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GSE58827: Dynamics of the Mouse Liver

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Results for Rfx5

Z-value: 0.78

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Transcription factors associated with Rfx5

Gene Symbol Gene ID Gene Info
Rfx5
ENSMUSG00000005774.13 regulatory factor X, 5 (influences HLA class II expression)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx5mm39_v1_chr3_+_94861386_948615370.241.7e-01Click!

Activity profile of Rfx5 motif

Sorted Z-values of Rfx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_28453374 6.89 ENSMUST00000028161.6
Cel
carboxyl ester lipase
chr17_+_34524841 4.17 ENSMUST00000235530.2
H2-Eb1
histocompatibility 2, class II antigen E beta
chr18_+_60936910 4.15 ENSMUST00000097563.9
ENSMUST00000050487.16
ENSMUST00000167610.2
Cd74
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
chr17_+_34524884 3.98 ENSMUST00000074557.11
H2-Eb1
histocompatibility 2, class II antigen E beta
chr17_+_34482183 3.65 ENSMUST00000040828.7
ENSMUST00000237342.2
ENSMUST00000237866.2
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr5_-_145816774 3.58 ENSMUST00000035918.8
Cyp3a11
cytochrome P450, family 3, subfamily a, polypeptide 11
chr1_+_88139678 3.51 ENSMUST00000073049.7
Ugt1a1
UDP glucuronosyltransferase 1 family, polypeptide A1
chr17_+_34416707 2.99 ENSMUST00000025196.9
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
chr17_+_34372046 2.80 ENSMUST00000114232.4
H2-DMb1
histocompatibility 2, class II, locus Mb1
chr17_+_34406523 2.71 ENSMUST00000170086.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34406762 2.70 ENSMUST00000041633.15
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34416689 2.68 ENSMUST00000173441.9
Psmb8
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
chr17_-_34406193 2.22 ENSMUST00000173831.3
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr17_+_34354556 1.78 ENSMUST00000236322.2
ENSMUST00000237402.2
H2-DMa
histocompatibility 2, class II, locus DMa
chr17_+_35598583 1.70 ENSMUST00000081435.5
H2-Q4
histocompatibility 2, Q region locus 4
chr17_-_34219225 1.45 ENSMUST00000238098.2
ENSMUST00000087189.7
ENSMUST00000173075.3
ENSMUST00000172912.8
ENSMUST00000236740.2
ENSMUST00000025181.18
H2-K1
histocompatibility 2, K1, K region
chr11_+_115054157 1.28 ENSMUST00000021077.4
Slc9a3r1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr17_+_37581103 1.27 ENSMUST00000038580.7
H2-M3
histocompatibility 2, M region locus 3
chr9_+_44684285 1.19 ENSMUST00000239014.2
Ift46
intraflagellar transport 46
chr5_-_125371162 1.16 ENSMUST00000127148.2
Scarb1
scavenger receptor class B, member 1
chr9_+_44684206 1.10 ENSMUST00000002099.11
Ift46
intraflagellar transport 46
chr17_+_34457868 1.09 ENSMUST00000095342.11
ENSMUST00000167280.8
ENSMUST00000236838.2
H2-Ob
histocompatibility 2, O region beta locus
chr9_+_44684248 1.01 ENSMUST00000128150.8
Ift46
intraflagellar transport 46
chr9_+_44684450 1.00 ENSMUST00000238800.2
ENSMUST00000147559.8
Ift46
intraflagellar transport 46
chr10_-_78143384 1.00 ENSMUST00000150828.2
ENSMUST00000239481.2
Agpat3
ENSMUSG00000118646.2
1-acylglycerol-3-phosphate O-acyltransferase 3
chr17_+_35658131 0.99 ENSMUST00000071951.14
ENSMUST00000116598.10
ENSMUST00000078205.14
ENSMUST00000076256.8
H2-Q7
histocompatibility 2, Q region locus 7
chr17_+_25105617 0.91 ENSMUST00000117890.8
ENSMUST00000168265.8
ENSMUST00000120943.8
ENSMUST00000068508.13
ENSMUST00000119829.8
Spsb3
splA/ryanodine receptor domain and SOCS box containing 3
chr9_+_44684324 0.87 ENSMUST00000214854.3
ENSMUST00000125877.8
Ift46
intraflagellar transport 46
chr17_+_34364206 0.72 ENSMUST00000041982.9
ENSMUST00000171231.8
H2-DMb2
histocompatibility 2, class II, locus Mb2
chr2_-_92264374 0.68 ENSMUST00000111278.2
ENSMUST00000090559.12
Cry2
cryptochrome 2 (photolyase-like)
chr6_+_94477294 0.63 ENSMUST00000061118.11
Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr7_+_44926925 0.61 ENSMUST00000210861.2
Slc6a21
solute carrier family 6 member 21
chr7_+_101027390 0.59 ENSMUST00000084895.12
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr5_-_140346132 0.55 ENSMUST00000196130.5
Snx8
sorting nexin 8
chr8_+_27532583 0.55 ENSMUST00000033875.10
ENSMUST00000209525.2
Plpbp
pyridoxal phosphate binding protein
chr8_+_27532623 0.47 ENSMUST00000209856.2
ENSMUST00000098851.12
ENSMUST00000211393.2
ENSMUST00000211518.2
Plpbp
pyridoxal phosphate binding protein
chr2_+_121978156 0.46 ENSMUST00000102476.5
B2m
beta-2 microglobulin
chr5_-_36987917 0.44 ENSMUST00000031002.10
Man2b2
mannosidase 2, alpha B2
chr7_-_44741138 0.43 ENSMUST00000210527.2
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr17_+_36172210 0.36 ENSMUST00000074259.15
ENSMUST00000174873.2
Nrm
nurim (nuclear envelope membrane protein)
chr5_-_134485081 0.30 ENSMUST00000111244.5
Gtf2ird1
general transcription factor II I repeat domain-containing 1
chr3_-_95789505 0.28 ENSMUST00000159863.2
ENSMUST00000159739.8
ENSMUST00000036418.10
ENSMUST00000161866.8
Ciart
circadian associated repressor of transcription
chr3_-_95789338 0.27 ENSMUST00000161994.2
Ciart
circadian associated repressor of transcription
chr11_+_61395964 0.27 ENSMUST00000102657.10
B9d1
B9 protein domain 1
chr7_-_45343785 0.17 ENSMUST00000040636.9
Sec1
secretory blood group 1
chr7_-_101570382 0.15 ENSMUST00000098236.9
Lrrc51
leucine rich repeat containing 51
chr3_-_57599956 0.13 ENSMUST00000238789.2
ENSMUST00000197088.5
ENSMUST00000099091.4
Ankub1
ankrin repeat and ubiquitin domain containing 1
chr5_+_104318542 0.12 ENSMUST00000112771.2
Dspp
dentin sialophosphoprotein
chr10_+_90665270 0.11 ENSMUST00000182202.8
ENSMUST00000182966.8
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_-_101570393 0.10 ENSMUST00000106965.8
ENSMUST00000106968.8
ENSMUST00000106967.8
Lrrc51
leucine rich repeat containing 51
chr10_-_128579879 0.08 ENSMUST00000026414.9
Dgka
diacylglycerol kinase, alpha
chr7_+_100186259 0.07 ENSMUST00000054310.4
Coa4
cytochrome c oxidase assembly factor 4
chr7_+_46490899 0.07 ENSMUST00000147535.8
Ldha
lactate dehydrogenase A
chr1_+_194302123 0.07 ENSMUST00000027952.12
Plxna2
plexin A2
chr17_+_36172235 0.05 ENSMUST00000172931.2
Nrm
nurim (nuclear envelope membrane protein)
chr10_+_90665399 0.04 ENSMUST00000179694.9
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr10_-_7539333 0.04 ENSMUST00000162606.8
Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
chr8_-_105236506 0.03 ENSMUST00000064576.8
Terb1
telomere repeat binding bouquet formation protein 1
chr14_+_111912529 0.02 ENSMUST00000042767.9
Slitrk5
SLIT and NTRK-like family, member 5
chr1_+_133279647 0.02 ENSMUST00000112287.2
Ren1
renin 1 structural
chr4_+_137989783 0.01 ENSMUST00000105821.3
Kif17
kinesin family member 17
chrX_+_111150171 0.00 ENSMUST00000164272.3
ENSMUST00000132037.2
4933403O08Rik
RIKEN cDNA 4933403O08 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0046967 cytosol to ER transport(GO:0046967)
1.2 3.6 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
1.2 3.5 GO:0018879 biphenyl metabolic process(GO:0018879)
0.9 17.6 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.9 1.7 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.5 1.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.5 8.1 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.4 1.3 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416)
0.4 1.4 GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.2 0.7 GO:2000850 negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.2 4.9 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.2 0.6 GO:0051182 coenzyme transport(GO:0051182)
0.1 10.0 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.6 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.0 0.6 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.6 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 22.3 GO:0042613 MHC class II protein complex(GO:0042613)
1.3 7.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.7 5.4 GO:0042825 TAP complex(GO:0042825)
0.4 5.8 GO:0042611 MHC protein complex(GO:0042611)
0.2 3.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 6.9 GO:0042588 zymogen granule(GO:0042588)
0.1 5.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 2.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.4 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0030904 retromer complex(GO:0030904)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.9 GO:0050253 sterol esterase activity(GO:0004771) retinyl-palmitate esterase activity(GO:0050253)
1.8 5.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.7 4.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.4 3.6 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.3 1.3 GO:0045159 myosin II binding(GO:0045159)
0.3 7.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 1.2 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.3 4.1 GO:0046977 TAP binding(GO:0046977)
0.3 6.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 3.6 GO:1990405 protein antigen binding(GO:1990405)
0.1 3.5 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.6 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.2 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.1 0.7 GO:0009881 photoreceptor activity(GO:0009881)
0.0 1.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.7 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.6 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.4 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 1.0 GO:0030170 pyridoxal phosphate binding(GO:0030170)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 5.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.3 PID TXA2PATHWAY Thromboxane A2 receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 5.9 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 7.8 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.2 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 1.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression