reticuloendotheliosis viral (v-rel) oncogene related B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Relbmm39_v1_chr7_-_19362328_19362398-0.182.9e-01Click!

Activity profile of Relb motif

Sorted Z-values of Relb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_99276310 2.72 ENSMUST00000178124.3
Tpbgl
trophoblast glycoprotein-like
chr17_-_56312555 2.23 ENSMUST00000043785.8
Stap2
signal transducing adaptor family member 2
chr2_-_5719302 2.01 ENSMUST00000044009.14
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr1_-_171023798 1.72 ENSMUST00000111332.2
Pcp4l1
Purkinje cell protein 4-like 1
chr17_+_56312672 1.68 ENSMUST00000133998.8
Mpnd
MPN domain containing
chr6_-_124718316 1.62 ENSMUST00000004389.6
Grcc10
gene rich cluster, C10 gene
chr14_+_55797934 1.56 ENSMUST00000121622.8
ENSMUST00000143431.2
ENSMUST00000150481.8
Dcaf11
DDB1 and CUL4 associated factor 11
chr15_-_31367872 1.47 ENSMUST00000123325.9
Ankrd33b
ankyrin repeat domain 33B
chr15_-_31367668 1.45 ENSMUST00000110410.10
ENSMUST00000076942.5
Ankrd33b
ankyrin repeat domain 33B
chr15_-_98575332 1.44 ENSMUST00000120997.2
ENSMUST00000109149.9
ENSMUST00000003451.11
Rnd1
Rho family GTPase 1
chr12_+_41074089 1.34 ENSMUST00000132121.8
Immp2l
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr12_+_41074328 1.28 ENSMUST00000134965.8
Immp2l
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr16_-_30086317 1.27 ENSMUST00000064856.9
Cpn2
carboxypeptidase N, polypeptide 2
chr12_+_111132847 1.02 ENSMUST00000021706.11
Traf3
TNF receptor-associated factor 3
chr12_-_54909568 0.99 ENSMUST00000078124.8
Cfl2
cofilin 2, muscle
chr12_+_111132779 0.96 ENSMUST00000117269.8
Traf3
TNF receptor-associated factor 3
chr4_-_116991150 0.89 ENSMUST00000076859.12
Plk3
polo like kinase 3
chr7_+_28466160 0.84 ENSMUST00000122915.8
ENSMUST00000072965.5
ENSMUST00000170068.9
Sirt2
sirtuin 2
chr12_+_111132908 0.77 ENSMUST00000139162.8
ENSMUST00000060274.7
Traf3
TNF receptor-associated factor 3
chr17_+_37504783 0.77 ENSMUST00000038844.7
Ubd
ubiquitin D
chr18_+_53995260 0.74 ENSMUST00000237880.2
Csnk1g3
casein kinase 1, gamma 3
chr12_-_55539372 0.70 ENSMUST00000021413.9
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
chr5_-_121975676 0.69 ENSMUST00000197892.3
Sh2b3
SH2B adaptor protein 3
chr10_+_96452860 0.62 ENSMUST00000038377.9
Btg1
BTG anti-proliferation factor 1
chr18_+_36693024 0.62 ENSMUST00000134146.8
Ankhd1
ankyrin repeat and KH domain containing 1
chr4_-_42168603 0.57 ENSMUST00000098121.4
Gm13305
predicted gene 13305
chr4_-_42665763 0.57 ENSMUST00000238770.2
Il11ra2
interleukin 11 receptor, alpha chain 2
chr7_-_28465870 0.55 ENSMUST00000085851.12
ENSMUST00000032815.11
Nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
chrX_+_162691978 0.54 ENSMUST00000069041.15
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_23720953 0.52 ENSMUST00000102864.5
Rel
reticuloendotheliosis oncogene
chr5_+_91039092 0.47 ENSMUST00000031327.9
Cxcl1
chemokine (C-X-C motif) ligand 1
chr5_-_132570710 0.44 ENSMUST00000182974.9
Auts2
autism susceptibility candidate 2
chr1_+_132996237 0.43 ENSMUST00000239467.2
Pik3c2b
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
chr2_+_59442378 0.42 ENSMUST00000112568.8
ENSMUST00000037526.11
Tanc1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr8_+_47192767 0.42 ENSMUST00000034041.9
ENSMUST00000208507.2
ENSMUST00000207105.2
Irf2
interferon regulatory factor 2
chrX_+_140258381 0.41 ENSMUST00000112931.8
ENSMUST00000112930.8
Col4a5
collagen, type IV, alpha 5
chr10_-_93146937 0.37 ENSMUST00000008542.12
Elk3
ELK3, member of ETS oncogene family
chr16_+_91343936 0.35 ENSMUST00000023687.9
Ifngr2
interferon gamma receptor 2
chr6_+_67873135 0.33 ENSMUST00000103310.3
Igkv14-126
immunoglobulin kappa variable 14-126
chr4_-_82423985 0.33 ENSMUST00000107245.9
ENSMUST00000107246.2
Nfib
nuclear factor I/B
chr5_-_37981919 0.32 ENSMUST00000063116.10
Msx1
msh homeobox 1
chr13_+_83672389 0.32 ENSMUST00000200394.5
Mef2c
myocyte enhancer factor 2C
chr2_+_18677195 0.31 ENSMUST00000171845.8
ENSMUST00000061158.5
Commd3
COMM domain containing 3
chr2_-_160155536 0.30 ENSMUST00000109475.3
Gm826
predicted gene 826
chrX_+_162692126 0.30 ENSMUST00000033734.14
ENSMUST00000112294.9
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr4_-_82423944 0.30 ENSMUST00000107248.8
ENSMUST00000107247.8
Nfib
nuclear factor I/B
chr12_+_102915102 0.29 ENSMUST00000101099.12
Unc79
unc-79 homolog
chr11_+_89921121 0.29 ENSMUST00000092788.4
Tmem100
transmembrane protein 100
chr4_-_91288221 0.29 ENSMUST00000102799.10
Elavl2
ELAV like RNA binding protein 1
chr2_-_5068807 0.29 ENSMUST00000114996.8
Optn
optineurin
chr2_-_34848148 0.28 ENSMUST00000201690.2
ENSMUST00000172159.8
Traf1
TNF receptor-associated factor 1
chr1_+_15357478 0.28 ENSMUST00000175681.3
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr16_-_17711950 0.28 ENSMUST00000155943.9
Dgcr2
DiGeorge syndrome critical region gene 2
chr10_-_127358231 0.27 ENSMUST00000219239.2
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr10_-_127358300 0.25 ENSMUST00000026470.6
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr10_+_102348076 0.24 ENSMUST00000219445.2
Rassf9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr7_-_19363280 0.24 ENSMUST00000094762.10
ENSMUST00000049912.15
ENSMUST00000098754.5
Relb
avian reticuloendotheliosis viral (v-rel) oncogene related B
chr16_+_17712061 0.23 ENSMUST00000046937.4
Tssk1
testis-specific serine kinase 1
chr10_-_93146825 0.23 ENSMUST00000151153.2
Elk3
ELK3, member of ETS oncogene family
chr14_-_55828511 0.21 ENSMUST00000161807.8
ENSMUST00000111378.10
ENSMUST00000159687.2
Psme2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_-_26917921 0.20 ENSMUST00000102890.11
ENSMUST00000153388.2
ENSMUST00000045702.6
Slc2a6
solute carrier family 2 (facilitated glucose transporter), member 6
chr2_-_5068743 0.20 ENSMUST00000027986.5
Optn
optineurin
chrX_+_102365004 0.20 ENSMUST00000033689.3
Cdx4
caudal type homeobox 4
chr4_+_126156118 0.20 ENSMUST00000030660.9
Trappc3
trafficking protein particle complex 3
chr17_-_71153283 0.19 ENSMUST00000156484.2
Tgif1
TGFB-induced factor homeobox 1
chr6_+_39848367 0.19 ENSMUST00000239008.2
Tmem178b
transmembrane protein 178B
chr7_-_70010341 0.19 ENSMUST00000032768.15
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr1_+_192984278 0.19 ENSMUST00000016315.16
Lamb3
laminin, beta 3
chr16_-_18052937 0.17 ENSMUST00000076957.7
Zdhhc8
zinc finger, DHHC domain containing 8
chr8_+_47192911 0.16 ENSMUST00000208433.2
Irf2
interferon regulatory factor 2
chr2_-_118377500 0.15 ENSMUST00000125860.3
Bmf
BCL2 modifying factor
chr1_-_135186176 0.15 ENSMUST00000185752.2
ENSMUST00000003135.14
Elf3
E74-like factor 3
chr14_+_55170152 0.14 ENSMUST00000037863.6
Il25
interleukin 25
chr16_+_88525719 0.14 ENSMUST00000060494.8
Krtap13-1
keratin associated protein 13-1
chr18_-_20247666 0.14 ENSMUST00000224432.2
Dsc1
desmocollin 1
chr4_-_40239778 0.14 ENSMUST00000037907.13
Ddx58
DEAD/H box helicase 58
chr14_-_10185787 0.14 ENSMUST00000225871.2
Gm49355
predicted gene, 49355
chr17_-_57456633 0.13 ENSMUST00000019633.8
Cd70
CD70 antigen
chr19_+_46293160 0.12 ENSMUST00000073116.13
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr19_+_45003304 0.08 ENSMUST00000039016.14
Lzts2
leucine zipper, putative tumor suppressor 2
chr11_+_102775991 0.07 ENSMUST00000100369.4
Fam187a
family with sequence similarity 187, member A
chr8_+_106075475 0.07 ENSMUST00000073149.7
Slc9a5
solute carrier family 9 (sodium/hydrogen exchanger), member 5
chr7_+_43112644 0.07 ENSMUST00000203769.2
Vsig10l
V-set and immunoglobulin domain containing 10 like
chr9_-_77452109 0.06 ENSMUST00000183734.2
Lrrc1
leucine rich repeat containing 1
chr4_+_129713991 0.06 ENSMUST00000030578.14
Ptp4a2
protein tyrosine phosphatase 4a2
chr6_-_69920632 0.06 ENSMUST00000198880.5
ENSMUST00000103371.3
Igkv12-38
immunoglobulin kappa chain variable 12-38
chr10_-_18891095 0.05 ENSMUST00000019997.11
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr4_-_148584906 0.05 ENSMUST00000030840.4
Angptl7
angiopoietin-like 7
chr17_+_34129221 0.04 ENSMUST00000174541.9
Daxx
Fas death domain-associated protein
chr4_+_151012375 0.04 ENSMUST00000139826.8
ENSMUST00000116257.8
Tnfrsf9
tumor necrosis factor receptor superfamily, member 9
chr2_+_119803180 0.03 ENSMUST00000066058.8
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr15_-_79048674 0.03 ENSMUST00000230261.2
ENSMUST00000040019.5
Sox10
SRY (sex determining region Y)-box 10
chr1_+_74830675 0.02 ENSMUST00000006718.15
Wnt10a
wingless-type MMTV integration site family, member 10A
chr6_+_68547717 0.01 ENSMUST00000196839.5
ENSMUST00000103327.3
Igkv12-98
immunoglobulin kappa variable 12-98
chr14_+_53878403 0.01 ENSMUST00000184874.2
Trav14-2
T cell receptor alpha variable 14-2
chrX_-_133012457 0.00 ENSMUST00000159259.3
ENSMUST00000113275.10
Nox1
NADPH oxidase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Relb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0061300 cerebellum vasculature development(GO:0061300)
0.6 1.7 GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.3 1.6 GO:0036343 psychomotor behavior(GO:0036343)
0.2 2.7 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 2.0 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.2 1.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 0.5 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.2 1.0 GO:0030043 actin filament fragmentation(GO:0030043)
0.2 0.5 GO:0070947 neutrophil mediated killing of fungus(GO:0070947)
0.2 0.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.3 GO:2001055 positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.1 0.4 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.5 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.6 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.8 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.4 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.2 GO:1904093 regulation of autophagic cell death(GO:1904092) negative regulation of autophagic cell death(GO:1904093)
0.0 0.2 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.8 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.3 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:0009624 response to nematode(GO:0009624)
0.0 0.3 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.1 GO:0070429 regulation of granuloma formation(GO:0002631) negative regulation of granuloma formation(GO:0002632) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429)
0.0 0.4 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.7 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.2 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.8 GO:0036465 synaptic vesicle recycling(GO:0036465)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.2 2.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.8 GO:0033010 paranodal junction(GO:0033010)
0.1 0.4 GO:0098645 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.5 GO:0070552 BRISC complex(GO:0070552)
0.0 1.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.2 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.8 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.2 3.0 GO:0031996 thioesterase binding(GO:0031996)
0.2 0.5 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372)
0.1 0.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.5 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.3 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 2.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.4 GO:0035005 lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 2.6 GO:0008236 serine-type peptidase activity(GO:0008236)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID FOXO PATHWAY FoxO family signaling
0.0 0.4 PID IL23 PATHWAY IL23-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 1.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 0.7 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 0.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.3 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters