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GSE58827: Dynamics of the Mouse Liver

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Results for Six3_Six1_Six2

Z-value: 0.57

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Transcription factors associated with Six3_Six1_Six2

Gene Symbol Gene ID Gene Info
Six3
ENSMUSG00000038805.11 sine oculis-related homeobox 3
Six1
ENSMUSG00000051367.9 sine oculis-related homeobox 1
Six2
ENSMUSG00000024134.12 sine oculis-related homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six2mm39_v1_chr17_-_85995680_859957030.251.3e-01Click!
Six3mm39_v1_chr17_+_85928459_859284690.231.8e-01Click!
Six1mm39_v1_chr12_-_73093953_730939530.192.6e-01Click!

Activity profile of Six3_Six1_Six2 motif

Sorted Z-values of Six3_Six1_Six2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_117688486 14.38 ENSMUST00000106331.2
6030468B19Rik
RIKEN cDNA 6030468B19 gene
chr9_+_110856425 5.19 ENSMUST00000199313.2
Ltf
lactotransferrin
chr3_-_37778470 3.50 ENSMUST00000108105.2
ENSMUST00000079755.5
ENSMUST00000099128.2
Gm5148
predicted gene 5148
chr17_+_41121979 3.08 ENSMUST00000024721.8
ENSMUST00000233740.2
Rhag
Rhesus blood group-associated A glycoprotein
chr7_+_89814713 2.54 ENSMUST00000207084.2
Picalm
phosphatidylinositol binding clathrin assembly protein
chrX_-_141749704 2.46 ENSMUST00000041317.3
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr6_+_123099615 2.41 ENSMUST00000161636.8
ENSMUST00000161365.8
Clec4a2
C-type lectin domain family 4, member a2
chr14_+_56003406 2.34 ENSMUST00000057569.4
Ltb4r1
leukotriene B4 receptor 1
chr17_+_35460722 2.20 ENSMUST00000068056.12
ENSMUST00000174757.8
ENSMUST00000173731.8
Ddx39b
DEAD box helicase 39b
chr6_+_123100382 1.78 ENSMUST00000032248.8
Clec4a2
C-type lectin domain family 4, member a2
chr6_+_123100272 1.70 ENSMUST00000041779.13
Clec4a2
C-type lectin domain family 4, member a2
chr1_+_139382485 1.70 ENSMUST00000200083.5
ENSMUST00000053364.12
Aspm
abnormal spindle microtubule assembly
chr9_+_98305014 1.53 ENSMUST00000052068.11
Rbp1
retinol binding protein 1, cellular
chr15_-_82128888 1.41 ENSMUST00000089155.6
ENSMUST00000089157.11
Cenpm
centromere protein M
chr15_-_103218876 1.22 ENSMUST00000079824.6
Gpr84
G protein-coupled receptor 84
chrX_-_73416824 1.22 ENSMUST00000178691.2
ENSMUST00000114146.8
Ubl4a
Slc10a3
ubiquitin-like 4A
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr19_-_38032006 1.20 ENSMUST00000172095.3
ENSMUST00000041475.16
Myof
myoferlin
chr3_+_32760447 1.19 ENSMUST00000194781.6
Actl6a
actin-like 6A
chrX_-_73416869 1.11 ENSMUST00000073067.11
ENSMUST00000037967.6
Slc10a3
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr1_+_136395673 1.06 ENSMUST00000189413.7
ENSMUST00000047817.12
Kif14
kinesin family member 14
chr10_-_81463631 1.05 ENSMUST00000042923.9
Sirt6
sirtuin 6
chr8_+_95720864 1.04 ENSMUST00000212141.2
Adgrg1
adhesion G protein-coupled receptor G1
chr2_+_127178072 0.98 ENSMUST00000028846.7
Dusp2
dual specificity phosphatase 2
chr7_-_79765042 0.95 ENSMUST00000206714.2
ENSMUST00000107384.10
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr7_-_100504610 0.92 ENSMUST00000156855.8
Relt
RELT tumor necrosis factor receptor
chr2_-_88534814 0.87 ENSMUST00000216928.2
ENSMUST00000216977.2
Olfr1196
olfactory receptor 1196
chr12_-_114252202 0.87 ENSMUST00000195124.6
ENSMUST00000103481.3
Ighv3-6
immunoglobulin heavy variable 3-6
chr19_-_38031774 0.84 ENSMUST00000226068.2
Myof
myoferlin
chr2_+_31135813 0.70 ENSMUST00000000199.8
Ncs1
neuronal calcium sensor 1
chr13_+_104365880 0.67 ENSMUST00000022227.8
Cenpk
centromere protein K
chr5_+_140593075 0.66 ENSMUST00000031555.3
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_+_79048884 0.62 ENSMUST00000137667.3
Fanci
Fanconi anemia, complementation group I
chr15_+_101152078 0.56 ENSMUST00000228985.2
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr17_-_53846438 0.55 ENSMUST00000056198.4
Pp2d1
protein phosphatase 2C-like domain containing 1
chr8_+_57908920 0.54 ENSMUST00000034023.4
Scrg1
scrapie responsive gene 1
chr17_+_36176485 0.52 ENSMUST00000127442.8
ENSMUST00000144382.8
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr5_+_21748523 0.51 ENSMUST00000035651.6
Lrrc17
leucine rich repeat containing 17
chr15_+_82136598 0.51 ENSMUST00000136948.3
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr12_-_113589576 0.49 ENSMUST00000103446.2
Ighv5-6
immunoglobulin heavy variable 5-6
chrX_+_168468186 0.48 ENSMUST00000112107.8
ENSMUST00000112104.8
Mid1
midline 1
chr6_-_119925387 0.48 ENSMUST00000162541.8
Wnk1
WNK lysine deficient protein kinase 1
chr2_-_13276074 0.46 ENSMUST00000137670.3
ENSMUST00000114791.9
Rsu1
Ras suppressor protein 1
chr2_-_13276205 0.45 ENSMUST00000191959.6
ENSMUST00000028059.9
Rsu1
Ras suppressor protein 1
chr8_-_4325886 0.44 ENSMUST00000003029.14
Timm44
translocase of inner mitochondrial membrane 44
chr2_+_106523532 0.41 ENSMUST00000111063.8
Mpped2
metallophosphoesterase domain containing 2
chr6_-_120893771 0.41 ENSMUST00000004560.12
Bid
BH3 interacting domain death agonist
chr19_+_46329552 0.39 ENSMUST00000128041.8
Mfsd13a
major facilitator superfamily domain containing 13a
chr2_-_118859821 0.38 ENSMUST00000110833.2
ENSMUST00000036470.14
ENSMUST00000110834.8
Ccdc32
coiled-coil domain containing 32
chr8_+_70285282 0.38 ENSMUST00000131637.9
Pbx4
pre B cell leukemia homeobox 4
chr7_-_101552989 0.37 ENSMUST00000106969.9
Tomt
transmembrane O-methyltransferase
chr7_-_104991477 0.37 ENSMUST00000213290.2
Olfr691
olfactory receptor 691
chr11_-_99121822 0.34 ENSMUST00000103133.4
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr8_+_85558151 0.34 ENSMUST00000036734.6
Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr2_+_117080212 0.34 ENSMUST00000028825.5
Fam98b
family with sequence similarity 98, member B
chr4_+_132903646 0.31 ENSMUST00000105912.2
Wasf2
WASP family, member 2
chr4_+_11758147 0.30 ENSMUST00000029871.12
ENSMUST00000108303.2
Cdh17
cadherin 17
chr9_-_119170456 0.29 ENSMUST00000139870.2
Myd88
myeloid differentiation primary response gene 88
chr2_+_86128161 0.26 ENSMUST00000054746.5
Olfr1052
olfactory receptor 1052
chr17_-_35978438 0.26 ENSMUST00000043674.15
Vars2
valyl-tRNA synthetase 2, mitochondrial
chr8_+_70285133 0.25 ENSMUST00000081503.13
Pbx4
pre B cell leukemia homeobox 4
chr7_-_103778992 0.25 ENSMUST00000053743.6
Ubqln5
ubiquilin 5
chr19_-_5452521 0.24 ENSMUST00000235569.2
Tsga10ip
testis specific 10 interacting protein
chr6_-_69741999 0.23 ENSMUST00000103365.3
Igkv12-46
immunoglobulin kappa variable 12-46
chr6_-_57827328 0.22 ENSMUST00000203310.3
ENSMUST00000203488.3
Vmn1r21
vomeronasal 1 receptor 21
chr9_+_106099797 0.22 ENSMUST00000062241.11
Tlr9
toll-like receptor 9
chr14_+_58035640 0.22 ENSMUST00000111269.2
Sap18
Sin3-associated polypeptide 18
chr9_+_38725910 0.22 ENSMUST00000213164.2
Olfr922
olfactory receptor 922
chr1_-_65162267 0.22 ENSMUST00000050047.4
ENSMUST00000148020.8
D630023F18Rik
RIKEN cDNA D630023F18 gene
chr18_+_37840092 0.21 ENSMUST00000195823.2
Pcdhga6
protocadherin gamma subfamily A, 6
chr2_-_89408791 0.20 ENSMUST00000217402.2
Olfr1245
olfactory receptor 1245
chr16_-_18052937 0.19 ENSMUST00000076957.7
Zdhhc8
zinc finger, DHHC domain containing 8
chr9_+_65048454 0.18 ENSMUST00000034961.6
ENSMUST00000217371.2
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr10_-_128016135 0.14 ENSMUST00000238843.2
ENSMUST00000099139.9
Rbms2
RNA binding motif, single stranded interacting protein 2
chr8_-_87611849 0.14 ENSMUST00000034074.8
N4bp1
NEDD4 binding protein 1
chr11_+_101877876 0.11 ENSMUST00000010985.8
Cfap97d1
CFAP97 domain containing 1
chr12_-_75596441 0.11 ENSMUST00000218716.2
Ppp2r5e
protein phosphatase 2, regulatory subunit B', epsilon
chr14_+_51181956 0.11 ENSMUST00000178092.2
ENSMUST00000227052.2
Pnp
Gm49342
purine-nucleoside phosphorylase
predicted gene, 49342
chr18_+_89224219 0.09 ENSMUST00000236835.2
Cd226
CD226 antigen
chr6_-_57306479 0.09 ENSMUST00000227283.2
ENSMUST00000228356.2
Vmn1r16
vomeronasal 1 receptor 16
chr14_+_54440591 0.07 ENSMUST00000103725.2
Traj16
T cell receptor alpha joining 16
chr19_+_9824919 0.07 ENSMUST00000179814.3
Scgb2a2
secretoglobin, family 2A, member 2
chr2_+_157870399 0.06 ENSMUST00000103123.10
Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr17_+_47221377 0.04 ENSMUST00000024773.6
Prph2
peripherin 2
chr1_+_40305738 0.04 ENSMUST00000114795.3
Il1r1
interleukin 1 receptor, type I
chr7_-_102507962 0.03 ENSMUST00000213481.2
ENSMUST00000209952.2
Olfr566
olfactory receptor 566
chr11_+_49379915 0.03 ENSMUST00000214948.2
Olfr1385
olfactory receptor 1385
chr13_+_94219934 0.02 ENSMUST00000156071.2
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr6_-_120893725 0.02 ENSMUST00000145948.2
Bid
BH3 interacting domain death agonist
chr4_-_32950812 0.01 ENSMUST00000084750.8
ENSMUST00000084748.9
Ankrd6
ankyrin repeat domain 6
chr6_+_90246088 0.01 ENSMUST00000058039.3
Vmn1r54
vomeronasal 1 receptor 54
chr9_+_38686470 0.01 ENSMUST00000071681.4
Olfr921
olfactory receptor 921
chr12_-_114451189 0.01 ENSMUST00000103493.3
Ighv1-4
immunoglobulin heavy variable 1-4

Network of associatons between targets according to the STRING database.

First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0051673 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) membrane disruption in other organism(GO:0051673) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.8 3.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.5 1.5 GO:0033189 response to vitamin A(GO:0033189)
0.4 2.5 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.4 1.1 GO:0021693 cerebellar Purkinje cell layer structural organization(GO:0021693)
0.3 1.0 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.3 0.9 GO:1904464 regulation of matrix metallopeptidase secretion(GO:1904464) matrix metallopeptidase secretion(GO:1990773)
0.3 2.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 1.7 GO:0051661 maintenance of centrosome location(GO:0051661)
0.2 0.7 GO:0007386 compartment pattern specification(GO:0007386)
0.1 1.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 2.0 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.5 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.1 0.6 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.2 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
0.1 0.3 GO:0072566 chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.1 0.5 GO:0048539 bone marrow development(GO:0048539)
0.1 0.1 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.0 0.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.4 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.3 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 1.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 2.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.8 GO:0001706 endoderm formation(GO:0001706)
0.0 0.1 GO:0060369 positive regulation of natural killer cell cytokine production(GO:0002729) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.9 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 7.2 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.0 GO:0010286 heat acclimation(GO:0010286)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.2 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.4 2.5 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.2 2.2 GO:0005687 U4 snRNP(GO:0005687)
0.1 1.7 GO:0072687 meiotic spindle(GO:0072687)
0.1 1.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 1.0 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 1.0 GO:0097451 glial limiting end-foot(GO:0097451)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0036019 endolysosome(GO:0036019)
0.0 0.7 GO:0031045 dense core granule(GO:0031045)
0.0 0.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 1.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.1 GO:0000776 kinetochore(GO:0000776)
0.0 1.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.9 GO:0005901 caveola(GO:0005901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.4 2.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.3 1.0 GO:0032129 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.3 2.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 0.9 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.2 0.7 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 1.2 GO:0004966 galanin receptor activity(GO:0004966)
0.2 2.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 5.2 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 3.1 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.1 0.4 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 1.5 GO:0019841 retinol binding(GO:0019841)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.3 GO:0070976 TIR domain binding(GO:0070976)
0.1 1.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 5.8 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.0 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID MYC PATHWAY C-MYC pathway
0.0 1.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.5 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 3.1 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 2.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.6 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation