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GSE58827: Dynamics of the Mouse Liver

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Results for Sox30

Z-value: 0.58

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Transcription factors associated with Sox30

Gene Symbol Gene ID Gene Info
Sox30
ENSMUSG00000040489.6 SRY (sex determining region Y)-box 30

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox30mm39_v1_chr11_+_45871135_458711640.183.0e-01Click!

Activity profile of Sox30 motif

Sorted Z-values of Sox30 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_113198765 5.08 ENSMUST00000179568.3
Amy2a4
amylase 2a4
chr17_-_31363245 3.22 ENSMUST00000024826.8
Tff2
trefoil factor 2 (spasmolytic protein 1)
chr6_-_136899167 2.72 ENSMUST00000032343.7
Erp27
endoplasmic reticulum protein 27
chr19_+_44282113 2.68 ENSMUST00000026221.7
Scd2
stearoyl-Coenzyme A desaturase 2
chr7_+_43874752 2.15 ENSMUST00000075162.5
Klk1
kallikrein 1
chr4_-_119047202 2.03 ENSMUST00000239029.2
ENSMUST00000138395.9
ENSMUST00000156746.3
Ermap
erythroblast membrane-associated protein
chr4_-_119047167 1.68 ENSMUST00000030396.15
Ermap
erythroblast membrane-associated protein
chrX_+_92698469 1.67 ENSMUST00000113933.9
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr4_-_119047146 1.31 ENSMUST00000124626.9
Ermap
erythroblast membrane-associated protein
chr4_-_119047180 1.28 ENSMUST00000150864.3
ENSMUST00000141227.9
Ermap
erythroblast membrane-associated protein
chr1_+_135656885 1.21 ENSMUST00000027677.8
Csrp1
cysteine and glycine-rich protein 1
chr5_+_146769700 1.14 ENSMUST00000035983.12
Rpl21
ribosomal protein L21
chr6_-_136758716 1.11 ENSMUST00000078095.11
ENSMUST00000032338.10
Gucy2c
guanylate cyclase 2c
chr9_-_103357564 1.07 ENSMUST00000124310.5
Bfsp2
beaded filament structural protein 2, phakinin
chr10_-_62628008 1.04 ENSMUST00000217768.2
ENSMUST00000020268.7
ENSMUST00000218946.2
ENSMUST00000219527.2
Ccar1
cell division cycle and apoptosis regulator 1
chr14_+_117162791 0.96 ENSMUST00000088483.10
Gpc6
glypican 6
chr3_-_102871440 0.95 ENSMUST00000058899.13
Nr1h5
nuclear receptor subfamily 1, group H, member 5
chr17_-_79662514 0.84 ENSMUST00000068958.9
Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr5_-_137101108 0.81 ENSMUST00000077523.4
ENSMUST00000041388.11
Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
chr19_+_34194990 0.77 ENSMUST00000119603.2
Stambpl1
STAM binding protein like 1
chr2_-_84652890 0.66 ENSMUST00000028471.6
Smtnl1
smoothelin-like 1
chr4_+_109200225 0.63 ENSMUST00000030281.12
Eps15
epidermal growth factor receptor pathway substrate 15
chr6_-_87312743 0.61 ENSMUST00000042025.12
ENSMUST00000205033.2
Antxr1
anthrax toxin receptor 1
chr3_+_90383425 0.59 ENSMUST00000001042.10
Ilf2
interleukin enhancer binding factor 2
chr11_+_3933699 0.55 ENSMUST00000063004.14
Gal3st1
galactose-3-O-sulfotransferase 1
chr10_+_96453408 0.52 ENSMUST00000218953.2
Btg1
BTG anti-proliferation factor 1
chr11_+_3933636 0.51 ENSMUST00000078757.8
Gal3st1
galactose-3-O-sulfotransferase 1
chr4_-_116263183 0.48 ENSMUST00000123072.8
ENSMUST00000144281.2
Mast2
microtubule associated serine/threonine kinase 2
chr19_-_24454720 0.45 ENSMUST00000099556.2
Fam122a
family with sequence similarity 122, member A
chr11_-_99134885 0.42 ENSMUST00000103132.10
ENSMUST00000038214.7
Krt222
keratin 222
chr1_-_176641607 0.37 ENSMUST00000195717.6
ENSMUST00000192961.6
Cep170
centrosomal protein 170
chr10_+_17672004 0.37 ENSMUST00000037964.7
Txlnb
taxilin beta
chr18_-_68562385 0.36 ENSMUST00000052347.8
Mc2r
melanocortin 2 receptor
chr10_-_37014859 0.34 ENSMUST00000092584.6
Marcks
myristoylated alanine rich protein kinase C substrate
chr9_-_72019053 0.34 ENSMUST00000183492.8
ENSMUST00000184523.8
ENSMUST00000034755.13
Tcf12
transcription factor 12
chr9_-_72019109 0.34 ENSMUST00000183404.8
ENSMUST00000184783.8
Tcf12
transcription factor 12
chr6_-_24168082 0.31 ENSMUST00000031713.9
Slc13a1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr1_+_38037086 0.30 ENSMUST00000027252.8
Eif5b
eukaryotic translation initiation factor 5B
chr3_-_9029097 0.30 ENSMUST00000091354.12
ENSMUST00000094381.11
Tpd52
tumor protein D52
chr3_-_9898713 0.27 ENSMUST00000161949.8
Pag1
phosphoprotein associated with glycosphingolipid microdomains 1
chr9_-_72018453 0.25 ENSMUST00000183992.8
Tcf12
transcription factor 12
chr5_+_139197689 0.24 ENSMUST00000148772.8
ENSMUST00000110882.8
Sun1
Sad1 and UNC84 domain containing 1
chr13_-_43632368 0.24 ENSMUST00000222651.2
Ranbp9
RAN binding protein 9
chr1_-_151376544 0.23 ENSMUST00000187991.2
ENSMUST00000187048.7
ENSMUST00000186415.7
Rnf2
ring finger protein 2
chr9_+_7764042 0.23 ENSMUST00000052865.16
Tmem123
transmembrane protein 123
chr12_-_99849660 0.23 ENSMUST00000221929.2
ENSMUST00000046485.5
Efcab11
EF-hand calcium binding domain 11
chr11_+_21041291 0.22 ENSMUST00000093290.12
Peli1
pellino 1
chr2_+_3115250 0.22 ENSMUST00000072955.12
Fam171a1
family with sequence similarity 171, member A1
chr8_-_86281946 0.21 ENSMUST00000034138.7
Dnaja2
DnaJ heat shock protein family (Hsp40) member A2
chr2_+_127750978 0.20 ENSMUST00000110344.2
Acoxl
acyl-Coenzyme A oxidase-like
chr18_-_88945571 0.18 ENSMUST00000147313.2
Socs6
suppressor of cytokine signaling 6
chr19_-_56810593 0.17 ENSMUST00000118592.8
Ccdc186
coiled-coil domain containing 186
chr9_+_39985125 0.16 ENSMUST00000054051.5
Olfr982
olfactory receptor 982
chr6_-_12749192 0.16 ENSMUST00000172356.8
Thsd7a
thrombospondin, type I, domain containing 7A
chr9_+_111014254 0.16 ENSMUST00000198986.2
Lrrfip2
leucine rich repeat (in FLII) interacting protein 2
chr11_-_106606076 0.15 ENSMUST00000080853.11
ENSMUST00000183610.8
ENSMUST00000103069.10
ENSMUST00000106796.9
Pecam1
platelet/endothelial cell adhesion molecule 1
chr9_-_60418286 0.15 ENSMUST00000098660.10
Thsd4
thrombospondin, type I, domain containing 4
chr17_-_34337446 0.12 ENSMUST00000095347.13
Brd2
bromodomain containing 2
chr9_-_19968858 0.12 ENSMUST00000216538.2
ENSMUST00000212098.3
Olfr867
olfactory receptor 867
chr11_-_106605772 0.12 ENSMUST00000124958.3
Pecam1
platelet/endothelial cell adhesion molecule 1
chr9_+_7571397 0.11 ENSMUST00000120900.8
ENSMUST00000151853.8
ENSMUST00000152878.3
Mmp27
matrix metallopeptidase 27
chr5_-_136275407 0.11 ENSMUST00000196245.2
Sh2b2
SH2B adaptor protein 2
chr6_-_129449739 0.10 ENSMUST00000112076.9
ENSMUST00000184581.3
Clec7a
C-type lectin domain family 7, member a
chr9_-_72018933 0.09 ENSMUST00000185117.8
Tcf12
transcription factor 12
chr4_+_109092610 0.09 ENSMUST00000106628.8
Calr4
calreticulin 4
chr4_+_136011969 0.09 ENSMUST00000144217.8
Zfp46
zinc finger protein 46
chr3_-_9898676 0.08 ENSMUST00000108384.9
Pag1
phosphoprotein associated with glycosphingolipid microdomains 1
chr11_-_58521327 0.07 ENSMUST00000214132.2
Olfr323
olfactory receptor 323
chr2_-_119617985 0.06 ENSMUST00000110793.8
ENSMUST00000099529.9
ENSMUST00000048493.12
Rpap1
RNA polymerase II associated protein 1
chr4_+_109092459 0.06 ENSMUST00000106631.9
Calr4
calreticulin 4
chr18_+_37875135 0.06 ENSMUST00000003599.9
Pcdhgb6
protocadherin gamma subfamily B, 6
chr2_-_181240921 0.06 ENSMUST00000060173.9
Samd10
sterile alpha motif domain containing 10
chr17_+_53786240 0.06 ENSMUST00000017975.7
Rab5a
RAB5A, member RAS oncogene family
chr14_-_19873839 0.06 ENSMUST00000022341.7
Rtraf
RNA transcription, translation and transport factor
chr11_-_116572116 0.06 ENSMUST00000144398.2
St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr18_+_37858753 0.05 ENSMUST00000066149.9
Pcdhga8
protocadherin gamma subfamily A, 8
chr18_+_37130860 0.04 ENSMUST00000115659.6
Pcdha9
protocadherin alpha 9
chr11_+_51152546 0.04 ENSMUST00000130641.8
Clk4
CDC like kinase 4
chr4_+_83335947 0.04 ENSMUST00000030206.10
ENSMUST00000071544.11
Snapc3
small nuclear RNA activating complex, polypeptide 3
chr7_+_43661592 0.03 ENSMUST00000048945.6
Klk1b26
kallikrein 1-related petidase b26
chr5_+_102992873 0.03 ENSMUST00000070000.6
Arhgap24
Rho GTPase activating protein 24
chr6_-_12749409 0.03 ENSMUST00000119581.7
Thsd7a
thrombospondin, type I, domain containing 7A
chr4_-_73869071 0.02 ENSMUST00000095023.2
ENSMUST00000030101.4
2310002L09Rik
RIKEN cDNA 2310002L09 gene
chr18_+_37610858 0.02 ENSMUST00000051442.7
Pcdhb16
protocadherin beta 16
chr2_+_85545763 0.02 ENSMUST00000216443.3
Olfr1009
olfactory receptor 1009
chr11_+_67128843 0.01 ENSMUST00000018632.11
Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr4_-_114991478 0.01 ENSMUST00000106545.8
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox30

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.4 2.7 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3 0.8 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 1.1 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.3 GO:0090673 endothelial cell-matrix adhesion(GO:0090673)
0.1 1.1 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.5 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.6 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.1 0.8 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.2 GO:0043578 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.6 GO:1905050 positive regulation of metallopeptidase activity(GO:1905050)
0.0 0.5 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.2 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.0 0.2 GO:0035660 MyD88-dependent toll-like receptor 4 signaling pathway(GO:0035660)
0.0 0.1 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 1.1 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 1.7 GO:0001541 ovarian follicle development(GO:0001541)
0.0 0.7 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.0 0.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.2 GO:0070527 platelet aggregation(GO:0070527)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.0 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0031430 M band(GO:0031430)
0.0 1.5 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.1 GO:0004556 alpha-amylase activity(GO:0004556)
0.4 2.7 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.4 1.7 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3 1.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.2 3.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.4 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 1.1 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.5 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 2.1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.2 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 1.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.6 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions