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GSE58827: Dynamics of the Mouse Liver

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Results for Sox8

Z-value: 0.40

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Transcription factors associated with Sox8

Gene Symbol Gene ID Gene Info
Sox8
ENSMUSG00000024176.11 SRY (sex determining region Y)-box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox8mm39_v1_chr17_-_25789652_257896700.134.5e-01Click!

Activity profile of Sox8 motif

Sorted Z-values of Sox8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_65008735 2.40 ENSMUST00000213533.2
ENSMUST00000035499.5
ENSMUST00000077696.13
ENSMUST00000166273.2
Igdcc4
immunoglobulin superfamily, DCC subclass, member 4
chr7_-_126399574 1.71 ENSMUST00000106348.8
Aldoa
aldolase A, fructose-bisphosphate
chr7_-_100164007 1.68 ENSMUST00000207405.2
Dnajb13
DnaJ heat shock protein family (Hsp40) member B13
chr1_-_134006847 1.66 ENSMUST00000020692.7
Btg2
BTG anti-proliferation factor 2
chr7_-_126399208 1.66 ENSMUST00000133514.8
ENSMUST00000151137.8
Aldoa
aldolase A, fructose-bisphosphate
chr7_-_126399778 1.56 ENSMUST00000141355.4
Aldoa
aldolase A, fructose-bisphosphate
chr10_+_11157326 1.34 ENSMUST00000070300.5
Fbxo30
F-box protein 30
chr5_-_44259010 1.26 ENSMUST00000087441.11
Prom1
prominin 1
chr5_-_44259293 1.24 ENSMUST00000074113.13
Prom1
prominin 1
chr15_-_103123711 0.97 ENSMUST00000122182.2
ENSMUST00000108813.10
ENSMUST00000127191.2
Cbx5
chromobox 5
chr2_+_4405769 0.88 ENSMUST00000075767.14
Frmd4a
FERM domain containing 4A
chr6_-_72357398 0.87 ENSMUST00000101285.10
ENSMUST00000074231.6
Vamp5
vesicle-associated membrane protein 5
chr4_-_116263183 0.85 ENSMUST00000123072.8
ENSMUST00000144281.2
Mast2
microtubule associated serine/threonine kinase 2
chr8_+_95472218 0.84 ENSMUST00000034231.4
Ccl22
chemokine (C-C motif) ligand 22
chr1_+_136059101 0.78 ENSMUST00000075164.11
Kif21b
kinesin family member 21B
chr11_+_114618209 0.75 ENSMUST00000069325.14
Dnai2
dynein axonemal intermediate chain 2
chr11_-_69649452 0.68 ENSMUST00000058470.16
Polr2a
polymerase (RNA) II (DNA directed) polypeptide A
chr13_-_31134281 0.62 ENSMUST00000102946.8
Exoc2
exocyst complex component 2
chrX_+_157993303 0.54 ENSMUST00000112493.8
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr4_+_11758147 0.51 ENSMUST00000029871.12
ENSMUST00000108303.2
Cdh17
cadherin 17
chr2_+_85809620 0.47 ENSMUST00000056849.3
Olfr1030
olfactory receptor 1030
chr10_+_58207229 0.47 ENSMUST00000238939.2
Lims1
LIM and senescent cell antigen-like domains 1
chr1_-_79838897 0.46 ENSMUST00000190724.2
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr11_+_113550109 0.39 ENSMUST00000137878.2
Cog1
component of oligomeric golgi complex 1
chrX_-_23151771 0.39 ENSMUST00000115319.9
Klhl13
kelch-like 13
chr12_-_115722081 0.34 ENSMUST00000103541.3
Ighv1-72
immunoglobulin heavy variable 1-72
chr10_-_128016135 0.33 ENSMUST00000238843.2
ENSMUST00000099139.9
Rbms2
RNA binding motif, single stranded interacting protein 2
chr14_-_8457069 0.30 ENSMUST00000022257.4
Atxn7
ataxin 7
chr19_-_33764859 0.28 ENSMUST00000148137.9
Lipo1
lipase, member O1
chr19_-_40365318 0.27 ENSMUST00000239304.2
Sorbs1
sorbin and SH3 domain containing 1
chr12_-_114955196 0.25 ENSMUST00000194865.2
Ighv1-47
immunoglobulin heavy variable 1-47
chr9_+_109881083 0.24 ENSMUST00000164930.8
ENSMUST00000199498.5
Map4
microtubule-associated protein 4
chr6_-_58452315 0.24 ENSMUST00000177318.3
ENSMUST00000176147.9
ENSMUST00000176023.3
ENSMUST00000228586.2
Vmn1r31
vomeronasal 1 receptor 31
chr2_+_109522781 0.23 ENSMUST00000111050.10
Bdnf
brain derived neurotrophic factor
chr9_-_95697441 0.22 ENSMUST00000119760.2
Pls1
plastin 1 (I-isoform)
chr12_-_115083839 0.21 ENSMUST00000103521.3
Ighv1-50
immunoglobulin heavy variable 1-50
chr12_-_115425105 0.20 ENSMUST00000103532.3
Ighv1-62-3
immunoglobulin heavy variable 1-62-3
chr13_+_19528728 0.20 ENSMUST00000179181.3
Trgc4
T cell receptor gamma, constant 4
chr13_+_93441307 0.17 ENSMUST00000080127.12
Homer1
homer scaffolding protein 1
chr1_+_135710803 0.17 ENSMUST00000132795.8
Tnni1
troponin I, skeletal, slow 1
chr14_+_21881794 0.15 ENSMUST00000152562.8
Vdac2
voltage-dependent anion channel 2
chr18_+_37637317 0.15 ENSMUST00000052179.8
Pcdhb20
protocadherin beta 20
chr17_-_26052335 0.15 ENSMUST00000044911.10
ENSMUST00000237186.2
Stub1
STIP1 homology and U-Box containing protein 1
chrX_-_71961890 0.14 ENSMUST00000152200.2
Cetn2
centrin 2
chrX_+_133305529 0.13 ENSMUST00000113224.9
ENSMUST00000113226.2
Drp2
dystrophin related protein 2
chr11_-_99884818 0.13 ENSMUST00000105049.2
Krtap17-1
keratin associated protein 17-1
chr7_+_102423702 0.13 ENSMUST00000098217.3
Olfr561
olfactory receptor 561
chr1_+_109911467 0.09 ENSMUST00000172005.8
Cdh7
cadherin 7, type 2
chr18_+_65831324 0.09 ENSMUST00000115097.8
ENSMUST00000117694.2
ENSMUST00000235962.2
Oacyl
O-acyltransferase like
chr16_-_29360301 0.07 ENSMUST00000057018.15
ENSMUST00000182627.8
Atp13a4
ATPase type 13A4
chr4_+_154226819 0.07 ENSMUST00000030895.12
Wrap73
WD repeat containing, antisense to Trp73
chr11_+_69882410 0.06 ENSMUST00000108592.2
Gabarap
gamma-aminobutyric acid receptor associated protein
chr6_-_42524521 0.06 ENSMUST00000217978.2
Olfr455
olfactory receptor 455
chr12_-_114843941 0.05 ENSMUST00000191862.6
ENSMUST00000103513.3
Ighv1-36
immunoglobulin heavy variable 1-36
chrX_-_49517375 0.05 ENSMUST00000215270.2
Olfr1324
olfactory receptor 1324
chr18_+_37085673 0.05 ENSMUST00000192512.6
ENSMUST00000192295.2
ENSMUST00000115661.5
Pcdha4
Gm42416
protocadherin alpha 4
predicted gene, 42416
chr3_-_92393193 0.05 ENSMUST00000054599.8
Sprr1a
small proline-rich protein 1A
chr4_+_127062924 0.04 ENSMUST00000046659.14
Dlgap3
DLG associated protein 3
chr11_-_43638790 0.04 ENSMUST00000048578.3
ENSMUST00000109278.8
Ttc1
tetratricopeptide repeat domain 1
chr4_-_133972890 0.04 ENSMUST00000030644.8
Zfp593
zinc finger protein 593
chr12_-_115172211 0.04 ENSMUST00000103526.3
Ighv1-55
immunoglobulin heavy variable 1-55
chr12_+_113038376 0.03 ENSMUST00000109729.3
Tex22
testis expressed gene 22
chr12_-_114451189 0.03 ENSMUST00000103493.3
Ighv1-4
immunoglobulin heavy variable 1-4
chr13_-_19579898 0.03 ENSMUST00000197565.3
ENSMUST00000221380.2
ENSMUST00000200323.3
ENSMUST00000199924.2
ENSMUST00000222869.2
Stard3nl
STARD3 N-terminal like
chr6_+_41039255 0.03 ENSMUST00000103266.3
Trbv5
T cell receptor beta, variable 5
chr11_-_46057224 0.02 ENSMUST00000020679.3
Nipal4
NIPA-like domain containing 4
chr5_+_43672856 0.02 ENSMUST00000076939.10
C1qtnf7
C1q and tumor necrosis factor related protein 7
chr4_-_129472328 0.01 ENSMUST00000052835.9
Fam167b
family with sequence similarity 167, member B
chr3_+_101917392 0.00 ENSMUST00000196324.2
Nhlh2
nescient helix loop helix 2
chr7_+_119773070 0.00 ENSMUST00000033201.7
Anks4b
ankyrin repeat and sterile alpha motif domain containing 4B

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.4 1.7 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.3 4.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 0.5 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 0.5 GO:0042628 mating plug formation(GO:0042628) single-organism reproductive behavior(GO:0044704) post-mating behavior(GO:0045297) seminal vesicle development(GO:0061107)
0.1 0.6 GO:0001927 exocyst assembly(GO:0001927)
0.1 1.7 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1 0.2 GO:0061193 taste bud development(GO:0061193)
0.1 0.9 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.1 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0090035 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.0 0.7 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.9 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.8 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0071914 prominosome(GO:0071914)
0.2 4.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.7 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.5 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 1.0 GO:0010369 chromocenter(GO:0010369)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 0.9 GO:0031201 SNARE complex(GO:0031201)
0.0 1.6 GO:0005930 axoneme(GO:0005930)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.5 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 2.5 GO:0042805 actinin binding(GO:0042805)
0.0 0.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 1.7 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.0 GO:0035064 methylated histone binding(GO:0035064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.4 PID AURORA B PATHWAY Aurora B signaling
0.0 0.5 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.9 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.7 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets