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GSE58827: Dynamics of the Mouse Liver

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Results for Sox4

Z-value: 1.19

Motif logo

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Transcription factors associated with Sox4

Gene Symbol Gene ID Gene Info
Sox4
ENSMUSG00000076431.5 SRY (sex determining region Y)-box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox4mm39_v1_chr13_-_29137673_291376960.539.3e-04Click!

Activity profile of Sox4 motif

Sorted Z-values of Sox4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_114914880 13.53 ENSMUST00000161601.8
Tal1
T cell acute lymphocytic leukemia 1
chrX_+_72683020 13.31 ENSMUST00000019701.9
Dusp9
dual specificity phosphatase 9
chr7_-_103502404 12.51 ENSMUST00000033229.5
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr17_+_12338161 8.18 ENSMUST00000024594.9
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr7_-_100164007 7.58 ENSMUST00000207405.2
Dnajb13
DnaJ heat shock protein family (Hsp40) member B13
chr8_+_85696695 6.60 ENSMUST00000164807.2
Prdx2
peroxiredoxin 2
chr13_+_117356808 6.54 ENSMUST00000022242.9
Emb
embigin
chr12_+_24758724 5.96 ENSMUST00000153058.8
Rrm2
ribonucleotide reductase M2
chr8_+_85696453 5.87 ENSMUST00000125893.8
Prdx2
peroxiredoxin 2
chr8_+_85696396 5.84 ENSMUST00000109733.8
Prdx2
peroxiredoxin 2
chr9_-_103357564 5.59 ENSMUST00000124310.5
Bfsp2
beaded filament structural protein 2, phakinin
chr17_-_79662514 5.40 ENSMUST00000068958.9
Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr8_+_95720864 5.30 ENSMUST00000212141.2
Adgrg1
adhesion G protein-coupled receptor G1
chr12_+_24758968 5.23 ENSMUST00000154588.2
Rrm2
ribonucleotide reductase M2
chr16_+_16964801 5.18 ENSMUST00000232479.2
ENSMUST00000232344.2
ENSMUST00000069064.7
Ydjc
YdjC homolog (bacterial)
chr8_+_95721019 5.12 ENSMUST00000212976.2
ENSMUST00000212995.2
Adgrg1
adhesion G protein-coupled receptor G1
chr17_+_29712008 5.03 ENSMUST00000234665.2
Pim1
proviral integration site 1
chr8_+_95721378 4.82 ENSMUST00000212956.2
ENSMUST00000212531.2
Adgrg1
adhesion G protein-coupled receptor G1
chr5_+_110987839 4.53 ENSMUST00000200172.2
ENSMUST00000066160.3
Chek2
checkpoint kinase 2
chr7_-_143102792 4.33 ENSMUST00000072727.7
ENSMUST00000207948.2
ENSMUST00000208190.2
Nap1l4
nucleosome assembly protein 1-like 4
chr15_+_76131020 4.30 ENSMUST00000229380.2
Grina
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr15_-_79169671 4.24 ENSMUST00000170955.2
ENSMUST00000165408.8
Baiap2l2
BAI1-associated protein 2-like 2
chr9_-_110886306 4.05 ENSMUST00000195968.2
ENSMUST00000111888.3
Ccrl2
chemokine (C-C motif) receptor-like 2
chr11_+_69737437 3.70 ENSMUST00000152566.8
ENSMUST00000108633.9
Plscr3
phospholipid scramblase 3
chr11_+_69737491 3.63 ENSMUST00000019605.4
Plscr3
phospholipid scramblase 3
chr11_+_69737200 3.38 ENSMUST00000108632.8
Plscr3
phospholipid scramblase 3
chrX_-_144288071 3.37 ENSMUST00000112835.8
ENSMUST00000143610.3
Amot
angiomotin
chr19_-_7218512 3.37 ENSMUST00000025675.11
Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr6_-_47571901 3.25 ENSMUST00000081721.13
ENSMUST00000114618.8
ENSMUST00000114616.8
Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr12_+_24881582 3.07 ENSMUST00000221952.2
ENSMUST00000078902.8
ENSMUST00000110942.11
Mboat2
membrane bound O-acyltransferase domain containing 2
chr8_-_4309257 3.05 ENSMUST00000053252.9
Ctxn1
cortexin 1
chr11_-_106050927 3.03 ENSMUST00000045923.10
Limd2
LIM domain containing 2
chr11_+_101333238 2.99 ENSMUST00000107249.8
Rpl27
ribosomal protein L27
chr4_+_129407374 2.90 ENSMUST00000062356.7
Marcksl1
MARCKS-like 1
chr11_+_121128042 2.88 ENSMUST00000103015.4
Narf
nuclear prelamin A recognition factor
chrX_+_70600481 2.85 ENSMUST00000123100.2
Hmgb3
high mobility group box 3
chr6_+_71684846 2.75 ENSMUST00000212792.2
Reep1
receptor accessory protein 1
chr19_-_46315543 2.70 ENSMUST00000223917.2
ENSMUST00000224447.2
ENSMUST00000041391.5
ENSMUST00000096029.12
Psd
pleckstrin and Sec7 domain containing
chr11_+_45946800 2.69 ENSMUST00000011400.8
Adam19
a disintegrin and metallopeptidase domain 19 (meltrin beta)
chr1_-_79838897 2.63 ENSMUST00000190724.2
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr11_+_101333115 2.57 ENSMUST00000077856.13
Rpl27
ribosomal protein L27
chrX_+_162873183 2.57 ENSMUST00000015545.10
Cltrn
collectrin, amino acid transport regulator
chr13_+_21365308 2.56 ENSMUST00000221464.2
Trim27
tripartite motif-containing 27
chr12_-_75678092 2.54 ENSMUST00000238938.2
Rplp2-ps1
ribosomal protein, large P2, pseudogene 1
chr7_-_143102524 2.50 ENSMUST00000208093.2
ENSMUST00000209098.2
Nap1l4
nucleosome assembly protein 1-like 4
chr15_+_76130947 2.42 ENSMUST00000229772.2
ENSMUST00000230347.2
ENSMUST00000023225.8
Grina
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr10_-_116899664 2.39 ENSMUST00000218719.2
ENSMUST00000219573.2
ENSMUST00000047672.9
Cct2
chaperonin containing Tcp1, subunit 2 (beta)
chrX_+_158623460 2.37 ENSMUST00000112451.8
ENSMUST00000112453.9
Sh3kbp1
SH3-domain kinase binding protein 1
chr6_-_16898440 2.31 ENSMUST00000031533.11
Tfec
transcription factor EC
chr19_+_7394951 2.31 ENSMUST00000159348.3
2700081O15Rik
RIKEN cDNA 2700081O15 gene
chr1_-_55066629 2.27 ENSMUST00000027127.14
Sf3b1
splicing factor 3b, subunit 1
chr1_-_153363354 2.24 ENSMUST00000186380.7
ENSMUST00000188345.2
ENSMUST00000042141.12
Dhx9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr3_-_95041246 2.21 ENSMUST00000172572.9
ENSMUST00000173462.3
Scnm1
sodium channel modifier 1
chr16_-_90841360 2.21 ENSMUST00000118522.8
Paxbp1
PAX3 and PAX7 binding protein 1
chr7_-_126831803 2.11 ENSMUST00000133913.8
Septin1
septin 1
chr3_-_143910926 2.10 ENSMUST00000120539.8
ENSMUST00000196264.5
Lmo4
LIM domain only 4
chr5_+_25452342 2.05 ENSMUST00000114950.2
Galnt11
polypeptide N-acetylgalactosaminyltransferase 11
chr7_+_44866095 1.88 ENSMUST00000209437.2
Tead2
TEA domain family member 2
chr12_-_110662723 1.86 ENSMUST00000021698.13
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr3_+_89072096 1.83 ENSMUST00000121212.9
ENSMUST00000152205.5
ENSMUST00000090927.12
ENSMUST00000148265.8
ENSMUST00000121931.8
Clk2
CDC-like kinase 2
chr12_-_110662677 1.77 ENSMUST00000124156.8
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr7_+_121818692 1.76 ENSMUST00000033152.5
Chp2
calcineurin-like EF hand protein 2
chr7_-_110681402 1.60 ENSMUST00000159305.2
Eif4g2
eukaryotic translation initiation factor 4, gamma 2
chr12_-_111638722 1.58 ENSMUST00000001304.9
Ckb
creatine kinase, brain
chr17_+_75312520 1.58 ENSMUST00000234490.2
ENSMUST00000001927.12
Ltbp1
latent transforming growth factor beta binding protein 1
chr1_-_36982747 1.53 ENSMUST00000185964.3
Tmem131
transmembrane protein 131
chr6_+_71684872 1.49 ENSMUST00000212631.2
Reep1
receptor accessory protein 1
chr16_-_18885809 1.49 ENSMUST00000200211.2
Iglj3
immunoglobulin lambda joining 3
chr13_-_59930059 1.43 ENSMUST00000225581.2
Gm49354
predicted gene, 49354
chr2_-_165740864 1.38 ENSMUST00000136842.2
Zmynd8
zinc finger, MYND-type containing 8
chr1_-_131127825 1.34 ENSMUST00000068564.15
Rassf5
Ras association (RalGDS/AF-6) domain family member 5
chr14_-_61283911 1.25 ENSMUST00000111234.10
ENSMUST00000224371.2
Tnfrsf19
tumor necrosis factor receptor superfamily, member 19
chr5_+_122534900 1.25 ENSMUST00000196969.5
Arpc3
actin related protein 2/3 complex, subunit 3
chr8_-_85696040 1.20 ENSMUST00000214133.2
ENSMUST00000147812.8
Gm49661
Rnaseh2a
predicted gene, 49661
ribonuclease H2, large subunit
chr18_+_82572595 1.16 ENSMUST00000152071.9
ENSMUST00000142850.9
ENSMUST00000080658.12
ENSMUST00000133193.9
ENSMUST00000123251.9
ENSMUST00000153478.9
ENSMUST00000075372.13
ENSMUST00000102812.12
ENSMUST00000062446.15
ENSMUST00000114674.11
ENSMUST00000132369.3
Mbp
myelin basic protein
chr12_-_81827893 1.15 ENSMUST00000035987.9
Map3k9
mitogen-activated protein kinase kinase kinase 9
chr12_-_79343040 1.12 ENSMUST00000218377.2
ENSMUST00000021547.8
Zfyve26
zinc finger, FYVE domain containing 26
chr1_+_31215482 1.02 ENSMUST00000062560.14
Lgsn
lengsin, lens protein with glutamine synthetase domain
chr11_-_115704447 0.93 ENSMUST00000041684.11
ENSMUST00000156812.2
Caskin2
CASK-interacting protein 2
chr1_-_36596598 0.93 ENSMUST00000191642.6
ENSMUST00000193382.6
ENSMUST00000195620.6
Sema4c
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr3_+_146205562 0.93 ENSMUST00000090031.12
ENSMUST00000118280.2
Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr15_-_44291699 0.88 ENSMUST00000038719.8
Nudcd1
NudC domain containing 1
chr2_-_26854283 0.84 ENSMUST00000136710.2
ENSMUST00000064244.11
ENSMUST00000114020.10
Rexo4
REX4, 3'-5' exonuclease
chr5_-_136227760 0.81 ENSMUST00000149151.2
ENSMUST00000151786.8
Prkrip1
Prkr interacting protein 1 (IL11 inducible)
chr9_+_59614877 0.78 ENSMUST00000128944.8
ENSMUST00000098661.10
Gramd2
GRAM domain containing 2
chr2_+_32460868 0.75 ENSMUST00000140592.8
ENSMUST00000028151.7
Dpm2
dolichol-phosphate (beta-D) mannosyltransferase 2
chrX_+_132751729 0.69 ENSMUST00000033602.9
Tnmd
tenomodulin
chr7_+_126832399 0.68 ENSMUST00000056232.7
Zfp553
zinc finger protein 553
chr3_-_127631068 0.68 ENSMUST00000051737.8
ENSMUST00000200409.5
Ap1ar
adaptor-related protein complex 1 associated regulatory protein
chr14_-_52495160 0.67 ENSMUST00000200169.6
Chd8
chromodomain helicase DNA binding protein 8
chr8_-_85696369 0.66 ENSMUST00000109736.9
ENSMUST00000140561.8
Rnaseh2a
ribonuclease H2, large subunit
chr3_+_146205864 0.65 ENSMUST00000119130.2
Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr16_-_19334384 0.65 ENSMUST00000054606.2
Olfr167
olfactory receptor 167
chr15_+_44291470 0.62 ENSMUST00000226827.2
ENSMUST00000060652.5
Eny2
ENY2 transcription and export complex 2 subunit
chr4_+_83335947 0.62 ENSMUST00000030206.10
ENSMUST00000071544.11
Snapc3
small nuclear RNA activating complex, polypeptide 3
chr3_-_143908111 0.60 ENSMUST00000121796.8
Lmo4
LIM domain only 4
chr9_+_13677266 0.59 ENSMUST00000152532.8
Mtmr2
myotubularin related protein 2
chr3_+_8574420 0.58 ENSMUST00000029002.9
Stmn2
stathmin-like 2
chr19_+_34899778 0.57 ENSMUST00000223907.2
Kif20b
kinesin family member 20B
chr11_+_54205722 0.52 ENSMUST00000072178.11
ENSMUST00000101211.9
ENSMUST00000101213.9
ENSMUST00000064690.10
ENSMUST00000108899.8
Acsl6
acyl-CoA synthetase long-chain family member 6
chr11_+_22462088 0.50 ENSMUST00000059319.8
Tmem17
transmembrane protein 17
chr11_+_94858417 0.49 ENSMUST00000038928.7
H1f9
H1.9 linker histone
chr3_-_143908060 0.48 ENSMUST00000121112.6
Lmo4
LIM domain only 4
chr2_+_78699360 0.44 ENSMUST00000028398.14
Ube2e3
ubiquitin-conjugating enzyme E2E 3
chr7_-_30614249 0.44 ENSMUST00000190950.7
ENSMUST00000187137.7
ENSMUST00000190638.7
Mag
myelin-associated glycoprotein
chr19_+_34899752 0.44 ENSMUST00000087341.7
Kif20b
kinesin family member 20B
chr3_-_50398027 0.43 ENSMUST00000029297.6
ENSMUST00000194462.6
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr16_+_84631789 0.42 ENSMUST00000114184.8
Gabpa
GA repeat binding protein, alpha
chr4_-_141327146 0.40 ENSMUST00000141518.8
ENSMUST00000127455.8
ENSMUST00000105784.8
Fblim1
filamin binding LIM protein 1
chr7_+_126832215 0.39 ENSMUST00000106312.4
Zfp553
zinc finger protein 553
chr10_-_17823736 0.38 ENSMUST00000037879.8
Heca
hdc homolog, cell cycle regulator
chr17_-_36015484 0.38 ENSMUST00000117301.8
Ddr1
discoidin domain receptor family, member 1
chr1_+_39940189 0.33 ENSMUST00000191761.6
ENSMUST00000193682.6
ENSMUST00000195860.6
ENSMUST00000195259.6
ENSMUST00000195636.6
ENSMUST00000192509.6
Map4k4
mitogen-activated protein kinase kinase kinase kinase 4
chr15_+_30457772 0.32 ENSMUST00000228282.2
Ctnnd2
catenin (cadherin associated protein), delta 2
chr19_+_5790918 0.31 ENSMUST00000081496.6
Ltbp3
latent transforming growth factor beta binding protein 3
chr1_-_131441962 0.27 ENSMUST00000185445.3
Srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr11_+_67128843 0.26 ENSMUST00000018632.11
Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr14_+_102077937 0.23 ENSMUST00000159026.8
Lmo7
LIM domain only 7
chr12_-_72283465 0.19 ENSMUST00000021497.16
ENSMUST00000137990.2
Rtn1
reticulon 1
chr12_-_72455708 0.19 ENSMUST00000078505.14
Rtn1
reticulon 1
chr5_+_20112704 0.17 ENSMUST00000115267.7
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chrX_-_9983836 0.17 ENSMUST00000115543.3
ENSMUST00000044789.10
ENSMUST00000115544.9
Srpx
sushi-repeat-containing protein
chr6_+_48578935 0.17 ENSMUST00000204095.3
Zfp775
zinc finger protein 775
chr18_+_37622518 0.16 ENSMUST00000055949.4
Pcdhb18
protocadherin beta 18
chr11_-_49077864 0.15 ENSMUST00000153999.3
ENSMUST00000066531.13
Btnl9
butyrophilin-like 9
chr11_-_49077986 0.15 ENSMUST00000046522.13
Btnl9
butyrophilin-like 9
chr17_-_36014892 0.14 ENSMUST00000097333.10
ENSMUST00000003628.13
Ddr1
discoidin domain receptor family, member 1
chr5_+_20112500 0.12 ENSMUST00000101558.10
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr12_+_86999366 0.11 ENSMUST00000191463.2
Cipc
CLOCK interacting protein, circadian
chr3_-_96833336 0.10 ENSMUST00000062944.7
Gja8
gap junction protein, alpha 8
chr5_-_24650164 0.09 ENSMUST00000115043.8
ENSMUST00000115041.2
ENSMUST00000030800.13
Fastk
Fas-activated serine/threonine kinase
chr16_-_31094095 0.09 ENSMUST00000060188.14
Ppp1r2
protein phosphatase 1, regulatory inhibitor subunit 2
chr17_-_36008863 0.07 ENSMUST00000146472.8
Ddr1
discoidin domain receptor family, member 1
chr4_+_136013372 0.00 ENSMUST00000069195.5
ENSMUST00000130658.2
Zfp46
zinc finger protein 46

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0060217 hemangioblast cell differentiation(GO:0060217)
1.9 7.6 GO:1904158 axonemal central apparatus assembly(GO:1904158)
1.5 18.3 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536)
1.4 12.5 GO:0015671 oxygen transport(GO:0015671)
1.4 4.2 GO:0051325 interphase(GO:0051325) mitotic interphase(GO:0051329)
1.1 3.4 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
1.1 3.2 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.9 2.6 GO:0044704 mating plug formation(GO:0042628) single-organism reproductive behavior(GO:0044704) post-mating behavior(GO:0045297) seminal vesicle development(GO:0061107)
0.6 15.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.6 13.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.5 6.5 GO:0035879 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.5 3.6 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.5 11.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 2.9 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.4 2.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.4 2.6 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.4 5.0 GO:1902033 vitamin D receptor signaling pathway(GO:0070561) regulation of hematopoietic stem cell proliferation(GO:1902033)
0.3 1.0 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.3 5.4 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.3 1.9 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.3 2.4 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.3 1.2 GO:1904209 chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.3 5.1 GO:0070307 lens fiber cell development(GO:0070307)
0.3 2.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.2 1.4 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.2 6.7 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.2 3.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.2 4.2 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.6 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 1.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 2.2 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.1 4.2 GO:0051764 actin crosslink formation(GO:0051764)
0.1 3.4 GO:0043968 N-terminal protein amino acid acetylation(GO:0006474) histone H2A acetylation(GO:0043968)
0.1 0.7 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.7 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.5 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.1 0.3 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 1.8 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 10.7 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 1.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.5 GO:0032954 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 6.8 GO:0006334 nucleosome assembly(GO:0006334)
0.1 2.7 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.8 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 1.9 GO:0030903 notochord development(GO:0030903)
0.1 0.3 GO:0031269 pseudopodium assembly(GO:0031269)
0.1 0.6 GO:2000645 regulation of receptor catabolic process(GO:2000644) negative regulation of receptor catabolic process(GO:2000645)
0.1 0.7 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 0.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.9 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 1.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.6 GO:0009301 snRNA transcription(GO:0009301)
0.0 10.7 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.0 2.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.4 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.4 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.0 2.3 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.3 GO:0001825 blastocyst formation(GO:0001825)
0.0 0.2 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 1.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.9 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 5.1 GO:0006364 rRNA processing(GO:0006364)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 1.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 1.2 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.5 GO:0033193 Lsd1/2 complex(GO:0033193)
1.9 11.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.6 12.5 GO:0005833 hemoglobin complex(GO:0005833)
1.4 15.2 GO:0097451 glial limiting end-foot(GO:0097451)
0.6 3.6 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.5 1.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.5 1.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.4 2.9 GO:0005638 lamin filament(GO:0005638)
0.4 1.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.4 2.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.3 4.2 GO:0071439 clathrin complex(GO:0071439)
0.3 1.9 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 2.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.2 0.7 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 1.2 GO:0033269 internode region of axon(GO:0033269)
0.1 2.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 4.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 1.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 3.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 5.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 2.6 GO:0030904 retromer complex(GO:0030904)
0.1 3.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 15.4 GO:0043209 myelin sheath(GO:0043209)
0.0 2.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 5.1 GO:0005882 intermediate filament(GO:0005882)
0.0 5.6 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.6 GO:0000124 SAGA complex(GO:0000124)
0.0 6.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 3.3 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.3 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 2.4 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.5 GO:0031721 hemoglobin alpha binding(GO:0031721)
1.9 11.2 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.2 18.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.8 3.4 GO:0043532 angiostatin binding(GO:0043532)
0.8 13.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.7 2.2 GO:0033680 ATP-dependent DNA/RNA helicase activity(GO:0033680) triplex DNA binding(GO:0045142)
0.6 4.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.5 3.6 GO:0002135 CTP binding(GO:0002135)
0.4 3.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.4 1.6 GO:0050436 microfibril binding(GO:0050436)
0.4 5.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.4 3.4 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.4 10.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.4 8.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 1.0 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.3 3.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.3 1.9 GO:0004111 creatine kinase activity(GO:0004111)
0.3 1.9 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 5.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 4.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.2 1.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 0.7 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.2 4.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 15.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.7 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 10.1 GO:0070888 E-box binding(GO:0070888)
0.1 2.9 GO:0005521 lamin binding(GO:0005521)
0.1 2.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 6.8 GO:0031491 nucleosome binding(GO:0031491)
0.1 10.0 GO:0051082 unfolded protein binding(GO:0051082)
0.1 1.9 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 0.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 2.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 1.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.4 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 5.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 1.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 3.0 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 1.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 4.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.2 5.0 PID IL5 PATHWAY IL5-mediated signaling events
0.1 3.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 11.2 PID E2F PATHWAY E2F transcription factor network
0.1 4.2 PID ATM PATHWAY ATM pathway
0.0 3.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.4 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.3 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 4.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 PID EPHB FWD PATHWAY EPHB forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 11.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 4.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 3.1 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.2 8.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.2 3.6 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 3.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 2.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 2.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 5.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.6 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.7 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 2.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 2.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs