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GSE58827: Dynamics of the Mouse Liver

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Results for Srf

Z-value: 1.22

Motif logo

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Transcription factors associated with Srf

Gene Symbol Gene ID Gene Info
Srf
ENSMUSG00000015605.7 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Srfmm39_v1_chr17_-_46867083_468671140.634.0e-05Click!

Activity profile of Srf motif

Sorted Z-values of Srf motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_142215027 27.22 ENSMUST00000105936.8
Igf2
insulin-like growth factor 2
chr7_-_142215595 10.27 ENSMUST00000145896.3
Igf2
insulin-like growth factor 2
chr8_-_124621483 9.43 ENSMUST00000034453.6
ENSMUST00000212584.2
Acta1
actin, alpha 1, skeletal muscle
chr4_-_119047202 8.94 ENSMUST00000239029.2
ENSMUST00000138395.9
ENSMUST00000156746.3
Ermap
erythroblast membrane-associated protein
chr10_-_111833138 8.85 ENSMUST00000074805.12
Glipr1
GLI pathogenesis-related 1 (glioma)
chr4_+_43957401 8.63 ENSMUST00000030202.14
Glipr2
GLI pathogenesis-related 2
chr6_-_83513222 7.84 ENSMUST00000075161.12
Actg2
actin, gamma 2, smooth muscle, enteric
chr4_-_119047167 7.50 ENSMUST00000030396.15
Ermap
erythroblast membrane-associated protein
chr4_+_43957677 7.38 ENSMUST00000107855.2
Glipr2
GLI pathogenesis-related 2
chr2_-_113883285 6.46 ENSMUST00000090269.7
Actc1
actin, alpha, cardiac muscle 1
chr10_+_79824418 6.00 ENSMUST00000004784.11
ENSMUST00000105374.2
Cnn2
calponin 2
chr2_+_156617329 5.58 ENSMUST00000088552.7
Myl9
myosin, light polypeptide 9, regulatory
chr4_-_119047180 5.23 ENSMUST00000150864.3
ENSMUST00000141227.9
Ermap
erythroblast membrane-associated protein
chr11_-_120239339 5.21 ENSMUST00000071555.13
Actg1
actin, gamma, cytoplasmic 1
chr11_-_120239301 5.11 ENSMUST00000062147.14
ENSMUST00000128055.2
Actg1
actin, gamma, cytoplasmic 1
chr6_-_83513184 5.08 ENSMUST00000205926.2
Actg2
actin, gamma 2, smooth muscle, enteric
chr1_-_33796790 4.86 ENSMUST00000187602.2
ENSMUST00000044691.9
Bag2
BCL2-associated athanogene 2
chr7_+_3341597 4.35 ENSMUST00000164553.8
Myadm
myeloid-associated differentiation marker
chr2_+_154390808 4.16 ENSMUST00000045116.11
ENSMUST00000109709.4
1700003F12Rik
RIKEN cDNA 1700003F12 gene
chr5_-_100720063 4.14 ENSMUST00000031264.12
Plac8
placenta-specific 8
chr2_+_127178072 3.95 ENSMUST00000028846.7
Dusp2
dual specificity phosphatase 2
chr11_-_120238917 3.83 ENSMUST00000106215.11
Actg1
actin, gamma, cytoplasmic 1
chr2_-_152256947 3.72 ENSMUST00000099207.5
Zcchc3
zinc finger, CCHC domain containing 3
chr7_+_127846121 3.62 ENSMUST00000167965.8
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr4_-_132078947 3.60 ENSMUST00000105951.8
Rcc1
regulator of chromosome condensation 1
chr9_+_72952115 3.53 ENSMUST00000184146.8
ENSMUST00000034722.5
Rab27a
RAB27A, member RAS oncogene family
chr7_+_127845984 3.47 ENSMUST00000164710.8
ENSMUST00000070656.12
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr7_+_19144950 3.20 ENSMUST00000208710.2
ENSMUST00000003643.3
Ckm
creatine kinase, muscle
chr2_+_124910037 3.14 ENSMUST00000070353.4
Slc24a5
solute carrier family 24, member 5
chr2_+_150628655 3.14 ENSMUST00000045441.8
Pygb
brain glycogen phosphorylase
chr1_-_43203051 3.02 ENSMUST00000008280.14
Fhl2
four and a half LIM domains 2
chr4_-_116228921 2.99 ENSMUST00000239239.2
ENSMUST00000239177.2
Mast2
microtubule associated serine/threonine kinase 2
chr17_-_57501170 2.95 ENSMUST00000005976.8
Tnfsf14
tumor necrosis factor (ligand) superfamily, member 14
chrX_+_100492684 2.79 ENSMUST00000033674.6
Itgb1bp2
integrin beta 1 binding protein 2
chr19_+_53517528 2.39 ENSMUST00000038287.7
Dusp5
dual specificity phosphatase 5
chr19_-_5962798 2.37 ENSMUST00000118623.2
Dpf2
D4, zinc and double PHD fingers family 2
chr19_-_5962862 2.35 ENSMUST00000136983.8
Dpf2
D4, zinc and double PHD fingers family 2
chr11_-_99383938 2.34 ENSMUST00000006969.8
Krt23
keratin 23
chr7_+_101545547 2.12 ENSMUST00000035395.14
ENSMUST00000106973.8
ENSMUST00000144207.9
Anapc15
anaphase promoting complex C subunit 15
chr3_+_89979948 2.10 ENSMUST00000121503.8
ENSMUST00000119570.8
Tpm3
tropomyosin 3, gamma
chr3_+_134918298 2.06 ENSMUST00000062893.12
Cenpe
centromere protein E
chr11_-_5848771 1.95 ENSMUST00000102921.4
Myl7
myosin, light polypeptide 7, regulatory
chr18_+_34994253 1.91 ENSMUST00000165033.2
Egr1
early growth response 1
chr1_+_74448535 1.88 ENSMUST00000027366.13
Vil1
villin 1
chr12_-_103322226 1.86 ENSMUST00000021617.14
Asb2
ankyrin repeat and SOCS box-containing 2
chr5_+_103902020 1.82 ENSMUST00000054979.10
Aff1
AF4/FMR2 family, member 1
chr17_+_8144822 1.72 ENSMUST00000036370.8
Tagap
T cell activation Rho GTPase activating protein
chr7_+_101546059 1.70 ENSMUST00000143835.8
Anapc15
anaphase promoting complex C subunit 15
chr17_-_46464441 1.69 ENSMUST00000171172.3
Mad2l1bp
MAD2L1 binding protein
chr6_-_36787096 1.67 ENSMUST00000201321.2
ENSMUST00000101534.5
Ptn
pleiotrophin
chr2_-_13276074 1.65 ENSMUST00000137670.3
ENSMUST00000114791.9
Rsu1
Ras suppressor protein 1
chr2_-_13276205 1.64 ENSMUST00000191959.6
ENSMUST00000028059.9
Rsu1
Ras suppressor protein 1
chr5_-_134581235 1.58 ENSMUST00000036999.10
ENSMUST00000100647.7
Clip2
CAP-GLY domain containing linker protein 2
chr15_-_77726333 1.49 ENSMUST00000016771.13
Myh9
myosin, heavy polypeptide 9, non-muscle
chr10_+_4216353 1.44 ENSMUST00000045730.7
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr2_+_164782642 1.43 ENSMUST00000137626.2
Mmp9
matrix metallopeptidase 9
chr6_+_42326528 1.42 ENSMUST00000203329.3
Zyx
zyxin
chr9_+_110592709 1.41 ENSMUST00000079784.12
Myl3
myosin, light polypeptide 3
chr6_+_136509922 1.39 ENSMUST00000187429.4
Atf7ip
activating transcription factor 7 interacting protein
chr15_-_36794741 1.26 ENSMUST00000110361.8
ENSMUST00000022894.14
ENSMUST00000110359.2
Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_+_18865610 1.18 ENSMUST00000165913.2
Fbxo46
F-box protein 46
chr8_+_15107646 1.17 ENSMUST00000033842.4
Myom2
myomesin 2
chr15_+_102427149 1.14 ENSMUST00000146756.8
ENSMUST00000142194.3
Tarbp2
TARBP2, RISC loading complex RNA binding subunit
chr9_+_75213570 1.11 ENSMUST00000213990.2
Gnb5
guanine nucleotide binding protein (G protein), beta 5
chr16_-_4698148 1.10 ENSMUST00000037843.7
Ubald1
UBA-like domain containing 1
chr17_+_24022153 1.09 ENSMUST00000190686.7
ENSMUST00000088621.11
ENSMUST00000233636.2
Srrm2
serine/arginine repetitive matrix 2
chr12_+_108389075 1.08 ENSMUST00000109860.8
Eml1
echinoderm microtubule associated protein like 1
chr6_+_17306334 0.98 ENSMUST00000007799.13
ENSMUST00000115456.6
Cav1
caveolin 1, caveolae protein
chr13_+_23930717 0.95 ENSMUST00000099703.5
H2bc3
H2B clustered histone 3
chr7_-_101859379 0.92 ENSMUST00000210682.2
Nup98
nucleoporin 98
chr12_+_85520652 0.92 ENSMUST00000021674.7
Fos
FBJ osteosarcoma oncogene
chr17_+_5991555 0.91 ENSMUST00000115791.10
ENSMUST00000080283.13
Synj2
synaptojanin 2
chr14_-_34310602 0.91 ENSMUST00000064098.14
ENSMUST00000090040.12
ENSMUST00000022330.9
ENSMUST00000022327.13
Ldb3
LIM domain binding 3
chr4_+_19280850 0.85 ENSMUST00000102999.2
Cngb3
cyclic nucleotide gated channel beta 3
chr9_-_58220469 0.80 ENSMUST00000061799.10
Loxl1
lysyl oxidase-like 1
chr4_-_141327146 0.79 ENSMUST00000141518.8
ENSMUST00000127455.8
ENSMUST00000105784.8
Fblim1
filamin binding LIM protein 1
chr14_+_20979466 0.74 ENSMUST00000022369.9
Vcl
vinculin
chr6_-_113354337 0.73 ENSMUST00000043333.9
Tada3
transcriptional adaptor 3
chr1_-_127605660 0.71 ENSMUST00000160616.8
Tmem163
transmembrane protein 163
chr7_-_101859308 0.67 ENSMUST00000070165.7
ENSMUST00000211235.2
ENSMUST00000211022.2
Nup98
nucleoporin 98
chr14_-_34310637 0.66 ENSMUST00000227819.2
Ldb3
LIM domain binding 3
chr18_+_13107535 0.65 ENSMUST00000234035.2
ENSMUST00000235053.2
Impact
impact, RWD domain protein
chr11_+_101221431 0.65 ENSMUST00000103105.10
Aoc3
amine oxidase, copper containing 3
chr6_+_113355076 0.65 ENSMUST00000156898.5
ENSMUST00000203578.3
ENSMUST00000171058.8
Arpc4
actin related protein 2/3 complex, subunit 4
chr5_-_148336574 0.62 ENSMUST00000202457.4
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr15_+_84926909 0.52 ENSMUST00000229203.2
Fam118a
family with sequence similarity 118, member A
chr5_-_113044216 0.50 ENSMUST00000086617.11
Myo18b
myosin XVIIIb
chr10_+_32959472 0.43 ENSMUST00000095762.5
ENSMUST00000218281.2
ENSMUST00000217779.2
ENSMUST00000219665.2
ENSMUST00000219931.2
Trdn
triadin
chr3_+_106020545 0.42 ENSMUST00000079132.12
ENSMUST00000139086.2
Chia1
chitinase, acidic 1
chr17_-_46867083 0.40 ENSMUST00000015749.7
Srf
serum response factor
chr16_+_57369595 0.38 ENSMUST00000159414.2
Filip1l
filamin A interacting protein 1-like
chr11_+_82802079 0.36 ENSMUST00000018989.14
ENSMUST00000164945.3
Unc45b
unc-45 myosin chaperone B
chr6_-_97156032 0.31 ENSMUST00000095664.6
Tmf1
TATA element modulatory factor 1
chr4_-_122779837 0.30 ENSMUST00000106255.8
ENSMUST00000106257.10
Cap1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr2_-_127363251 0.29 ENSMUST00000028850.15
ENSMUST00000103215.11
Kcnip3
Kv channel interacting protein 3, calsenilin
chr19_+_12655487 0.25 ENSMUST00000215134.2
ENSMUST00000049724.8
Olfr1443
olfactory receptor 1443
chr17_+_28259749 0.24 ENSMUST00000233869.2
Anks1
ankyrin repeat and SAM domain containing 1
chr15_+_39255185 0.22 ENSMUST00000228839.2
Rims2
regulating synaptic membrane exocytosis 2
chr9_+_74959259 0.22 ENSMUST00000170310.2
ENSMUST00000166549.2
Arpp19
cAMP-regulated phosphoprotein 19
chr10_+_90412827 0.21 ENSMUST00000182550.8
ENSMUST00000099364.12
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr4_-_43025792 0.17 ENSMUST00000067481.6
Pigo
phosphatidylinositol glycan anchor biosynthesis, class O
chr7_-_101859033 0.16 ENSMUST00000211005.2
Nup98
nucleoporin 98
chr6_-_113354468 0.15 ENSMUST00000099118.8
Tada3
transcriptional adaptor 3
chr6_+_87350292 0.15 ENSMUST00000032128.6
Gkn2
gastrokine 2
chr4_-_43025756 0.14 ENSMUST00000098109.9
Pigo
phosphatidylinositol glycan anchor biosynthesis, class O
chr14_-_34310438 0.14 ENSMUST00000228044.2
ENSMUST00000022328.14
Ldb3
LIM domain binding 3
chr6_-_68840015 0.13 ENSMUST00000103336.2
Igkv1-88
immunoglobulin kappa chain variable 1-88
chr7_-_119319965 0.12 ENSMUST00000033236.9
Thumpd1
THUMP domain containing 1
chr11_+_19874354 0.10 ENSMUST00000093299.13
Spred2
sprouty-related EVH1 domain containing 2
chr13_-_103094784 0.10 ENSMUST00000172264.8
ENSMUST00000099202.10
Mast4
microtubule associated serine/threonine kinase family member 4
chr13_+_109397184 0.08 ENSMUST00000153234.8
Pde4d
phosphodiesterase 4D, cAMP specific
chr3_+_68375495 0.07 ENSMUST00000182532.8
Schip1
schwannomin interacting protein 1
chr15_+_11000802 0.03 ENSMUST00000117100.4
Slc45a2
solute carrier family 45, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Srf

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 37.5 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
1.6 15.9 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
1.2 3.5 GO:1903433 regulation of constitutive secretory pathway(GO:1903433)
1.0 2.9 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.8 3.1 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.7 7.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.6 1.9 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.5 4.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.5 2.1 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.5 1.4 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.5 1.9 GO:1902896 terminal web assembly(GO:1902896)
0.4 1.7 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.4 1.5 GO:1903921 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.4 1.8 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.2 2.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.2 3.8 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.2 6.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.2 3.0 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.2 1.3 GO:0090168 Golgi reassembly(GO:0090168)
0.2 14.1 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.2 1.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.2 15.6 GO:0045214 sarcomere organization(GO:0045214)
0.2 0.5 GO:0072755 cellular response to benomyl(GO:0072755) response to benomyl(GO:1901561)
0.2 1.0 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.1 2.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 3.6 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.1 4.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 1.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.3 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
0.1 1.7 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 3.6 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 3.9 GO:0001706 endoderm formation(GO:0001706)
0.1 0.4 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 6.3 GO:0070527 platelet aggregation(GO:0070527)
0.1 1.1 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 1.4 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 1.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.9 GO:0046855 inositol phosphate dephosphorylation(GO:0046855) intracellular distribution of mitochondria(GO:0048312)
0.0 0.5 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.9 GO:0035994 response to muscle stretch(GO:0035994)
0.0 3.3 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 3.2 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.0 0.6 GO:0015809 arginine transport(GO:0015809)
0.0 0.6 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.7 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.2 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 4.7 GO:0006457 protein folding(GO:0006457)
0.0 1.1 GO:0007405 neuroblast proliferation(GO:0007405)
0.0 0.2 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) positive regulation of inhibitory postsynaptic potential(GO:0097151) spontaneous synaptic transmission(GO:0098814)
0.0 0.7 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0042643 actomyosin, actin portion(GO:0042643)
0.4 3.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.4 1.8 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.3 1.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 14.9 GO:0043034 costamere(GO:0043034)
0.2 1.5 GO:0097513 myosin II filament(GO:0097513)
0.2 11.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 0.9 GO:0035976 AP1 complex(GO:0035976)
0.2 5.1 GO:0016460 myosin II complex(GO:0016460)
0.1 2.1 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 3.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 4.7 GO:0090544 BAF-type complex(GO:0090544)
0.1 0.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 5.4 GO:0031672 A band(GO:0031672)
0.1 1.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068) RISC-loading complex(GO:0070578)
0.1 1.6 GO:0042599 lamellar body(GO:0042599)
0.1 1.9 GO:0032433 filopodium tip(GO:0032433)
0.1 0.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 1.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 1.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.5 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 16.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.7 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 9.2 GO:0031965 nuclear membrane(GO:0031965)
0.0 6.9 GO:0072562 blood microparticle(GO:0072562)
0.0 2.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.3 GO:0005882 intermediate filament(GO:0005882)
0.0 42.5 GO:0005615 extracellular space(GO:0005615)
0.0 3.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 9.3 GO:0005925 focal adhesion(GO:0005925)
0.0 2.1 GO:0001726 ruffle(GO:0001726)
0.0 17.1 GO:0031410 cytoplasmic vesicle(GO:0031410)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.1 GO:0048495 Roundabout binding(GO:0048495)
0.8 37.5 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.8 3.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.5 3.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.5 3.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.5 3.2 GO:0004111 creatine kinase activity(GO:0004111)
0.4 4.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 1.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.4 6.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 2.1 GO:0043515 kinetochore binding(GO:0043515)
0.3 1.9 GO:0044729 double-stranded methylated DNA binding(GO:0010385) hemi-methylated DNA-binding(GO:0044729)
0.3 5.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 1.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.2 0.7 GO:0052594 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.2 1.0 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.2 1.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 0.9 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.1 10.0 GO:0017022 myosin binding(GO:0017022)
0.1 2.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 13.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.5 GO:0043495 protein anchor(GO:0043495)
0.1 0.3 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 1.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.9 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.1 0.6 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 2.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.7 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 2.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0004568 chitinase activity(GO:0004568)
0.0 1.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.8 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 1.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.6 GO:0031005 filamin binding(GO:0031005)
0.0 0.4 GO:0070878 primary miRNA binding(GO:0070878)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 2.6 GO:0005178 integrin binding(GO:0005178)
0.0 4.1 GO:0008017 microtubule binding(GO:0008017)
0.0 5.1 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 27.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.4 37.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 11.5 PID RHOA PATHWAY RhoA signaling pathway
0.1 1.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 6.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 8.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 2.0 PID CONE PATHWAY Visual signal transduction: Cones
0.1 1.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 1.4 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 3.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.0 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 2.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 2.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 37.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 21.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 3.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 3.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 0.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 9.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.3 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.1 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 1.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 3.6 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 2.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 3.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)