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GSE58827: Dynamics of the Mouse Liver

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Results for Spic

Z-value: 4.44

Motif logo

Transcription factors associated with Spic

Gene Symbol Gene ID Gene Info
ENSMUSG00000004359.17 Spi-C transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Spicmm39_v1_chr10_-_88518878_885188920.962.7e-20Click!

Activity profile of Spic motif

Sorted Z-values of Spic motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_87684299 52.25 ENSMUST00000020779.11
myeloperoxidase
chr10_+_79715448 50.13 ENSMUST00000006679.15
proteinase 3
chr2_-_165242307 44.90 ENSMUST00000029213.5
osteoclast stimulatory transmembrane protein
chr11_+_87684548 38.63 ENSMUST00000143021.9
myeloperoxidase
chr14_+_80237691 35.89 ENSMUST00000228749.2
ENSMUST00000088735.4
olfactomedin 4
chr6_-_136918671 32.21 ENSMUST00000032344.12
Rho, GDP dissociation inhibitor (GDI) beta
chr6_-_136918844 30.36 ENSMUST00000204934.2
Rho, GDP dissociation inhibitor (GDI) beta
chr7_-_126303351 27.54 ENSMUST00000106364.8
coronin, actin binding protein 1A
chr7_-_126303887 26.86 ENSMUST00000131415.8
coronin, actin binding protein 1A
chr11_+_98798627 25.76 ENSMUST00000092706.13
cell division cycle 6
chr5_+_149201577 25.15 ENSMUST00000071130.5
arachidonate 5-lipoxygenase activating protein
chr5_+_149202157 23.84 ENSMUST00000200806.4
arachidonate 5-lipoxygenase activating protein
chr6_-_136918885 23.84 ENSMUST00000111891.4
Rho, GDP dissociation inhibitor (GDI) beta
chr15_+_78128990 23.63 ENSMUST00000096357.12
neutrophil cytosolic factor 4
chr9_+_7558449 23.53 ENSMUST00000018765.4
matrix metallopeptidase 8
chr5_-_138169509 23.53 ENSMUST00000153867.8
minichromosome maintenance complex component 7
chr5_-_134258435 23.31 ENSMUST00000016094.13
ENSMUST00000111275.8
ENSMUST00000144086.2
neutrophil cytosolic factor 1
chr5_-_138169253 22.59 ENSMUST00000139983.8
minichromosome maintenance complex component 7
chr8_-_123159639 22.13 ENSMUST00000212600.2
cytochrome b-245, alpha polypeptide
chrX_+_8137372 21.93 ENSMUST00000127103.8
ENSMUST00000115591.8
solute carrier family 38, member 5
chr10_-_117118226 21.61 ENSMUST00000092163.9
lysozyme 2
chr7_-_44888220 20.85 ENSMUST00000210372.2
ENSMUST00000209779.2
ENSMUST00000098461.10
ENSMUST00000211373.2
CD37 antigen
chr7_+_28682253 20.76 ENSMUST00000085835.8
mitogen-activated protein kinase kinase kinase kinase 1
chrX_+_8137620 20.28 ENSMUST00000033512.11
solute carrier family 38, member 5
chr19_+_6135013 19.97 ENSMUST00000025704.3
cell division cycle associated 5
chr7_-_126303689 19.56 ENSMUST00000135087.8
coronin, actin binding protein 1A
chr2_+_152689881 19.44 ENSMUST00000164120.8
ENSMUST00000178997.8
ENSMUST00000109816.8
TPX2, microtubule-associated
chr7_-_126641593 19.32 ENSMUST00000032915.8
kinesin family member 22
chr7_+_142014546 18.59 ENSMUST00000105968.8
ENSMUST00000018963.11
ENSMUST00000105967.8
lymphocyte specific 1
chr9_-_114610879 18.17 ENSMUST00000084867.9
ENSMUST00000216760.2
ENSMUST00000035009.16
CKLF-like MARVEL transmembrane domain containing 7
chr15_-_63932176 18.14 ENSMUST00000226675.2
ENSMUST00000228226.2
ENSMUST00000227024.2
CYFIP related Rac1 interactor B
chr15_+_78129040 17.75 ENSMUST00000133618.3
neutrophil cytosolic factor 4
chr1_+_87548026 17.19 ENSMUST00000169754.8
ENSMUST00000042275.15
ENSMUST00000168783.8
inositol polyphosphate-5-phosphatase D
chr8_-_123159663 17.08 ENSMUST00000017604.10
cytochrome b-245, alpha polypeptide
chr10_+_75778885 17.04 ENSMUST00000121151.2
pre-B lymphocyte gene 3
chr8_+_85428059 16.40 ENSMUST00000238364.2
ENSMUST00000238562.2
ENSMUST00000037165.6
lymphoblastomic leukemia 1
chr1_-_20890437 16.35 ENSMUST00000053266.11
minichromosome maintenance complex component 3
chr7_-_19005721 16.29 ENSMUST00000032561.9
vasodilator-stimulated phosphoprotein
chr4_-_133601990 16.25 ENSMUST00000168974.9
ribosomal protein S6 kinase polypeptide 1
chr17_+_57586094 16.18 ENSMUST00000169220.9
ENSMUST00000005889.16
ENSMUST00000112870.5
vav 1 oncogene
chr10_+_115653152 16.12 ENSMUST00000080630.11
ENSMUST00000179196.3
ENSMUST00000035563.15
tetraspanin 8
chr7_+_127661835 15.86 ENSMUST00000106242.10
ENSMUST00000120355.8
ENSMUST00000106240.9
ENSMUST00000098015.10
integrin alpha M
predicted gene, 49368
chr9_-_20556031 15.85 ENSMUST00000148631.8
ENSMUST00000131128.2
ENSMUST00000151861.9
ENSMUST00000131343.8
ENSMUST00000086458.10
F-box and leucine-rich repeat protein 12
chr4_+_130640436 15.84 ENSMUST00000151698.8
lysosomal-associated protein transmembrane 5
chr5_-_116162415 15.54 ENSMUST00000031486.14
ENSMUST00000111999.8
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr4_+_130640611 15.04 ENSMUST00000156225.8
ENSMUST00000156742.8
lysosomal-associated protein transmembrane 5
chr2_+_152689913 14.90 ENSMUST00000028969.9
TPX2, microtubule-associated
chr7_-_126641565 14.77 ENSMUST00000205806.2
kinesin family member 22
chr6_-_136918495 14.66 ENSMUST00000111892.8
Rho, GDP dissociation inhibitor (GDI) beta
chr8_+_95722289 14.60 ENSMUST00000211984.2
adhesion G protein-coupled receptor G1
chr8_+_118225008 14.49 ENSMUST00000081232.9
phospholipase C, gamma 2
chr15_+_103362195 14.40 ENSMUST00000047405.9
NCK associated protein 1 like
chr8_+_70826191 14.20 ENSMUST00000003659.9
cartilage oligomeric matrix protein
chr7_+_28140352 14.10 ENSMUST00000078845.13
glia maturation factor, gamma
chr17_-_6923299 14.08 ENSMUST00000179554.3
dynein light chain Tctex-type 1F
chr7_-_44888532 14.08 ENSMUST00000033063.15
CD37 antigen
chr13_-_97274360 13.94 ENSMUST00000225410.2
NSA2 ribosome biogenesis homolog
chr1_-_144651157 13.76 ENSMUST00000027603.4
regulator of G-protein signaling 18
chr2_+_24235300 13.74 ENSMUST00000114485.9
ENSMUST00000114482.3
interleukin 1 receptor antagonist
chr2_+_22664094 13.45 ENSMUST00000014290.15
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr16_-_75706161 13.36 ENSMUST00000114239.9
SAM domain, SH3 domain and nuclear localization signals, 1
chr4_-_41314877 13.30 ENSMUST00000030145.9
DDB1 and CUL4 associated factor 12
chr17_-_6367692 13.19 ENSMUST00000232499.2
ENSMUST00000169415.3
dynein light chain Tctex-type 1A
chr1_+_152683627 13.09 ENSMUST00000027754.7
neutrophil cytosolic factor 2
chr7_-_44888465 13.01 ENSMUST00000210078.2
CD37 antigen
chr1_+_40123858 13.00 ENSMUST00000027243.13
interleukin 1 receptor, type II
chr17_+_6869070 12.60 ENSMUST00000092966.5
dynein light chain Tctex-type 1C
chrX_-_165992311 12.42 ENSMUST00000112172.4
thymosin, beta 4, X chromosome
chr5_-_138169476 12.40 ENSMUST00000147920.2
minichromosome maintenance complex component 7
chr11_-_16958647 12.38 ENSMUST00000102881.10
pleckstrin
chr11_-_79414542 12.26 ENSMUST00000179322.2
ecotropic viral integration site 2b
chr17_+_47905553 12.21 ENSMUST00000182846.3
cyclin D3
chr15_-_78189917 12.14 ENSMUST00000096356.5
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr13_-_110493665 12.14 ENSMUST00000058806.7
ENSMUST00000224534.2
Grb2-binding adaptor, transmembrane
chrX_-_48877080 12.13 ENSMUST00000114893.8
immunoglobulin superfamily, member 1
chr9_+_109704609 11.68 ENSMUST00000094324.8
cell division cycle 25A
chr6_+_129326927 11.46 ENSMUST00000065289.6
C-type lectin domain family 12, member a
chr5_+_35156389 11.39 ENSMUST00000114281.8
ENSMUST00000114280.8
regulator of G-protein signaling 12
chr13_-_97274430 11.39 ENSMUST00000073456.9
NSA2 ribosome biogenesis homolog
chr6_+_123206802 11.34 ENSMUST00000112554.9
ENSMUST00000024118.11
ENSMUST00000117130.8
C-type lectin domain family 4, member n
chr19_+_4204605 11.32 ENSMUST00000061086.9
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr14_-_56026266 11.29 ENSMUST00000168716.8
ENSMUST00000178399.3
ENSMUST00000022830.14
receptor-interacting serine-threonine kinase 3
chr7_+_28140450 11.27 ENSMUST00000135686.2
glia maturation factor, gamma
chr7_+_43057611 10.97 ENSMUST00000005592.7
sialic acid binding Ig-like lectin G
chr4_+_140428777 10.68 ENSMUST00000138808.8
ENSMUST00000038893.6
regulator of chromosome condensation 2
chr17_+_8144822 10.39 ENSMUST00000036370.8
T cell activation Rho GTPase activating protein
chr7_+_28533279 10.38 ENSMUST00000208971.2
ENSMUST00000066723.15
lectin, galactose binding, soluble 4
chr11_+_32226400 10.33 ENSMUST00000020531.9
hemoglobin X, alpha-like embryonic chain in Hba complex
chr3_-_67371161 10.31 ENSMUST00000058981.3
latexin
chr11_-_115024807 10.11 ENSMUST00000106561.8
ENSMUST00000051264.14
ENSMUST00000106562.3
CD300 molecule like family member F
chr2_+_163916042 10.11 ENSMUST00000018353.14
serine/threonine kinase 4
chr1_+_152683568 10.11 ENSMUST00000190323.7
neutrophil cytosolic factor 2
chr2_+_164647002 10.08 ENSMUST00000052107.5
zinc finger SWIM-type containing 3
chr16_+_91203123 10.08 ENSMUST00000023691.12
interleukin 10 receptor, beta
chr17_-_34174631 10.07 ENSMUST00000174609.9
ENSMUST00000008812.9
ribosomal protein S18
chr15_-_78189822 9.96 ENSMUST00000230115.3
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr1_-_170886924 9.94 ENSMUST00000164044.8
ENSMUST00000169017.8
Fc receptor, IgG, low affinity III
chr4_-_86775602 9.90 ENSMUST00000102814.5
ribosomal protein S6
chrX_+_20570145 9.59 ENSMUST00000033383.3
ubiquitin specific peptidase 11
chr1_+_153628598 9.57 ENSMUST00000182538.3
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr12_+_98234884 9.50 ENSMUST00000075072.6
G-protein coupled receptor 65
chr1_-_167112784 9.43 ENSMUST00000053686.9
uridine-cytidine kinase 2
chr11_+_120348919 9.37 ENSMUST00000058370.14
ENSMUST00000175970.8
ENSMUST00000176120.2
coiled-coil domain containing 137
chr7_+_126808016 9.34 ENSMUST00000206204.2
ENSMUST00000206772.2
myosin light chain, phosphorylatable, fast skeletal muscle
chr7_+_127661807 9.25 ENSMUST00000064821.14
integrin alpha M
chr16_+_36755338 9.24 ENSMUST00000023531.15
hematopoietic cell specific Lyn substrate 1
chr7_-_4728081 9.22 ENSMUST00000086363.5
ENSMUST00000086364.11
transmembrane protein 150B
chr8_+_94941192 9.13 ENSMUST00000079961.14
ENSMUST00000212824.2
nucleoporin 93
chr7_-_100613579 9.08 ENSMUST00000060174.6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_+_179373935 9.06 ENSMUST00000040706.9
consortin, connexin sorting protein
chr2_+_91480460 9.06 ENSMUST00000111331.9
Rho GTPase activating protein 1
chr3_+_88528410 9.02 ENSMUST00000029694.14
ENSMUST00000176804.8
rho/rac guanine nucleotide exchange factor (GEF) 2
chr14_-_47514248 8.95 ENSMUST00000187531.8
ENSMUST00000111790.2
WD repeat and HMG-box DNA binding protein 1
chr17_+_34823236 8.95 ENSMUST00000174041.8
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr2_+_120294046 8.89 ENSMUST00000028749.15
ENSMUST00000110721.9
ENSMUST00000239364.2
calpain 3
chr1_-_33708876 8.80 ENSMUST00000027312.11
DNA primase, p58 subunit
chr8_+_85428391 8.80 ENSMUST00000238338.2
lymphoblastomic leukemia 1
chr7_-_35096133 8.79 ENSMUST00000154597.2
ENSMUST00000032704.12
Fanconi anemia core complex associated protein 24
chr2_+_166857113 8.78 ENSMUST00000018143.16
ENSMUST00000176066.8
ENSMUST00000150571.2
DEAD box helicase 27
chrX_-_7830405 8.76 ENSMUST00000128449.2
GATA binding protein 1
chr1_-_170755136 8.75 ENSMUST00000046322.14
ENSMUST00000159171.2
Fc receptor-like A
chr7_-_100505486 8.65 ENSMUST00000139604.8
RELT tumor necrosis factor receptor
chr11_-_102771751 8.53 ENSMUST00000021306.14
elongation factor Tu GTP binding domain containing 2
chr10_-_128462616 8.50 ENSMUST00000026420.7
ribosomal protein S26
chr15_-_66684442 8.34 ENSMUST00000100572.10
src-like adaptor
chr11_-_102771806 8.32 ENSMUST00000107060.8
elongation factor Tu GTP binding domain containing 2
chr14_-_47514308 8.28 ENSMUST00000111792.9
WD repeat and HMG-box DNA binding protein 1
chr3_-_106697459 8.25 ENSMUST00000038845.10
CD53 antigen
chr19_-_40982576 8.17 ENSMUST00000117695.8
B cell linker
chr2_+_118943274 8.17 ENSMUST00000140939.8
ENSMUST00000028795.10
RAD51 recombinase
chr8_+_123829089 8.12 ENSMUST00000000756.6
ribosomal protein L13
chr4_-_43562397 8.12 ENSMUST00000030187.14
talin 1
chr12_-_79027531 8.04 ENSMUST00000174072.8
transmembrane protein 229B
chrX_-_56371953 8.01 ENSMUST00000176986.8
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_+_91480513 7.97 ENSMUST00000090614.11
Rho GTPase activating protein 1
chr4_-_136620376 7.97 ENSMUST00000046332.6
complement component 1, q subcomponent, C chain
chr3_+_109030419 7.77 ENSMUST00000029477.11
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
chr3_-_105839980 7.75 ENSMUST00000098758.5
RIKEN cDNA I830077J02 gene
chr8_-_71349927 7.64 ENSMUST00000212709.2
ENSMUST00000212796.2
ENSMUST00000212378.2
ENSMUST00000054220.10
ENSMUST00000212494.2
ribosomal protein L18A
chr7_+_126184108 7.64 ENSMUST00000039522.8
apolipoprotein B receptor
chr1_+_72750418 7.60 ENSMUST00000059980.11
ribosomal protein L37a
chr17_+_29579882 7.45 ENSMUST00000024810.8
FYVE, RhoGEF and PH domain containing 2
chr8_-_123278054 7.38 ENSMUST00000156333.9
ENSMUST00000067252.14
piezo-type mechanosensitive ion channel component 1
chr7_-_121732067 7.37 ENSMUST00000106469.8
ENSMUST00000063587.13
ENSMUST00000106468.7
ENSMUST00000098068.10
partner and localizer of BRCA2
chr9_+_108385247 7.34 ENSMUST00000207810.2
ENSMUST00000207862.2
ENSMUST00000208581.2
ENSMUST00000134939.9
ENSMUST00000207713.2
glutaminyl-tRNA synthetase
chr7_+_99030621 7.33 ENSMUST00000037528.10
glycerophosphodiester phosphodiesterase domain containing 5
chr7_-_43193842 7.08 ENSMUST00000039861.7
CD33 antigen
chr10_-_116899239 6.99 ENSMUST00000219036.2
ENSMUST00000218059.2
chaperonin containing Tcp1, subunit 2 (beta)
chr13_+_30933209 6.95 ENSMUST00000021784.10
ENSMUST00000110307.3
ENSMUST00000222125.2
interferon regulatory factor 4
chr5_-_137145030 6.78 ENSMUST00000054384.6
ENSMUST00000152207.2
tripartite motif-containing 56
chr4_-_116484675 6.77 ENSMUST00000081182.5
ENSMUST00000030457.12
nuclear autoantigenic sperm protein (histone-binding)
chr12_+_112727089 6.77 ENSMUST00000063888.5
phospholipase D family, member 4
chr5_+_35156454 6.69 ENSMUST00000114283.8
regulator of G-protein signaling 12
chr11_+_70396070 6.66 ENSMUST00000019063.3
transmembrane 4 superfamily member 5
chr19_+_53517528 6.60 ENSMUST00000038287.7
dual specificity phosphatase 5
chr1_+_171668173 6.36 ENSMUST00000136479.8
CD84 antigen
chr4_-_136613498 6.28 ENSMUST00000046384.9
complement component 1, q subcomponent, beta polypeptide
chr6_-_56681657 6.17 ENSMUST00000176595.3
ENSMUST00000170382.5
ENSMUST00000203958.2
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
chr5_+_143803540 6.16 ENSMUST00000100487.6
eukaryotic translation initiation factor 2 alpha kinase 1
chr3_-_95799242 6.12 ENSMUST00000171519.2
ENSMUST00000036360.13
ENSMUST00000090476.10
cDNA sequence BC028528
chr2_+_164782642 6.08 ENSMUST00000137626.2
matrix metallopeptidase 9
chr7_+_35096470 6.08 ENSMUST00000079414.12
centrosomal protein 89
chr4_-_117749191 6.04 ENSMUST00000030265.4
DPH2 homolog
chr14_+_117163215 5.98 ENSMUST00000078849.12
glypican 6
chr1_+_191058109 5.97 ENSMUST00000027940.6
proton activated chloride channel 1
chr11_-_98291278 5.96 ENSMUST00000090827.12
post-GPI attachment to proteins 3
chr5_-_110987441 5.95 ENSMUST00000145318.2
HscB iron-sulfur cluster co-chaperone
chr1_-_149836974 5.88 ENSMUST00000190507.2
ENSMUST00000070200.15
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_+_96069271 5.76 ENSMUST00000054356.16
myotubularin related protein 11
chr7_-_19338349 5.71 ENSMUST00000086041.7
CLK4-associating serine/arginine rich protein
chr13_-_58276353 5.68 ENSMUST00000007980.7
heterogeneous nuclear ribonucleoprotein A0
chr18_-_24736848 5.67 ENSMUST00000070726.10
solute carrier family 39 (metal ion transporter), member 6
chr6_-_124710030 5.65 ENSMUST00000173647.2
protein tyrosine phosphatase, non-receptor type 6
chr14_+_117162914 5.64 ENSMUST00000125435.2
glypican 6
chr11_-_97673203 5.60 ENSMUST00000128801.2
ENSMUST00000103146.5
ribosomal protein L23
chr19_-_41884599 5.54 ENSMUST00000038677.5
ribosomal RNA processing 12 homolog
chr8_+_95393349 5.51 ENSMUST00000109527.6
ADP-ribosylation factor-like 2 binding protein
chr14_+_30201569 5.49 ENSMUST00000022535.9
ENSMUST00000223658.2
decapping mRNA 1A
chr2_+_43638814 5.46 ENSMUST00000112824.8
ENSMUST00000055776.8
Rho GTPase activating protein 15
chr11_+_31823096 5.46 ENSMUST00000155278.2
cytoplasmic polyadenylation element binding protein 4
chr4_-_136626073 5.45 ENSMUST00000046285.6
complement component 1, q subcomponent, alpha polypeptide
chr17_+_35354655 5.30 ENSMUST00000174478.8
ENSMUST00000174281.9
ENSMUST00000173550.8
BCL2-associated athanogene 6
chr8_+_107783502 5.25 ENSMUST00000034392.13
ENSMUST00000170962.3
NIP7, nucleolar pre-rRNA processing protein
chr19_-_11582207 5.21 ENSMUST00000025582.11
membrane-spanning 4-domains, subfamily A, member 6D
chr17_-_24292453 5.19 ENSMUST00000017090.6
potassium channel tetramerisation domain containing 5
chr2_+_179899166 5.18 ENSMUST00000059080.7
ribosomal protein S21
chr7_-_126807581 5.17 ENSMUST00000120705.3
TBC1 domain family, member 10b
chr17_+_35354430 5.16 ENSMUST00000173535.8
ENSMUST00000173952.8
BCL2-associated athanogene 6
chr2_+_129434738 5.15 ENSMUST00000153491.8
ENSMUST00000161620.8
ENSMUST00000179001.8
signal-regulatory protein alpha
chr10_-_116899664 5.11 ENSMUST00000218719.2
ENSMUST00000219573.2
ENSMUST00000047672.9
chaperonin containing Tcp1, subunit 2 (beta)
chr4_-_116485118 5.07 ENSMUST00000030456.14
nuclear autoantigenic sperm protein (histone-binding)
chr1_-_170755109 5.06 ENSMUST00000162136.2
ENSMUST00000162887.2
Fc receptor-like A
chr18_+_12261798 5.02 ENSMUST00000025270.8
RIO kinase 3
chr7_-_44773750 4.99 ENSMUST00000211725.2
ENSMUST00000003521.10
ribosomal protein S11
chr15_+_102058936 4.90 ENSMUST00000023806.14
sterol O-acyltransferase 2
chr11_+_101623776 4.79 ENSMUST00000039152.14
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr10_+_122514669 4.76 ENSMUST00000161487.8
ENSMUST00000067918.12
protein phosphatase 1H (PP2C domain containing)
chr5_+_66018555 4.71 ENSMUST00000031106.8
ras homolog family member H
chr8_+_93581946 4.69 ENSMUST00000046290.3
ENSMUST00000210099.2
lysophosphatidylcholine acyltransferase 2
chr13_-_98399533 4.69 ENSMUST00000040972.4
UTP15 small subunit processome component

Network of associatons between targets according to the STRING database.

First level regulatory network of Spic

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
30.3 90.9 GO:0002148 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
13.1 39.2 GO:0014805 smooth muscle adaptation(GO:0014805)
11.2 101.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
11.2 44.9 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
10.0 50.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
9.2 74.0 GO:0061502 uropod organization(GO:0032796) early endosome to recycling endosome transport(GO:0061502)
8.5 25.4 GO:0071846 actin filament debranching(GO:0071846)
8.2 49.0 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
7.8 23.3 GO:0070947 neutrophil mediated killing of fungus(GO:0070947)
5.6 66.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
5.3 26.7 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
4.6 23.2 GO:0006742 NADP catabolic process(GO:0006742)
4.4 13.2 GO:0010924 regulation of inositol-polyphosphate 5-phosphatase activity(GO:0010924) positive regulation of inositol-polyphosphate 5-phosphatase activity(GO:0010925) phospholipase C-inhibiting G-protein coupled receptor signaling pathway(GO:0030845) regulation of cell diameter(GO:0060305)
4.4 47.9 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
4.3 17.2 GO:0045659 negative regulation of neutrophil differentiation(GO:0045659)
4.0 20.0 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
3.6 18.1 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
3.6 14.4 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
3.6 10.7 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
3.4 17.2 GO:0070829 heterochromatin maintenance(GO:0070829)
3.4 13.8 GO:0002337 B-1a B cell differentiation(GO:0002337)
3.3 9.9 GO:0001788 antibody-dependent cellular cytotoxicity(GO:0001788)
3.1 9.4 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206) CMP metabolic process(GO:0046035)
3.1 25.1 GO:0014004 microglia differentiation(GO:0014004) microglia development(GO:0014005)
2.9 8.8 GO:0030221 basophil differentiation(GO:0030221)
2.8 17.0 GO:1903336 endosome localization(GO:0032439) negative regulation of vacuolar transport(GO:1903336)
2.8 11.3 GO:2000449 regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449)
2.8 5.6 GO:0072717 cellular response to actinomycin D(GO:0072717)
2.6 21.1 GO:0033277 abortive mitotic cell cycle(GO:0033277)
2.5 10.1 GO:2000426 TRIF-dependent toll-like receptor signaling pathway(GO:0035666) interleukin-4-mediated signaling pathway(GO:0035771) response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) negative regulation of apoptotic cell clearance(GO:2000426)
2.5 10.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
2.3 42.2 GO:0015816 glycine transport(GO:0015816)
2.3 7.0 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
2.3 7.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) interleukin-13 biosynthetic process(GO:0042231) regulation of interleukin-10 biosynthetic process(GO:0045074) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
2.3 9.1 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
2.3 9.0 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
2.2 4.5 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
2.2 8.9 GO:1990091 sodium-dependent self proteolysis(GO:1990091)
2.2 8.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
2.1 17.1 GO:0036506 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
2.1 25.2 GO:0001955 blood vessel maturation(GO:0001955)
2.0 6.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
1.9 9.6 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
1.9 13.4 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
1.8 14.5 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
1.8 9.0 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
1.8 16.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
1.7 3.4 GO:0032741 positive regulation of interleukin-18 production(GO:0032741)
1.7 17.0 GO:0051025 negative regulation of immunoglobulin secretion(GO:0051025)
1.7 5.1 GO:0032685 negative regulation of granulocyte macrophage colony-stimulating factor production(GO:0032685)
1.7 21.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
1.6 4.9 GO:0007439 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
1.6 12.7 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
1.6 10.9 GO:0033625 positive regulation of integrin activation(GO:0033625)
1.5 9.2 GO:0015867 ATP transport(GO:0015867)
1.5 3.0 GO:1903969 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
1.3 9.1 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
1.3 5.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
1.3 41.4 GO:0045730 respiratory burst(GO:0045730)
1.2 6.2 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
1.2 6.0 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
1.2 42.1 GO:0006270 DNA replication initiation(GO:0006270)
1.2 23.1 GO:0030574 collagen catabolic process(GO:0030574)
1.1 10.3 GO:0015671 oxygen transport(GO:0015671)
1.1 9.0 GO:0071802 negative regulation of podosome assembly(GO:0071802)
1.1 34.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
1.1 11.8 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.0 9.1 GO:0030321 transepithelial chloride transport(GO:0030321)
1.0 3.0 GO:0090673 endothelial cell-matrix adhesion(GO:0090673)
1.0 8.0 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.0 7.0 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
1.0 5.9 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
1.0 2.9 GO:1903904 negative regulation of establishment of T cell polarity(GO:1903904)
0.9 4.7 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.9 33.1 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.9 10.0 GO:0035878 nail development(GO:0035878)
0.9 2.7 GO:0046203 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612) spermidine catabolic process(GO:0046203)
0.9 1.8 GO:0002649 regulation of tolerance induction to self antigen(GO:0002649)
0.9 5.2 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.9 2.6 GO:0032066 nucleolus to nucleoplasm transport(GO:0032066)
0.8 4.2 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.8 5.0 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.8 4.9 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.7 6.0 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.7 2.8 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.7 2.8 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.7 12.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.7 4.1 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
0.7 5.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.7 3.4 GO:0042631 cellular response to water deprivation(GO:0042631)
0.7 5.4 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.7 9.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854) positive regulation of macrophage differentiation(GO:0045651)
0.6 2.5 GO:1904579 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.6 5.5 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.6 14.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.6 8.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.6 3.3 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.5 36.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.5 23.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.5 12.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.5 8.9 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.5 4.7 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.5 1.6 GO:0006393 termination of mitochondrial transcription(GO:0006393)
0.5 1.5 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.5 9.6 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.5 2.0 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.5 15.0 GO:0050832 defense response to fungus(GO:0050832)
0.5 1.9 GO:0002266 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.5 8.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.4 6.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.4 2.2 GO:0097309 cap1 mRNA methylation(GO:0097309)
0.4 3.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.4 11.2 GO:0003417 growth plate cartilage development(GO:0003417)
0.4 2.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.4 8.9 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.4 9.6 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.4 10.3 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.4 11.7 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.4 4.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.4 4.5 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.4 9.5 GO:0010447 response to acidic pH(GO:0010447)
0.4 2.6 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.4 2.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.4 2.5 GO:0051013 microtubule severing(GO:0051013)
0.4 2.8 GO:0071763 nuclear membrane organization(GO:0071763)
0.3 1.0 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
0.3 8.3 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.3 1.0 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.3 6.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 4.8 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.3 7.3 GO:0021895 cerebral cortex neuron differentiation(GO:0021895)
0.3 5.7 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.3 13.7 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.3 6.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.3 1.5 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.3 4.3 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.3 16.1 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.3 1.9 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.3 13.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.3 3.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.2 2.7 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 3.2 GO:0051014 actin filament severing(GO:0051014)
0.2 10.7 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.2 0.9 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.2 2.4 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 2.1 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.2 0.9 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.2 9.7 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 2.0 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.2 1.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 0.7 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.2 2.5 GO:0035330 regulation of hippo signaling(GO:0035330)
0.2 2.4 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.2 2.8 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 2.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 0.7 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.2 31.8 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.2 2.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 3.6 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 0.6 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 16.3 GO:0051289 protein homotetramerization(GO:0051289)
0.1 1.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 4.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 2.2 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 4.2 GO:0034508 centromere complex assembly(GO:0034508)
0.1 0.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 2.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.4 GO:0060988 lipid tube assembly(GO:0060988)
0.1 0.9 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.1 14.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.6 GO:0000469 cleavage involved in rRNA processing(GO:0000469)
0.1 5.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 5.3 GO:0042255 ribosome assembly(GO:0042255)
0.1 0.8 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.1 8.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 2.7 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 0.7 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 0.4 GO:0045359 positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 1.4 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.1 0.8 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.1 1.6 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 18.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 2.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 3.4 GO:0032272 negative regulation of protein polymerization(GO:0032272)
0.0 4.5 GO:0000956 nuclear-transcribed mRNA catabolic process(GO:0000956)
0.0 0.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.1 GO:0030033 microvillus assembly(GO:0030033)
0.0 4.7 GO:0035305 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0 1.6 GO:0010107 potassium ion import(GO:0010107)
0.0 6.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.3 GO:0071231 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.0 0.4 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.0 1.3 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 5.6 GO:0051607 defense response to virus(GO:0051607)
0.0 0.7 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 9.5 GO:0006397 mRNA processing(GO:0006397)
0.0 1.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 2.5 GO:0050821 protein stabilization(GO:0050821)
0.0 1.1 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.0 0.4 GO:0045026 plasma membrane fusion(GO:0045026)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 0.4 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 127.1 GO:0043020 NADPH oxidase complex(GO:0043020)
5.3 90.9 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
4.7 74.9 GO:0042555 MCM complex(GO:0042555)
3.2 22.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
3.0 74.0 GO:0032426 stereocilium tip(GO:0032426)
2.6 34.3 GO:0005818 aster(GO:0005818)
2.4 17.0 GO:0097443 sorting endosome(GO:0097443)
2.1 37.3 GO:0042581 specific granule(GO:0042581)
1.9 17.1 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
1.8 21.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.7 20.0 GO:0008278 cohesin complex(GO:0008278)
1.6 17.9 GO:0097451 glial limiting end-foot(GO:0097451)
1.3 10.3 GO:0005833 hemoglobin complex(GO:0005833)
1.3 8.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.2 13.4 GO:0042101 T cell receptor complex(GO:0042101)
1.1 11.3 GO:0097342 ripoptosome(GO:0097342)
1.1 4.5 GO:0008275 gamma-tubulin small complex(GO:0008275)
1.1 5.3 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
1.0 15.3 GO:0031209 SCAR complex(GO:0031209)
1.0 31.4 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
1.0 56.4 GO:0001772 immunological synapse(GO:0001772)
1.0 4.9 GO:0000938 GARP complex(GO:0000938) EARP complex(GO:1990745)
0.9 3.7 GO:0032021 NELF complex(GO:0032021)
0.9 29.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.9 29.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.9 7.0 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.8 2.5 GO:0070985 TFIIK complex(GO:0070985)
0.8 35.1 GO:0051233 spindle midzone(GO:0051233)
0.7 2.9 GO:0060171 stereocilium membrane(GO:0060171)
0.7 18.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.6 38.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.6 2.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.6 12.7 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.6 9.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.6 24.5 GO:0008305 integrin complex(GO:0008305)
0.6 7.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.6 3.4 GO:0036019 endolysosome(GO:0036019)
0.6 9.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.5 12.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.5 2.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.5 8.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.5 5.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.5 2.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.4 3.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.4 15.8 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4 5.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.4 1.9 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.4 29.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 2.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.4 4.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.4 2.8 GO:0033263 CORVET complex(GO:0033263)
0.3 24.2 GO:0005871 kinesin complex(GO:0005871)
0.3 6.1 GO:0097539 ciliary transition fiber(GO:0097539)
0.3 15.7 GO:0097440 apical dendrite(GO:0097440)
0.3 1.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.3 12.2 GO:0002102 podosome(GO:0002102)
0.3 2.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.3 4.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 9.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 5.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 9.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 7.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 1.9 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 2.2 GO:0034709 methylosome(GO:0034709)
0.2 1.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 12.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 99.2 GO:0031012 extracellular matrix(GO:0031012)
0.2 19.1 GO:0005581 collagen trimer(GO:0005581)
0.2 8.2 GO:0035861 site of double-strand break(GO:0035861)
0.2 2.3 GO:0005916 fascia adherens(GO:0005916)
0.2 3.4 GO:0046930 pore complex(GO:0046930)
0.2 3.4 GO:0031011 Ino80 complex(GO:0031011)
0.1 49.4 GO:0031965 nuclear membrane(GO:0031965)
0.1 2.1 GO:0005686 U2 snRNP(GO:0005686)
0.1 18.3 GO:0030863 cortical cytoskeleton(GO:0030863)
0.1 2.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 16.2 GO:0030175 filopodium(GO:0030175)
0.1 23.4 GO:0001726 ruffle(GO:0001726)
0.1 9.3 GO:0016459 myosin complex(GO:0016459)
0.1 23.8 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 1.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.9 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 13.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 10.0 GO:0030315 T-tubule(GO:0030315)
0.1 3.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 2.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 8.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 7.7 GO:0016363 nuclear matrix(GO:0016363)
0.1 0.6 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 6.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.5 GO:0030904 retromer complex(GO:0030904)
0.1 3.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 13.7 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 10.6 GO:0001650 fibrillar center(GO:0001650)
0.1 1.5 GO:0042588 zymogen granule(GO:0042588)
0.1 0.9 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 4.7 GO:0005795 Golgi stack(GO:0005795)
0.1 5.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 13.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.9 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 14.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 10.4 GO:0009986 cell surface(GO:0009986)
0.0 43.8 GO:0005615 extracellular space(GO:0005615)
0.0 1.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 14.9 GO:0005911 cell-cell junction(GO:0005911)
0.0 9.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 5.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.6 GO:0030686 90S preribosome(GO:0030686)
0.0 37.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.4 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 3.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.1 GO:0005819 spindle(GO:0005819)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 1.1 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.3 GO:0055037 recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.2 101.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
9.8 49.0 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
6.8 87.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
4.6 13.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
3.9 39.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
3.8 34.3 GO:0061676 importin-alpha family protein binding(GO:0061676)
3.6 25.1 GO:0001851 complement component C3b binding(GO:0001851)
3.5 74.0 GO:0032036 myosin heavy chain binding(GO:0032036)
3.0 42.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
2.9 8.8 GO:0003896 DNA primase activity(GO:0003896)
2.5 10.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
2.4 7.3 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
2.3 9.1 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
2.1 17.2 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312) PTB domain binding(GO:0051425)
1.9 13.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
1.8 7.3 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
1.8 25.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.8 14.2 GO:0005499 vitamin D binding(GO:0005499)
1.7 21.6 GO:0003796 lysozyme activity(GO:0003796)
1.6 21.1 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
1.6 11.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
1.6 4.7 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
1.5 1.5 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
1.5 6.2 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
1.4 13.0 GO:0019966 interleukin-1 binding(GO:0019966)
1.4 10.1 GO:0004920 interleukin-10 receptor activity(GO:0004920)
1.3 12.1 GO:0034711 inhibin binding(GO:0034711)
1.3 9.4 GO:0004849 uridine kinase activity(GO:0004849)
1.3 57.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.3 20.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
1.2 3.6 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
1.2 3.6 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
1.1 10.3 GO:0005344 oxygen transporter activity(GO:0005344)
1.1 76.9 GO:0004601 peroxidase activity(GO:0004601)
1.0 3.1 GO:0030622 U4atac snRNA binding(GO:0030622)
1.0 16.3 GO:0005522 profilin binding(GO:0005522)
1.0 3.0 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.0 5.9 GO:0045322 unmethylated CpG binding(GO:0045322)
0.9 7.4 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.9 11.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.9 1.8 GO:0030621 U4 snRNA binding(GO:0030621)
0.9 10.5 GO:0071253 connexin binding(GO:0071253)
0.9 3.5 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.9 17.1 GO:0015643 toxic substance binding(GO:0015643)
0.9 18.8 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.8 9.0 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.7 5.0 GO:0089720 caspase binding(GO:0089720)
0.7 7.8 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleotide transmembrane transporter activity(GO:0015216)
0.7 25.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 7.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.7 2.6 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.7 5.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.6 8.1 GO:0030274 LIM domain binding(GO:0030274)
0.6 8.9 GO:0031432 titin binding(GO:0031432)
0.6 1.8 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.6 1.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.6 8.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.5 1.6 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.5 2.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.5 2.6 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.5 18.5 GO:0043394 proteoglycan binding(GO:0043394)
0.5 8.8 GO:0008301 DNA binding, bending(GO:0008301)
0.5 10.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 1.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.4 2.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.4 4.2 GO:0051434 BH3 domain binding(GO:0051434)
0.4 6.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 2.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.4 7.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.4 40.5 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.4 8.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 10.3 GO:0097602 cullin family protein binding(GO:0097602)
0.4 2.2 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.4 16.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 4.1 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.3 3.4 GO:0015288 porin activity(GO:0015288)
0.3 72.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 13.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 2.7 GO:0016936 galactoside binding(GO:0016936)
0.3 12.4 GO:0003785 actin monomer binding(GO:0003785)
0.3 2.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 17.1 GO:0070063 RNA polymerase binding(GO:0070063)
0.3 2.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 19.9 GO:0019843 rRNA binding(GO:0019843)
0.3 18.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) ATP-dependent helicase activity(GO:0008026) RNA-dependent ATPase activity(GO:0008186) purine NTP-dependent helicase activity(GO:0070035)
0.3 8.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3 14.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 15.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 15.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 4.8 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.2 0.7 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.2 14.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 4.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.2 10.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 14.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 33.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 8.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 16.3 GO:0004386 helicase activity(GO:0004386)
0.2 68.7 GO:0005096 GTPase activator activity(GO:0005096)
0.2 2.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 2.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 1.0 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.2 2.5 GO:0051400 BH domain binding(GO:0051400)
0.2 0.5 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.1 2.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 0.6 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.1 18.4 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 5.7 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.8 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 5.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 4.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 1.4 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 14.0 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 13.7 GO:0051087 chaperone binding(GO:0051087)
0.1 13.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 2.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 15.6 GO:0005178 integrin binding(GO:0005178)
0.1 10.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 21.8 GO:0005125 cytokine activity(GO:0005125)
0.1 2.9 GO:0032183 SUMO binding(GO:0032183)
0.1 0.9 GO:0017166 vinculin binding(GO:0017166)
0.1 2.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 10.0 GO:0019905 syntaxin binding(GO:0019905)
0.1 5.5 GO:0019894 kinesin binding(GO:0019894)
0.1 2.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 8.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.9 GO:0070840 dynein complex binding(GO:0070840)
0.1 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.3 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 1.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.5 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 6.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 2.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 4.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.1 GO:0016208 AMP binding(GO:0016208)
0.1 41.4 GO:0003682 chromatin binding(GO:0003682)
0.0 19.6 GO:0045296 cadherin binding(GO:0045296)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 3.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 3.2 GO:0042393 histone binding(GO:0042393)
0.0 1.1 GO:0071949 FAD binding(GO:0071949)
0.0 5.2 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.3 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 10.5 GO:0003779 actin binding(GO:0003779)
0.0 2.1 GO:0030674 protein binding, bridging(GO:0030674)
0.0 35.5 GO:0003723 RNA binding(GO:0003723)
0.0 2.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 11.8 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 110.7 PID ATR PATHWAY ATR signaling pathway
1.4 23.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
1.4 85.6 PID IL23 PATHWAY IL23-mediated signaling events
1.1 122.1 PID RHOA REG PATHWAY Regulation of RhoA activity
1.1 90.3 PID RAC1 PATHWAY RAC1 signaling pathway
1.1 52.8 PID EPO PATHWAY EPO signaling pathway
1.0 24.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.7 34.6 PID AURORA A PATHWAY Aurora A signaling
0.7 25.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.6 18.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.5 25.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.5 9.9 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.4 58.3 PID CMYB PATHWAY C-MYB transcription factor network
0.4 2.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 6.1 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.4 21.8 PID LKB1 PATHWAY LKB1 signaling events
0.4 8.1 PID NECTIN PATHWAY Nectin adhesion pathway
0.4 16.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.4 12.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.3 9.7 PID IL1 PATHWAY IL1-mediated signaling events
0.3 7.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 4.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.2 16.2 PID E2F PATHWAY E2F transcription factor network
0.2 4.1 PID ARF 3PATHWAY Arf1 pathway
0.2 22.9 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 45.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 7.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 1.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 5.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 4.1 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 2.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 15.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.4 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 1.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 14.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 PID BCR 5PATHWAY BCR signaling pathway
0.0 3.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 2.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 74.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
3.9 11.7 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
2.5 19.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
2.0 98.2 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.7 25.8 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.5 21.6 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
1.3 18.8 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
1.1 16.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
1.0 3.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.0 33.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.8 25.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.7 23.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.7 24.0 REACTOME KINESINS Genes involved in Kinesins
0.7 155.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.7 8.8 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.6 42.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.6 40.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.5 13.1 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.5 11.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.5 6.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.5 8.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.5 13.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.5 23.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 19.8 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.4 8.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.4 11.4 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.4 20.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.4 13.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.4 17.7 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.4 29.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.4 2.6 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.4 3.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.4 7.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.4 9.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.3 25.1 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.3 7.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.3 9.0 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.3 14.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 4.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3 12.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.3 9.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.2 26.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 4.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 4.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 4.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 2.9 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.2 6.0 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 5.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.8 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 12.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 2.7 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 0.9 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 6.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 9.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.1 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.1 17.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 1.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 2.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 3.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.6 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 2.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.7 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 2.6 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 1.2 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 1.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex