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GSE58827: Dynamics of the Mouse Liver

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Results for Sox1

Z-value: 0.60

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Transcription factors associated with Sox1

Gene Symbol Gene ID Gene Info
Sox1
ENSMUSG00000096014.2 SRY (sex determining region Y)-box 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox1mm39_v1_chr8_+_12445287_124452950.029.1e-01Click!

Activity profile of Sox1 motif

Sorted Z-values of Sox1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_13357892 7.48 ENSMUST00000108525.4
Sult2a5
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5
chr19_-_8196196 2.89 ENSMUST00000113298.9
Slc22a29
solute carrier family 22. member 29
chr17_-_34506744 2.60 ENSMUST00000174751.2
ENSMUST00000040655.14
H2-Aa
histocompatibility 2, class II antigen A, alpha
chr17_+_34482183 2.57 ENSMUST00000040828.7
ENSMUST00000237342.2
ENSMUST00000237866.2
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr6_+_37507108 1.94 ENSMUST00000040987.11
Akr1d1
aldo-keto reductase family 1, member D1
chr7_-_13856967 1.82 ENSMUST00000098809.4
Sult2a3
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
chr5_+_21391282 1.82 ENSMUST00000036031.13
ENSMUST00000198937.2
Gsap
gamma-secretase activating protein
chr14_-_30645711 1.74 ENSMUST00000006697.17
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr7_+_67305162 1.74 ENSMUST00000107470.2
Ttc23
tetratricopeptide repeat domain 23
chr5_+_21942139 1.51 ENSMUST00000030882.12
Pmpcb
peptidase (mitochondrial processing) beta
chr14_-_30645503 1.43 ENSMUST00000227995.2
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
chr10_-_125225298 1.30 ENSMUST00000210780.2
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr15_-_74869684 0.97 ENSMUST00000190188.2
ENSMUST00000189068.7
ENSMUST00000186526.7
ENSMUST00000187171.2
ENSMUST00000187994.7
Ly6a
lymphocyte antigen 6 complex, locus A
chr13_+_42454922 0.89 ENSMUST00000021796.9
Edn1
endothelin 1
chr15_-_74869483 0.86 ENSMUST00000023248.13
Ly6a
lymphocyte antigen 6 complex, locus A
chr9_+_123921573 0.85 ENSMUST00000111442.3
ENSMUST00000171499.3
Ccr5
chemokine (C-C motif) receptor 5
chr16_-_37474772 0.76 ENSMUST00000023514.4
Ndufb4
NADH:ubiquinone oxidoreductase subunit B4
chr1_-_194813631 0.70 ENSMUST00000194111.6
ENSMUST00000193094.6
Cr1l
complement component (3b/4b) receptor 1-like
chr6_+_121160626 0.62 ENSMUST00000118234.8
ENSMUST00000088561.10
ENSMUST00000137432.8
ENSMUST00000120066.8
Pex26
peroxisomal biogenesis factor 26
chr9_-_108183140 0.59 ENSMUST00000195615.2
Tcta
T cell leukemia translocation altered gene
chr12_+_52144511 0.53 ENSMUST00000040090.16
Nubpl
nucleotide binding protein-like
chr8_+_13209141 0.53 ENSMUST00000033824.8
Lamp1
lysosomal-associated membrane protein 1
chr1_-_194813843 0.49 ENSMUST00000075451.12
ENSMUST00000191775.2
Cr1l
complement component (3b/4b) receptor 1-like
chr2_+_34296783 0.46 ENSMUST00000149383.8
ENSMUST00000124443.8
ENSMUST00000141253.2
ENSMUST00000113124.8
Mapkap1
mitogen-activated protein kinase associated protein 1
chr13_-_112788890 0.45 ENSMUST00000099166.10
Ddx4
DEAD box helicase 4
chr2_-_84481058 0.39 ENSMUST00000111670.9
ENSMUST00000111697.9
ENSMUST00000111696.8
ENSMUST00000111678.8
ENSMUST00000111690.8
ENSMUST00000111695.8
ENSMUST00000111677.8
ENSMUST00000111698.8
ENSMUST00000099941.9
ENSMUST00000111676.8
ENSMUST00000111694.8
ENSMUST00000111675.8
ENSMUST00000111689.8
ENSMUST00000111687.8
ENSMUST00000111692.8
ENSMUST00000111685.8
ENSMUST00000111686.8
ENSMUST00000111688.8
ENSMUST00000111693.8
ENSMUST00000111684.8
Ctnnd1
catenin (cadherin associated protein), delta 1
chr13_-_112788829 0.39 ENSMUST00000075748.7
Ddx4
DEAD box helicase 4
chr19_+_18818001 0.37 ENSMUST00000237020.2
Trpm6
transient receptor potential cation channel, subfamily M, member 6
chr7_+_79992839 0.36 ENSMUST00000032747.7
ENSMUST00000206480.2
ENSMUST00000206074.2
ENSMUST00000206122.2
Hddc3
HD domain containing 3
chr4_-_120604445 0.35 ENSMUST00000030376.8
Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr2_-_84481101 0.34 ENSMUST00000111691.2
Ctnnd1
catenin (cadherin associated protein), delta 1
chr6_+_117818135 0.31 ENSMUST00000112859.8
ENSMUST00000137224.8
ENSMUST00000164472.8
ENSMUST00000112861.8
ENSMUST00000223041.2
Zfp637
zinc finger protein 637
chr11_+_96024612 0.31 ENSMUST00000167258.8
Ttll6
tubulin tyrosine ligase-like family, member 6
chr6_+_114625771 0.26 ENSMUST00000182510.8
Atg7
autophagy related 7
chr15_+_81511486 0.21 ENSMUST00000206833.2
Ep300
E1A binding protein p300
chr11_+_96025045 0.20 ENSMUST00000107680.2
Ttll6
tubulin tyrosine ligase-like family, member 6
chr17_-_48003391 0.18 ENSMUST00000113300.8
Prickle4
prickle planar cell polarity protein 4
chr10_+_84591919 0.16 ENSMUST00000060397.13
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr1_-_173703424 0.14 ENSMUST00000186442.7
Mndal
myeloid nuclear differentiation antigen like
chr7_-_127490139 0.14 ENSMUST00000205300.2
ENSMUST00000121394.3
Prss53
protease, serine 53
chr7_+_119289249 0.13 ENSMUST00000047045.10
Acsm4
acyl-CoA synthetase medium-chain family member 4
chr7_-_46569617 0.13 ENSMUST00000210664.2
ENSMUST00000156335.9
Tsg101
tumor susceptibility gene 101
chr7_-_103710652 0.12 ENSMUST00000074064.5
4930516K23Rik
RIKEN cDNA 4930516K23 gene
chr17_-_29162794 0.12 ENSMUST00000232977.2
Pxt1
peroxisomal, testis specific 1
chr1_+_171723231 0.10 ENSMUST00000097466.3
Gm10521
predicted gene 10521
chr18_+_37630044 0.10 ENSMUST00000059571.7
Pcdhb19
protocadherin beta 19
chr16_+_8500694 0.09 ENSMUST00000202157.2
Gm5767
predicted gene 5767
chr19_-_8382424 0.05 ENSMUST00000064507.12
ENSMUST00000120540.2
ENSMUST00000096269.11
Slc22a30
solute carrier family 22, member 30
chr2_+_87185159 0.04 ENSMUST00000215163.3
Olfr1120
olfactory receptor 1120
chr9_+_44238089 0.04 ENSMUST00000054708.5
Dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr5_-_129747129 0.02 ENSMUST00000049778.7
Zfp11
zinc finger protein 11
chrX_+_111510223 0.01 ENSMUST00000113409.8
Zfp711
zinc finger protein 711

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0002344 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.6 1.9 GO:0030573 bile acid catabolic process(GO:0030573)
0.3 0.9 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 2.9 GO:0015747 urate transport(GO:0015747)
0.2 1.3 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.2 0.5 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.2 0.8 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.1 2.6 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1 0.7 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.1 1.2 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.1 1.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 1.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.6 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.1 0.5 GO:0051013 microtubule severing(GO:0051013)
0.1 0.2 GO:0014737 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) positive regulation of muscle atrophy(GO:0014737)
0.1 3.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.5 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 0.3 GO:0034727 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521) amino acid homeostasis(GO:0080144) negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis(GO:0090157)
0.1 0.4 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.6 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.8 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 1.3 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.1 GO:2000397 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 0.5 GO:0061474 phagolysosome membrane(GO:0061474)
0.1 0.8 GO:0071547 piP-body(GO:0071547)
0.1 1.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.7 GO:0005915 zonula adherens(GO:0005915)
0.0 0.5 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.8 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.3 GO:0050656 alcohol sulfotransferase activity(GO:0004027) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.4 1.9 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.2 0.9 GO:0031708 endothelin B receptor binding(GO:0031708)
0.2 1.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 2.8 GO:1990405 protein antigen binding(GO:1990405)
0.2 2.9 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 2.6 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.3 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.1 0.8 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.5 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 1.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 3.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 0.5 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.8 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.1 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 1.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport