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GSE58827: Dynamics of the Mouse Liver

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Results for Smad2

Z-value: 0.41

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Transcription factors associated with Smad2

Gene Symbol Gene ID Gene Info
Smad2
ENSMUSG00000024563.17 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad2mm39_v1_chr18_+_76375206_763752450.372.5e-02Click!

Activity profile of Smad2 motif

Sorted Z-values of Smad2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_30639217 4.63 ENSMUST00000031806.10
Cpa1
carboxypeptidase A1, pancreatic
chr7_+_19144950 2.61 ENSMUST00000208710.2
ENSMUST00000003643.3
Ckm
creatine kinase, muscle
chr7_-_126062272 2.37 ENSMUST00000032974.13
Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr15_-_101833160 0.75 ENSMUST00000023797.8
Krt4
keratin 4
chr1_-_172125555 0.66 ENSMUST00000085913.11
ENSMUST00000097464.4
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr2_-_148285450 0.56 ENSMUST00000099269.4
Cd93
CD93 antigen
chr3_-_116762617 0.50 ENSMUST00000143611.2
ENSMUST00000040097.14
Palmd
palmdelphin
chr2_+_38229270 0.42 ENSMUST00000143783.9
Lhx2
LIM homeobox protein 2
chr5_-_113938417 0.38 ENSMUST00000160374.2
ENSMUST00000067853.6
Tmem119
transmembrane protein 119
chr2_+_173918715 0.35 ENSMUST00000087908.10
ENSMUST00000044638.13
ENSMUST00000156054.2
Stx16
syntaxin 16
chr7_+_24069680 0.35 ENSMUST00000205428.2
ENSMUST00000171904.3
ENSMUST00000205626.2
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr11_+_63022328 0.34 ENSMUST00000018361.10
Pmp22
peripheral myelin protein 22
chr17_-_46343291 0.33 ENSMUST00000071648.12
ENSMUST00000142351.9
Vegfa
vascular endothelial growth factor A
chr3_-_116762476 0.33 ENSMUST00000119557.8
Palmd
palmdelphin
chr7_+_142030744 0.30 ENSMUST00000149521.8
Lsp1
lymphocyte specific 1
chr6_-_142647985 0.29 ENSMUST00000205202.3
ENSMUST00000073173.12
ENSMUST00000111771.8
Abcc9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr7_-_44702269 0.27 ENSMUST00000057293.8
Prr12
proline rich 12
chr3_-_75864195 0.27 ENSMUST00000038563.14
ENSMUST00000167078.8
ENSMUST00000117242.8
Golim4
golgi integral membrane protein 4
chr4_-_126057263 0.27 ENSMUST00000097891.4
Sh3d21
SH3 domain containing 21
chr4_-_126056412 0.26 ENSMUST00000094760.9
Sh3d21
SH3 domain containing 21
chr10_-_37014859 0.24 ENSMUST00000092584.6
Marcks
myristoylated alanine rich protein kinase C substrate
chr9_-_65487322 0.23 ENSMUST00000068944.9
Plekho2
pleckstrin homology domain containing, family O member 2
chr3_+_87878378 0.23 ENSMUST00000090973.12
Nes
nestin
chr6_-_124733441 0.22 ENSMUST00000088357.12
Atn1
atrophin 1
chr3_+_87878436 0.22 ENSMUST00000160694.2
Nes
nestin
chr12_-_103304573 0.19 ENSMUST00000149431.2
Asb2
ankyrin repeat and SOCS box-containing 2
chr16_+_18166045 0.18 ENSMUST00000239533.1
ENSMUST00000239534.1
ARVCF
armadillo repeat deleted in velocardiofacial syndrome
chr16_-_18165876 0.18 ENSMUST00000125287.9
Tango2
transport and golgi organization 2
chr17_+_36176485 0.17 ENSMUST00000127442.8
ENSMUST00000144382.8
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr1_-_150868802 0.17 ENSMUST00000074783.12
ENSMUST00000137197.9
Hmcn1
hemicentin 1
chr16_-_17540805 0.17 ENSMUST00000012259.9
ENSMUST00000232236.2
Med15
mediator complex subunit 15
chr3_+_135144481 0.17 ENSMUST00000199582.5
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr6_-_142647944 0.16 ENSMUST00000100827.5
ENSMUST00000087527.11
Abcc9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr11_+_69737437 0.16 ENSMUST00000152566.8
ENSMUST00000108633.9
Plscr3
phospholipid scramblase 3
chr7_-_99276310 0.15 ENSMUST00000178124.3
Tpbgl
trophoblast glycoprotein-like
chrX_-_20797736 0.15 ENSMUST00000001156.8
Cfp
complement factor properdin
chr6_-_90758954 0.14 ENSMUST00000238821.2
Iqsec1
IQ motif and Sec7 domain 1
chr11_+_69737491 0.14 ENSMUST00000019605.4
Plscr3
phospholipid scramblase 3
chr6_+_54016543 0.13 ENSMUST00000046856.14
Chn2
chimerin 2
chr17_+_36176948 0.12 ENSMUST00000122899.8
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr17_-_36291087 0.12 ENSMUST00000055454.14
Prr3
proline-rich polypeptide 3
chr12_+_80837284 0.12 ENSMUST00000220238.2
ENSMUST00000068519.7
Susd6
sushi domain containing 6
chr7_+_28151370 0.12 ENSMUST00000190954.7
Lrfn1
leucine rich repeat and fibronectin type III domain containing 1
chr9_+_35332837 0.11 ENSMUST00000119129.10
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr10_-_5019044 0.11 ENSMUST00000095899.5
Syne1
spectrin repeat containing, nuclear envelope 1
chr18_+_37847792 0.10 ENSMUST00000192511.2
ENSMUST00000193476.2
Pcdhga7
protocadherin gamma subfamily A, 7
chr9_+_123307758 0.10 ENSMUST00000026269.4
Limd1
LIM domains containing 1
chr1_-_173195236 0.08 ENSMUST00000005470.5
ENSMUST00000111220.8
Cadm3
cell adhesion molecule 3
chr11_-_96720738 0.07 ENSMUST00000107657.8
ENSMUST00000081775.12
Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chr3_+_135144287 0.07 ENSMUST00000196591.5
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr17_-_26080429 0.06 ENSMUST00000079461.15
ENSMUST00000176923.9
Wdr90
WD repeat domain 90
chr4_-_94940425 0.06 ENSMUST00000107094.2
Jun
jun proto-oncogene
chr13_-_100240570 0.05 ENSMUST00000038104.12
Bdp1
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr5_-_146521629 0.04 ENSMUST00000200112.2
ENSMUST00000197431.2
ENSMUST00000197825.2
Gpr12
G-protein coupled receptor 12
chr8_-_69636825 0.04 ENSMUST00000185176.8
Lzts1
leucine zipper, putative tumor suppressor 1
chr7_-_26928029 0.03 ENSMUST00000003850.8
Itpkc
inositol 1,4,5-trisphosphate 3-kinase C
chr13_-_104953370 0.02 ENSMUST00000022228.13
Cwc27
CWC27 spliceosome-associated protein
chr5_+_115769960 0.01 ENSMUST00000031492.15
Rab35
RAB35, member RAS oncogene family
chr13_-_104953631 0.01 ENSMUST00000154165.2
Cwc27
CWC27 spliceosome-associated protein
chr1_-_160079007 0.01 ENSMUST00000191909.6
Rabgap1l
RAB GTPase activating protein 1-like
chr17_-_34834938 0.00 ENSMUST00000097345.10
ENSMUST00000015611.14
Egfl8
EGF-like domain 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0090076 maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)
0.2 0.7 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 0.3 GO:0038190 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190)
0.0 0.4 GO:1903012 positive regulation of bone development(GO:1903012)
0.0 2.6 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.0 0.2 GO:0009405 pathogenesis(GO:0009405)
0.0 0.4 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.3 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.3 GO:0032060 bleb assembly(GO:0032060)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0031673 H zone(GO:0031673)
0.1 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.8 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)
0.0 0.3 GO:0043218 compact myelin(GO:0043218)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0004111 creatine kinase activity(GO:0004111)
0.2 2.4 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 4.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.3 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.7 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239)
0.0 0.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.0 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 2.7 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases